Product name:tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate Cas No:198904-85-7 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but
Cas:198904-85-7
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:198904-85-7
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:198904-85-7
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inquiryUnique advantages of tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate Cas 198904-85-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Appearance:White powder Storage:cool dry place Package:25kg/drum A
Cas:198904-85-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
Cas:198904-85-7
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inquirytert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate CAS No.:198904-85-7 Name: tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate Synonyms: 2-[[4-(2-Pyridinyl)phe
Cas:198904-85-7
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
Cas:198904-85-7
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:198904-85-7
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:198904-85-7
Min.Order:1 Gram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:198904-85-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1489.html Product Name tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate
Cas:198904-85-7
Min.Order:1 Gram
FOB Price: $5.0
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
Cas:198904-85-7
Min.Order:1 Metric Ton
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:198904-85-7
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:198904-85-7
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryProduct Name tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine carboxylate CAS number 198904-85-7 Molecular formula C17H21N3O2 Molecular weight 2
Cas:198904-85-7
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:198904-85-7
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:198904-85-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquirytert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate CAS: 198904-85-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, s
Cas:198904-85-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:198904-85-7
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:198904-85-7
Min.Order:0
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Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:198904-85-7
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Atazanavir Sulfate 2 Transportation:By Sea/Air/Courier Port:Qin
Cas:198904-85-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:198904-85-7
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryWe are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Application:Pharmaceutical intermediate Port:Chinese main port
Cas:198904-85-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:198904-85-7
Min.Order:0
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Type:Lab/Research institutions
inquiryour strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery
Cas:198904-85-7
Min.Order:1 Gram
Negotiable
Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:198904-85-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:198904-85-7
Min.Order:100 Gram
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:198904-85-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:Off-white to white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide inter
Cas:198904-85-7
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiry2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
With hydrogen; sodium carbonate; triethylamine; 5%-palladium/activated carbon at 40℃; under 760.051 Torr; for 8h; | 99.76% |
With hydrogen; 5%-palladium/activated carbon at 5 - 58℃; under 1520.1 Torr; for 5 - 8h; Nitrogen; | 99.14% |
With hydrogen; palladium on carbon In methanol under 517.162 Torr; for 4h; | 96.5% |
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
A
2-(4-methylphenyl)pyridine
B
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
With hydrogen; triethylamine; 5%-palladium/activated carbon at 40℃; under 760.051 Torr; for 5h; | A 0.69% B 99.17% |
With hydrogen; sodium carbonate; 5%-palladium/activated carbon at 40℃; under 760.051 Torr; for 5h; | A 0.25% B 99.16% |
With hydrogen; 5%-palladium/activated carbon In methanol at 50℃; under 760.051 Torr; for 5h; | A 2.69% B 97.11% |
at 40 - 62℃; under 1520.1 Torr; for 5h; Hydrogen/nitrogen (1/2); | A 0.1% B 97.2% |
With hydrogen; 5%-palladium/activated carbon at 5 - 58℃; under 1520.1 Torr; for 5 - 8h; Nitrogen gas; | A 2.11% B 94.41% |
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In methanol for 4h; | 98% |
With hydrogen; palladium 10% on activated carbon In methanol | 98% |
With hydrogen; palladium on activated charcoal In methanol | 89% |
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
B
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
palladium-carbon In n-heptane; hydrogen | A n/a B 84% |
2-(4-formylphenyl)pyridine
t-butoxycarbonylhydrazine
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
With borane pyridine; acetic acid In methanol at 0 - 20℃; for 2h; | 78% |
2-bromo-pyridine
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol View Scheme | |
Multi-step reaction with 3 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 150 °C / 6750.68 Torr / Sealed tube; Microwave irradiation 2: trimethylsilyl trifluoromethanesulfonate / toluene; isopropyl alcohol / 22 - 50 °C / Microwave irradiation; Sealed tube 3: palladium 10% on activated carbon; sodium formate / ethanol; water / 1.5 h / 57 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C View Scheme | |
Multi-step reaction with 3 steps 1: palladium diacetate; triphenylphosphine; potassium hydroxide / methanol; tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Schlenk technique 2: toluene; isopropyl alcohol / 16 h / 20 - 85 °C / Inert atmosphere; Schlenk technique 3: palladium 10% on activated carbon; sodium formate / ethanol; water View Scheme |
2-(4-formylphenyl)pyridine
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / ethanol / 4 h / Heating 2: 89 percent / H2 / 10percent Pd/C / methanol View Scheme | |
Multi-step reaction with 2 steps 1: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 2: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C View Scheme | |
Multi-step reaction with 2 steps 1: toluene; isopropyl alcohol / 16 h / 20 - 85 °C / Inert atmosphere; Schlenk technique 2: palladium 10% on activated carbon; sodium formate / ethanol; water View Scheme |
1,1-dimethoxy-1-(4-bromophenyl)methane
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol View Scheme |
4-formylphenylboronic acid,
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 150 °C / 6750.68 Torr / Sealed tube; Microwave irradiation 2: trimethylsilyl trifluoromethanesulfonate / toluene; isopropyl alcohol / 22 - 50 °C / Microwave irradiation; Sealed tube 3: palladium 10% on activated carbon; sodium formate / ethanol; water / 1.5 h / 57 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C View Scheme | |
Multi-step reaction with 3 steps 1: palladium diacetate; triphenylphosphine; potassium hydroxide / methanol; tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Schlenk technique 2: toluene; isopropyl alcohol / 16 h / 20 - 85 °C / Inert atmosphere; Schlenk technique 3: palladium 10% on activated carbon; sodium formate / ethanol; water View Scheme |
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol for 24h; Inert atmosphere; Reflux; Large scale; | 85.4% |
In isopropyl alcohol Heating / reflux; | 75% |
In isopropyl alcohol for 16h; Heating; | 69% |
C20H32NO7P
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
C37H53N4O9P
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 15h; | 78% |
(2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoic Acid
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 25℃; for 16h; | 75% |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(Pyridin-2-yl)-phenyl]-4(S)-hydroxy-2-(N-Boc-amino)-5(S)-trifluoroacetyl-amino-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 16h; | 60% |
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol at 65℃; for 16h; | 57% |
In isopropyl alcohol at 65 - 85℃; for 16h; Product distribution / selectivity; | 35% |
In isopropyl alcohol at 85℃; for 16h; | 35% |
N-methoxycarbonyl-L-valine
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Methyl (1S)-2-methyl-1-({2-[4-(2-pyridinyl)benzyl]hydrazino}carbonyl)propylcarbamate
Conditions | Yield |
---|---|
Stage #1: N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine With trifluoroacetic acid In dichloromethane at 25℃; for 1h; Stage #2: N-methoxycarbonyl-L-valine With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 25℃; for 3h; | 47% |
Stage #1: N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine With trifluoroacetic acid In dichloromethane at 25℃; for 1h; Stage #2: N-methoxycarbonyl-L-valine With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 25℃; for 3h; | 47% |
(1S)-1-(2-oxiranyl)-2-phenyl-N-(trifluoromethyl)ethanamine
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Tert-butyl 2-{(2S,3S)-2-hydroxy-4-phenyl-3-[(trifluoromethyl)amino]butyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate
Conditions | Yield |
---|---|
In isopropyl alcohol at 65℃; for 16h; | 28% |
In isopropyl alcohol at 65℃; for 16h; | 28% |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
2(R)-3(S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane
tert-butyl 2-((2S,3S)-2-hydroxy-4-phenyl-3-{[(benzyloxy)carbonyl]amino}butyl)-2-(4-pyridin-2-ylbenzyl)hydrazinecarboxylate
Conditions | Yield |
---|---|
In isopropyl alcohol for 18h; Heating / reflux; | 7% |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
[ring-13C6]-N-(tert-butoxycarbonyl)-2(S)-amino-1-phenyl-3(R)-3,4-epoxy-bytane
[ring-13C6]-1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxy-carbonyl)-amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol at 75℃; for 12h; |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-(4-(pyridin-2-yl)benzyl)hydrazine
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 50℃; for 3h; |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: propan-2-ol / 24 h / 80 °C 2: HCl / dioxane / 4 h / 50 °C 3: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: propan-2-ol / 24 h / 80 °C 2: HCl / dioxane / 4 h / 50 °C 3: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: propan-2-ol / 24 h / 80 °C 2: HCl / dioxane / 4 h / 50 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
(S)-{2,2-dimethyl-1-[N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
{(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 3: 25 percent / propan-2-ol / 24 h / Heating 4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
{(1S,2S)-1-benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 3: 25 percent / propan-2-ol / 24 h / Heating View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 3: 25 percent / propan-2-ol / 24 h / Heating 4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 5: 78 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / K2HPO4 / CH2Cl2; H2O / 12 h / 20 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 3: 25 percent / propan-2-ol / 24 h / Heating 4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 5: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme | |
Multi-step reaction with 3 steps 1: 69 percent / propan-2-ol / 16 h / Heating 2: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 3: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 3 steps 1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale 2: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: propan-2-ol / 12 h / 75 °C 2: HCl / tetrahydrofuran; H2O / 30 h / 60 °C View Scheme |
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: propan-2-ol / 12 h / 75 °C 2: HCl / tetrahydrofuran; H2O / 30 h / 60 °C 3: 0.899 g / 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)-propyl]-3-ethyl-carbodiimide*HCl; diisopropylethylamine / CH2Cl2 / 17 h / 20 °C View Scheme |
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