Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:220991-20-8
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:220991-20-8
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:220991-20-8
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:220991-20-8
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:220991-20-8
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:220991-20-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:220991-20-8
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inquiryLUMIRACOXIBCAS:220991-20-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:220991-20-8
Min.Order:4 Kilogram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:220991-20-8
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:220991-20-8
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inquiryProduct Name: LUMIRACOXIB Synonyms: 2-[2-[(2-chloro-6-fluoro-phenyl)amino]-5-methyl-phenyl]acetic acid;2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic Acid;CGS 35189;COX 189;Prexige;Lumaricoxib;Benzeneacetic acid, 2-((2-chloro-6-fluoro
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:220991-20-8
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
good quality and cheap priceAppearance:powder Package:1kg,5kg,25kg Application:as raw material Transportation:by sea/air/courier
Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:220991-20-8
Min.Order:0
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Type:Lab/Research institutions
inquiryAmoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi
Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Lumiracoxib cas 220991-20-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one
lumiracoxib
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water Heating; | 90% |
With hydrogenchloride; sodium hydroxide In ethanol; water |
potassium 2-iodo-5-methylphenylacetate
2-chloro-6-fluoroaniline
lumiracoxib
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate at 100℃; Ullmann coupling; | 41% |
2-chloro-6-fluoroaniline
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C 1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C 2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 5.1: 82 percent / toluene / 80 - 90 °C 6.1: 80 percent / AlCl3 / 3 h / 170 °C 7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 76 percent / pTsOH*H2O / toluene / 18 h / Heating 2: 76 percent / I2; DBU / xylene / 36 h / 155 °C 3: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
p-toluidine
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-bromo-3-fluoro-chlorobenzene
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
4-Cyanochlorobenzene
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C 1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C 2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 5.1: 82 percent / toluene / 80 - 90 °C 6.1: 80 percent / AlCl3 / 3 h / 170 °C 7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-chloro-6-fluorophenol
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: propan-2-ol / Heating 2: MeONa / methanol / 2 h / 85 °C 3: 82 percent / toluene / 80 - 90 °C 4: 80 percent / AlCl3 / 3 h / 170 °C 5: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
N-(p-tolyl)-2-chloroacetamide
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: propan-2-ol / Heating 2: MeONa / methanol / 2 h / 85 °C 3: 82 percent / toluene / 80 - 90 °C 4: 80 percent / AlCl3 / 3 h / 170 °C 5: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
N-(2-chloro-6-fluoro-phenyl)-4-methylaniline
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 82 percent / toluene / 80 - 90 °C 2: 80 percent / AlCl3 / 3 h / 170 °C 3: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
4-(2-chloro-6-fluorophenylamino)benzonitrile
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 1.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 2.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 3.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 4.1: 82 percent / toluene / 80 - 90 °C 5.1: 80 percent / AlCl3 / 3 h / 170 °C 6.1: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 76 percent / I2; DBU / xylene / 36 h / 155 °C 2: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / AlCl3 / 3 h / 170 °C 2: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: MeONa / methanol / 2 h / 85 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 2: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 3: 82 percent / toluene / 80 - 90 °C 4: 80 percent / AlCl3 / 3 h / 170 °C 5: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-Amino-5-methylbenzoic acid
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 4: dimethyl sulfoxide / 1.5 h / Inert atmosphere 5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 4: dimethyl sulfoxide / 1.5 h / Inert atmosphere 5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethyl sulfoxide / 1.5 h / Inert atmosphere 2: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 2: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 3: dimethyl sulfoxide / 1.5 h / Inert atmosphere 4: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 2: dimethyl sulfoxide / 1.5 h / Inert atmosphere 3: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetonitrile
lumiracoxib
Conditions | Yield |
---|---|
With water; barium(II) hydroxide In 1,4-dioxane for 30h; Reflux; Inert atmosphere; |
1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one
lumiracoxib
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water Heating; | 90% |
With hydrogenchloride; sodium hydroxide In ethanol; water |
potassium 2-iodo-5-methylphenylacetate
2-chloro-6-fluoroaniline
lumiracoxib
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate at 100℃; Ullmann coupling; | 41% |
4-Cyanochlorobenzene
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C 1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C 2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 5.1: 82 percent / toluene / 80 - 90 °C 6.1: 80 percent / AlCl3 / 3 h / 170 °C 7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-chloro-6-fluorophenol
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: propan-2-ol / Heating 2: MeONa / methanol / 2 h / 85 °C 3: 82 percent / toluene / 80 - 90 °C 4: 80 percent / AlCl3 / 3 h / 170 °C 5: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-chloro-6-fluoroaniline
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C 1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C 2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 5.1: 82 percent / toluene / 80 - 90 °C 6.1: 80 percent / AlCl3 / 3 h / 170 °C 7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 76 percent / pTsOH*H2O / toluene / 18 h / Heating 2: 76 percent / I2; DBU / xylene / 36 h / 155 °C 3: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
p-toluidine
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
N-(p-tolyl)-2-chloroacetamide
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: propan-2-ol / Heating 2: MeONa / methanol / 2 h / 85 °C 3: 82 percent / toluene / 80 - 90 °C 4: 80 percent / AlCl3 / 3 h / 170 °C 5: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-bromo-3-fluoro-chlorobenzene
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
N-(2-chloro-6-fluoro-phenyl)-4-methylaniline
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 82 percent / toluene / 80 - 90 °C 2: 80 percent / AlCl3 / 3 h / 170 °C 3: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
4-(2-chloro-6-fluorophenylamino)benzonitrile
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 1.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 2.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 3.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 4.1: 82 percent / toluene / 80 - 90 °C 5.1: 80 percent / AlCl3 / 3 h / 170 °C 6.1: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 76 percent / I2; DBU / xylene / 36 h / 155 °C 2: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / AlCl3 / 3 h / 170 °C 2: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: MeONa / methanol / 2 h / 85 °C 2: 82 percent / toluene / 80 - 90 °C 3: 80 percent / AlCl3 / 3 h / 170 °C 4: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 2: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C 3: 82 percent / toluene / 80 - 90 °C 4: 80 percent / AlCl3 / 3 h / 170 °C 5: 90 percent / aq. NaOH / ethanol; H2O / Heating View Scheme |
2-Amino-5-methylbenzoic acid
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 4: dimethyl sulfoxide / 1.5 h / Inert atmosphere 5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 4: dimethyl sulfoxide / 1.5 h / Inert atmosphere 5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethyl sulfoxide / 1.5 h / Inert atmosphere 2: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 2: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 3: dimethyl sulfoxide / 1.5 h / Inert atmosphere 4: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C 2: dimethyl sulfoxide / 1.5 h / Inert atmosphere 3: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere View Scheme |
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetonitrile
lumiracoxib
Conditions | Yield |
---|---|
With water; barium(II) hydroxide In 1,4-dioxane for 30h; Reflux; Inert atmosphere; |
methanol
lumiracoxib
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: methanol; lumiracoxib With hydrogenchloride In water for 8h; Reflux; Stage #2: With sodium carbonate In water | 89% |
Stage #1: methanol; lumiracoxib With hydrogenchloride In water for 8h; Reflux; Stage #2: With sodium hydrogencarbonate In water Cooling with ice; Saturated solution; | 89% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; | 74% |
lumiracoxib
1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h; | 85% |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 8 h / Reflux 2: hydrazine hydrate / methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 8 h / Reflux 1.2: Cooling with ice; Saturated solution 2.1: hydrazine hydrate / methanol / 24 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 2: hydrazine hydrate / ethanol / 1.5 h / Reflux View Scheme |
lumiracoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 8 h / Reflux 2: hydrazine hydrate / methanol / 24 h / Reflux 3: acetic acid / 7 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water / 8 h / Reflux 1.2: Cooling with ice; Saturated solution 2.1: hydrazine hydrate / methanol / 24 h / Reflux 3.1: acetic acid / 7 h / Reflux View Scheme |
lumiracoxib
C15H14ClFN2O2
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 2: potassium cyanide; water; hydroxylamine / methanol; tetrahydrofuran / 18 h / 20 °C View Scheme |
lumiracoxib
C16H13ClFN3O2
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 2: hydrazine hydrate / ethanol / 1.5 h / Reflux 3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme |
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