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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(R)-(+)-4-Hydroxy-2-pyrrolidinone Manufacturer/High quality/Best price/In stock

Cas:22677-21-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (R)-4-Hydroxy-2-Pyrrolidinone supplier in China

Cas:22677-21-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Basic information Product Name: (R)-(+)-4-HYDROXY-2-PYRROLIDINONE Synonyms: (R)-(+)-4-HYDROXY-2-PYRROLIDINONE;

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE

Cas:22677-21-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-4-Hydroxy-2-pyrrolidinone

Cas:22677-21-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE CAS:22677-21-0

Cas:22677-21-0

Min.Order:1 Kilogram

FOB Price: $250.0 / 300.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--22677-21-0--High purity (R)-(+)-4-HYDROXY-2-PYRROLIDINONE factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had establ

TIANFUCHEM--22677-21-0--High purity (R)-(+)-4-HYDROXY-2-PYRROLIDINONE factory price

Cas:22677-21-0

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 22677-21-0 with best quality

Cas:22677-21-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2-Pyrrolidinone,4-hydroxy-, (4R)-

Cas:22677-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE CAS:22677-21-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE CAS:22677-21-0

Cas:22677-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:22677-21-0

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(4R)-4-hydroxypyrrolidin-2-one

Cas:22677-21-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (R)-4-hydroxy-2-pyrrolidone

Cas:22677-21-0

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Pyrrolidinone,4-hydroxy-, (4R)-

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE CAS NO.22677-21-0

Cas:22677-21-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(R)-4-Hydroxypyrrolidin-2-one

Cas:22677-21-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Pyrrolidinone,4-hydroxy-, (4R)-

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Pyrrolidinone,4-hydroxy-, (4R)-

Cas:22677-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou ZeErRui Chemical Co., Ltd.

Product name (S)-4-Hydroxy-2-pyrrolidinone Content ≥98% CAS NO. 68108-18-9 Package Structure Formula Appearance:Det

(R)-BETA-HYDROXY-GAMMA-BUTYROLACTAM;RHPD

Cas:22677-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white to light yellow crystal powde Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:intermediate in the preparation

R)-(+)-4-HYDROXY-2-PYRROLIDINONE

Cas:22677-21-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(R)-(+)-4-Hydroxy-2-Pyrrolidinone cas no. 22677-21-0 98%

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

R-4-Hydroxy-2-pyrrolidone

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

(R)-4-hydroxy-2-pyrrolidone

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Other

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Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Best price (R)-4-Hydroxy-2-Pyrrolidinone 22677-21-0

Cas:22677-21-0

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(R)-4-Hydroxy-2-Pyrrolidinone

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(R)-(+)-4-Hydroxy-2-pyrrolidinone

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

"HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products. We supply Multiple s

(4R)-4-hydroxypyrrolidin-2-one

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

(R)-(+)-4-Hydroxy-2-pyrrolidinone cas 22677-21-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(R)-(+)-4-Hydroxy-2-pyrrolidinone cas 22677-21-0

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Best quality with low priceAppearance:white to light yellow crystal powder Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

(R)-4-hydroxy-2-pyrrolidone

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

2-Pyrrolidinone,4-hydroxy-, (4R)-

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

22677-21-0 Application:intermediate

2-Pyrrolidinone, 4-hydroxy-, (4R)-

Cas:22677-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

ethyl (L)-4-chloro-3-hydroxybutyrate
10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4

ethyl (L)-4-chloro-3-hydroxybutyrate

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
With ammonium hydroxide at 80℃; for 3h;82%
1-(1'-phenylethyl)-4-phenylmethoxypyrrolidin-2-one
135056-42-7

1-(1'-phenylethyl)-4-phenylmethoxypyrrolidin-2-one

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
With ammonia; sodium In tetrahydrofuran for 1h;51%
(4R)-4-hydroxy-1-<(1S)-1-phenylethyl>pyrrolidin-2-one
131653-48-0

(4R)-4-hydroxy-1-<(1S)-1-phenylethyl>pyrrolidin-2-one

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
With ammonia; lithium In tetrahydrofuran; tert-butyl alcohol at -60℃; for 0.25h;
(R)-4-Hydroxy-4,5-dihydro-3H-pyrrole-2-carboxylic acid anion

(R)-4-Hydroxy-4,5-dihydro-3H-pyrrole-2-carboxylic acid anion

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide at 40℃; for 0.75h; Yield given;
ethyl (R)-4-amino-3-hydroxybutanoate hydrochloride

ethyl (R)-4-amino-3-hydroxybutanoate hydrochloride

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

3(R)-hydroxy-4-aminobutyric acid ethyl ester
208103-39-3

3(R)-hydroxy-4-aminobutyric acid ethyl ester

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
In ethanol
Ru2Cl4((S)-BINAP)2·NEt3in

Ru2Cl4((S)-BINAP)2·NEt3in

ammonium salt of methyl 4-amino-3-oxobutanoate

ammonium salt of methyl 4-amino-3-oxobutanoate

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
In methanol
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one
131653-51-5

(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.5h; Condensation;99%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h;95%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h;91%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(R)-4-[tert-butyl(diphenyl)silanyloxy]pyrrolidin-2-one
945635-00-7

(R)-4-[tert-butyl(diphenyl)silanyloxy]pyrrolidin-2-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 0.5h;96%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

(R)-4-Amino-3-hydroxybutanoic acid
7013-07-2

(R)-4-Amino-3-hydroxybutanoic acid

Conditions
ConditionsYield
With hydrogenchloride for 4h; Heating;94%
With lithium hydroxide for 24h; Ambient temperature;89%
With hydrogenchloride for 2h; Heating;70%
With barium dihydroxide
With hydrogenchloride for 10h; Heating; Yield given;
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

C13H27NO2Si

C13H27NO2Si

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; Cooling with ice;81%
4-(4,6-dichloropyridin-2-yl)morpholine
852333-59-6

4-(4,6-dichloropyridin-2-yl)morpholine

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

(4R)-1-[4-chloro-6-(morpholin-4-yl)pyridin-2-yl]-4-hydroxypyrrolidin-2-one

(4R)-1-[4-chloro-6-(morpholin-4-yl)pyridin-2-yl]-4-hydroxypyrrolidin-2-one

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; water at 100℃; for 2h; Inert atmosphere;78%
lauric acid
143-07-7

lauric acid

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

(R)-4-lauroyloxy-2-pyrrolidinone

(R)-4-lauroyloxy-2-pyrrolidinone

Conditions
ConditionsYield
With pyridine; dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;60%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

7-bromo-2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazoline
1362910-89-1

7-bromo-2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazoline

(R)-1-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)-4-hydroxypyrrolidin-2-one
1362910-95-9

(R)-1-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)-4-hydroxypyrrolidin-2-one

Conditions
ConditionsYield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Inert atmosphere;48%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

7-chloro-1-(2,4-difluorophenyl)-4-oxo-N-[(2S)-1,1,1-trifluorobutan-2-yl]-1,4-dihydro-1,8-naphthyridine-3-carboxamide

7-chloro-1-(2,4-difluorophenyl)-4-oxo-N-[(2S)-1,1,1-trifluorobutan-2-yl]-1,4-dihydro-1,8-naphthyridine-3-carboxamide

1-(2,4-difluorophenyl)-7-[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]-4-oxo-N-[(2S)-1,1,1-trifluorobutan-2-yl]-1,4-dihydro-1,8-naphthyridine-3-carboxamide

1-(2,4-difluorophenyl)-7-[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]-4-oxo-N-[(2S)-1,1,1-trifluorobutan-2-yl]-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 80℃; Inert atmosphere;39%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

1-bromo-4-iodo-2-methylbenzene
202865-85-8

1-bromo-4-iodo-2-methylbenzene

(R)-1-(4-bromo-3-methyl-phenyl)-4-hydroxy-pyrrolidin-2-one
1253926-33-8

(R)-1-(4-bromo-3-methyl-phenyl)-4-hydroxy-pyrrolidin-2-one

Conditions
ConditionsYield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; Inert atmosphere;38%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

(S)-4-azidopyrrolidin-2-one
899806-32-7

(S)-4-azidopyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: (R)-4-hydroxy-2-pyrrolidinone With methanesulfonyl chloride; triethylamine In dichloromethane at 20℃; for 1h;
Stage #2: With sodium azide In N,N-dimethyl-formamide at 60℃; for 3h;
32%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

(R)-4-[(4-chlorobenzyl)oxy]-2-pyrrolidinone

(R)-4-[(4-chlorobenzyl)oxy]-2-pyrrolidinone

Conditions
ConditionsYield
Stage #1: (R)-4-hydroxy-2-pyrrolidinone With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: 1-Chloro-4-(chloromethyl)benzene In N,N-dimethyl-formamide at 20℃;
30%
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (R)-4-hydroxy-2-oxo-1-pyrrolidineacetate
68252-27-7

ethyl (R)-4-hydroxy-2-oxo-1-pyrrolidineacetate

Conditions
ConditionsYield
With sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane 1) reflux, 2 h; 2) acetonitrile, reflux, 30 min; Multistep reaction;
methanol
67-56-1

methanol

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

(R)-4-Hydroxy-5-methoxy-pyrrolidin-2-one

(R)-4-Hydroxy-5-methoxy-pyrrolidin-2-one

Conditions
ConditionsYield
With sodium phenylsulfonate at 15℃; Product distribution; Further Variations:; Reagents; electrode material; current density; Oxidation; methoxylation; Electrochemical reaction;
With sodium phenylsulfonate at 15℃; Oxidation; methoxylation; Electrochemical reaction;
With sodium phenylsulfonate at 20℃; Etherification; Electrolysis;
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

t-BuMe2SiX

t-BuMe2SiX

(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one
131653-51-5

(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one

Conditions
ConditionsYield
Substitution;
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

[2-(4-(bromomethyl)phenyl)ethyl]carbamic acid tert-butyl ester
914103-95-0

[2-(4-(bromomethyl)phenyl)ethyl]carbamic acid tert-butyl ester

tert-butyl [2-(4-{[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]methyl}phenyl)ethyl]carbamate
914104-03-3

tert-butyl [2-(4-{[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]methyl}phenyl)ethyl]carbamate

Conditions
ConditionsYield
Stage #1: (R)-4-hydroxy-2-pyrrolidinone; [2-(4-(bromomethyl)phenyl)ethyl]carbamic acid tert-butyl ester With sodium hydride In N,N-dimethyl-formamide at 1 - 30℃; for 1h;
Stage #2: With potassium hydrogensulfate; water In ethyl acetate; N,N-dimethyl-formamide
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

thioacetic acid
507-09-5

thioacetic acid

diethylazodicarboxylate
1972-28-7

diethylazodicarboxylate

(4S)-4-acetylthio-2-pyrrolidone

(4S)-4-acetylthio-2-pyrrolidone

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran
With triphenylphosphine In tetrahydrofuran
6-bromo-N-[(2,6-dimethylphenyl)methyl]-2,3-dimethylimidazo[1,2-a]pyridin-8-amine
212267-75-9

6-bromo-N-[(2,6-dimethylphenyl)methyl]-2,3-dimethylimidazo[1,2-a]pyridin-8-amine

(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

(4R)-1-(8-{[(2,6-dimethylphenyl)methyl]amino}-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-4-hydroxy-2-pyrrolidinone

(4R)-1-(8-{[(2,6-dimethylphenyl)methyl]amino}-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-4-hydroxy-2-pyrrolidinone

Conditions
ConditionsYield
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 140℃; for 14h; Ullmann-type coupling; Microwave synthesizer;
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

methyl iodide
74-88-4

methyl iodide

4-methoxy-1-methylpyrrolidin-2-one
787636-39-9

4-methoxy-1-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: (R)-4-hydroxy-2-pyrrolidinone With sodium hydride In tetrahydrofuran at 20 - 50℃; for 22h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 70h;
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

4-(4-bromo-6-methylquinolin-2-yl)-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide
1422497-68-4

4-(4-bromo-6-methylquinolin-2-yl)-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide

(4R)-1-[2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-yl]-4-hydroxypyrrolidin-2-one
1422500-11-5

(4R)-1-[2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-yl]-4-hydroxypyrrolidin-2-one

Conditions
ConditionsYield
With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate In diethylene glycol dimethyl ether at 140℃; for 2h; Microwave irradiation;160 mg
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

C11H13NO4S

C11H13NO4S

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃; for 16h;
(R)-4-hydroxy-2-pyrrolidinone
22677-21-0

(R)-4-hydroxy-2-pyrrolidinone

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

C15H31NO4Si

C15H31NO4Si

Conditions
ConditionsYield
Stage #1: (R)-4-hydroxy-2-pyrrolidinone; di-tert-butyl dicarbonate
Stage #2: tert-butyldimethylsilyl chloride With lithium triethylborohydride

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