Appearance:WHITE TO ALMOST WHITE CRYSTALLOID Storage: room temperature Application:Citalopram Pharmaceutical intermediates Port:Shanghai
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:82104-74-3
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inquiryProduct description: Product name 5-Cyanophthalide CAS number 82104-74-3 Assay ≥98% Appearance White to yellowish crystalline solid Capacity 100mt/year Application Citalopram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryGood quantity 5-Cyanophthalide Basic information Product Name: 5-Cyanophthalide Synonyms: 5-CYANO-3H-ISOBENZOFURANONE;5-CYANOPHTHALIDE;1,3-DIHYDRO-1-OXO-5-ISOBENZOFURANCARBONITRILE;1,3
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName: 5-Cyanophthalide Synonyms: 5-Cyano-3h-Isobenzofuranone; 1,3-Dihydro-1-Oxo-5-Isobenzofurancarbonitrile; 1,3-Dihydro-1-Oxoisobenzofuran-5-Carbonitrile; 1-Oxo-1,3-Dihydro-2-Benzofuran-5-Carbonitrile; 5-Phthalidenitrile; 5-Cyano-Phthalide; 5-Cya
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Cas:82104-74-3
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Name: 5-Cyanophthalide Synonyms: 1-OXO-1,3-DIHYDRO-2-BENZOFURAN-5-CARBONITRILE;5-Phthalidenitrile;5-CYANO- PHTHALIDE/1-(4-FLUOROPHENYL)-1,3-DIHYROSOBENZOFURAN-5-CARBONITRILE;5-Cyanophthaleine;1,3-Dihydro-1-oxo-5-isobenzofurancarbonitrile
Cas:82104-74-3
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:white to pale yellow crystalline solid Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china
Cas:82104-74-3
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Cas:82104-74-3
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inquiry5-hydroxamyl phthalide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With thionyl chloride at 80℃; for 6h; Product distribution / selectivity; Heating / reflux; | 91% |
5-carboxyphtalide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 5-carboxyphtalide With ethyl phosphate; ammonium carbonate In acetonitrile at 0 - 25℃; for 6h; Stage #2: at 90 - 95℃; for 12h; | 89.5% |
With thionyl chloride; SULFAMIDE In sulfolane; water | |
With thionyl chloride; SULFAMIDE In sulfolane; water |
5-bromophthalide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: potassium cyanide With acetic acid In ethylene glycol at 20℃; Sealed tube; Stage #2: 5-bromophthalide With P(t-Bu)3 Palladacycle Gen. 3; potassium acetate In 1,4-dioxane; water at 60℃; for 16h; Sealed tube; | 84% |
5-bromophthalide
2-methyl-2-phenylmalononitrile
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With C10H8Br2N2Ni*(x)H2O; zinc In N,N-dimethyl acetamide at 80℃; for 16h; Inert atmosphere; Sealed tube; | 57% |
4-cyanopyridine N-oxide
5-bromophthalide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With potassium fluoride; 4,4'-dimethyl-2,2'-bipyridines; trifluoroacetic acid; sodium iodide; nickel dichloride; zinc In N,N-dimethyl acetamide at 60℃; for 36h; | 38% |
1-oxo-3-hydroxy-1,3-dihydro-N-phenylisoindole-5-carbonitrile
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 1-oxo-3-hydroxy-1,3-dihydro-N-phenylisoindole-5-carbonitrile With sodium tetrahydroborate In methanol at 20℃; for 24h; Stage #2: With hydrogenchloride In methanol at 20℃; for 48h; pH=1; | 35% |
5-amino-3H-isobenzofuran-1-one
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With potassium cyanide; copper(II) sulfate ueber eine wss. Diazoniumsalz-Loesung; |
4-cyanobenzanilide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.67 h / -20 - 20 °C 1.2: 68 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C 2.1: NaBH4 / methanol / 24 h / 20 °C 2.2: 35 percent / aq. HCl / methanol / 48 h / 20 °C / pH 1 View Scheme |
4-cyanobenzoyl chlorIde
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 92 percent / pyridine / CH2Cl2 / 20 h 2.1: BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.67 h / -20 - 20 °C 2.2: 68 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C 3.1: NaBH4 / methanol / 24 h / 20 °C 3.2: 35 percent / aq. HCl / methanol / 48 h / 20 °C / pH 1 View Scheme |
(E,Z)-1-oxo-1,3-dihydroisobenzofuran-5-carbaldehyde oxime
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: (E,Z)-1-oxo-1,3-dihydroisobenzofuran-5-carbaldehyde oxime With triethylamine; trifluoroacetic acid In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water |
4,4-dimethyl-2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)oxazoline
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
In thionyl chloride; water; N,N-dimethyl-formamide; toluene | 11.9 g (75%) |
thionyl chloride
1-oxo-1,3-dihydroisobenzofuran-5-carboxamide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; toluene |
5-bromophthalide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
In water |
5-bromophthalide
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
tetrakis(triphenylphosphine)palladium (0) In N,N-dimethyl-formamide | |
With NaCN; tetrakis(triphenylphosphine)palladium (0) In N,N-dimethyl-formamide |
5-iodoisobenzofuran-1(3H)-one
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
tetrakis(triphenylphosphine)palladium (0) In N,N-dimethyl-formamide |
5-chloro-3H-isobenzofuran-1-one
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With NaCN; triphenylphosphine; nickel dichloride In tetrahydrofuran; water; acetonitrile |
(1-oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl chloride
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With SULFAMIDE In sulfolane; water |
3,4-bis(hydroxymethyl)benzonitrile
A
6-cyanoisobenzofuran-1(3H)-one
B
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With Oxone; 2-iodo-3,4,5,6-tetramethylbenzoic acid In water; acetonitrile at 30℃; for 8h; Green chemistry; Overall yield = 56 %; |
methanol
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride at 90℃; for 72h; Stage #2: methanol With N-ethyl-N,N-diisopropylamine In ethanol; dichloromethane pH=8; | 99% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
4-dimethylamino-benzaldehyde
Conditions | Yield |
---|---|
With sodium methylate In ethyl acetate for 0.166667h; Heating; | 98% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With sodium hydroxide In water for 2h; Reflux; | 97% |
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h; |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With potassium hydroxide In water; isopropyl alcohol at 35 - 40℃; for 2h; | 97% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With ammonia; hydrogen In water; isopropyl alcohol at 80℃; under 15001.5 Torr; for 24h; Autoclave; Stage #2: With hydrogenchloride In methanol; ethyl acetate Cooling with ice; | 95% |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With ammonium hydroxide; hydrogen In water; isopropyl alcohol under 37503.8 Torr; for 4h; Autoclave; Heating; Stage #2: With hydrogenchloride In methanol | 90% |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With borane-ammonia complex; C17H16BrMnN2O3S In hexane at 60℃; for 12h; Stage #2: With hydrogenchloride In diethyl ether; water | 50% |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon / 1,4-dioxane; water / 16 h / 80 °C 2: hydrogenchloride / water / 100 °C View Scheme |
3-(N,N-dimethylamino)propylmagnesium chloride
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
4-flourophenylmagnesium bromide
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide With diethylene glycol dimethyl ether; tetrabutyl-ammonium chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 90% |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at 0 - 20℃; for 3.5h; Grignard reaction; Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at 0 - 20℃; Grignard reaction; | 79% |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at -5℃; for 0.25h; Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at -5℃; | |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at -5℃; for 0.25h; Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at -5 - 20℃; for 0.5h; Stage #3: With hydrogenchloride; water In tetrahydrofuran pH=2; Product distribution / selectivity; | |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran at 5 - 15℃; for 4h; Inert atmosphere; Stage #2: 3-(N,N-dimethylamino)propylmagnesium chloride In tetrahydrofuran at 0 - 15℃; for 4h; | 98.8 g |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
4-cyano-2-hydroxymethylbenzoic acid
Conditions | Yield |
---|---|
With lithium hydroxide In methanol; water for 5h; Solvent; Reagent/catalyst; | 87.3% |
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.25h; |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
pivaloyl chloride
4-flourophenylmagnesium bromide
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran; dichloromethane at 0 - 25℃; for 18h; Stage #2: pivaloyl chloride In tetrahydrofuran; dichloromethane at 60℃; for 2h; | 87% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
methylmagnesium bromide
3-(hydroxymethyl)-4-(1-hydroxy-1-methylethyl)benzonitrile
Conditions | Yield |
---|---|
In tetrahydrofuran at -30℃; for 1h; | 87% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
In tetrahydrofuran; chloroform | 86.5% |
In tetrahydrofuran; 1,2-dichloro-ethane | 85% |
In tetrahydrofuran; chlorobenzene | 78% |
In tetrahydrofuran; benzene | 78% |
In tetrahydrofuran; toluene | 70% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
4-flourophenylmagnesium bromide
4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran; 1,2-dimethoxyethane at -10℃; for 3.5h; Stage #2: With water; ammonium chloride In tetrahydrofuran; 1,2-dimethoxyethane at 20℃; for 0.0833333h; | 86.2% |
In tetrahydrofuran at 0 - 5℃; for 5h; Solvent; Temperature; | 85% |
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide In tetrahydrofuran; dichloromethane at -6 - -2℃; Stage #2: With water; ammonium chloride In tetrahydrofuran; dichloromethane | |
In tetrahydrofuran; toluene at -4 - -2℃; Product distribution / selectivity; |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
N'-hydroxy-1-oxo-1,3-dihydroisobenzofuran-5-carboximidamide
Conditions | Yield |
---|---|
With hydroxylamine In ethanol; water at 20℃; for 63h; Heating / reflux; | 86.2% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
magnesium
1-Bromo-4-fluorobenzene
1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
Stage #1: magnesium; 1-Bromo-4-fluorobenzene; iodine In tetrahydrofuran Stage #2: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile In tetrahydrofuran; dichloromethane at -6 - -2℃; | 86% |
Stage #1: magnesium; 1-Bromo-4-fluorobenzene; iodine In tetrahydrofuran Stage #2: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile In tetrahydrofuran; toluene at -6 - -2℃; |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
4-flourophenylmagnesium bromide
4-(bis(4-fluorophenyl)hydroxymethyl)-3-(hydroxymethyl)benzonitrile
Conditions | Yield |
---|---|
In toluene at 0 - 80℃; for 10h; Temperature; Solvent; | 84% |
In tetrahydrofuran at 0 - 20℃; for 17h; Inert atmosphere; | 64.18% |
In tetrahydrofuran at 25 - 35℃; |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
2-Methyl-1-phenyl-2-propanol
Conditions | Yield |
---|---|
With sulfuric acid In toluene at 0 - 20℃; | 82% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
3,4-bis(hydroxymethyl)benzonitrile
Conditions | Yield |
---|---|
With phenylsilane; potassium hydroxide In tetrahydrofuran at 66℃; for 6h; | 75% |
With phenylsilane; potassium hydroxide In tetrahydrofuran for 4h; Schlenk technique; Inert atmosphere; Reflux; | 68% |
Conditions | Yield |
---|---|
With tris[2-phenylpyridinato-C2,N]iridium(III); sodium acetate In N,N-dimethyl acetamide at 20℃; for 2h; Inert atmosphere; Glovebox; Irradiation; diastereoselective reaction; | 73% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
1-(tert-butoxycarbonyl)-L-proline
tert-butyl 2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With Ir[p-F(tert-butyl)2-phenylpyridine]3; cesium fluoride In dimethyl sulfoxide at 20℃; for 48h; Inert atmosphere; Irradiation; | 70% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
N-carbobenzyloxyproline
Conditions | Yield |
---|---|
With 1-(4-(9H-carbazol-9-yl)phenyl)-3-amino-9H-fluorene-2,4-dicarbonitrile; cesium fluoride In dimethyl sulfoxide at 20℃; for 24h; Inert atmosphere; Irradiation; | 69% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
1-Bromo-4-fluorobenzene
4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran Reflux; Inert atmosphere; Stage #2: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; | 63% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
ethyl hexa-2,3-dienoate
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere; Stage #2: ethyl hexa-2,3-dienoate In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; regioselective reaction; | 60% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
di-tert-butyl dicarbonate
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 0 - 20℃; for 12h; Inert atmosphere; | 56% |
formic acid
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Conditions | Yield |
---|---|
With palladium 10% on activated carbon In 1,4-dioxane; water at 80℃; for 16h; | 55% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
(E)-1-phenyl-N-(piperidin-1-yl)methanimine
Conditions | Yield |
---|---|
With tris[2-phenylpyridinato-C2,N]iridium(III); lithium acetate In dimethyl sulfoxide at 40℃; for 0.166667h; Inert atmosphere; Irradiation; | A 15% B 50% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
Methyltriphenylphosphonium bromide
4-flourophenylmagnesium bromide
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide Stage #2: Methyltriphenylphosphonium bromide With potassium tert-butylate | 47% |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
ethyl 4-phenylbuta-2,3-dienoate
Conditions | Yield |
---|---|
Stage #1: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere; Stage #2: ethyl 4-phenylbuta-2,3-dienoate In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; regioselective reaction; | 45% |
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