CAS No.62498-67-3,1-(4-fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]isobenzofuran-5-carbonitrile Suppliers

Hebei Nengqian Chemical Import and Export Co., LTD

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1-(4-fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]isobenzofuran-5-carbonitrile

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

62498-67-3 CAS NO.62498-67-3

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Antimex Chemical Limied

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BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

Citalopram Related Compou

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1-(4-fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]isob...

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Zibo Hangyu Biotechnology Development Co., Ltd

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1-(4-fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]isobenzofuran-5-carbonitrile

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Jilin haofei import and export trade Co.,Ltd

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62498-67-3 CAS NO.62498-67-3

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Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

Citalopram Impurity- D(USP/EP-IMP-D)Desmethyl CTR

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Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the rac Demethyl Citalopram, CAS:62498-67-3 with the most competitive price and the best

rac Demethyl Citalopram

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SHANGHAI ZZBIO CO., LTD.

Comprehensive range product line, COA with HPLC, MS and NMR spectra. Package:1mg Application:pharmaceutical industry, biotech industry, research institutions.

[2H4]-Desmethylcitalopram

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Synthetic route

: 59729-33-8
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

: 62498-67-3
rac-desmethylcitalopram

Conditions

Conditions	Yield
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile With carbonochloridic acid 1-chloro-ethyl ester In dichloromethane; toluene at 10 - 20℃; Industry scale; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 20 - 65℃; Industry scale;	91.5%
Multi-step reaction with 2 steps 1: 6 h / 130 °C 2: 0.31 g / MeOH / 5 h / Heating View Scheme
Multi-step reaction with 2 steps 1.1: 6 h / 130 °C 2.1: MeOH / 5 h / Heating 2.2: 0.31 g / NaOH / tetrahydrofuran; H2O View Scheme
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile With carbonochloridic acid, chloromethyl ester In 1,2-dichloro-ethane at 0 - 90℃; Stage #2: With methanol at 60 - 65℃; Stage #3: With ammonia In water at 20 - 35℃; pH=9.5;
Stage #1: 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate In 1,2-dichloro-ethane for 4h; Inert atmosphere; Reflux; Stage #2: In methanol for 2h; Reflux;

: 59729-32-7
citalopram hydrobromide

: 62498-67-3
rac-desmethylcitalopram

Conditions

Conditions	Yield
Stage #1: citalopram hydrobromide With ammonium hydroxide In water Stage #2: With carbonochloridic acid 1-chloro-ethyl ester In 1,2-dichloro-ethane at 0℃; for 18h; Inert atmosphere; Reflux;	78%

: citalopram hydrobromide

: 62498-67-3
rac-desmethylcitalopram

Conditions

Conditions	Yield
Stage #1: citalopram hydrobromide With carbonochloridic acid 1-chloro-ethyl ester In methanol at 65 - 130℃; for 11h; Stage #2: With sodium hydroxide In tetrahydrofuran at 25℃; for 14h;	74%

: 1025972-63-7
{3-[5-cyano-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-1-yl]-propyl}-methyl-carbamic acid 1-chloro-ethyl ester

A: 1-(4-fluoro-phenyl)-1-(3-methylamino-propyl)-1,3-dihydro-isobenzofuran-5-carboxylic acid methyl ester

B: 62498-67-3
rac-desmethylcitalopram

Conditions

Conditions	Yield
With methanol for 5h; Heating; Title compound not separated from byproducts;	A n/a B 0.31 g

: 1025972-63-7
{3-[5-cyano-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-1-yl]-propyl}-methyl-carbamic acid 1-chloro-ethyl ester

A: sodium; 1-(4-fluoro-phenyl)-1-(3-methylamino-propyl)-1,3-dihydro-isobenzofuran-5-carboxylate

B: 62498-67-3
rac-desmethylcitalopram

Conditions

Conditions	Yield
Stage #1: {3-[5-cyano-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-1-yl]-propyl}-methyl-carbamic acid 1-chloro-ethyl ester With methanol for 5h; Heating; Stage #2: With sodium hydroxide In tetrahydrofuran; water	A n/a B 0.31 g

: C19H17FN2O

: 62498-67-3
rac-desmethylcitalopram

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 10 - 20℃; for 0.5h;

: 64169-39-7
3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

: 544-92-3
copper(I) cyanide

A: 62498-67-3
rac-desmethylcitalopram

B: 59729-33-8
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
at 140 - 150℃;
In DMF (N,N-dimethyl-formamide) at 40 - 165℃; for 6.5 - 8.5h;

...Expand

: 59729-33-8
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

A: 62498-67-3
rac-desmethylcitalopram

B: 63284-72-0
Citalopram N-Oxide

Conditions

Conditions	Yield
With NADH In methanol at 37℃; for 0.5h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 62498-67-3
rac-desmethylcitalopram

: 2913-97-5
N-phthalimidyl-2-aminoacetaldehyde

: 1507402-14-3
1-(3-((2-(1,3-dioxoisoindolin-2-yl)ethyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	96%

: 4687-25-6
1-benzofuran-3-carbaldehyde

: 62498-67-3
rac-desmethylcitalopram

: 1507401-92-4
1-(3-((benzofuran-3-yl-methyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	95%

: 62498-67-3
rac-desmethylcitalopram

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1507401-87-7
1-(3-((cyclopropylmethyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	94%

: 872-85-5
pyridine-4-carbaldehyde

: 62498-67-3
rac-desmethylcitalopram

: 1507401-96-8
1-(4-fluorophenyl)-1-(3-(methyl(pyridin-4-yl)amino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	94%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 62498-67-3
rac-desmethylcitalopram

: 1507402-18-7
1-(4-fluorophenyl)-1-(3-(methyl(1,4-dioxaspiro[4.5]decan-8-yl)-amino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	94%

: 5381-20-4
benzothiophene-3-carboxaldehyde

: 62498-67-3
rac-desmethylcitalopram

: 1507401-93-5
1-(3-((benzo[b]thiophen-3-yl-methyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	94%

: 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbaldehyde

: 62498-67-3
rac-desmethylcitalopram

: 1507402-05-2
1-(3-(((1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)methyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	94%

: 62498-67-3
rac-desmethylcitalopram

: 123-72-8
butyraldehyde

: 1507401-89-9
1-(3-(butyl(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	93%

: 62498-67-3
rac-desmethylcitalopram

: 123-38-6
propionaldehyde

: 1507401-88-8
1-(4-fluorophenyl)-1-(3-(methyl(propyl)amino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	92%

: 62498-67-3
rac-desmethylcitalopram

: 66-99-9
β-naphthaldehyde

: 1507402-01-8
1-(4-fluorophenyl)-1-(3-(methyl(naphthalen-2-ylmethyl)amino)-propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	92%

: 62498-67-3
rac-desmethylcitalopram

: 30084-90-3
9H-fluorene-2-carbaldehyde

: 1507402-03-0
1-(3-(((9H-fluoren-2-yl)methyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	92%

: 62498-67-3
rac-desmethylcitalopram

: 3-formyl-5-methoxy-indole-1-carboxylic acid tert-butyl ester

: 1507402-11-0
tert-butyl-3-(((3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propyl)(methyl)amino)methyl)-5-methoxy-1H-indole-1-carboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	91%

: 62498-67-3
rac-desmethylcitalopram

: 100-10-7
4-dimethylamino-benzaldehyde

: 1507401-94-6
1-(3-((4-(dimethylamino)benzyl)(methyl)amino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	90%

: 4363-93-3
quinoline-4-carboxaldehyde

: 62498-67-3
rac-desmethylcitalopram

: 1507401-98-0
1-(4-fluorophenyl)-1-(3-(methyl(quinolin-4-ylmethyl)amino)-propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	89%

: 62498-67-3
rac-desmethylcitalopram

: 57476-50-3
1-tert-butoxycarbonyl-3-formylindole

: 1507402-07-4
tert-butyl-3-(((3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propyl)(methyl)amino)methyl)-1H-indole-1-carboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	87%

: 62498-67-3
rac-desmethylcitalopram

: 122-78-1
phenylacetaldehyde

: 1507401-90-2
1-(4-fluorophenyl)-1-(3-(methyl(phenethyl)amino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	86%

: 62498-67-3
rac-desmethylcitalopram

: 18328-11-5
3-benzyl propionaldehyde

: 1507401-91-3
1-(4-fluorophenyl)-1-(3-(methyl(4-phenylbutyl)amino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	72%

: 62498-67-3
rac-desmethylcitalopram

: 32634-66-5
Di-p-toluoyl-L-tartaric acid

: 1084839-40-6
(+)-desmethyl citalopram DPTTA salt

Conditions

Conditions	Yield
In isopropyl alcohol at 20 - 45℃; Product distribution / selectivity; Industry scale;	44.6%

: 62498-67-3
rac-desmethylcitalopram

2-(4Chlorobutyl)-dioxolan-4-ylmethoxymethyl polystyrene: 2-(4Chlorobutyl)-dioxolan-4-ylmethoxymethyl polystyrene

: 59-88-1
phenylhydrazine hydrochloride

: 144-55-8
sodium hydrogencarbonate

: 1-[3-[[3-(1H-Indol-3-yl)propyl]methylamino]propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
With sodium iodide; ammonia; N-ethyl-N,N-diisopropylamine; Zinc chloride In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide	42%

...Expand

: 62498-67-3
rac-desmethylcitalopram

: 14777-29-8, 85273-25-2
methyl acetimidate

: N-{3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]propyl}-N-methyl-ethanimidamide

Conditions

Conditions	Yield
In toluene at 80℃; for 14h; Inert atmosphere;	40%

: 5693-62-9
2,3,4,5-tetrahydro-6-methoxypyridine

: 62498-67-3
rac-desmethylcitalopram

: 1-(4-fluorophenyl)-1-{3-[methyl(3,4,5,6-tetrahydropyridin-2-yl)amino]propyl}-1,3-dihydro-2-benzofuran-5-carbonitrile

Conditions

Conditions	Yield
at 80℃; for 15h;	24%

: 62498-67-3
rac-desmethylcitalopram

: methyl benzenecarboximidoate hydrochloride

: N-{3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]propyl}-N-methyl-phenylmethanimidamide

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 15h;	19%

: 62498-67-3
rac-desmethylcitalopram

: 87-69-4
L-Tartaric acid

: 526204-73-9
desmethylcitalopram L-tartrate

Conditions

Conditions	Yield
In methanol; water at 20℃; for 1h;

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KAISA GROUP INC

Bluecrystal chem-union

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BOC Sciences

Changchun Artel lmport and Export trade company

Hangzhou Sartort Biopharma Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd

Jilin haofei import and export trade Co.,Ltd

Simson Pharma Limited

Finetech Industry Limited

SHANGHAI ZZBIO CO., LTD.

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