DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:198904-31-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:198904-31-3
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to almost white crystalline powder Storage:-20°C Freeze
Cas:198904-31-3
Min.Order:100 Gram
FOB Price: $1.2 / 2.9
Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:198904-31-3
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:198904-31-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:198904-31-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:198904-31-3
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:198904-31-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryName:Atazanavir CAS: 198904-31-3 Molecular Formula:C38H52N6O7 Property: white powder Assay: 99% A
Cas:198904-31-3
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:198904-31-3
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:198904-31-3
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:198904-31-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAtazanavir CAS:198904-31-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:198904-31-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:198904-31-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:198904-31-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:198904-31-3
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:198904-31-3
Min.Order:200 Milligram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:198904-31-3
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:198904-31-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:198904-31-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:198904-31-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:198904-31-3
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryC14H18N4O4
atazanavir
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate In water at 5 - 40℃; | 100% |
{(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
atazanavir
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane | 95% |
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate In water at 5 - 40℃; for 1.5 - 2h; | 95% |
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
atazanavir
Conditions | Yield |
---|---|
With pyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate at 35℃; for 1.5h; Temperature; Concentration; | 91.6% |
(S)-{2,2-dimethyl-1-[N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester
methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate
atazanavir
Conditions | Yield |
---|---|
In dichloromethane for 64h; Silica gel; | 87% |
silica gel In dichloromethane for 64h; | 87% |
In isopropyl alcohol at 90℃; for 12h; |
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
atazanavir
Conditions | Yield |
---|---|
With 4-methyl-morpholine; diisopropyl-carbodiimide In dichloromethane; isopropyl alcohol at -10 - 20℃; Product distribution / selectivity; Inert atmosphere; | 84% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 22 - 25℃; Reagent/catalyst; Large scale; | 82.1% |
With O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight; Yield given. Multistep reaction; |
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane
atazanavir
Conditions | Yield |
---|---|
Stage #1: (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid With thionyl chloride; triethylamine In dichloromethane at 42℃; for 3h; Stage #2: 1-[4-(pyridine-2-yl)phenyl]-(5S)-2,5-diamino-(4S)-hydroxy-6-phenyl-2-azahexane In dichloromethane at 20℃; Solvent; Temperature; Concentration; | 74.2% |
atazanavir
Conditions | Yield |
---|---|
With sodium tetrahydroborate In 2-methyltetrahydrofuran for 4h; Cooling with ice; | 70% |
With lithium tri-t-butoxyaluminum hydride In diethyl ether at 0℃; for 4h; diastereoselective reaction; | 39 g |
1-(4-(pyridin-2-yl)benzyl)hydrazine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 2: 25 percent / propan-2-ol / 24 h / Heating 3: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 4: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme |
(S)-{2,2-dimethyl-1-[N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 25 percent / propan-2-ol / 24 h / Heating 2: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 3: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 1.2: 0.25 h / 20 °C 2.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme |
{(1S,2S)-1-benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propyl}-carbamic acid tert-butyl ester
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 2: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme |
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 25 percent / propan-2-ol / 24 h / Heating 2: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 3: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme | |
Multi-step reaction with 3 steps 1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale 2: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme |
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 2: 25 percent / propan-2-ol / 24 h / Heating 3: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 4: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme | |
Multi-step reaction with 3 steps 1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 - 20 °C 2.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 2.2: 0.25 h / 20 °C 3.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0.5 h 1.2: 16 h 2.1: hydrogenchloride / tetrahydrofuran / 2 h / 20 °C 3.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere 3.2: 4 h / Inert atmosphere; Reflux 4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 12 h / 20 °C / 760.05 Torr 5.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 5.2: 0.25 h / 20 °C 6.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 - 25 °C 2: dipotassium hydrogenphosphate / water / 5 - 40 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 3: 25 percent / propan-2-ol / 24 h / Heating 4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 5: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme | |
Multi-step reaction with 3 steps 1: 69 percent / propan-2-ol / 16 h / Heating 2: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 3: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 3 steps 1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale 2: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme |
2-bromo-pyridine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol 4: 69 percent / propan-2-ol / 16 h / Heating 5: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 6: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 6 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale 5: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme |
2-(4-formylphenyl)pyridine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / ethanol / 4 h / Heating 2: 89 percent / H2 / 10percent Pd/C / methanol 3: 69 percent / propan-2-ol / 16 h / Heating 4: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 5: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 5 steps 1: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 2: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale 4: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere 1.2: 4 h / Inert atmosphere; Reflux 2.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 12 h / 20 °C / 760.05 Torr 3.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 3.2: 0.25 h / 20 °C 4.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme |
L-tert-Leucine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / 2N aq. NaOH / dioxane / 18 h / 60 °C 2: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water / 18 h / 60 °C 1.2: 25 °C 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 25 - 30 °C 2.2: 3 h View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydroxide / tetrahydrofuran / 60 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 - 20 °C 3.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 3.2: 0.25 h / 20 °C 4.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide / tetrahydrofuran / 60 °C 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / ethyl acetate / 0.5 h 2.2: 16 h 3.1: hydrogenchloride / tetrahydrofuran / 2 h / 20 °C 4.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere 4.2: 4 h / Inert atmosphere; Reflux 5.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 12 h / 20 °C / 760.05 Torr 6.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 6.2: 0.25 h / 20 °C 7.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme |
1,1-dimethoxy-1-(4-bromophenyl)methane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol 4: 69 percent / propan-2-ol / 16 h / Heating 5: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 6: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 6 steps 1.1: magnesium; iodine / tetrahydrofuran / 2 h / 20 °C / Heating 1.2: 2.25 h / 20 °C 2.1: hydrogenchloride / water; tetrahydrofuran / Cooling with ice 3.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere 3.2: 4 h / Inert atmosphere; Reflux 4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 12 h / 20 °C / 760.05 Torr 5.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 5.2: 0.25 h / 20 °C 6.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C View Scheme |
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89 percent / H2 / 10percent Pd/C / methanol 2: 69 percent / propan-2-ol / 16 h / Heating 3: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 4: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 2: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C 2: dipotassium hydrogenphosphate / water / 5 - 40 °C View Scheme |
atazanavir
Conditions | Yield |
---|---|
In ethanol; dichloromethane; water; ethyl acetate | |
In ethanol; dichloromethane; water; ethyl acetate |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 2.5h; |
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
atazanavir
Conditions | Yield |
---|---|
Stage #1: (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25 - 30℃; Stage #2: (2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane; water for 3h; Product distribution / selectivity; |
methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: water / 60 - 65 °C 2.1: hydrogenchloride; water / tetrahydrofuran / 6 h / 60 - 65 °C 3.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3.5 h / -5 - 15 °C / Inert atmosphere 3.2: 16 h / 10 - 35 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: water; dichloromethane / 40 - 65 °C 2.1: hydrogenchloride / tetrahydrofuran; water / 6 h / 60 - 65 °C 3.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / -5 - 20 °C / Inert atmosphere 3.2: 10 - 15 °C 3.3: 10 - 35 °C View Scheme |
1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-N-tert-butoxycarbonylamino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride; water / tetrahydrofuran / 6 h / 60 - 65 °C 2.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3.5 h / -5 - 15 °C / Inert atmosphere 2.2: 16 h / 10 - 35 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogenchloride / tetrahydrofuran; water / 6 h / 60 - 65 °C 2.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / -5 - 20 °C / Inert atmosphere 2.2: 10 - 15 °C 2.3: 10 - 35 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid With thionyl chloride; benzotriazol-1-ol; triethylamine In dichloromethane at -5 - 15℃; for 3.5h; Inert atmosphere; Stage #2: 1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-amino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane dihydrochioride With dipotassium hydrogenphosphate In dichloromethane; water at 10 - 35℃; for 16h; | |
Stage #1: (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid With thionyl chloride; benzotriazol-1-ol; triethylamine In dichloromethane at -5 - 20℃; Inert atmosphere; Stage #2: With dipotassium hydrogenphosphate In dichloromethane; water at 10 - 15℃; Stage #3: 1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-amino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane dihydrochioride In dichloromethane; water at 10 - 35℃; |
(2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: hydrogenchloride; water / tetrahydrofuran / 4 h / 50 - 55 °C 2.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere 2.2: 12 h / 30 - 35 °C 3.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 3 h / 0 - 10 °C 4.1: water / 60 - 65 °C 5.1: hydrogenchloride; water / tetrahydrofuran / 6 h / 60 - 65 °C 6.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3.5 h / -5 - 15 °C / Inert atmosphere 6.2: 16 h / 10 - 35 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: hydrogenchloride / tetrahydrofuran; water / 4 h / 50 - 55 °C 2.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere 2.2: 10 - 15 °C 2.3: 12 h / 30 - 35 °C 3.1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 3 h / 0 - 10 °C 4.1: water; dichloromethane / 40 - 65 °C 5.1: hydrogenchloride / tetrahydrofuran; water / 6 h / 60 - 65 °C 6.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / -5 - 20 °C / Inert atmosphere 6.2: 10 - 15 °C 6.3: 10 - 35 °C View Scheme |
(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere 1.2: 12 h / 30 - 35 °C 2.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 3 h / 0 - 10 °C 3.1: water / 60 - 65 °C 4.1: hydrogenchloride; water / tetrahydrofuran / 6 h / 60 - 65 °C 5.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3.5 h / -5 - 15 °C / Inert atmosphere 5.2: 16 h / 10 - 35 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere 1.2: 10 - 15 °C 1.3: 12 h / 30 - 35 °C 2.1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 3 h / 0 - 10 °C 3.1: water; dichloromethane / 40 - 65 °C 4.1: hydrogenchloride / tetrahydrofuran; water / 6 h / 60 - 65 °C 5.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / -5 - 20 °C / Inert atmosphere 5.2: 10 - 15 °C 5.3: 10 - 35 °C View Scheme |
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 3 h / 0 - 10 °C 2.1: water / 60 - 65 °C 3.1: hydrogenchloride; water / tetrahydrofuran / 6 h / 60 - 65 °C 4.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / 3.5 h / -5 - 15 °C / Inert atmosphere 4.2: 16 h / 10 - 35 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 3 h / 0 - 10 °C 2.1: water; dichloromethane / 40 - 65 °C 3.1: hydrogenchloride / tetrahydrofuran; water / 6 h / 60 - 65 °C 4.1: benzotriazol-1-ol; triethylamine; thionyl chloride / dichloromethane / -5 - 20 °C / Inert atmosphere 4.2: 10 - 15 °C 4.3: 10 - 35 °C View Scheme |
atazanavir
Conditions | Yield |
---|---|
With sulfuric acid In acetone at 0 - 50℃; for 2h; | 95% |
With sulfuric acid In ethanol at 20 - 30℃; Temperature; Concentration; | 95.2% |
With sulfuric acid; pyrographite In 1,2-dimethoxyethane; dimethyl sulfoxide at 35℃; Solvent; Inert atmosphere; | 94% |
atazanavir
Conditions | Yield |
---|---|
With hydrogen bromide In acetone at 20 - 55℃; for 2.5h; Concentration; Solvent; Temperature; | 92.3% |
N-benzyl-N-(tert-butoxycarbonyl)glycine
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 72h; Inert atmosphere; | 80% |
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 72h; Inert atmosphere; Glovebox; | 146.1 mg |
dimethyl sulfoxide
atazanavir
Conditions | Yield |
---|---|
With acetic anhydride; acetic acid at 20℃; for 48h; Inert atmosphere; | 79% |
BOC-glycine
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 14h; Inert atmosphere; | 76% |
atazanavir
Conditions | Yield |
---|---|
Stage #1: atazanavir In ethanol at 25 - 30℃; for 0.5h; Stage #2: With sulfuric acid In ethanol; n-heptane; acetone at 15 - 40℃; Temperature; | 75.5% |
t-Boc-L-valine
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h; Inert atmosphere; | 74.1% |
N-tert-butoxycarbonyl-L-phenylalanine
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere; | 74% |
Boc-D-Phe-OH
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere; | 71.2% |
carbonochloridic acid 1-chloro-ethyl ester
atazanavir
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 3h; | 70% |
(S)-2-(2-N-tert-butoxycarbonylamino)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-propanoic acid
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere; | 67.7% |
carbonochloridic acid, chloromethyl ester
atazanavir
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 3h; | 66% |
Conditions | Yield |
---|---|
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 72h; Reagent/catalyst; Inert atmosphere; | 65% |
L-N-Boc-Ala
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere; | 64.4% |
N-(tert-butoxycarbonyl)sarcosine
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; | 64% |
Dibenzyl N,N-diisopropylphosphoramidite
atazanavir
Conditions | Yield |
---|---|
Stage #1: Dibenzyl N,N-diisopropylphosphoramidite; atazanavir With 1H-tetrazole In acetonitrile at 20℃; for 8h; Inert atmosphere; Stage #2: With dihydrogen peroxide In water; acetonitrile at 0℃; for 0.166667h; | 62.4% |
Boc-(R)-Ala
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere; | 60.3% |
Boc-Phe(p-F)
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere; | 58.1% |
dimethylaminoacetic acid
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere; | 57.1% |
Conditions | Yield |
---|---|
With pentamethylcyclopentadienyl(benzene)cobalt(III) hexafluorophosphate; potassium carbonate; silver carbonate In 2-methyltetrahydrofuran at 100℃; for 16h; Inert atmosphere; Sealed tube; | 55% |
Boc-Trp-OH
atazanavir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 14h; Inert atmosphere; | 51.6% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View