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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Clomipramine Manufacturer/High quality/Best price/In stock

Cas:303-49-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

high quality Clomipramine cas no 303-49-1

Cas:303-49-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Clomipramine

Cas:303-49-1

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Clomipramine

Cas:303-49-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Clomipramine

Cas:303-49-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 303-49-1 with competitive price

Cas:303-49-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

First-class antidepressant Clomipramine 303-49-1 on hot selling 1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appea

First-class antidepressant Clomipramine 303-49-1 on hot selling

Cas:303-49-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl- 303-49-1

Cas:303-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Clomipramine CAS: 303-49-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Clomipramine CAS: 303-49-1

Cas:303-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-

Cas:303-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-

Cas:303-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Clomipramine

Cas:303-49-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Clomipramine cas 303-49-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Clomipramine cas 303-49-1

Cas:303-49-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-

Cas:303-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Clomipramina

Cas:303-49-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Clomipramine

Cas:303-49-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

303-49-1 Clomipramine

Cas:303-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Clomipramine

Cas:303-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Clomipramine

Cas:303-49-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Clomipramine Synonyms: g34586;Hydiphen;Monochlorimipramine;RARECHEM AX KI 5027;CLOMIPRAMINE HYDROCLORIDE;AURORA KA-7606;CHLORIMIPRAMINE;CHLORIMIPRAMINE HYDROCHLORIDE CAS: 303-49-1 MF: C19H23ClN2 MW:

Clomipramine

Cas:303-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Clomipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cas no.303-49-1 98% Clomipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Clomipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Chlorimipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Clomipramine 303-49-1

Cas:303-49-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Clomipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Chlorimipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Clomipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-

Cas:303-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Clomipramine

Cas:303-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

clomipramine N-oxide
14171-67-6

clomipramine N-oxide

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
With sodium tetrahydroborate In water at 50 - 60℃; chemoselective reaction;82%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

N,N-dimethyl-3-bromopropylamine
53929-74-1

N,N-dimethyl-3-bromopropylamine

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In tetrahydrofuran at 110℃; for 2h; Glovebox; Inert atmosphere; Schlenk technique;
Stage #2: N,N-dimethyl-3-bromopropylamine In tetrahydrofuran at 110℃; for 22h; Glovebox; Inert atmosphere; Schlenk technique;
66%
3-chloro-5H-dibenzo[b,f]azepine
39607-90-4

3-chloro-5H-dibenzo[b,f]azepine

3-(Dimethylamino)propyl chloride
109-54-6

3-(Dimethylamino)propyl chloride

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Stage #1: 3-chloro-5H-dibenzo[b,f]azepine With methanol; magnesium at 50℃; for 1.5h;
Stage #2: 3-(Dimethylamino)propyl chloride
bromochlorobenzene
106-39-8

bromochlorobenzene

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: caesium carbonate; triphenylphosphine; palladium diacetate; potassium iodide / N,N-dimethyl-formamide / 46 h / 105 °C / Schlenk technique; Inert atmosphere
2: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere
3: magnesium; methanol / 1.5 h / 50 °C
View Scheme
2-bromoaniline
615-36-1

2-bromoaniline

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: caesium carbonate; triphenylphosphine; palladium diacetate; potassium iodide / N,N-dimethyl-formamide / 46 h / 105 °C / Schlenk technique; Inert atmosphere
2: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere
3: magnesium; methanol / 1.5 h / 50 °C
View Scheme
3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine
25961-11-9

3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydroxide; triethyl borane / tetrahydrofuran / 24 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
3.1: sodium hydride / tetrahydrofuran / 2 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
3.2: 22 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
View Scheme
C20H23BClNO2

C20H23BClNO2

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.1: sodium hydride / tetrahydrofuran / 2 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
2.2: 22 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
View Scheme
Clomipramine
303-49-1

Clomipramine

C19H13(2)H10ClN2

C19H13(2)H10ClN2

Conditions
ConditionsYield
Stage #1: Clomipramine With hydrogenchloride In 1,4-dioxane; ethyl acetate Inert atmosphere;
Stage #2: With 3,6-bis(dimethylamino)-9-(2,6-dimethylphenyl)-10-methylacridinium bromide; water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; for 24h; Inert atmosphere; Irradiation; regioselective reaction;
98%
2-(2-methylphenyl)pyridine
10273-89-9

2-(2-methylphenyl)pyridine

Clomipramine
303-49-1

Clomipramine

C31H33N3

C31H33N3

Conditions
ConditionsYield
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 24h; Inert atmosphere;97%
Clomipramine
303-49-1

Clomipramine

C19H21(2)H2ClN2

C19H21(2)H2ClN2

Conditions
ConditionsYield
Stage #1: Clomipramine With hydrogenchloride In 1,4-dioxane; ethyl acetate Inert atmosphere;
Stage #2: With 9-(4-methoxyphenyl)-10-methylacridinium bromide; water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; for 24h; Inert atmosphere; Irradiation; regioselective reaction;
88%
Clomipramine
303-49-1

Clomipramine

tris-iso-propylsilyl acetylene
89343-06-6

tris-iso-propylsilyl acetylene

N,N-dimethyl-3-(3-((triisopropylsilyl)ethynyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-((triisopropylsilyl)ethynyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate In acetonitrile at 85℃; for 7h; Sonogashira Cross-Coupling;87%
Clomipramine
303-49-1

Clomipramine

C19H15(2)H8ClN2

C19H15(2)H8ClN2

Conditions
ConditionsYield
Stage #1: Clomipramine With hydrogenchloride In 1,4-dioxane; ethyl acetate Inert atmosphere;
Stage #2: With 9-(4-fluorophenyl)-10-methylacridinium bromide; water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; for 24h; Inert atmosphere; Irradiation; regioselective reaction;
86%
Clomipramine
303-49-1

Clomipramine

3-(2,4-dibromo-7-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

3-(2,4-dibromo-7-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

Conditions
ConditionsYield
With hydrogen bromide; dimethyl sulfoxide In water; ethyl acetate at 60℃; for 5h;83%
Clomipramine
303-49-1

Clomipramine

C19H9(2)H14ClN2

C19H9(2)H14ClN2

Conditions
ConditionsYield
Stage #1: Clomipramine With hydrogenchloride In 1,4-dioxane; ethyl acetate Inert atmosphere;
Stage #2: With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; for 24h; Inert atmosphere; Irradiation;
80%
Clomipramine
303-49-1

Clomipramine

3-(3-deuterio-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
1610958-41-2

3-(3-deuterio-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; d8-isopropanol; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 100℃; for 2.5h; Inert atmosphere; Microwave irradiation;79%
Clomipramine
303-49-1

Clomipramine

C19H9(2)H14ClN2*ClH

C19H9(2)H14ClN2*ClH

Conditions
ConditionsYield
Stage #1: Clomipramine With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; water-d2; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; for 24h; Irradiation;
Stage #2: With hydrogenchloride In 1-methyl-pyrrolidin-2-one Irradiation;
76%
Clomipramine
303-49-1

Clomipramine

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

C21H25N3

C21H25N3

Conditions
ConditionsYield
Stage #1: Clomipramine; ethyl 2-cyanoacetate With N-(2-methylnaphthalen-1-yl)-N’-(pyridin-2-ylmethyl)oxalamide; copper(I) bromide; sodium t-butanolate In isopropyl alcohol at 105℃; for 24h; Schlenk technique; Inert atmosphere;
Stage #2: With water In isopropyl alcohol at 105℃; for 12h; Schlenk technique; Inert atmosphere; Cooling;
72%
Clomipramine
303-49-1

Clomipramine

sodium trimethylsilyldimethylsilanolate

sodium trimethylsilyldimethylsilanolate

N,N-dimethyl-3-(3-trimethylsilyl-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine

N,N-dimethyl-3-(3-trimethylsilyl-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel(0); Dimethyl(phenyl)phosphine In toluene at 70℃; for 24h; Schlenk technique;69%
Clomipramine
303-49-1

Clomipramine

3-(tetrahydropyran-2'-yloxy)propyne
6089-04-9

3-(tetrahydropyran-2'-yloxy)propyne

N,N-dimethyl-3-(3-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Stage #1: Clomipramine With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate In acetonitrile for 0.416667h; Sonogashira Cross-Coupling; Glovebox;
Stage #2: 3-(tetrahydropyran-2'-yloxy)propyne In acetonitrile at 80℃; for 20h; Sonogashira Cross-Coupling; Sealed tube;
63%
Clomipramine
303-49-1

Clomipramine

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane
745783-97-5

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

N,N-dimethyl-3-(3-(triethylsilyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine

N,N-dimethyl-3-(3-(triethylsilyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine

Conditions
ConditionsYield
With 3,4,7,8-Tetramethyl-o-phenanthrolin; ferrous iodide; sodium t-butanolate In tetrahydrofuran at 120℃; for 12h; Schlenk technique; Glovebox; Inert atmosphere;54%
Clomipramine
303-49-1

Clomipramine

trimethyl(difluoromethyl)silane
65864-64-4

trimethyl(difluoromethyl)silane

3-(3-(difluoromethyl)-10,11-dihydro-5H-dibenzo[b,f ]-azepin-5-yl)-N,N-dimethylpropan-1-amine

3-(3-(difluoromethyl)-10,11-dihydro-5H-dibenzo[b,f ]-azepin-5-yl)-N,N-dimethylpropan-1-amine

Conditions
ConditionsYield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; cesium fluoride; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 100℃; for 16h; Reagent/catalyst; Glovebox; Sealed tube;48%
Clomipramine
303-49-1

Clomipramine

A

clomipramine N-oxide
14171-67-6

clomipramine N-oxide

B

impramine
50-49-7

impramine

C

3-hydroxyimipramine

3-hydroxyimipramine

D

3-hydroxyimipramine-N-oxide

3-hydroxyimipramine-N-oxide

Conditions
ConditionsYield
With oxygen In methanol; phosphate buffer at 25 - 28℃; pH=7.4; Product distribution; Further Variations:; Reagents; Photolysis; UV-irradiation;A 15%
B 15%
C 40%
D 20%
Clomipramine
303-49-1

Clomipramine

desmethylclomipramine
303-48-0

desmethylclomipramine

Conditions
ConditionsYield
With oxygen; palladium on activated charcoal In methanol for 24h; Ambient temperature;
Clomipramine
303-49-1

Clomipramine

clomipramine N-oxide
14171-67-6

clomipramine N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide In methanol for 168h;
Clomipramine
303-49-1

Clomipramine

N,N-dimethyl-3-(3-(3-(2-(2-(naphthalene-1-yl)ethoxy)ethoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(2-(2-(naphthalene-1-yl)ethoxy)ethoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 40 °C / Inert atmosphere
View Scheme
Clomipramine
303-49-1

Clomipramine

N,N-dimethyl-3-(3-(3-(2-(2-(naphthalene-1-yloxy)ethoxy)ethoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(2-(2-(naphthalene-1-yloxy)ethoxy)ethoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
View Scheme
Clomipramine
303-49-1

Clomipramine

N,N-dimethyl-3-(3-(3-(2-(2-(naphthalene-1-ylthio)ethoxy)ethoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(2-(2-(naphthalene-1-ylthio)ethoxy)ethoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
View Scheme
Clomipramine
303-49-1

Clomipramine

3-(3-(3-(3-(10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)-N,N-dimethylpropane-1-amine

3-(3-(3-(3-(10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)-N,N-dimethylpropane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
View Scheme
Clomipramine
303-49-1

Clomipramine

3-(3-(3-(3-(3-(10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propoxy)propoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)-N,N-dimethylpropane-1-amine

3-(3-(3-(3-(3-(10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propoxy)propoxy)prop-1-yn-1-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)-N,N-dimethylpropane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
View Scheme
Clomipramine
303-49-1

Clomipramine

N,N-dimethyl-3-(3-(3-(naphthalene-1-ylmethoxy)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(naphthalene-1-ylmethoxy)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
4.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate
View Scheme
Clomipramine
303-49-1

Clomipramine

N,N-dimethyl-3-(3-(3-(2-(naphthalene-1-yloxy)ethoxy)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(2-(naphthalene-1-yloxy)ethoxy)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere
4.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate
View Scheme
Multi-step reaction with 4 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate
4.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 40 °C / Inert atmosphere
View Scheme
Clomipramine
303-49-1

Clomipramine

N,N-dimethyl-3-(3-(3-(3-(naphthalene-1-yloxy)propoxy)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

N,N-dimethyl-3-(3-(3-(3-(naphthalene-1-yloxy)propoxy)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-yl)propane-1-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 40 °C / Inert atmosphere
4.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate
View Scheme
Multi-step reaction with 4 steps
1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / acetonitrile / 0.42 h / Glovebox
1.2: 20 h / 80 °C / Sealed tube
2.1: toluene-4-sulfonic acid / methanol / 2 h
3.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate
4.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 40 °C / Inert atmosphere
View Scheme

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