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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Cinoxacino manufacturer/supplier

Cas:28657-80-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% CINOXACIN 28657-80-9 GMP Manufacturer

Cas:28657-80-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-

Cas:28657-80-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Cinoxacin

Cas:28657-80-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - CINOXACIN

Cas:28657-80-9

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 28657-80-9 with fast shipping

Cas:28657-80-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

CINOXACIN

Cas:28657-80-9

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo- 28657-80-9

Cas:28657-80-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

CINOXACIN CAS:28657-80-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

CINOXACIN CAS:28657-80-9

Cas:28657-80-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-

Cas:28657-80-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

CINOXACIN28657-80-9

Cas:28657-80-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-

Cas:28657-80-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

CINOXACIN

Cas:28657-80-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

CINOXACIN28657-80-9

Cas:28657-80-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

CINOXACIN28657-80-9

Cas:28657-80-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

CINOXACIN28657-80-9

Cas:28657-80-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

CINOXACIN28657-80-9

Cas:28657-80-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC CINOXACIN 28657-80-9

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Stable stock and competitive priceAppearance:powder Storage:available Package:1KG 5KG 25KG Application:As Pharm raw material Transportation:By Courier,Sea or air

Cinoxacin

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Cinoxacin 250mg

Cas:28657-80-9

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

DISULFOTON-SULFOXIDE

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

cinoxacin

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

CINOXACIN

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

CINOXACIN

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing

Cinoxacin

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

[1,3]Dioxolo[4,5-g]cinnoline-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

CINOXACIN28657-80-9 Application:CINOXACIN28657-80-9

CINOXACIN28657-80-9

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:White to Off-White Solid Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by Sea

CINOXACIN

Cas:28657-80-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl bromide
74-96-4

ethyl bromide

6,7-methylenedioxy-4(1H)-oxo-cinnolin-3-carboxylic acid ethylester
90447-46-4

6,7-methylenedioxy-4(1H)-oxo-cinnolin-3-carboxylic acid ethylester

Aliquat 336
5137-55-3

Aliquat 336

cinoxacin
28657-80-9

cinoxacin

Conditions
ConditionsYield
With sodium hydroxide; potassium carbonate In water; toluene
cinoxacin
28657-80-9

cinoxacin

sodium hexaflorophosphate

sodium hexaflorophosphate

ethanol
64-17-5

ethanol

[Ru([9]aneS3)(dmso)3](PF6)2

[Ru([9]aneS3)(dmso)3](PF6)2

[Ru([9]aneS3)(dmso-κS)(cin-κ2O,O)](PF6)*EtOH

[Ru([9]aneS3)(dmso-κS)(cin-κ2O,O)](PF6)*EtOH

Conditions
ConditionsYield
With sodium methylate In methanol for 2h; Reflux;92.9%
cinoxacin
28657-80-9

cinoxacin

nickel(II) sulfate heptahydrate

nickel(II) sulfate heptahydrate

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

{Ni(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2(dimethyl sulfoxide)2}*4H2O

{Ni(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2(dimethyl sulfoxide)2}*4H2O

B

{Ni(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2(H2O)2}
151933-03-8

{Ni(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2(H2O)2}

Conditions
ConditionsYield
With NaOH; H2O In dimethyl sulfoxide mixing DMSO soln. of cinoxacin and of the Ni salt, slow addn. of 5 ml of aq. NaOH with stirring, crystn. of Ni(cinoxacinate)2*2H2O after 1 d; filtration, washing (water), drying at 90°C, crystn. of the Ni complex contg. dimethyl sulfoxide ligands after 2-3 months from the remaining soln., filtration, drying at room temp., elem. anal.;A 10%
B 80%
cinoxacin
28657-80-9

cinoxacin

1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

3-(1H-benzo[d][1,2,3]triazole-1-carbonyl)-1-ethyl-[1,3]dioxolo[4,5-g]cinnolin-4(1H)-one
1173208-74-6

3-(1H-benzo[d][1,2,3]triazole-1-carbonyl)-1-ethyl-[1,3]dioxolo[4,5-g]cinnolin-4(1H)-one

Conditions
ConditionsYield
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In dichloromethane at 25℃; for 0.5h;
Stage #2: cinoxacin In dichloromethane at 25℃; for 2h;
80%
cinoxacin
28657-80-9

cinoxacin

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

zinc(II) chloride
7646-85-7

zinc(II) chloride

A

{Zn(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2}*4H2O

{Zn(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2}*4H2O

{Zn(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2(dimethyl sulfoxide)2}*4H2O

{Zn(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-carboxylate)2(dimethyl sulfoxide)2}*4H2O

Conditions
ConditionsYield
With NaOH; H2O In dimethyl sulfoxide mixing of a DMSO soln. of cinoxacin and of ZnCl2, addn. of 1 ml of aq. NaOH with stirring, pptn. of Zn(cinoxacinate)2*4H2O after 12-14 d; filtration, washing (water), drying at 90°C, remaining soln. standing at room temp., crystn. of the Zn complex (contg. additionally DMSO ligands) after a few d, filtration, drying at room temp., elem. anal.;A 75%
B 6%
cinoxacin
28657-80-9

cinoxacin

1-ethyl-5-nitro-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-3-carboxylic acid
1429439-48-4

1-ethyl-5-nitro-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-3-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate at 0 - 20℃; for 13h; Inert atmosphere;75%
cinoxacin
28657-80-9

cinoxacin

methanol
67-56-1

methanol

methyl 1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydrocinnolin-3-carboxylate
1429438-89-0

methyl 1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydrocinnolin-3-carboxylate

Conditions
ConditionsYield
Stage #1: cinoxacin With boron tribromide In dichloromethane at -30 - 20℃; for 41h; Inert atmosphere;
Stage #2: methanol In dichloromethane at -30 - 20℃; Inert atmosphere;
74.5%
cinoxacin
28657-80-9

cinoxacin

A

1-Ethyl-1H-[1,3]dioxolo[4,5-g]cinnolin-4-one
109773-20-8

1-Ethyl-1H-[1,3]dioxolo[4,5-g]cinnolin-4-one

B

1-Ethyl-3-hydroxy-1H-[1,3]dioxolo[4,5-g]cinnolin-4-one

1-Ethyl-3-hydroxy-1H-[1,3]dioxolo[4,5-g]cinnolin-4-one

Conditions
ConditionsYield
With oxygen In methanol for 12h; Ambient temperature; Irradiation; in PBS-solution (pH=8); Yields of byproduct given;A n/a
B 62%
With oxygen In methanol for 12h; Mechanism; Product distribution; Ambient temperature; Irradiation; Iin PBS-solution (pH=8);
With oxygen In methanol for 12h; Ambient temperature; Irradiation; in PBS-solution (pH=8); Yields of byproduct given;A 0.580 mol
B n/a
cinoxacin
28657-80-9

cinoxacin

5'-monomethoxytrityl-protected 5'-amino-5'-deoxythymidine phosphoramidite

5'-monomethoxytrityl-protected 5'-amino-5'-deoxythymidine phosphoramidite

dGdCdGdCdA-resin

dGdCdGdCdA-resin

cinoxacin 5'-amino-5'-deoxydTdGdCdGdCdA

cinoxacin 5'-amino-5'-deoxydTdGdCdGdCdA

Conditions
ConditionsYield
Multistep reaction.;55%
cinoxacin
28657-80-9

cinoxacin

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

water
7732-18-5

water

toluene
108-88-3

toluene

chlorido(η6-p-cymene)(cinoxacinato-κ2O,O')ruthenium(II)*water*0.5toluene

chlorido(η6-p-cymene)(cinoxacinato-κ2O,O')ruthenium(II)*water*0.5toluene

Conditions
ConditionsYield
With NaOCH3 In methanol; chloroform byproducts: NaCl; addn. of sodium methylate to soln. of ruthenium compd. and sodium nalidixicate in CHCl3/methanol (1/1), refluxing for 6 h; filtration through celite, addn. of toluene, keeping at room temp. with slow evapn. for 3 d, isolation of crystals, washing with hexane, elem. anal.;55%
cinoxacin
28657-80-9

cinoxacin

1-ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carbonitrile
28657-79-6

1-ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carbonitrile

Conditions
ConditionsYield
Stage #1: cinoxacin With polyphosphate ester; ammonia In chloroform at 119 - 123℃; for 24h;
Stage #2: With polyphosphate ester at 120℃; for 1h;
21%
cinoxacin
28657-80-9

cinoxacin

aqueous cadmium chloride

aqueous cadmium chloride

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

{Cd2(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-caboxylate)4(DMSO)2} * 2H2O

{Cd2(1-ethyl-1,4-dihydro-4-oxo(1,3)dioxolo(4,5-g)cinnoline-3-caboxylate)4(DMSO)2} * 2H2O

Conditions
ConditionsYield
With NaOH In dimethyl sulfoxide mixing DMSO solns. of cinoxacin (0.4 mmol) and CdCl2*2.5H2O (0.1 mmol); slow addn. of NaOH (0.1 M) with continuous stirring;; slow evapn. at room temp.; crystn. after 2-3 mo; elem. anal.;;12%
cinoxacin
28657-80-9

cinoxacin

5-ethyl-5H-[1,3]dioxolo[4,5-f]indole-6,7-dione
67124-17-8

5-ethyl-5H-[1,3]dioxolo[4,5-f]indole-6,7-dione

Conditions
ConditionsYield
In formic acid; water (electrochemical reduction);
cinoxacin
28657-80-9

cinoxacin

2-mercaptoethylamine hydrochloride
156-57-0

2-mercaptoethylamine hydrochloride

1-Ethyl-N-(2-mercaptoethyl)-6,7-methylene-dioxy-4(1H)-oxocinnoline-3-carboxamide
86222-61-9

1-Ethyl-N-(2-mercaptoethyl)-6,7-methylene-dioxy-4(1H)-oxocinnoline-3-carboxamide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide
cinoxacin
28657-80-9

cinoxacin

1-Ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid, methyl ester
86222-62-0

1-Ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid, methyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; water
cinoxacin
28657-80-9

cinoxacin

cobalt(II) perchlorate hexahydrate

cobalt(II) perchlorate hexahydrate

sodium tris(1-ethyl-4(1H)-oxo-(1,3)dioxolo(4,5-g)cinnoline-3-carboxylato)cobaltate(II)*10H2O

sodium tris(1-ethyl-4(1H)-oxo-(1,3)dioxolo(4,5-g)cinnoline-3-carboxylato)cobaltate(II)*10H2O

Conditions
ConditionsYield
With sodium hydroxide In water; dimethyl sulfoxide Co(ClO4)2*6H2O mixed with cinoxacin; soln. NaOH added with stirring for1 h; filtered; washed (DMSO); dreid in vac. at 50°C to const. wt.; elem. anal.; powd. XRD; TG-DTA;
cinoxacin
28657-80-9

cinoxacin

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

bis(1-ethyl-4(1H)-oxo-(1,3)dioxolo(4,5-g)cinnoline-3-carboxylato)copper(II) hydrate

bis(1-ethyl-4(1H)-oxo-(1,3)dioxolo(4,5-g)cinnoline-3-carboxylato)copper(II) hydrate

Conditions
ConditionsYield
With sodium hydroxide In water; dimethyl sulfoxide cinoxacin mixed with Cu(NO3)2*3H2O; NaOH added with stirring; ppt. filtered; washed (DMSO); dried in vac. at 50°C; elem. anal.; powd. XRD, TG-DTA;
cinoxacin
28657-80-9

cinoxacin

nickel(II) perchlorate hexahydrate

nickel(II) perchlorate hexahydrate

tris(1-ethyl-4(1H)-oxo-(1,3)dioxolo(4,5-g)cinnoline-3-carboxylato)dinickel(II) perchlorate octahydrate

tris(1-ethyl-4(1H)-oxo-(1,3)dioxolo(4,5-g)cinnoline-3-carboxylato)dinickel(II) perchlorate octahydrate

Conditions
ConditionsYield
With sodium hydroxide In methanol; water cinoxacin mixed with Ni(ClO4)2*6H2O; NaOH added with stirring; evapn. at room temp. for several d; filtered; washed (methanol); dried in vac. at 50°C; elem. anal.; powd. XRD, TG-DTA;
cinoxacin
28657-80-9

cinoxacin

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

histamine
51-45-6

histamine

A

[Cu(cinoxacinate)2]
186689-97-4

[Cu(cinoxacinate)2]

[Cu(histamine)(cinoxacinate)NO3]H2O

[Cu(histamine)(cinoxacinate)NO3]H2O

Conditions
ConditionsYield
With NaOH In ethanol; water addn. of freshly prepared soln. of histamine in ethanol to aq. soln. of copper salt, addn. of an aq. soln. of cinoxacin with NaOH; cooling overnight, filtration, cooling filtrate in refrigerator for 7- 8months; elem. anal.;
cinoxacin
28657-80-9

cinoxacin

copper dichloride

copper dichloride

aquachloro(1-ethyl-1,4-dihydro-4-oxo-1,3-dioxolo[4,5-g]cinnoline-3-carboxylato-O(3),O(4))(1-ethyl-1,4-dihydro-4-oxo-1,3-dioxolo[4,5-g]cinnoline-3-carboxylic acid-O(3),O(4))copper(II)

aquachloro(1-ethyl-1,4-dihydro-4-oxo-1,3-dioxolo[4,5-g]cinnoline-3-carboxylato-O(3),O(4))(1-ethyl-1,4-dihydro-4-oxo-1,3-dioxolo[4,5-g]cinnoline-3-carboxylic acid-O(3),O(4))copper(II)

Conditions
ConditionsYield
In methanol stoich. amts., warm solvent; pptn. on standing for few d, collection (filtration); single crystals fro mother liquor on slow evapn.;
cinoxacin
28657-80-9

cinoxacin

C119H147N34O53P8Pol

C119H147N34O53P8Pol

C131H155N36O57P8Pol

C131H155N36O57P8Pol

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide
cinoxacin
28657-80-9

cinoxacin

1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4(1H)-one
1429438-94-7

1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)cinnolin-4(1H)-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: boron tribromide / dichloromethane / 41 h / -30 - 20 °C / Inert atmosphere
1.2: -30 - 20 °C / Inert atmosphere
2.1: potassium carbonate; potassium iodide / acetone / Inert atmosphere; Reflux
3.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux
3.2: 20 °C / pH 1 / Inert atmosphere
4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4.2: 2 h / 20 °C / Inert atmosphere
5.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere
6.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 1.5 h / 20 °C / Inert atmosphere
View Scheme
cinoxacin
28657-80-9

cinoxacin

C27H25ClN2O6

C27H25ClN2O6

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane / 41 h / -30 - 20 °C / Inert atmosphere
1.2: -30 - 20 °C / Inert atmosphere
2.1: potassium carbonate; potassium iodide / acetone / Inert atmosphere; Reflux
3.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux
3.2: 20 °C / pH 1 / Inert atmosphere
4.1: thionyl chloride / dichloromethane / 1 h / Inert atmosphere; Reflux
View Scheme
cinoxacin
28657-80-9

cinoxacin

1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydrocinnolin-3-carboxamide
1429438-99-2

1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydrocinnolin-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: boron tribromide / dichloromethane / 41 h / -30 - 20 °C / Inert atmosphere
1.2: -30 - 20 °C / Inert atmosphere
2.1: potassium carbonate; potassium iodide / acetone / Inert atmosphere; Reflux
3.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux
3.2: 20 °C / pH 1 / Inert atmosphere
4.1: thionyl chloride / dichloromethane / 1 h / Inert atmosphere; Reflux
5.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice
View Scheme
cinoxacin
28657-80-9

cinoxacin

1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(piperidin-1-ylmethyl)cinnolin-4(1H)-one
1429439-01-9

1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(piperidin-1-ylmethyl)cinnolin-4(1H)-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: boron tribromide / dichloromethane / 41 h / -30 - 20 °C / Inert atmosphere
1.2: -30 - 20 °C / Inert atmosphere
2.1: potassium carbonate; potassium iodide / acetone / Inert atmosphere; Reflux
3.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux
3.2: 20 °C / pH 1 / Inert atmosphere
4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4.2: 2 h / 20 °C / Inert atmosphere
5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere
5.2: Inert atmosphere
View Scheme
cinoxacin
28657-80-9

cinoxacin

5-amino-1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-3-carboxylic acid
1429439-49-5

5-amino-1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; potassium nitrate / 13 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 5 h / 2585.81 Torr / Inert atmosphere
View Scheme
cinoxacin
28657-80-9

cinoxacin

3-carboxy-1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-5-diazonium chloride
1429439-50-8

3-carboxy-1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnolin-5-diazonium chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid; potassium nitrate / 13 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 5 h / 2585.81 Torr / Inert atmosphere
3: hydrogenchloride; sodium nitrite / water / 5 h / 45 °C / Inert atmosphere
View Scheme
cinoxacin
28657-80-9

cinoxacin

5-chloro-1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydrocinnolin-3-carboxylic acid
1429439-51-9

5-chloro-1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydrocinnolin-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; potassium nitrate / 13 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 5 h / 2585.81 Torr / Inert atmosphere
3: hydrogenchloride; sodium nitrite / water / 5 h / 45 °C / Inert atmosphere
4: sulfuric acid / 20 h / 95 °C / Inert atmosphere
View Scheme

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