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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Citalopram Manufacturer/High quality/Best price/In stock

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Citalopram

Cas:59729-33-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% citalopram 59729-33-8 Producer

Cas:59729-33-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Citalopram

Cas:59729-33-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Citalopram CAS 59729-33-8

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 59729-33-8 with competitive price

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 59729-33-8 Citalopram

Cas:59729-33-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Citalopram Other Name Celexa, Cipramil CAS: 59729-33-8 MF: C20H21FN2

Citalopram

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white crystalline powder Storage:R.T Package:25kg/Barrel Application:Antidepressant effect Transportation:Express/Sea/Air Port:Any port in China

Good producer Citalopram powder

Cas:59729-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu

Supplier Top quality Citalopram CAS:59729-33-8

Cas:59729-33-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro- 59729-33-8

Cas:59729-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Citalopram manufacturer with low price

Cas:59729-33-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:59729-33-8

Cas:59729-33-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Citalopram

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Citalopram

Cas:59729-33-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Citalopram cas 59729-33-8 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Citalopram cas 59729-33-8

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

CITALOPRAM

Cas:59729-33-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Citalopram

Cas:59729-33-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Citalopram

Cas:59729-33-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Citalopram

Cas:59729-33-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

TIANFU Citalopram

Cas:59729-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High quality Citalopram

Cas:59729-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Citalopram

Cas:59729-33-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Citalopram

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Citalopram

Cas:59729-33-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Citalopram

Cas:59729-33-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Citalopram

Cas:59729-33-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Citalopram

Cas:59729-33-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-

Cas:59729-33-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

citalopram hydrobromide
59729-32-7

citalopram hydrobromide

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide In water100%
With sodium hydroxide In water; toluene for 0.25h; pH=10;93%
With ammonia In water at 20℃; for 3h; pH=9; Product distribution / selectivity;
With sodium hydroxide In water; toluene at 20℃; pH=9 - 10; Industry scale;
3-chloromethyl-4-(4-fluoro-benzoyl)-benzonitrile
445312-08-3

3-chloromethyl-4-(4-fluoro-benzoyl)-benzonitrile

3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With ammonium chloride In tetrahydrofuran; water; toluene95%
With hydrogen bromide In tetrahydrofuran; 1,2-dimethoxyethane75%
1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
64169-67-1

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

3-(Dimethylamino)propyl chloride
109-54-6

3-(Dimethylamino)propyl chloride

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; 3-(Dimethylamino)propyl chloride With sodium hydride In 1,3-dimethyl-2-imidazolidinone; toluene at 40 - 50℃; for 0.666667h;
Stage #2: With hydrogenchloride; water at 65 - 70℃; for 3h;
Stage #3: With sodium hydroxide In water; toluene Product distribution / selectivity;
93%
Stage #1: 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; 3-(Dimethylamino)propyl chloride With sodium hydride In tetrahydrofuran; toluene at 40 - 50℃; for 0.666667h;
Stage #2: With dimethyl sulfoxide at 65 - 70℃; for 3h;
Stage #3: With acetic acid In water; toluene Product distribution / selectivity;
51.6%
With sodium hydride In dimethyl sulfoxide; toluene at 20 - 25℃; for 3h; Product distribution / selectivity;
1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide
64372-56-1

1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With trichlorophosphate In acetonitrile at 60℃; Heating / reflux;92%
Stage #1: 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide With thionyl chloride In toluene at 85 - 95℃; for 1h;
Stage #2: With ammonia In water; toluene pH=7.5 - 7.8; Purification / work up;
dl-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran oxalate salt

dl-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran oxalate salt

copper(I) cyanide
544-92-3

copper(I) cyanide

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: dl-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran oxalate salt; copper(I) cyanide With copper(l) iodide In DMF (N,N-dimethyl-formamide) at 145 - 150℃; for 28h;
Stage #2: With ethylenediamine In DMF (N,N-dimethyl-formamide); water at 25 - 30℃; for 2h;
87%
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
103146-25-4

4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile With phosphoric acid In toluene at 80℃; for 2.5h;
Stage #2: With sodium hydroxide In water; toluene at 50℃; pH=10;
86%
With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 3h;55%
With triphenylphosphine; sodium t-butanolate; diethylazodicarboxylate In tetrahydrofuran at 0℃;
With sulfuric acid In water at 70℃; for 6h; Product distribution / selectivity;
potassium cyanide

potassium cyanide

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
64169-39-7

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: potassium cyanide With acetic acid In ethylene glycol Sealed tube;
Stage #2: 3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine With P(t-Bu)3 Palladacycle Gen. 3; potassium acetate In 1,4-dioxane; water at 60℃; for 16h; Sealed tube;
86%
3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
64169-39-7

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine With sodium cyanide; copper(I) cyanide In DMF (N,N-dimethyl-formamide); toluene at 154 - 159℃; Heating / reflux;
Stage #2: With sodium cyanide In DMF (N,N-dimethyl-formamide); water at 60 - 70℃;
Stage #3: With ethylenediamine In DMF (N,N-dimethyl-formamide); water; toluene
84%
aqueous ethylenediamine

aqueous ethylenediamine

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
64169-39-7

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

copper(l) cyanide

copper(l) cyanide

pyrographite
7440-44-0

pyrographite

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene84%
3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
64169-39-7

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

copper(l) cyanide

copper(l) cyanide

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 150℃; for 24h; Rosenmund-van Braun Cyanation; Sealed tube; Inert atmosphere;74%
3-[i-(4-fluorophenyl)-1,3 dihydro-isobenzofiran-1-yl]propylldirnethylamine 5-magnesium bromide

3-[i-(4-fluorophenyl)-1,3 dihydro-isobenzofiran-1-yl]propylldirnethylamine 5-magnesium bromide

[3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl]dimethyl amine

[3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl]dimethyl amine

1-cyanobenzotriazole
15328-32-2

1-cyanobenzotriazole

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With ammonium chloride In tetrahydrofuran; water; toluene71.4%
3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
125803-03-4

3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

A

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

B

HBr salt of citalopram

HBr salt of citalopram

Conditions
ConditionsYield
With ammonium hydroxide; hydrogen bromide; copper(I) chloride; silica gel In pyridine; n-heptane; isopropyl alcohol; acetoneA 14%
B 66%
C19H16FNO

C19H16FNO

dimethyl amine
124-40-3

dimethyl amine

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: C19H16FNO With sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide
Stage #2: dimethyl amine With sodium tris(acetoxy)borohydride
62%
4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline
265137-38-0

4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline With pyridine; thionyl chloride at 20 - 25℃; for 1h;
Stage #2: With trichlorophosphate for 4h;
48%
With pyridine; trichlorophosphate at 20 - 90℃; for 5h;38%
5-Amino-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran

5-Amino-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With NaCN; sulfuric acid; sodium carbonate; sodium nitrite; CuCN In water; toluene32%
Reaxys ID: 11465244

Reaxys ID: 11465244

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide In water Conversion of starting material;
3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
64169-39-7

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

copper(I) cyanide
544-92-3

copper(I) cyanide

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine; copper(I) cyanide at 140 - 150℃; for 6h;
Stage #2: With N,N-dimethyl-formamide at 140 - 150℃; for 0.0833333h;
Stage #3: With ethylenediamine In water; toluene at 80℃; for 0.416667h;
With alpha-D-glucopyranose; potassium iodide In DMF (N,N-dimethyl-formamide) at 140 - 160℃;
3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
64169-39-7

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

copper(I) cyanide
544-92-3

copper(I) cyanide

A

rac-desmethylcitalopram
62498-67-3

rac-desmethylcitalopram

B

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
at 140 - 150℃;
In DMF (N,N-dimethyl-formamide) at 40 - 165℃; for 6.5 - 8.5h;
Citalopram oxalate

Citalopram oxalate

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With ammonia In water; toluene
With ammonia In water pH=9.0 - 9.2;
With ammonia In water for 0.5h; pH=6.2 - 9.2; Product distribution / selectivity;
Br(1-)*C20H22FN2O2(1-)*Mg(2+)

Br(1-)*C20H22FN2O2(1-)*Mg(2+)

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With phosphoric acid In tetrahydrofuran; water at 10 - 80℃;
formaldehyd
50-00-0

formaldehyd

rac-desmethylcitalopram
62498-67-3

rac-desmethylcitalopram

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
Stage #1: formaldehyd; rac-desmethylcitalopram With formic acid In chloroform for 8h; Heating / reflux;
Stage #2: With ammonia In chloroform; water at 20℃; pH=8 - 9;
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
103146-25-4

4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

A

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

B

1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide
64372-56-1

1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide

Conditions
ConditionsYield
Stage #1: 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile With phosphoric acid In water at 105℃; for 14h;
Stage #2: With ammonia In water pH=8 - 10; Purification / work up;
formaldehyd
50-00-0

formaldehyd

formic acid
64-18-6

formic acid

didesmethylcitalopram
62498-69-5

didesmethylcitalopram

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
In water at 95 - 100℃; for 12h; Heating / reflux;
Citalopram hydrochloride

Citalopram hydrochloride

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 3h; pH=9; Product distribution / selectivity;
C20H21FN2O*H2O4S

C20H21FN2O*H2O4S

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With ammonia In water; toluene at 10 - 15℃; Product distribution / selectivity;
C2H4O2*C20H21FN2O
500733-84-6

C2H4O2*C20H21FN2O

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 3h; pH=9; Product distribution / selectivity;
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Di-p-toluoyl-L-tartaric acid
32634-66-5

Di-p-toluoyl-L-tartaric acid

C20H18O8*C20H21FN2O
1373405-39-0

C20H18O8*C20H21FN2O

Conditions
ConditionsYield
In isopropyl alcohol Reflux;100%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide
64372-56-1

1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxamide

Conditions
ConditionsYield
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile In dimethyl sulfoxide for 0.5h;
Stage #2: With dihydrogen peroxide In dimethyl sulfoxide Cooling with ice; Inert atmosphere;
95%
With dihydrogen peroxide; potassium hydroxide In ethanol; dimethyl sulfoxide at 60℃; for 2h;49%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
125803-03-4

3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Inert atmosphere; Reflux;94%
With hydrogen In para-xylene at 130℃; under 750.075 Torr; for 24h; chemoselective reaction;75%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

citalopram hydrobromide
59729-32-7

citalopram hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; toluene at 5 - 10℃; Heating / reflux;93.6%
With hydrogen bromide In water; isopropyl alcohol pH=6 - 7;88.2%
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile With hydrogen bromide In acetone at 20 - 25℃; Gas phase;
Stage #2:
Stage #3: In water
77.3%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

1,1-difluoro-2,2-diphenylethylene
569-72-2

1,1-difluoro-2,2-diphenylethylene

C34H30F2N2O

C34H30F2N2O

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; sodium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; Irradiation;84%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

C24H30N2O5S

C24H30N2O5S

C44H51FN4O6S

C44H51FN4O6S

Conditions
ConditionsYield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; sodium acetate In N,N-dimethyl-formamide at 20℃; for 16h; Irradiation; Inert atmosphere; diastereoselective reaction;82%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

2(13)CN(1-)*Zn(2+)

2(13)CN(1-)*Zn(2+)

C19(13)CH21FN2O

C19(13)CH21FN2O

Conditions
ConditionsYield
With C10H12O2NiC8H12-1,5-cyclo; triphenylborane; diphenyl(methyl)phosphine In 1-methyl-pyrrolidin-2-one at 80℃; for 18h; Reagent/catalyst; Inert atmosphere; Glovebox; Sealed tube;75%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

methylmagnesium bromide
75-16-1

methylmagnesium bromide

1-[1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-yl]-ethanone

1-[1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-yl]-ethanone

Conditions
ConditionsYield
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile; methylmagnesium bromide In toluene Heating;
Stage #2: With hydrogenchloride In water for 2h; Heating;
73%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

2-methyl-3-(phenylethynyl)benzo[b]thiophene

2-methyl-3-(phenylethynyl)benzo[b]thiophene

C37H33FN2OS

C37H33FN2OS

Conditions
ConditionsYield
With potassium tert-butylate; lithium hexamethyldisilazane at 120℃; for 24h;67%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane
745783-97-5

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

benzaldehyde
100-52-7

benzaldehyde

1-{10-[3-(dimethylamino)-2-methylpropyl]-10H-phenothiazin-3-yl}-2-phenyl-2-[(triethylsilyl)oxy]ethan-1-one

1-{10-[3-(dimethylamino)-2-methylpropyl]-10H-phenothiazin-3-yl}-2-phenyl-2-[(triethylsilyl)oxy]ethan-1-one

Conditions
ConditionsYield
Stage #1: triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane; benzaldehyde With copper(I) thiophene-2-carboxylate; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride; sodium t-butanolate In toluene at 20℃; for 0.166667h; Inert atmosphere; Sealed tube;
Stage #2: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile In toluene at 80℃; for 3h; Inert atmosphere;
Stage #3: With acetic acid In water; toluene for 1h; Inert atmosphere;
64%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

4-(E)-4-(dimethylamino)-1-(4-fluorophenyl)but-1-enyl-3-(hydroxymethyl)benzonitrile
1370643-23-4

4-(E)-4-(dimethylamino)-1-(4-fluorophenyl)but-1-enyl-3-(hydroxymethyl)benzonitrile

C40H41F2N4O(1+)*Cl(1-)
1370643-27-8

C40H41F2N4O(1+)*Cl(1-)

Conditions
ConditionsYield
With methanesulfonyl chloride; triethylamine In dichloromethane for 24h; Reflux;45%
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile
59729-33-8

1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

(2S,3S)-di-4-toluoyltartaric acid
32634-68-7

(2S,3S)-di-4-toluoyltartaric acid

C20H18O8*C20H21FN2O
1373405-37-8

C20H18O8*C20H21FN2O

Conditions
ConditionsYield
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile; (2S,3S)-di-4-toluoyltartaric acid In acetonitrile at 20℃;
Stage #2: In methanol; acetonitrile at 0 - 75℃;
36%
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile; (2S,3S)-di-4-toluoyltartaric acid In acetonitrile at 20℃; for 1h; Resolution of racemate;
Stage #2: With sodium hydroxide In water
Stage #3: (2S,3S)-di-4-toluoyltartaric acid optical yield given as %ee; Further stages;
11%

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