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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Lumiracoxib supplier in China

Cas:220991-20-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Lumiracoxib

Cas:220991-20-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% LUMIRACOXIB 220991-20-8 GMP Manufacturer

Cas:220991-20-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Lumiracoxib

Cas:220991-20-8

Min.Order:1 Kilogram

FOB Price: $4.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Lumiracoxib

Cas:220991-20-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

LUMIRACOXIB CAS 220991-20-8

Cas:220991-20-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM-LUMIRACOXIB

Cas:220991-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 220991-20-8 with competitive price

Cas:220991-20-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl- 220991-20-8

Cas:220991-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

LUMIRACOXIBCAS:220991-20-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

LUMIRACOXIBCAS:220991-20-8

Cas:220991-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

Cas:220991-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Lumiracoxib

Cas:220991-20-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Lumiracoxib

Cas:220991-20-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

Cas:220991-20-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Lumiracoxib

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Lumiracoxib

Cas:220991-20-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Lumiracoxib;COX-189;Benzeneaceticacid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

Cas:220991-20-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: LUMIRACOXIB Synonyms: 2-[2-[(2-chloro-6-fluoro-phenyl)amino]-5-methyl-phenyl]acetic acid;2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic Acid;CGS 35189;COX 189;Prexige;Lumaricoxib;Benzeneacetic acid, 2-((2-chloro-6-fluoro

LUMIRACOXIB

Cas:220991-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Lumiracoxib

Cas:220991-20-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Lumiracoxib

Cas:220991-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Lumiracoxib

Cas:220991-20-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Lumiracoxib

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Lumiracoxib

Cas:220991-20-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Lumiracoxib

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

good quality and cheap priceAppearance:powder Package:1kg,5kg,25kg Application:as raw material Transportation:by sea/air/courier

Lumiracoxib

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Lumiracoxib

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

LuMiracoxib

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Lumiracoxib CAS No.220991-20-8

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Lumiracoxib cas 220991-20-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Lumiracoxib cas 220991-20-8

Cas:220991-20-8

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one
332903-83-0

1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water Heating;90%
With hydrogenchloride; sodium hydroxide In ethanol; water
potassium 2-iodo-5-methylphenylacetate
1234562-75-4

potassium 2-iodo-5-methylphenylacetate

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate at 100℃; Ullmann coupling;41%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C
2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
5.1: 82 percent / toluene / 80 - 90 °C
6.1: 80 percent / AlCl3 / 3 h / 170 °C
7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
Multi-step reaction with 3 steps
1: 76 percent / pTsOH*H2O / toluene / 18 h / Heating
2: 76 percent / I2; DBU / xylene / 36 h / 155 °C
3: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
para-bromotoluene
106-38-7

para-bromotoluene

Mo(CO)6

Mo(CO)6

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
p-toluidine
106-49-0

p-toluidine

4-hydroxybenzaldehyde-linked-Wang-resin

4-hydroxybenzaldehyde-linked-Wang-resin

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-bromo-3-fluoro-chlorobenzene
309721-44-6

2-bromo-3-fluoro-chlorobenzene

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-Cyanochlorobenzene
623-03-0

4-Cyanochlorobenzene

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C
2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
5.1: 82 percent / toluene / 80 - 90 °C
6.1: 80 percent / AlCl3 / 3 h / 170 °C
7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-chloro-6-fluorophenol
2040-90-6

2-chloro-6-fluorophenol

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: propan-2-ol / Heating
2: MeONa / methanol / 2 h / 85 °C
3: 82 percent / toluene / 80 - 90 °C
4: 80 percent / AlCl3 / 3 h / 170 °C
5: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
N-(p-tolyl)-2-chloroacetamide
16634-82-5

N-(p-tolyl)-2-chloroacetamide

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: propan-2-ol / Heating
2: MeONa / methanol / 2 h / 85 °C
3: 82 percent / toluene / 80 - 90 °C
4: 80 percent / AlCl3 / 3 h / 170 °C
5: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
N-(2-chloro-6-fluoro-phenyl)-4-methylaniline
332903-74-9

N-(2-chloro-6-fluoro-phenyl)-4-methylaniline

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / toluene / 80 - 90 °C
2: 80 percent / AlCl3 / 3 h / 170 °C
3: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-(2-chloro-6-fluorophenylamino)benzonitrile
817621-48-0

4-(2-chloro-6-fluorophenylamino)benzonitrile

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
1.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
2.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
3.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
4.1: 82 percent / toluene / 80 - 90 °C
5.1: 80 percent / AlCl3 / 3 h / 170 °C
6.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester
817621-52-6

4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one
817621-77-5

1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / I2; DBU / xylene / 36 h / 155 °C
2: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide
332903-78-3

2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / AlCl3 / 3 h / 170 °C
2: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-(2-chloro-6-fluoro-phenoxy)-N-p-tolyl-acetamide

2-(2-chloro-6-fluoro-phenoxy)-N-p-tolyl-acetamide

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: MeONa / methanol / 2 h / 85 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-(2-chloro-6-fluoro-phenylamino)benzimidic acid ethyl ester hydrochloride

4-(2-chloro-6-fluoro-phenylamino)benzimidic acid ethyl ester hydrochloride

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
2: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
3: 82 percent / toluene / 80 - 90 °C
4: 80 percent / AlCl3 / 3 h / 170 °C
5: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-Amino-5-methylbenzoic acid
2941-78-8

2-Amino-5-methylbenzoic acid

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
4: dimethyl sulfoxide / 1.5 h / Inert atmosphere
5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
(2-chloro-6-fluorophenyl)boronic acid

(2-chloro-6-fluorophenyl)boronic acid

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
4: dimethyl sulfoxide / 1.5 h / Inert atmosphere
5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
C14H12Cl2FN

C14H12Cl2FN

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide / 1.5 h / Inert atmosphere
2: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid
619296-47-8

2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
2: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
3: dimethyl sulfoxide / 1.5 h / Inert atmosphere
4: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzenemethanol

2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzenemethanol

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
2: dimethyl sulfoxide / 1.5 h / Inert atmosphere
3: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetonitrile
1403226-56-1

2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetonitrile

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
With water; barium(II) hydroxide In 1,4-dioxane for 30h; Reflux; Inert atmosphere;
1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one
332903-83-0

1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water Heating;90%
With hydrogenchloride; sodium hydroxide In ethanol; water
potassium 2-iodo-5-methylphenylacetate
1234562-75-4

potassium 2-iodo-5-methylphenylacetate

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate at 100℃; Ullmann coupling;41%
4-Cyanochlorobenzene
623-03-0

4-Cyanochlorobenzene

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C
2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
5.1: 82 percent / toluene / 80 - 90 °C
6.1: 80 percent / AlCl3 / 3 h / 170 °C
7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
para-bromotoluene
106-38-7

para-bromotoluene

Mo(CO)6

Mo(CO)6

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-chloro-6-fluorophenol
2040-90-6

2-chloro-6-fluorophenol

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: propan-2-ol / Heating
2: MeONa / methanol / 2 h / 85 °C
3: 82 percent / toluene / 80 - 90 °C
4: 80 percent / AlCl3 / 3 h / 170 °C
5: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C
2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
5.1: 82 percent / toluene / 80 - 90 °C
6.1: 80 percent / AlCl3 / 3 h / 170 °C
7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / t-BuONa; t-Bu3P / Pd(dba)2 / toluene / 14 h / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
Multi-step reaction with 3 steps
1: 76 percent / pTsOH*H2O / toluene / 18 h / Heating
2: 76 percent / I2; DBU / xylene / 36 h / 155 °C
3: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
p-toluidine
106-49-0

p-toluidine

4-hydroxybenzaldehyde-linked-Wang-resin

4-hydroxybenzaldehyde-linked-Wang-resin

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
N-(p-tolyl)-2-chloroacetamide
16634-82-5

N-(p-tolyl)-2-chloroacetamide

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: propan-2-ol / Heating
2: MeONa / methanol / 2 h / 85 °C
3: 82 percent / toluene / 80 - 90 °C
4: 80 percent / AlCl3 / 3 h / 170 °C
5: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-bromo-3-fluoro-chlorobenzene
309721-44-6

2-bromo-3-fluoro-chlorobenzene

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / t-BuONa; (+)-BINAP / Pd(dba)2 / toluene / 110 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
N-(2-chloro-6-fluoro-phenyl)-4-methylaniline
332903-74-9

N-(2-chloro-6-fluoro-phenyl)-4-methylaniline

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / toluene / 80 - 90 °C
2: 80 percent / AlCl3 / 3 h / 170 °C
3: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-(2-chloro-6-fluorophenylamino)benzonitrile
817621-48-0

4-(2-chloro-6-fluorophenylamino)benzonitrile

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
1.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
2.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
3.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
4.1: 82 percent / toluene / 80 - 90 °C
5.1: 80 percent / AlCl3 / 3 h / 170 °C
6.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester
817621-52-6

4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one
817621-77-5

1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / I2; DBU / xylene / 36 h / 155 °C
2: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide
332903-78-3

2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / AlCl3 / 3 h / 170 °C
2: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-(2-chloro-6-fluoro-phenoxy)-N-p-tolyl-acetamide

2-(2-chloro-6-fluoro-phenoxy)-N-p-tolyl-acetamide

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: MeONa / methanol / 2 h / 85 °C
2: 82 percent / toluene / 80 - 90 °C
3: 80 percent / AlCl3 / 3 h / 170 °C
4: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
4-(2-chloro-6-fluoro-phenylamino)benzimidic acid ethyl ester hydrochloride

4-(2-chloro-6-fluoro-phenylamino)benzimidic acid ethyl ester hydrochloride

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
2: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
3: 82 percent / toluene / 80 - 90 °C
4: 80 percent / AlCl3 / 3 h / 170 °C
5: 90 percent / aq. NaOH / ethanol; H2O / Heating
View Scheme
2-Amino-5-methylbenzoic acid
2941-78-8

2-Amino-5-methylbenzoic acid

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
4: dimethyl sulfoxide / 1.5 h / Inert atmosphere
5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
(2-chloro-6-fluorophenyl)boronic acid

(2-chloro-6-fluorophenyl)boronic acid

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
4: dimethyl sulfoxide / 1.5 h / Inert atmosphere
5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
C14H12Cl2FN

C14H12Cl2FN

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide / 1.5 h / Inert atmosphere
2: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid
619296-47-8

2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzoic acid

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
2: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
3: dimethyl sulfoxide / 1.5 h / Inert atmosphere
4: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzenemethanol

2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzenemethanol

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C
2: dimethyl sulfoxide / 1.5 h / Inert atmosphere
3: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere
View Scheme
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetonitrile
1403226-56-1

2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetonitrile

lumiracoxib
220991-20-8

lumiracoxib

Conditions
ConditionsYield
With water; barium(II) hydroxide In 1,4-dioxane for 30h; Reflux; Inert atmosphere;
methanol
67-56-1

methanol

lumiracoxib
220991-20-8

lumiracoxib

2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid methyl ester
1175086-67-5

2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid methyl ester

Conditions
ConditionsYield
Stage #1: methanol; lumiracoxib With hydrogenchloride In water for 8h; Reflux;
Stage #2: With sodium carbonate In water
89%
Stage #1: methanol; lumiracoxib With hydrogenchloride In water for 8h; Reflux;
Stage #2: With sodium hydrogencarbonate In water Cooling with ice; Saturated solution;
89%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;74%
lumiracoxib
220991-20-8

lumiracoxib

1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one
332903-83-0

1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;85%
lumiracoxib
220991-20-8

lumiracoxib

2-{2-[(2-chloro-6-fluorophenyl)amine]-5-methylphenyl}acetohydrazide

2-{2-[(2-chloro-6-fluorophenyl)amine]-5-methylphenyl}acetohydrazide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 8 h / Reflux
2: hydrazine hydrate / methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 8 h / Reflux
1.2: Cooling with ice; Saturated solution
2.1: hydrazine hydrate / methanol / 24 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C
2: hydrazine hydrate / ethanol / 1.5 h / Reflux
View Scheme
lumiracoxib
220991-20-8

lumiracoxib

2-{2-[(2-chloro-6-fluorophenyl)amine]-5-methylphenyl}-N-(1,3-dioxy-1,3-dihydro-2H-isoindol-2-yl)acetamide

2-{2-[(2-chloro-6-fluorophenyl)amine]-5-methylphenyl}-N-(1,3-dioxy-1,3-dihydro-2H-isoindol-2-yl)acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 8 h / Reflux
2: hydrazine hydrate / methanol / 24 h / Reflux
3: acetic acid / 7 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water / 8 h / Reflux
1.2: Cooling with ice; Saturated solution
2.1: hydrazine hydrate / methanol / 24 h / Reflux
3.1: acetic acid / 7 h / Reflux
View Scheme
lumiracoxib
220991-20-8

lumiracoxib

C15H14ClFN2O2
1403226-61-8

C15H14ClFN2O2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C
2: potassium cyanide; water; hydroxylamine / methanol; tetrahydrofuran / 18 h / 20 °C
View Scheme
lumiracoxib
220991-20-8

lumiracoxib

C16H13ClFN3O2
1403226-62-9

C16H13ClFN3O2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C
2: hydrazine hydrate / ethanol / 1.5 h / Reflux
3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Inert atmosphere
View Scheme

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