(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol for 24h; Inert atmosphere; Reflux; Large scale; | 85.4% |
In isopropyl alcohol Heating / reflux; | 75% |
In isopropyl alcohol for 16h; Heating; | 69% |
1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With diisobutylaluminium hydride at 0℃; for 2.5h; | 60% |
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol at 65℃; for 16h; | 57% |
In isopropyl alcohol at 65 - 85℃; for 16h; Product distribution / selectivity; | 35% |
In isopropyl alcohol at 85℃; for 16h; | 35% |
2-bromo-pyridine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol 4: 69 percent / propan-2-ol / 16 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
2-(4-formylphenyl)pyridine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / ethanol / 4 h / Heating 2: 89 percent / H2 / 10percent Pd/C / methanol 3: 69 percent / propan-2-ol / 16 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 2: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
1,1-dimethoxy-1-(4-bromophenyl)methane
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol 4: 69 percent / propan-2-ol / 16 h / Heating View Scheme |
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / H2 / 10percent Pd/C / methanol 2: 69 percent / propan-2-ol / 16 h / Heating View Scheme |
t-butoxycarbonylhydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature 2: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 3: 1.) aq. borax; 2.) MTBD 4: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
Boc-L-phenylalaninal
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 39 percent / BnEt3N(1+)*Cl(1-) / H2O; CH2Cl2 / 0 °C 2: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature 3: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 4: 1.) aq. borax; 2.) MTBD 5: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 2: 1.) aq. borax; 2.) MTBD 3: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) aq. borax; 2.) MTBD 2: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-cyano-3-phenyl-propyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature 2: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 3: 1.) aq. borax; 2.) MTBD 4: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
A
C47H63N5O9
B
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol Reflux; |
(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dmap; triethylamine / toluene / 3 h / 50 °C / Large scale 1.2: 3 h / 0 - 5 °C / Large scale 2.1: ammonium fluoride; acetic acid / methanol / 11 h / 20 °C / Large scale 3.1: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C 4.1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
methanesulfonic acid 2-tert-butoxycarbonylamino-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-propyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium fluoride; acetic acid / methanol / 11 h / 20 °C / Large scale 2: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C 3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
4-formylphenylboronic acid,
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C 2: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 2: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran at 50℃; for 4h; | 100% |
With hydrogenchloride In tetrahydrofuran at 22 - 55℃; for 3h; Large scale; | 95% |
With hydrogenchloride In dichloromethane at 0 - 40℃; for 1.5h; | |
With hydrogenchloride In dichloromethane; water at 0.5 - 40℃; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 60℃; for 3h; | 100% |
In 1,4-dioxane; hydrogenchloride; methanol; N,N-dimethyl-formamide; toluene | |
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.333333h; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane; water at 40 - 45℃; for 3h; Solvent; Temperature; Concentration; | 96.1% |
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride; water In tetrahydrofuran at 60℃; for 3h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h; | 61% |
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h; Stage #2: With ethanol In tetrahydrofuran; water Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h; | 61% |
With hydrogenchloride In 1,4-dioxane at 50℃; for 4h; | |
With hydrogenchloride In dichloromethane |
di-tert-butyl dicarbonate
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Tert-butyl (1S,2S)-1-benzyl-2-hydroxy-3-{1-[4-(2-pyridinyl)benzyl]hydrazino}propylcarbamate
Conditions | Yield |
---|---|
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h; Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h; | 72% |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / dioxane / 4 h / 50 °C 2: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / dioxane / 4 h / 50 °C 2: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 2: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, overnight View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 2: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C 2: dipotassium hydrogenphosphate / water / 5 - 40 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In dichloromethane; water at 5 - 40℃; Stage #2: Stage #3: With water for 0.25h; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 45 - 55℃; for 3h; | |
With hydrogenchloride; water In dichloromethane Reflux; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With trimethylsilyl iodide In tetrahydrofuran |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale 3: sulfuric acid / ethanol / 22 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C 2: dipotassium hydrogenphosphate / water / 5 - 40 °C 3: sulfuric acid / acetone; 1-methyl-pyrrolidin-2-one / 0.5 h / 40 - 50 °C View Scheme |
The 1-[4-(Pyridin-2-yl)phenyl]-5-(s)-2,5-bis[(tert-butyloxycarbonyl)-amino]-4(s)-hydroxyl-6-phenyl-2-azahexane, with the CAS registry number 198904-86-8, is also known as Hydrazinecarboxylic acid, 2-[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester. It belongs to the product categories of Aromatics Compounds; Aromatics; Chiral Reagents; Heterocycles. This chemical's molecular formula is C32H42N4O5 and molecular weight is 562.6997. What's more, its systematic name is called Tert-butyl 2-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-2-(4-pyridin-2-ylbenzyl)hydrazinecarboxylate.
Physical properties about this chemical are: (1)ACD/LogP: 6.24; (2)#of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 6.16; (4)ACD/LogD (pH 7.4): 6.23; (5)ACD/BCF (pH 5.5): 27340.09; (6)ACD/BCF (pH 7.4): 32179.68; (7)ACD/KOC (pH 5.5): 49729.9; (8)ACD/KOC (pH 7.4): 58532.8; (9)#H bond acceptors: 9; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 15; (12)Polar Surface Area: 113.02 Å2; (13)Index of Refraction: 1.567; (14)Molar Refractivity: 159.04 cm3; (15)Molar Volume: 486.2 cm3; (16)Polarizability: 63.05×10-24 cm3; (17)Surface Tension: 47 dyne/cm; (18)Density: 1.157 g/cm3.
You can still convert the following datas into molecular structure:
(1) SMILES: CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(NC(=O)OC(C)(C)C)Cc2ccc(cc2)c3ccccn3
(2) InChI: InChI=1/C32H42N4O5/c1-31(2,3)40-29(38)34-27(20-23-12-8-7-9-13-23)28(37)22-36(35-30(39)41-32(4,5)6)21-24-15-17-25(18-16-24)26-14-10-11-19-33-26/h7-19,27-28,37H,20-22H2,1-6H3,(H,34,38)(H,35,39)/t27-,28-/m0/s1
(3) InChIKey: KYSDBVSJLBOZDZ-NSOVKSMOBH
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