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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Manufacturer/High quality/Best price/In stock

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Chloroiminodibenzyl supplier in China

Cas:32943-25-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

3-Chloroiminodibenzyl

Cas:32943-25-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine

Cas:32943-25-2

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Chloroiminodibenzyl

Cas:32943-25-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Synonyms: 4-CHLORO-2,2'-IMINODIBENZYL;3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;3-CHLOROIMINODIBENZYL;3-chloro-10,11-dihydro-5H-dibenz[b,f

TIANFU-CHEM 3-Chloroiminodibenzyl (Chlorimipramine)_

Cas:32943-25-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 32943-25-2 with fast shipping

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Synonyms: 4-CHLORO-2,2'-IMINODIBENZYL;3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;3-CHLOROIMINODIBENZYL;3-chloro-10,11-dihydro-5H-dibenz[b,

3-Chloroiminodibenzyl CAS: 32943-25-2

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

API 99% 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine 32943-25-2

Cas:32943-25-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5H-Dibenz[b,f]azepine,3-chloro-10,11-dihydro- 32943-25-2

Cas:32943-25-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5H-Dibenz[b,f]azepine,3-chloro-10,11-dihydro-

Cas:32943-25-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:32943-25-2

Cas:32943-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

3-Chloroiminodibenzyl CAS: 32943-25-2

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Chloroiminodibenzyl

Cas:32943-25-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-CHLOROIMINODIBENZYL

Cas:32943-25-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Chloroiminodibenzyl

Cas:32943-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:100 Gram

Negotiable

Type:Other

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Hangzhou Lingrui Chemical Co.,Ltd.

2-chloro-6,11-dihydro-5H-benzo[b][1]benzazepineAppearance:white powder Storage:In Shade Package:according to customers' requirements Application:pharmaceutical intermediate Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF

2-chloro-6,11-dihydro-5H-benzo[b][1]benzazepine

Cas:32943-25-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

API Manufacturer CAS 32943-25-2 Pharmaceutical Intermediate

Cas:32943-25-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystals powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermedi

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Synonyms: 4-CHLORO-2,2'-IMINODIBENZYL;3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;3-CHLOROIMINODIBENZYL;3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine;3-Chloro imindibenzyl;3-CHLO

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 3-Chloroiminodibenzyl CAS No.:32943-25-2 Molecule Formula:C14H12ClN Molecule Weight:229.70 Purity: 99.0% Package: 25kg/drum Description: Light yellow crystals powder Manufacture Standards:Enterprise Standard

High Quality 3-Chloroiminodibenzyl

Cas:32943-25-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Cas:32943-25-2

Min.Order:1 Metric Ton

Negotiable

Type:Other

inquiry

Synthetic route

3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine
25961-11-9

3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
With potassium hydroxide In methanol Heating;95%
Stage #1: 3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine With Triethoxysilane; sodium triethylborohydride In tert-butyl methyl ether at 80℃; for 6h;
Stage #2: With hydrogenchloride In tert-butyl methyl ether; water at 20℃; for 1h; Reagent/catalyst; Temperature; Concentration; chemoselective reaction;
91%
With triethyl borane; sodium hydroxide In tert-butyl methyl ether at 80℃; for 6h; Inert atmosphere; Sealed tube;86%
Multi-step reaction with 2 steps
1: potassium hydroxide; triethyl borane / tetrahydrofuran / 24 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube
2: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
View Scheme
With potassium hydroxide In toluene at 85℃; for 6h;
3-chloro-5H-dibenzo[b,f]azepine
39607-90-4

3-chloro-5H-dibenzo[b,f]azepine

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
With methanol; magnesium at 50℃; for 1.5h;95%
3-chloro-10,11-dihydro-dibenzo[b,f]azepine-5-carbaldehyde

3-chloro-10,11-dihydro-dibenzo[b,f]azepine-5-carbaldehyde

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 75℃; for 0.5h; Yield given;
4-chloro-2-nitrotoluene
89-59-8

4-chloro-2-nitrotoluene

copper-powder

copper-powder

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 28 h / Heating
2: 5 h / Heating
3: 83 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating
4: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature
5: 81 percent / HCOONa / 3 h / Heating
6: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C
7: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C
View Scheme
4-chloro-2-nitrobenzyl bromide
52311-59-8

4-chloro-2-nitrobenzyl bromide

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 5 h / Heating
2: 83 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating
3: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature
4: 81 percent / HCOONa / 3 h / Heating
5: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C
6: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C
View Scheme
2-[2-(2-bromo-phenyl)-ethyl]-5-chloro-phenylamine
223787-53-9

2-[2-(2-bromo-phenyl)-ethyl]-5-chloro-phenylamine

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / HCOONa / 3 h / Heating
2: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C
3: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C
View Scheme
1-[(E)-2-(2-Bromo-phenyl)-vinyl]-4-chloro-2-nitro-benzene

1-[(E)-2-(2-Bromo-phenyl)-vinyl]-4-chloro-2-nitro-benzene

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature
2: 81 percent / HCOONa / 3 h / Heating
3: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C
4: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C
View Scheme
4-chloro-2-nitrobenzylphosphonic acid diethyl ester
52311-60-1

4-chloro-2-nitrobenzylphosphonic acid diethyl ester

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 83 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating
2: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature
3: 81 percent / HCOONa / 3 h / Heating
4: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C
5: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C
View Scheme
N-{2-[2-(2-bromo-phenyl)-ethyl]-5-chloro-phenyl}-formamide
223787-58-4

N-{2-[2-(2-bromo-phenyl)-ethyl]-5-chloro-phenyl}-formamide

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C
2: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C
View Scheme
3-amino-5-acetyl-10,11-dihydro-5H-dibenzazepine
84803-67-8

3-amino-5-acetyl-10,11-dihydro-5H-dibenzazepine

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / isoamyl nitrite, CuCl2 / acetonitrile / Ambient temperature
2: 95 percent / KOH / methanol / Heating
View Scheme
clomipramine hydrochloride
17321-77-6

clomipramine hydrochloride

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
With horseradish peroxidase type VI; dihydrogen peroxide In water at 25℃; for 11h; Enzymatic reaction;
3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine
25961-11-9

3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine

A

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

B

ethanol
64-17-5

ethanol

C

C16H16ClN

C16H16ClN

Conditions
ConditionsYield
With Mo2((1)-H)2(OtBu)6; diphenylsilane In toluene at 111℃; for 25h; Inert atmosphere; Schlenk technique;
bromochlorobenzene
106-39-8

bromochlorobenzene

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: caesium carbonate; triphenylphosphine; palladium diacetate; potassium iodide / N,N-dimethyl-formamide / 46 h / 105 °C / Schlenk technique; Inert atmosphere
2: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere
3: magnesium; methanol / 1.5 h / 50 °C
View Scheme
2-bromoaniline
615-36-1

2-bromoaniline

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: caesium carbonate; triphenylphosphine; palladium diacetate; potassium iodide / N,N-dimethyl-formamide / 46 h / 105 °C / Schlenk technique; Inert atmosphere
2: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere
3: magnesium; methanol / 1.5 h / 50 °C
View Scheme
C19H16ClN

C19H16ClN

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere
2: magnesium; methanol / 1.5 h / 50 °C
View Scheme
C20H23BClNO2

C20H23BClNO2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran at 25℃; for 1h; Inert atmosphere; Schlenk technique; Sealed tube;0.18 g
chloropropionic acid
107-94-8

chloropropionic acid

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

C17H17Cl2N*ClH

C17H17Cl2N*ClH

Conditions
ConditionsYield
Stage #1: chloropropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃;
Stage #2: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium tetrahydroborate In toluene at 25 - 80℃; for 7h;
Stage #3: With hydrogenchloride In water; isopropyl alcohol
99%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

3-dimethylaminopropionic acid
6300-04-5

3-dimethylaminopropionic acid

clomipramine hydrochloride
17321-77-6

clomipramine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-dimethylaminopropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃;
Stage #2: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium tetrahydroborate In toluene at 25 - 80℃; for 5h;
Stage #3: With hydrogenchloride In water; isopropyl alcohol
98%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

allyl bromide
106-95-6

allyl bromide

3-chloro-5-(prop-2-enyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
1425793-87-8

3-chloro-5-(prop-2-enyl)-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Inert atmosphere;
97%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethanone
726140-60-9

2-chloro-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethanone

Conditions
ConditionsYield
In toluene at 100℃; for 1h;93%
In toluene at 100℃; for 1h;87%
In toluene for 12h; Heating;53%
In toluene Heating;
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

iodobenzene
591-50-4

iodobenzene

C20H16ClN

C20H16ClN

Conditions
ConditionsYield
With nickel(II) oxide; potassium tert-butylate; triphenylphosphine In tetrahydrofuran at 100℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;90%
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Reagent/catalyst; Inert atmosphere;83%
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Solvent; Sealed tube; Inert atmosphere;83%
bromobenzene
108-86-1

bromobenzene

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

C20H16ClN

C20H16ClN

Conditions
ConditionsYield
With nickel(II) oxide; potassium tert-butylate; triphenylphosphine In tetrahydrofuran at 100℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;90%
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Reagent/catalyst; Inert atmosphere;86%
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Solvent; Sealed tube; Inert atmosphere;86%
2-bromoacetyl chloride
22118-09-8

2-bromoacetyl chloride

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

2-bromo-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethan-1-one

2-bromo-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethan-1-one

Conditions
ConditionsYield
In toluene at 100℃; for 1h;90%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

2-Bromo-m-xylene
576-22-7

2-Bromo-m-xylene

3-chloro-N-(2,6-dimethylphenyl)iminodibenzyl

3-chloro-N-(2,6-dimethylphenyl)iminodibenzyl

Conditions
ConditionsYield
With C30H43O2P*C13H12N(1-)*CH3O3S(1-)*Pd(2+); lithium hexamethyldisilazane In 1,4-dioxane at 100℃; for 16h; Inert atmosphere;89%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

epichlorohydrin
106-89-8

epichlorohydrin

3-chloro-5-(oxiran-2-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
1423078-41-4

3-chloro-5-(oxiran-2-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere;
Stage #2: epichlorohydrin In tetrahydrofuran; hexane at 20℃; for 23h;
88%
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With n-butyllithium at -15 - -10℃; for 0.666667h; Inert atmosphere; Large scale;
Stage #2: epichlorohydrin at -25 - -20℃; for 1h; Inert atmosphere; Enzymatic reaction; Large scale; Further stages;
72%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

3-chloro-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-one

3-chloro-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-one

Conditions
ConditionsYield
In toluene at 100℃; for 4h;87%
In toluene at 100℃; for 1h;68%
With sodium hydroxide In methanol; ethyl acetate; toluene4.0 g (57%)
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

methanesulfonic acid 4-(tert-butoxycarbonyl-methyl-amino)-butyl ester
99230-20-3

methanesulfonic acid 4-(tert-butoxycarbonyl-methyl-amino)-butyl ester

tert-butyl [4-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)butyl]methylcarbamate

tert-butyl [4-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)butyl]methylcarbamate

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h;
Stage #2: methanesulfonic acid 4-(tert-butoxycarbonyl-methyl-amino)-butyl ester In N,N-dimethyl-formamide; mineral oil at 0 - 55℃;
86%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

chlorobenzene
108-90-7

chlorobenzene

C20H16ClN

C20H16ClN

Conditions
ConditionsYield
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere;85%
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Solvent; Sealed tube; Inert atmosphere;85%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

N,N-dimethyl-3-bromopropylamine
53929-74-1

N,N-dimethyl-3-bromopropylamine

Clomipramine
303-49-1

Clomipramine

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In tetrahydrofuran at 110℃; for 2h; Glovebox; Inert atmosphere; Schlenk technique;
Stage #2: N,N-dimethyl-3-bromopropylamine In tetrahydrofuran at 110℃; for 22h; Glovebox; Inert atmosphere; Schlenk technique;
66%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

2-(4-bromobutyl)isoindoline-1,3-dione
5394-18-3

2-(4-bromobutyl)isoindoline-1,3-dione

2-[4-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)butyl]-1H-isoindole-1,3(2H)-dione

2-[4-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)butyl]-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h;
Stage #2: 2-(4-bromobutyl)isoindoline-1,3-dione In N,N-dimethyl-formamide; mineral oil at 55℃; for 4h;
58%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester
273756-96-0

methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester

tert-butyl 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl(methyl)carbamate

tert-butyl 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl(methyl)carbamate

Conditions
ConditionsYield
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; for 0.75h;
Stage #2: methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester In tetrahydrofuran at 75℃; for 5h;
55%
sodium cyanide
773837-37-9

sodium cyanide

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

3-cyano-iminodibenzyl
66834-19-3

3-cyano-iminodibenzyl

Conditions
ConditionsYield
With nickel(II) bromide trihydrate In 1-methyl-pyrrolidin-2-one at 200℃; for 0.5h; Microwave irradiation;33%
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

(1S,9aR)-1-(chloromethyl)octahydro-2H-quinolizine
34298-00-5

(1S,9aR)-1-(chloromethyl)octahydro-2H-quinolizine

3-Chloro-5-[(1R,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-10,11-dihydro-5H-dibenzo[b,f]azepine; hydrochloride

3-Chloro-5-[(1R,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-10,11-dihydro-5H-dibenzo[b,f]azepine; hydrochloride

Conditions
ConditionsYield
With sodium amide 1.) xylene, reflux, 1 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction;
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

(1S,9aR)-1-(aminomethyl)-(octahydro-2H-quinolizine)
23506-89-0

(1S,9aR)-1-(aminomethyl)-(octahydro-2H-quinolizine)

3-Chloro-5-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-10,11-dihydro-5H-dibenzo[b,f]azepine

3-Chloro-5-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions
ConditionsYield
With sodium amide 1.) xylene, reflux, 1 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction;
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

1-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-2-(octahydro-quinolizin-1-ylmethylsulfanyl)-ethanone

1-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-2-(octahydro-quinolizin-1-ylmethylsulfanyl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / Heating
2: ethanol / Heating
View Scheme
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

3-chloro-5-(2-chloroethyl)-10,11-dihydro-5H-dibenz[b,f]azepine
351228-39-2

3-chloro-5-(2-chloroethyl)-10,11-dihydro-5H-dibenz[b,f]azepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 53 percent / toluene / 12 h / Heating
2: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C
View Scheme
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

2-(2-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)ethoxy)ethanol
351228-35-8

2-(2-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)ethoxy)ethanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 53 percent / toluene / 12 h / Heating
2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C
3.1: t-BuOK / 1 h / 50 °C
3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C
View Scheme
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

toluene-4-sulfonic acid 2-[2-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-ethoxy]-ethyl ester

toluene-4-sulfonic acid 2-[2-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-ethoxy]-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 53 percent / toluene / 12 h / Heating
2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C
3.1: t-BuOK / 1 h / 50 °C
3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C
4.2: hexane; tetrahydrofuran / 0.5 h / 20 °C
View Scheme
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

1-{2-[2-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-ethoxy]-ethyl}-piperidine-3-carboxylic acid

1-{2-[2-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-ethoxy]-ethyl}-piperidine-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 53 percent / toluene / 12 h / Heating
2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C
3.1: t-BuOK / 1 h / 50 °C
3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C
4.2: hexane; tetrahydrofuran / 0.5 h / 20 °C
5.1: K2CO3 / acetone / 120 h / 20 °C
6.1: aq. NaOH / ethanol / 20 °C
View Scheme
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
32943-25-2

3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

1-{2-[2-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-ethoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

1-{2-[2-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-ethoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 53 percent / toluene / 12 h / Heating
2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C
3.1: t-BuOK / 1 h / 50 °C
3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C
4.2: hexane; tetrahydrofuran / 0.5 h / 20 °C
5.1: K2CO3 / acetone / 120 h / 20 °C
View Scheme

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