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Shanghai Pinewood Fine Chemical Co., Ltd.

Appearance:WHITE TO ALMOST WHITE CRYSTALLOID Storage: room temperature Application:Citalopram Pharmaceutical intermediates Port:Shanghai

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Pound

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Cyano-Phthalide supplier in China

Cas:82104-74-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 82104-74-3 5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product description: Product name 5-Cyanophthalide CAS number 82104-74-3 Assay ≥98% Appearance White to yellowish crystalline solid Capacity 100mt/year Application Citalopram

5-Cyanophthalide

Cas:82104-74-3

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,3-dihydro-1-oxoisobenzofuran-5-carbonitrile

Cas:82104-74-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 82104-74-3 5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

5-Cyanophthalide

Cas:82104-74-3

Min.Order:0

Negotiable

Type:Trading Company

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Cyanophthalide

Cas:82104-74-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Good quantity 5-Cyanophthalide Basic information Product Name: 5-Cyanophthalide Synonyms: 5-CYANO-3H-ISOBENZOFURANONE;5-CYANOPHTHALIDE;1,3-DIHYDRO-1-OXO-5-ISOBENZOFURANCARBONITRILE;1,3

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 82104-74-3 with competitive price

Cas:82104-74-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

5-Cyanophthalide 82104-74-3

Cas:82104-74-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 5-Cyanophthalide Synonyms: 5-Cyano-3h-Isobenzofuranone; 1,3-Dihydro-1-Oxo-5-Isobenzofurancarbonitrile; 1,3-Dihydro-1-Oxoisobenzofuran-5-Carbonitrile; 1-Oxo-1,3-Dihydro-2-Benzofuran-5-Carbonitrile; 5-Phthalidenitrile; 5-Cyano-Phthalide; 5-Cya

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% 5-Cyanophthalide 82104-74-3 For Pharmaceutical Intermediates

Cas:82104-74-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Cyanophthalide 82104-74-3

Cas:82104-74-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

5-Cyanophthalide/ LIDE PHARMA- Factory supply / Best price

Cas:82104-74-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 5-Cyanophthalide CAS:82104-74-3

Cas:82104-74-3

Min.Order:1 Kilogram

FOB Price: $81.9 / 86.2

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

5-Cyanophthalide CAS:82104-74-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed

5-Cyanophthalide CAS:82104-74-3

Cas:82104-74-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:82104-74-3

Cas:82104-74-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 5-Cyanophthalide Synonyms: 1-OXO-1,3-DIHYDRO-2-BENZOFURAN-5-CARBONITRILE;5-Phthalidenitrile;5-CYANO- PHTHALIDE/1-(4-FLUOROPHENYL)-1,3-DIHYROSOBENZOFURAN-5-CARBONITRILE;5-Cyanophthaleine;1,3-Dihydro-1-oxo-5-isobenzofurancarbonitrile

5-Cyanophthalide high purity best quality

Cas:82104-74-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-Cyano-Phthalide

Cas:82104-74-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to pale yellow crystalline solid Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china

High Purity 82104-74-3 Citalopram 5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Kilogram

FOB Price: $60.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

5-Cyanophthalide

Cas:82104-74-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-Cyanophthalide

Cas:82104-74-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Cyanophthalide

Cas:82104-74-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 5-Cyanophthalide

Cas:82104-74-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 5-Cyano-Phthalide

Cas:82104-74-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

5-hydroxamyl phthalide
934473-85-5

5-hydroxamyl phthalide

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With thionyl chloride at 80℃; for 6h; Product distribution / selectivity; Heating / reflux;91%
5-carboxyphtalide
4792-29-4

5-carboxyphtalide

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 5-carboxyphtalide With ethyl phosphate; ammonium carbonate In acetonitrile at 0 - 25℃; for 6h;
Stage #2: at 90 - 95℃; for 12h;
89.5%
With thionyl chloride; SULFAMIDE In sulfolane; water
With thionyl chloride; SULFAMIDE In sulfolane; water
potassium cyanide

potassium cyanide

5-bromophthalide
64169-34-2

5-bromophthalide

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: potassium cyanide With acetic acid In ethylene glycol at 20℃; Sealed tube;
Stage #2: 5-bromophthalide With P(t-Bu)3 Palladacycle Gen. 3; potassium acetate In 1,4-dioxane; water at 60℃; for 16h; Sealed tube;
84%
5-bromophthalide
64169-34-2

5-bromophthalide

2-methyl-2-phenylmalononitrile
86164-70-7

2-methyl-2-phenylmalononitrile

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With C10H8Br2N2Ni*(x)H2O; zinc In N,N-dimethyl acetamide at 80℃; for 16h; Inert atmosphere; Sealed tube;57%
4-cyanopyridine N-oxide
14906-59-3

4-cyanopyridine N-oxide

5-bromophthalide
64169-34-2

5-bromophthalide

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With potassium fluoride; 4,4'-dimethyl-2,2'-bipyridines; trifluoroacetic acid; sodium iodide; nickel dichloride; zinc In N,N-dimethyl acetamide at 60℃; for 36h;38%
1-oxo-3-hydroxy-1,3-dihydro-N-phenylisoindole-5-carbonitrile
389613-68-7

1-oxo-3-hydroxy-1,3-dihydro-N-phenylisoindole-5-carbonitrile

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 1-oxo-3-hydroxy-1,3-dihydro-N-phenylisoindole-5-carbonitrile With sodium tetrahydroborate In methanol at 20℃; for 24h;
Stage #2: With hydrogenchloride In methanol at 20℃; for 48h; pH=1;
35%
5-amino-3H-isobenzofuran-1-one
65399-05-5

5-amino-3H-isobenzofuran-1-one

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With potassium cyanide; copper(II) sulfate ueber eine wss. Diazoniumsalz-Loesung;
4-cyanobenzanilide
17922-96-2

4-cyanobenzanilide

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.67 h / -20 - 20 °C
1.2: 68 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C
2.1: NaBH4 / methanol / 24 h / 20 °C
2.2: 35 percent / aq. HCl / methanol / 48 h / 20 °C / pH 1
View Scheme
4-cyanobenzoyl chlorIde
6068-72-0

4-cyanobenzoyl chlorIde

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 92 percent / pyridine / CH2Cl2 / 20 h
2.1: BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.67 h / -20 - 20 °C
2.2: 68 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C
3.1: NaBH4 / methanol / 24 h / 20 °C
3.2: 35 percent / aq. HCl / methanol / 48 h / 20 °C / pH 1
View Scheme
(E,Z)-1-oxo-1,3-dihydroisobenzofuran-5-carbaldehyde oxime
452978-39-1

(E,Z)-1-oxo-1,3-dihydroisobenzofuran-5-carbaldehyde oxime

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: (E,Z)-1-oxo-1,3-dihydroisobenzofuran-5-carbaldehyde oxime With triethylamine; trifluoroacetic acid In tetrahydrofuran at 0 - 20℃; for 1h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water
4,4-dimethyl-2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)oxazoline
265137-37-9

4,4-dimethyl-2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)oxazoline

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In thionyl chloride; water; N,N-dimethyl-formamide; toluene11.9 g (75%)
thionyl chloride
7719-09-7

thionyl chloride

1-oxo-1,3-dihydroisobenzofuran-5-carboxamide
85118-25-8

1-oxo-1,3-dihydroisobenzofuran-5-carboxamide

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene
5-bromophthalide
64169-34-2

5-bromophthalide

Cu(CN)2

Cu(CN)2

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In water
5-bromophthalide
64169-34-2

5-bromophthalide

Zn(CN)2

Zn(CN)2

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
tetrakis(triphenylphosphine)palladium (0) In N,N-dimethyl-formamide
With NaCN; tetrakis(triphenylphosphine)palladium (0) In N,N-dimethyl-formamide
5-iodoisobenzofuran-1(3H)-one
41284-92-8

5-iodoisobenzofuran-1(3H)-one

Zn(CN)2

Zn(CN)2

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
tetrakis(triphenylphosphine)palladium (0) In N,N-dimethyl-formamide
5-chloro-3H-isobenzofuran-1-one
54109-03-4

5-chloro-3H-isobenzofuran-1-one

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With NaCN; triphenylphosphine; nickel dichloride In tetrahydrofuran; water; acetonitrile
(1-oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl chloride
227954-90-7

(1-oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl chloride

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With SULFAMIDE In sulfolane; water
3,4-bis(hydroxymethyl)benzonitrile
1446757-51-2

3,4-bis(hydroxymethyl)benzonitrile

A

6-cyanoisobenzofuran-1(3H)-one
89877-62-3

6-cyanoisobenzofuran-1(3H)-one

B

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With Oxone; 2-iodo-3,4,5,6-tetramethylbenzoic acid In water; acetonitrile at 30℃; for 8h; Green chemistry; Overall yield = 56 %;
methanol
67-56-1

methanol

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

methyl 2-(chloromethyl)-4-cyanobenzoate

methyl 2-(chloromethyl)-4-cyanobenzoate

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride at 90℃; for 72h;
Stage #2: methanol With N-ethyl-N,N-diisopropylamine In ethanol; dichloromethane pH=8;
99%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

5-cyano-2-(p-dimethylaminophenyl)indan-1,3-dione

5-cyano-2-(p-dimethylaminophenyl)indan-1,3-dione

Conditions
ConditionsYield
With sodium methylate In ethyl acetate for 0.166667h; Heating;98%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

sodium 4-cyano-2-(hydroxymethyl)benzoate

sodium 4-cyano-2-(hydroxymethyl)benzoate

Conditions
ConditionsYield
With sodium hydroxide In water for 2h; Reflux;97%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h;
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

potassium 4-cyano-2-(hydroxymethyl)benzoate

potassium 4-cyano-2-(hydroxymethyl)benzoate

Conditions
ConditionsYield
With potassium hydroxide In water; isopropyl alcohol at 35 - 40℃; for 2h;97%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

(1-oxo-1,3-dihydroisobenzofuran-5-yl)methanaminium chloride

(1-oxo-1,3-dihydroisobenzofuran-5-yl)methanaminium chloride

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With ammonia; hydrogen In water; isopropyl alcohol at 80℃; under 15001.5 Torr; for 24h; Autoclave;
Stage #2: With hydrogenchloride In methanol; ethyl acetate Cooling with ice;
95%
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With ammonium hydroxide; hydrogen In water; isopropyl alcohol under 37503.8 Torr; for 4h; Autoclave; Heating;
Stage #2: With hydrogenchloride In methanol
90%
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With borane-ammonia complex; C17H16BrMnN2O3S In hexane at 60℃; for 12h;
Stage #2: With hydrogenchloride In diethyl ether; water
50%
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon / 1,4-dioxane; water / 16 h / 80 °C
2: hydrogenchloride / water / 100 °C
View Scheme
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
103146-25-4

4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide With diethylene glycol dimethyl ether; tetrabutyl-ammonium chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
90%
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at 0 - 20℃; for 3.5h; Grignard reaction;
Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at 0 - 20℃; Grignard reaction;
79%
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at -5℃; for 0.25h;
Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at -5℃;
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at -5℃; for 0.25h;
Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at -5 - 20℃; for 0.5h;
Stage #3: With hydrogenchloride; water In tetrahydrofuran pH=2; Product distribution / selectivity;
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at 5 - 15℃; for 4h; Inert atmosphere;
Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at 0 - 15℃; for 4h;
98.8 g
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

4-cyano-2-hydroxymethylbenzoic acid
1378843-02-7

4-cyano-2-hydroxymethylbenzoic acid

Conditions
ConditionsYield
With lithium hydroxide In methanol; water for 5h; Solvent; Reagent/catalyst;87.3%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.25h;
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

pivaloyl chloride
3282-30-2

pivaloyl chloride

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

5-cyano-2-(4-fluorobenzoyl)benzyl pivalate

5-cyano-2-(4-fluorobenzoyl)benzyl pivalate

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran; dichloromethane at 0 - 25℃; for 18h;
Stage #2: pivaloyl chloride In tetrahydrofuran; dichloromethane at 60℃; for 2h;
87%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

methylmagnesium bromide
75-16-1

methylmagnesium bromide

3-(hydroxymethyl)-4-(1-hydroxy-1-methylethyl)benzonitrile
1109262-40-9

3-(hydroxymethyl)-4-(1-hydroxy-1-methylethyl)benzonitrile

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 1h;87%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
64169-67-1

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In tetrahydrofuran; chloroform86.5%
In tetrahydrofuran; 1,2-dichloro-ethane85%
In tetrahydrofuran; chlorobenzene78%
In tetrahydrofuran; benzene78%
In tetrahydrofuran; toluene70%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile
260371-16-2

4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran; 1,2-dimethoxyethane at -10℃; for 3.5h;
Stage #2: With water; ammonium chloride In tetrahydrofuran; 1,2-dimethoxyethane at 20℃; for 0.0833333h;
86.2%
In tetrahydrofuran at 0 - 5℃; for 5h; Solvent; Temperature;85%
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran; dichloromethane at -6 - -2℃;
Stage #2: With water; ammonium chloride In tetrahydrofuran; dichloromethane
In tetrahydrofuran; toluene at -4 - -2℃; Product distribution / selectivity;
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

N'-hydroxy-1-oxo-1,3-dihydroisobenzofuran-5-carboximidamide
1146973-38-7

N'-hydroxy-1-oxo-1,3-dihydroisobenzofuran-5-carboximidamide

Conditions
ConditionsYield
With hydroxylamine In ethanol; water at 20℃; for 63h; Heating / reflux;86.2%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

magnesium
7439-95-4

magnesium

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
64169-67-1

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: magnesium; 1-Bromo-4-fluorobenzene; iodine In tetrahydrofuran
Stage #2: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile In tetrahydrofuran; dichloromethane at -6 - -2℃;
86%
Stage #1: magnesium; 1-Bromo-4-fluorobenzene; iodine In tetrahydrofuran
Stage #2: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile In tetrahydrofuran; toluene at -6 - -2℃;
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

4-(bis(4-fluorophenyl)hydroxymethyl)-3-(hydroxymethyl)benzonitrile
762266-07-9

4-(bis(4-fluorophenyl)hydroxymethyl)-3-(hydroxymethyl)benzonitrile

Conditions
ConditionsYield
In toluene at 0 - 80℃; for 10h; Temperature; Solvent;84%
In tetrahydrofuran at 0 - 20℃; for 17h; Inert atmosphere;64.18%
In tetrahydrofuran at 25 - 35℃;
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

2-Methyl-1-phenyl-2-propanol
100-86-7

2-Methyl-1-phenyl-2-propanol

5-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)isobenzofuran-1(3H)-one

5-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)isobenzofuran-1(3H)-one

Conditions
ConditionsYield
With sulfuric acid In toluene at 0 - 20℃;82%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

3,4-bis(hydroxymethyl)benzonitrile
1446757-51-2

3,4-bis(hydroxymethyl)benzonitrile

Conditions
ConditionsYield
With phenylsilane; potassium hydroxide In tetrahydrofuran at 66℃; for 6h;75%
With phenylsilane; potassium hydroxide In tetrahydrofuran for 4h; Schlenk technique; Inert atmosphere; Reflux;68%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

C16H25N

C16H25N

C24H29NO2

C24H29NO2

Conditions
ConditionsYield
With tris[2-phenylpyridinato-C2,N]iridium(III); sodium acetate In N,N-dimethyl acetamide at 20℃; for 2h; Inert atmosphere; Glovebox; Irradiation; diastereoselective reaction;73%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

tert-butyl 2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)pyrrolidine-1-carboxylate
1588517-25-2

tert-butyl 2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With Ir[p-F(tert-butyl)2-phenylpyridine]3; cesium fluoride In dimethyl sulfoxide at 20℃; for 48h; Inert atmosphere; Irradiation;70%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

N-carbobenzyloxyproline
1148-11-4

N-carbobenzyloxyproline

benzyl 2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)pyrrolidine-1-carboxylate

benzyl 2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With 1-(4-(9H-carbazol-9-yl)phenyl)-3-amino-9H-fluorene-2,4-dicarbonitrile; cesium fluoride In dimethyl sulfoxide at 20℃; for 24h; Inert atmosphere; Irradiation;69%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile
260371-16-2

4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran Reflux; Inert atmosphere;
Stage #2: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
63%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

ethyl hexa-2,3-dienoate
131431-64-6, 113644-17-0

ethyl hexa-2,3-dienoate

3-ethyl-9-hydroxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-6-carbonitrile

3-ethyl-9-hydroxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-6-carbonitrile

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere;
Stage #2: ethyl hexa-2,3-dienoate In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; regioselective reaction;
60%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl ((1-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)carbamate

tert-butyl ((1-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)carbamate

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 0 - 20℃; for 12h; Inert atmosphere;56%
formic acid
64-18-6

formic acid

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

N-((1-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)formamide

N-((1-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)formamide

Conditions
ConditionsYield
With palladium 10% on activated carbon In 1,4-dioxane; water at 80℃; for 16h;55%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

(E)-1-phenyl-N-(piperidin-1-yl)methanimine
1885-87-6

(E)-1-phenyl-N-(piperidin-1-yl)methanimine

A

1-[(E)-benzylideneamino]piperidine-2-carbonitrile

1-[(E)-benzylideneamino]piperidine-2-carbonitrile

B

5-[1-[(E)-benzylideneamino]-2-piperidyl]-3H-isobensofuran-1-one

5-[1-[(E)-benzylideneamino]-2-piperidyl]-3H-isobensofuran-1-one

Conditions
ConditionsYield
With tris[2-phenylpyridinato-C2,N]iridium(III); lithium acetate In dimethyl sulfoxide at 40℃; for 0.166667h; Inert atmosphere; Irradiation;A 15%
B 50%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

4-(1-(4-fluorophenyl)vinyl)-3-(hydroxymethyl)benzonitrile

4-(1-(4-fluorophenyl)vinyl)-3-(hydroxymethyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide
Stage #2: Methyltriphenylphosphonium bromide With potassium tert-butylate
47%
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
82104-74-3

1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

ethyl 4-phenylbuta-2,3-dienoate
91962-64-0

ethyl 4-phenylbuta-2,3-dienoate

9-hydroxy-1-oxo-3-phenyl-1,3-dihydronaphtho[2,3-c]furan-6-carbonitrile

9-hydroxy-1-oxo-3-phenyl-1,3-dihydronaphtho[2,3-c]furan-6-carbonitrile

Conditions
ConditionsYield
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere;
Stage #2: ethyl 4-phenylbuta-2,3-dienoate In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; regioselective reaction;
45%
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