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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Escitalopram Oxalate

Cas:219861-08-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 219861-08-2 Escitalopram Oxalate

Cas:219861-08-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White crystalline powder Storage:-20°C Freezer Package:1kg/fo

Manufacturer supply Escitalopram oxalate CAS 219861-08-2 with good quality

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $1000.0 / 1200.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Escitalopram Oxalate CAS No.219861-08-2

Cas:219861-08-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

EAST CHEMSOURCES LIMITED

Escitalopram oxalate English name: Escitalopram oxalate Chemical name: 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1, 3-dihydro-5-isobenzofuran-carbonitrile oxalate Category involved:

Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Escitalopram Oxalate

Cas:219861-08-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Escitalopram oxalate 219861-08-2 GMP Manufacturer

Cas:219861-08-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Escitalopram oxalate

Cas:219861-08-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 219861-08-2 with fast shipping

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ We can

Escitalopram oxalate cas219861-08-2

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

99%min Escitalopram Oxalate 219861-08-2

Cas:219861-08-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Pharmaceutical Intermediates Escitalopram/Escitalopram Oxalate CAS 219861-08-2

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp

Escitalopram oxalate CAS NO.: 219861-08-2

Cas:219861-08-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antidepressant Escitalopram oxalate with CAS:219861-08-2

Cas:219861-08-2

Min.Order:1 Gram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Escitalopram oxalate CAS:219861-08-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

Escitalopram oxalate CAS:219861-08-2

Cas:219861-08-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Cipralex Powder USP Standard

Cas:219861-08-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Escitalopram oxalate Synonyms: (S)-CITALOPRAM;1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran-carbonitrile oxalate;ESCITALOPRAM OXALATE;S-(+)-CITAPROLAM OXALATE;S-(+)-1-3-(dimethyl-amino)propyl-1-(p-fluoro

Escitalopram oxalate big supplier with lower price

Cas:219861-08-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Escitalopram oxalate

Cas:219861-08-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao

escitalopram oxalate 219861-08-2

Cas:219861-08-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Escitalopram oxalate

Cas:219861-08-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Escitalopram oxalate

Cas:219861-08-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS219861-08-2 Escitalopram oxalate

Cas:219861-08-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Escitalopram oxalate

Cas:219861-08-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Escitalopram Oxalate CAS 219861-08-2

Cas:219861-08-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Synthetic route

oxalic acid
144-62-7

oxalic acid

(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile
488787-59-3

(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile With methanesulfonyl chloride; triethylamine In dichloromethane at 5℃; for 2h;
Stage #2: oxalic acid
65%
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile With potassium carbonate; 2,5-dichloronitrobenzene In dimethyl sulfoxide at 20 - 100℃; for 15h;
Stage #2: oxalic acid In acetone at 30℃;
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile With bis(phenyl) carbonate; sodium methylate In acetonitrile at 79 - 80℃; for 4h;
Stage #2: oxalic acid In ethyl acetate for 3h; Reagent/catalyst; Reflux;
3.02 g
(1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hemi-(+)-di-(p-toluoyl) tartaric acid salt

(1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hemi-(+)-di-(p-toluoyl) tartaric acid salt

oxalic acid
144-62-7

oxalic acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: (1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hemi-(+)-di-(p-toluoyl) tartaric acid salt With sodium hydroxide In diethyl ether; water at 25℃; for 0.5h;
Stage #2: With triethylamine In diethyl ether; water; toluene at 5℃; for 0.5h;
Stage #3: oxalic acid Further stages;
85%
Stage #1: (1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hemi-(+)-di-(p-toluoyl) tartaric acid salt With ammonia In dichloromethane; water pH=9;
Stage #2: With triethylamine; p-toluenesulfonyl chloride In dichloromethane at 5℃; for 1h;
Stage #3: oxalic acid In acetone
n/a
(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(4-nitrobenzoyloxymethyl)benzonitrile hydrochloride

(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(4-nitrobenzoyloxymethyl)benzonitrile hydrochloride

oxalic acid
144-62-7

oxalic acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(4-nitrobenzoyloxymethyl)benzonitrile hydrochloride With sodium hydrogencarbonate In water; ethyl acetate
Stage #2: With potassium carbonate In dimethyl sulfoxide at 90 - 100℃; for 2h;
Stage #3: oxalic acid
82%
oxalic acid
144-62-7

oxalic acid

escitalopram
128196-01-0

escitalopram

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
In acetone at 25 - 30℃; Industry scale;98.57%
In acetonitrile at 50℃; for 0.5h;89%
In acetone at 25 - 45℃; for 1.5h;85%
(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride
878007-22-8

(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride

oxalic acid
144-62-7

oxalic acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride With potassium carbonate at 100℃; for 0.5h;
Stage #2: oxalic acid
64%
formaldehyd
50-00-0

formaldehyd

oxalic acid
144-62-7

oxalic acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: 1-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; (-)-di-p-toluoyl tartaric acid salt With sodium hydroxide In water; toluene pH=11 - 13;
Stage #2: formaldehyd; formic acid In water at 95 - 100℃; for 3 - 4h;
Stage #3: oxalic acid With hydrogenchloride more than 3 stages;
(S)-citalopram (L)-tartrate
1073819-95-0

(S)-citalopram (L)-tartrate

oxalic acid
144-62-7

oxalic acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: (S)-citalopram (L)-tartrate With sodium hydroxide In water; ethyl acetate pH=10;
Stage #2: oxalic acid In ethyl acetate
escitalopram
128196-01-0

escitalopram

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
With oxalic acid In acetone at 10℃; for 1h;
With oxalic acid In ethanol at 5 - 20℃; for 10.5h; Product distribution / selectivity;
oxalic acid
144-62-7

oxalic acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Stage #1: escitalopram With hydrogen bromide In isopropyl alcohol at 20℃; for 2.16667h; pH=3.5 - 4;
Stage #2: With ammonia In water; ethyl acetate for 0.5h; pH=9 - 9.5;
Stage #3: oxalic acid In isopropyl alcohol at 20 - 40℃; for 2.16667h; Purification / work up;
Stage #1: oxalic acid With ammonia In water; ethyl acetate pH=9 - 9.5;
Stage #2: oxalic acid In isopropyl alcohol at 20 - 40℃; for 2.16667h; Purification / work up;
Stage #1: (+)-(S)-citalopram hydrobromide With ammonia In water; ethyl acetate pH=9 - 9.5;
Stage #2: oxalic acid In isopropyl alcohol at 20 - 40℃; for 2.16667h; Purification / work up;
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
103146-25-4

4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 3 h / 20 - 45 °C
2.1: ammonia / water / pH ~ 9
2.2: 3 h / -5 °C
3.1: isopropyl alcohol / 0.5 h / 50 - 60 °C
View Scheme
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 25 - 70 °C / Resolution of racemate
2.1: ammonium hydroxide / dichloromethane; water / 1 h / 5 - 15 °C
2.2: -5 - 5 °C
3.1: acetone / 20 - 40 °C
View Scheme
Multi-step reaction with 4 steps
1.1: isopropyl alcohol / 25 - 35 °C
2.1: sodium hydroxide / diethyl ether; water / 0.5 h / 25 °C
3.1: triethylamine / toluene / 0.5 h / 5 °C
3.2: 1 h / 5 °C
4.1: acetone / 1.5 h / 25 - 45 °C
View Scheme
Citalopram oxalate

Citalopram oxalate

A

(-)-Citalopram oxalate

(-)-Citalopram oxalate

B

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
With stainless steel column (100 mm L x 4.6 mm i.d) packed with iniferter-mediated grafting of molecularly imprinted polymers on porous silica beads In acetonitrile at 40℃; pH=3; Resolution of racemate;
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 0.25 h / -5 °C
1.2: 0.5 h / -5 - 20 °C
1.3: pH 2
2.1: isopropyl alcohol / 3 h / 20 - 45 °C
3.1: ammonia / water / pH ~ 9
3.2: 3 h / -5 °C
4.1: isopropyl alcohol / 0.5 h / 50 - 60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 4 h / 5 - 15 °C / Inert atmosphere
1.2: 4 h / 0 - 15 °C
2.1: hydrogen bromide / 1.5 h / 5 - 30 °C
3.1: sodium hydroxide / water / 0.5 h / 25 °C
3.2: 4 h / 25 - 40 °C
4.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C
4.2: 0.25 h / 25 °C
4.3: 1 h / -15 °C
5.1: acetonitrile / 4.5 h / 25 - 50 °C
View Scheme
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 0.25 h / -5 °C
1.2: 0.5 h / -5 - 20 °C
1.3: pH 2
2.1: isopropyl alcohol / 3 h / 20 - 45 °C
3.1: ammonia / water / pH ~ 9
3.2: 3 h / -5 °C
4.1: isopropyl alcohol / 0.5 h / 50 - 60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 4 h / 5 - 15 °C / Inert atmosphere
1.2: 4 h / 0 - 15 °C
2.1: hydrogen bromide / 1.5 h / 5 - 30 °C
3.1: sodium hydroxide / water / 0.5 h / 25 °C
3.2: 4 h / 25 - 40 °C
4.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C
4.2: 0.25 h / 25 °C
4.3: 1 h / -15 °C
5.1: acetonitrile / 4.5 h / 25 - 50 °C
View Scheme
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iodine; magnesium / tetrahydrofuran / 5 h / 80 - 85 °C / Reflux
2.1: tetrahydrofuran / 0.25 h / -5 °C
2.2: 0.5 h / -5 - 20 °C
2.3: pH 2
3.1: isopropyl alcohol / 3 h / 20 - 45 °C
4.1: ammonia / water / pH ~ 9
4.2: 3 h / -5 °C
5.1: isopropyl alcohol / 0.5 h / 50 - 60 °C
View Scheme
3-(dimethylamino)propyl chloride hydrochloride
5407-04-5

3-(dimethylamino)propyl chloride hydrochloride

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium hydroxide / water / 0 - 5 °C
1.2: 4 h / 100 - 110 °C / Reflux
2.1: tetrahydrofuran / 0.25 h / -5 °C
2.2: 0.5 h / -5 - 20 °C
2.3: pH 2
3.1: isopropyl alcohol / 3 h / 20 - 45 °C
4.1: ammonia / water / pH ~ 9
4.2: 3 h / -5 °C
5.1: isopropyl alcohol / 0.5 h / 50 - 60 °C
View Scheme
(R)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid
917483-01-3

(R)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: ammonia / water / pH ~ 9
1.2: 3 h / -5 °C
2.1: isopropyl alcohol / 0.5 h / 50 - 60 °C
View Scheme
(-)-(S)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile (+)-di-p-toluoyl-D-tartaric acid salt

(-)-(S)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile (+)-di-p-toluoyl-D-tartaric acid salt

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: ammonium hydroxide / dichloromethane; water / 1 h / 5 - 15 °C
1.2: -5 - 5 °C
2.1: acetone / 20 - 40 °C
View Scheme
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 4 h / 5 - 15 °C / Inert atmosphere
1.2: 4 h / 0 - 15 °C
2.1: hydrogen bromide / 1.5 h / 5 - 30 °C
3.1: sodium hydroxide / water / 0.5 h / 25 °C
3.2: 4 h / 25 - 40 °C
4.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C
4.2: 0.25 h / 25 °C
4.3: 1 h / -15 °C
5.1: acetonitrile / 4.5 h / 25 - 50 °C
View Scheme
4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromide
103146-26-5

4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromide

escitalopram oxalate
219861-08-2

escitalopram oxalate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 0.5 h / 25 °C
1.2: 4 h / 25 - 40 °C
2.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C
2.2: 0.25 h / 25 °C
2.3: 1 h / -15 °C
3.1: acetonitrile / 4.5 h / 25 - 50 °C
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