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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4,4-Difluorocyclohexanone Manufacturer/High quality/Best price/In stock

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4,4-Difluoro-Cyclohexanone supplier in China

Cas:22515-18-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

High quality 4,4-Difluorocyclohexanone CAS 22515-18-0 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/F

High quality 4,4-Difluorocyclohexanone CAS 22515-18-0 with factory price

Cas:22515-18-0

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

4,4-DIFLUOROCYCLOHEXANONE Basic information Product Name: 4,4-DIFLUOROCYCLOHEXANONE Synonyms: 4,4-DIFLUOROCYCLOHEXANONE;4,4-Difluorocyclohexan-1-one;1,1,-Difluoro-4

4,4-DIFLUOROCYCLOHEXANONE

Cas:22515-18-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4,4-Difluoro-Cyclohexanone

Cas:22515-18-0

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

4, 4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM --4,4-DIFLUOROCYCLOHEXANONE

Cas:22515-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 22515-18-0 with best quality

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4,4-Difluorocyclohexanone 22515-18-0

Cas:22515-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

4,4-Difluorocyclohexanone 99%

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $88.0 / 95.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4,4-DIFLUOROCYCLOHEXANONE CAS:22515-18-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

4,4-DIFLUOROCYCLOHEXANONE CAS:22515-18-0

Cas:22515-18-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:22515-18-0

Cas:22515-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4,4-Difluoro-cyclohexanone

Cas:22515-18-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

4,4-DIFLUOROCYCLOHEXANONE

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4,4-difluorocyclohexanone

Cas:22515-18-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4,4-difluorocyclohexan-1-one

Cas:22515-18-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4,4-DIFLUOROCYCLOHEXANONE

Cas:22515-18-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4,4-Difluoro-Cyclohexanone

Cas:22515-18-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

4,4-DIFLUOROCYCLOHEXANONE Basic information Product Name: 4,4-DIFLUOROCYCLOHEXANONE Synonyms: 4,4-DIFLUOROCYCLOHEXANONE;4,4-Difluorocyclohexan-1-one;1,1,-Difluoro-4-oxocyclohexane;4,4-difluro-cyclohexanone;4,4-Difluorocyclohexanone;Cyclohexano

4,4-DIFLUOROCYCLOHEXANONE

Cas:22515-18-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4,4-difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4,4-difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kunshan Push Trading Co.,LTD

ADVANTAGE 1.Professional: More than 10 years chemical exporting experience. We have produced chemical more than fifteen years, 95% products are for export . More than 10 years chemical exporting experience. Good and stabilized factory price. 2.Reaso

4,4-difluorocyclohexan-1-one 22515-18-0

Cas:22515-18-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4,4-difluorocyclohexanone

Cas:22515-18-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4,4-Difluorocyclohexanone

Cas:22515-18-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

8,8-difluoro-1,4-dioxaspiro[4,5]decane
176251-49-3

8,8-difluoro-1,4-dioxaspiro[4,5]decane

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 12h;93%
With hydrogenchloride In acetone for 1h; Inert atmosphere;80%
With hydrogenchloride In water at 100℃; for 3h;71%
4,4-difluoroheptanedioic acid diethyl ester
22515-16-8

4,4-difluoroheptanedioic acid diethyl ester

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

Conditions
ConditionsYield
(i) NaOEt, EtOH, (ii) aq. KOH; Multistep reaction;
4-oxopimelate
6317-49-3

4-oxopimelate

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SF4 / CH2Cl2; H2O
2: (i) NaOEt, EtOH, (ii) aq. KOH
View Scheme
3-(fur-2-yl)crotonic acid
539-47-9

3-(fur-2-yl)crotonic acid

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HCl / Heating
2: SF4 / CH2Cl2; H2O
3: (i) NaOEt, EtOH, (ii) aq. KOH
View Scheme
cyclohexanedione monoethylene ketal
4746-97-8

cyclohexanedione monoethylene ketal

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride) / dichloromethane / 24 h / 20 °C / Inert atmosphere
2: hydrogenchloride / acetone / 1 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: morpholinosulfur trifluoride / dichloromethane / 72 h / 0 - 20 °C / Inert atmosphere
1.2: 24 h
2.1: hydrogenchloride / water / 3 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: (bis-(2-methoxyethyl)amino)sulfur trufluoride; ethanol / dichloromethane / 2 h / 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / water; acetone / 24 h / Reflux
View Scheme
Stage #1: cyclohexanedione monoethylene ketal With ethanol; (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #2: With toluene-4-sulfonic acid In water; acetone for 24h; Reflux;
Multi-step reaction with 2 steps
1.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / 0 - 35 °C
1.2: 20 °C
2.1: water; hydrogenchloride / 12 h / 100 °C
View Scheme
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

4,4-difluoro-1-[(trimethylsilyl)oxy]cyclohexane carbonitrile
1394347-52-4

4,4-difluoro-1-[(trimethylsilyl)oxy]cyclohexane carbonitrile

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 20℃;100%
With zinc(II) iodide In dichloromethane at 0 - 20℃; for 1h;
With zinc(II) iodide In dichloromethane at 0 - 20℃; for 1h;1.5 g
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

methyl 2-(4,4-difluorocyclohexylidene)acetate
1189770-25-9

methyl 2-(4,4-difluorocyclohexylidene)acetate

Conditions
ConditionsYield
In tetrahydrofuran at 65℃; for 20h; Schlenk technique; Inert atmosphere;100%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

4,4-difluorocyclohexanol
22419-35-8

4,4-difluorocyclohexanol

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 0 - 25℃; for 2h;99%
With methanol; sodium tetrahydroborate at 20℃; for 1h;94%
With methanol; sodium tetrahydroborate for 1h; Inert atmosphere; Cooling with ice;91%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

ethyl 2-(4,4-difluorocyclohexylidene)-acetate
1283719-20-9

ethyl 2-(4,4-difluorocyclohexylidene)-acetate

Conditions
ConditionsYield
In toluene at 100℃; for 16h;99%
In tetrahydrofuran at 65℃; Inert atmosphere;97%
t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

N'-(4,4-difluorocyclohexyl)hydrazinecarboxylic acid tert-butyl ester
1214910-72-1

N'-(4,4-difluorocyclohexyl)hydrazinecarboxylic acid tert-butyl ester

Conditions
ConditionsYield
With hydrogen; acetic acid; platinum(IV) oxide In isopropyl alcohol at 20℃; under 2585.81 Torr; for 12h;98%
With hydrogen; acetic anhydride; platinum(IV) oxide In isopropyl alcohol at 20℃; under 2585.81 Torr; for 12h;98%
With hydrogen; platinum(IV) oxide; acetic acid In isopropyl alcohol at 20℃; under 2585.81 Torr; for 12h;98%
1-phenylmethylpiperazine
2759-28-6

1-phenylmethylpiperazine

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

1-(4-benzylpiperazin-1-yl)-4,4-difluorocyclohexanecarbonitrile

1-(4-benzylpiperazin-1-yl)-4,4-difluorocyclohexanecarbonitrile

Conditions
ConditionsYield
Stage #1: 1-phenylmethylpiperazine; 4,4-difluorocyclohexanone With zinc(II) iodide In methanol; toluene at 25℃; for 1h; Inert atmosphere;
Stage #2: trimethylsilyl cyanide In methanol; toluene for 16h; Inert atmosphere; Heating;
97%
trimethyl phosphonoacetate
5927-18-4

trimethyl phosphonoacetate

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

methyl 2-(4,4-difluorocyclohexylidene)acetate
1189770-25-9

methyl 2-(4,4-difluorocyclohexylidene)acetate

Conditions
ConditionsYield
Stage #1: trimethyl phosphonoacetate With sodium hydride In tetrahydrofuran; mineral oil at 4℃; for 1h;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran; mineral oil at 0 - 20℃;
95%
Stage #1: trimethyl phosphonoacetate With sodium hydride In tetrahydrofuran at 0 - 5℃; for 1h;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran at 0 - 27℃; for 15h;
57%
Stage #1: trimethyl phosphonoacetate With sodium hydride In tetrahydrofuran at 5℃; for 1h;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran at 5 - 20℃;
Stage #3: With water In tetrahydrofuran
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

3,3-difluoro-2,3,4,9-tetrahydro-1H-carbazole
1423039-61-5

3,3-difluoro-2,3,4,9-tetrahydro-1H-carbazole

Conditions
ConditionsYield
With acetic acid at 140℃; Inert atmosphere;95%
With silica gel at 20℃; for 3h; Fischer Indole Synthesis; Milling;46%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

4,4-difluoro-1-vinylcyclohexan-1-ol

4,4-difluoro-1-vinylcyclohexan-1-ol

Conditions
ConditionsYield
In tetrahydrofuran at 0℃; for 1h; Grignard Reaction; Inert atmosphere;94%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

(E)-2-((dimethylamino)methylene)-4,4-difluorocyclohexanone

(E)-2-((dimethylamino)methylene)-4,4-difluorocyclohexanone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 18h;92%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester
100945-15-1

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

methyl 2-(((benzyloxy)carbonyl)amino)-2-(4,4-difluorocyclohexylidene)acetate

methyl 2-(((benzyloxy)carbonyl)amino)-2-(4,4-difluorocyclohexylidene)acetate

Conditions
ConditionsYield
Stage #1: N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1-methyl-pyrrolidin-2-one at 15℃; for 0.5h; Wittig-Horner Reaction; Large scale;
Stage #2: 4,4-difluorocyclohexanone In 1-methyl-pyrrolidin-2-one at 10 - 20℃; for 12h; Large scale;
90%
Stage #1: N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 10 - 35℃; for 0.5h;
Stage #2: 4,4-difluorocyclohexanone In acetonitrile at 10 - 35℃;
84%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

ethyl 2-((tert-butyldimethylsilyl)oxy)-2-(diethoxyphosphoryl)acetate
1242990-43-7

ethyl 2-((tert-butyldimethylsilyl)oxy)-2-(diethoxyphosphoryl)acetate

C16H28F2O3Si
1242990-75-5

C16H28F2O3Si

Conditions
ConditionsYield
Stage #1: ethyl 2-((tert-butyldimethylsilyl)oxy)-2-(diethoxyphosphoryl)acetate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran at -78 - 20℃;
88%
sodium cyanide
773837-37-9

sodium cyanide

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

8,8-difluoro-1,3-diazaspiro[4.5]decane-2,4-dione
1393823-97-6

8,8-difluoro-1,3-diazaspiro[4.5]decane-2,4-dione

Conditions
ConditionsYield
With ammonium carbonate In water at 0 - 60℃; for 26h;88%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

N-benzyl-3-butenylamine
17150-62-8

N-benzyl-3-butenylamine

1-benzyl-8,8-difluoro-4-methyl-1-azaspiro[4.5]decane

1-benzyl-8,8-difluoro-4-methyl-1-azaspiro[4.5]decane

Conditions
ConditionsYield
With Ir(dMeppy)3; cyclohexa-1,4-diene; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; propionic acid In dichloromethane at 20℃; for 48h; Molecular sieve; Sealed tube; Inert atmosphere; Irradiation;87%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

Ethyl 2-bromopropionate
535-11-5, 41978-69-2

Ethyl 2-bromopropionate

ethyl 2-(4,4-difluoro-1-hydroxycyclohexyl)propanoate

ethyl 2-(4,4-difluoro-1-hydroxycyclohexyl)propanoate

Conditions
ConditionsYield
With zinc In 1,4-dioxane at 100℃; for 24h;85%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

tert-butyl (R)-3-(((4-(aminomethyl)benzyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl (R)-3-(((4-(aminomethyl)benzyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl (R)-3-(((4-(((4,4-difluorocyclohexyl)amino)methyl)benzyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl (R)-3-(((4-(((4,4-difluorocyclohexyl)amino)methyl)benzyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions
ConditionsYield
Stage #1: 4,4-difluorocyclohexanone; tert-butyl (R)-3-(((4-(aminomethyl)benzyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate With acetic acid In dichloromethane at 20℃; for 2.5h; Inert atmosphere;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; Inert atmosphere;
84%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

cyanoacetic acid
372-09-8

cyanoacetic acid

C8H9F2N

C8H9F2N

Conditions
ConditionsYield
With ammonium acetate In toluene at 160℃; for 3h;84%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

tert-butyl diethylphosphonoacetate
27784-76-5

tert-butyl diethylphosphonoacetate

tert-butyl 2-(4,4-difluorocyclohexylidene)acetate
1584139-35-4

tert-butyl 2-(4,4-difluorocyclohexylidene)acetate

Conditions
ConditionsYield
Stage #1: tert-butyl diethylphosphonoacetate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
83%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

methyl 5,5-difluoro-2-oxocyclohexane-1-carboxylate

methyl 5,5-difluoro-2-oxocyclohexane-1-carboxylate

Conditions
ConditionsYield
Stage #1: 4,4-difluorocyclohexanone With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: carbonic acid dimethyl ester In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 16h;
83%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

allylmagnesium bromide
2622-05-1

allylmagnesium bromide

1-allyl-4,4-difluorocyclohexanol

1-allyl-4,4-difluorocyclohexanol

Conditions
ConditionsYield
In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;82%
In tetrahydrofuran at -74 - -60℃; for 2.66667h;46%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

trimethylsulphonium iodide
2181-42-2

trimethylsulphonium iodide

6,6-difluoro-1-oxaspiro[2.5]octane

6,6-difluoro-1-oxaspiro[2.5]octane

Conditions
ConditionsYield
Stage #1: trimethylsulphonium iodide With potassium tert-butylate In tetrahydrofuran at 15℃; for 0.5h; Inert atmosphere;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran at 15℃; for 16h;
82%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

trimethylsulfonium iodide
1030268-21-3

trimethylsulfonium iodide

6,6-difluoro-1-oxaspiro[2.5]octane

6,6-difluoro-1-oxaspiro[2.5]octane

Conditions
ConditionsYield
Stage #1: trimethylsulfonium iodide With potassium tert-butylate In tetrahydrofuran at 15℃; for 0.5h; Inert atmosphere;
Stage #2: 4,4-difluorocyclohexanone In tetrahydrofuran at 15℃; for 16h; Inert atmosphere;
82%
tert-Butoxybis(dimethylamino)methane
5815-08-7

tert-Butoxybis(dimethylamino)methane

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

(E)-2-((dimethylamino)methylene)-4,4-difluorocyclohexanone

(E)-2-((dimethylamino)methylene)-4,4-difluorocyclohexanone

Conditions
ConditionsYield
at 50℃; for 18h;82%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

C28H38N4O2

C28H38N4O2

C34H46F2N4O2

C34H46F2N4O2

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 12h;81%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

5-bromo-3-chloro-6-oxo-1,6-dihydropyridine-2-carboxamide

5-bromo-3-chloro-6-oxo-1,6-dihydropyridine-2-carboxamide

6-bromo-8-chloro-4',4'-difluoro-spiro[2himidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione

6-bromo-8-chloro-4',4'-difluoro-spiro[2himidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane at 100℃; for 8h;80%
2-(pyrrolidin-3-yl)-1H-benzo[d]imidazole-4-carboxamide

2-(pyrrolidin-3-yl)-1H-benzo[d]imidazole-4-carboxamide

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

2-(1-(4,4-difluorocyclohexyl)pyrrolidin-3-yl)-1H-benzo[d]imidazole-4-carboxamide

2-(1-(4,4-difluorocyclohexyl)pyrrolidin-3-yl)-1H-benzo[d]imidazole-4-carboxamide

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol at 20℃;78.4%
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl (1-(4,4-difluorocyclohexyl)piperidin-4-yl)carbamate
1262417-90-2

tert-butyl (1-(4,4-difluorocyclohexyl)piperidin-4-yl)carbamate

Conditions
ConditionsYield
With acetic acid; tetramethylammonium triacetoxyborohydride In N,N-dimethyl-formamide78%
Stage #1: 4,4-difluorocyclohexanone; (piperidin-4-yl)carbamic acid tert-butyl ester With acetic acid In tetrahydrofuran at 50℃; for 2h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 50℃; for 18h;
4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

4-aminophenylacetic acid
1197-55-3

4-aminophenylacetic acid

3-hydroxy-2-butanon
513-86-0, 52217-02-4

3-hydroxy-2-butanon

2-(4-(5,5-difluoro-2,3-dimethyl-4,5,6,7-tetrahydro-1H-indol-1-yl)phenyl)acetic acid

2-(4-(5,5-difluoro-2,3-dimethyl-4,5,6,7-tetrahydro-1H-indol-1-yl)phenyl)acetic acid

Conditions
ConditionsYield
With acetic acid In ethanol at 100℃; for 4h; Inert atmosphere; Sealed tube; Microwave irradiation;78%
indole
120-72-9

indole

4,4-difluorocyclohexanone
22515-18-0

4,4-difluorocyclohexanone

1-(4,4-difluorocyclohexyl)indole

1-(4,4-difluorocyclohexyl)indole

Conditions
ConditionsYield
With formic acid; 10 mol% Pd(OH)2/C In water at 100℃; for 24h; Inert atmosphere;78%
With formic acid; 10% palladium hydroxide on charcoal In water at 100℃; for 24h; Inert atmosphere;78%

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