DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:32943-25-2
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:32943-25-2
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inquiryProduct Name: 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Synonyms: 4-CHLORO-2,2'-IMINODIBENZYL;3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;3-CHLOROIMINODIBENZYL;3-chloro-10,11-dihydro-5H-dibenz[b,f
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name: 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Synonyms: 4-CHLORO-2,2'-IMINODIBENZYL;3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;3-CHLOROIMINODIBENZYL;3-chloro-10,11-dihydro-5H-dibenz[b,
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:32943-25-2
Min.Order:10 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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Cas:32943-25-2
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:32943-25-2
Min.Order:100 Gram
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inquiry2-chloro-6,11-dihydro-5H-benzo[b][1]benzazepineAppearance:white powder Storage:In Shade Package:according to customers' requirements Application:pharmaceutical intermediate Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF
Cas:32943-25-2
Min.Order:1 Gram
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:32943-25-2
Min.Order:100 Gram
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inquirySuperior quality, moderate price & quick delivery. Appearance:white crystals powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermedi
Cas:32943-25-2
Min.Order:1 Gram
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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Min.Order:1 Milligram
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inquiryProduct Name: 3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine Synonyms: 4-CHLORO-2,2'-IMINODIBENZYL;3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;3-CHLOROIMINODIBENZYL;3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine;3-Chloro imindibenzyl;3-CHLO
Cas:32943-25-2
Min.Order:1 Gram
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:32943-25-2
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
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inquiryProduct name: 3-Chloroiminodibenzyl CAS No.:32943-25-2 Molecule Formula:C14H12ClN Molecule Weight:229.70 Purity: 99.0% Package: 25kg/drum Description: Light yellow crystals powder Manufacture Standards:Enterprise Standard
Cas:32943-25-2
Min.Order:1 Kilogram
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryHunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant
Cas:32943-25-2
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inquiry3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
With potassium hydroxide In methanol Heating; | 95% |
Stage #1: 3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine With Triethoxysilane; sodium triethylborohydride In tert-butyl methyl ether at 80℃; for 6h; Stage #2: With hydrogenchloride In tert-butyl methyl ether; water at 20℃; for 1h; Reagent/catalyst; Temperature; Concentration; chemoselective reaction; | 91% |
With triethyl borane; sodium hydroxide In tert-butyl methyl ether at 80℃; for 6h; Inert atmosphere; Sealed tube; | 86% |
Multi-step reaction with 2 steps 1: potassium hydroxide; triethyl borane / tetrahydrofuran / 24 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube 2: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube View Scheme | |
With potassium hydroxide In toluene at 85℃; for 6h; |
3-chloro-5H-dibenzo[b,f]azepine
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
With methanol; magnesium at 50℃; for 1.5h; | 95% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
With sodium hydroxide In dimethyl sulfoxide at 75℃; for 0.5h; Yield given; |
4-chloro-2-nitrotoluene
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: N-bromosuccinimide, benzoyl peroxide / CCl4 / 28 h / Heating 2: 5 h / Heating 3: 83 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating 4: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature 5: 81 percent / HCOONa / 3 h / Heating 6: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C 7: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C View Scheme |
4-chloro-2-nitrobenzyl bromide
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 5 h / Heating 2: 83 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating 3: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature 4: 81 percent / HCOONa / 3 h / Heating 5: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C 6: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C View Scheme |
2-[2-(2-bromo-phenyl)-ethyl]-5-chloro-phenylamine
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 81 percent / HCOONa / 3 h / Heating 2: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C 3: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature 2: 81 percent / HCOONa / 3 h / Heating 3: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C 4: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C View Scheme |
4-chloro-2-nitrobenzylphosphonic acid diethyl ester
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 83 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating 2: 82 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature 3: 81 percent / HCOONa / 3 h / Heating 4: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C 5: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C View Scheme |
N-{2-[2-(2-bromo-phenyl)-ethyl]-5-chloro-phenyl}-formamide
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: K2CO3, Cu, CuBr / dimethylsulfoxide / 3 h / 160 °C 2: 5 N aq. NaOH / dimethylsulfoxide / 0.5 h / 75 °C View Scheme |
3-amino-5-acetyl-10,11-dihydro-5H-dibenzazepine
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / isoamyl nitrite, CuCl2 / acetonitrile / Ambient temperature 2: 95 percent / KOH / methanol / Heating View Scheme |
clomipramine hydrochloride
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
With horseradish peroxidase type VI; dihydrogen peroxide In water at 25℃; for 11h; Enzymatic reaction; |
3-chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(6,5)azepine
A
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
B
ethanol
Conditions | Yield |
---|---|
With Mo2((1)-H)2(OtBu)6; diphenylsilane In toluene at 111℃; for 25h; Inert atmosphere; Schlenk technique; |
bromochlorobenzene
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: caesium carbonate; triphenylphosphine; palladium diacetate; potassium iodide / N,N-dimethyl-formamide / 46 h / 105 °C / Schlenk technique; Inert atmosphere 2: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere 3: magnesium; methanol / 1.5 h / 50 °C View Scheme |
2-bromoaniline
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: caesium carbonate; triphenylphosphine; palladium diacetate; potassium iodide / N,N-dimethyl-formamide / 46 h / 105 °C / Schlenk technique; Inert atmosphere 2: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere 3: magnesium; methanol / 1.5 h / 50 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 24 h / 130 °C / Schlenk technique; Inert atmosphere 2: magnesium; methanol / 1.5 h / 50 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
With water; sodium hydroxide In tetrahydrofuran at 25℃; for 1h; Inert atmosphere; Schlenk technique; Sealed tube; | 0.18 g |
chloropropionic acid
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Stage #1: chloropropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃; Stage #2: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium tetrahydroborate In toluene at 25 - 80℃; for 7h; Stage #3: With hydrogenchloride In water; isopropyl alcohol | 99% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
3-dimethylaminopropionic acid
clomipramine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-dimethylaminopropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃; Stage #2: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium tetrahydroborate In toluene at 25 - 80℃; for 5h; Stage #3: With hydrogenchloride In water; isopropyl alcohol | 98% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
allyl bromide
3-chloro-5-(prop-2-enyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.333333h; Inert atmosphere; Stage #2: allyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Inert atmosphere; | 97% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
chloroacetyl chloride
2-chloro-1-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethanone
Conditions | Yield |
---|---|
In toluene at 100℃; for 1h; | 93% |
In toluene at 100℃; for 1h; | 87% |
In toluene for 12h; Heating; | 53% |
In toluene Heating; |
Conditions | Yield |
---|---|
With nickel(II) oxide; potassium tert-butylate; triphenylphosphine In tetrahydrofuran at 100℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry; | 90% |
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Reagent/catalyst; Inert atmosphere; | 83% |
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Solvent; Sealed tube; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With nickel(II) oxide; potassium tert-butylate; triphenylphosphine In tetrahydrofuran at 100℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry; | 90% |
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Reagent/catalyst; Inert atmosphere; | 86% |
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Solvent; Sealed tube; Inert atmosphere; | 86% |
2-bromoacetyl chloride
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
In toluene at 100℃; for 1h; | 90% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
2-Bromo-m-xylene
Conditions | Yield |
---|---|
With C30H43O2P*C13H12N(1-)*CH3O3S(1-)*Pd(2+); lithium hexamethyldisilazane In 1,4-dioxane at 100℃; for 16h; Inert atmosphere; | 89% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
epichlorohydrin
3-chloro-5-(oxiran-2-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: epichlorohydrin In tetrahydrofuran; hexane at 20℃; for 23h; | 88% |
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With n-butyllithium at -15 - -10℃; for 0.666667h; Inert atmosphere; Large scale; Stage #2: epichlorohydrin at -25 - -20℃; for 1h; Inert atmosphere; Enzymatic reaction; Large scale; Further stages; | 72% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
2-chloropropionyl chloride
Conditions | Yield |
---|---|
In toluene at 100℃; for 4h; | 87% |
In toluene at 100℃; for 1h; | 68% |
With sodium hydroxide In methanol; ethyl acetate; toluene | 4.0 g (57%) |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
methanesulfonic acid 4-(tert-butoxycarbonyl-methyl-amino)-butyl ester
Conditions | Yield |
---|---|
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Stage #2: methanesulfonic acid 4-(tert-butoxycarbonyl-methyl-amino)-butyl ester In N,N-dimethyl-formamide; mineral oil at 0 - 55℃; | 86% |
Conditions | Yield |
---|---|
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere; | 85% |
With potassium tert-butylate; copper(II) oxide In dimethyl sulfoxide at 80℃; for 18h; Solvent; Sealed tube; Inert atmosphere; | 85% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
N,N-dimethyl-3-bromopropylamine
Clomipramine
Conditions | Yield |
---|---|
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In tetrahydrofuran at 110℃; for 2h; Glovebox; Inert atmosphere; Schlenk technique; Stage #2: N,N-dimethyl-3-bromopropylamine In tetrahydrofuran at 110℃; for 22h; Glovebox; Inert atmosphere; Schlenk technique; | 66% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
2-(4-bromobutyl)isoindoline-1,3-dione
Conditions | Yield |
---|---|
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Stage #2: 2-(4-bromobutyl)isoindoline-1,3-dione In N,N-dimethyl-formamide; mineral oil at 55℃; for 4h; | 58% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester
Conditions | Yield |
---|---|
Stage #1: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; for 0.75h; Stage #2: methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester In tetrahydrofuran at 75℃; for 5h; | 55% |
sodium cyanide
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
3-cyano-iminodibenzyl
Conditions | Yield |
---|---|
With nickel(II) bromide trihydrate In 1-methyl-pyrrolidin-2-one at 200℃; for 0.5h; Microwave irradiation; | 33% |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
(1S,9aR)-1-(chloromethyl)octahydro-2H-quinolizine
Conditions | Yield |
---|---|
With sodium amide 1.) xylene, reflux, 1 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction; |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
(1S,9aR)-1-(aminomethyl)-(octahydro-2H-quinolizine)
Conditions | Yield |
---|---|
With sodium amide 1.) xylene, reflux, 1 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction; |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / Heating 2: ethanol / Heating View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
3-chloro-5-(2-chloroethyl)-10,11-dihydro-5H-dibenz[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 53 percent / toluene / 12 h / Heating 2: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
2-(2-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)ethoxy)ethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 53 percent / toluene / 12 h / Heating 2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C 3.1: t-BuOK / 1 h / 50 °C 3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 53 percent / toluene / 12 h / Heating 2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C 3.1: t-BuOK / 1 h / 50 °C 3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C 4.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C 4.2: hexane; tetrahydrofuran / 0.5 h / 20 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 53 percent / toluene / 12 h / Heating 2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C 3.1: t-BuOK / 1 h / 50 °C 3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C 4.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C 4.2: hexane; tetrahydrofuran / 0.5 h / 20 °C 5.1: K2CO3 / acetone / 120 h / 20 °C 6.1: aq. NaOH / ethanol / 20 °C View Scheme |
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 53 percent / toluene / 12 h / Heating 2.1: 80 percent / NaBH4; BF3*Et2O / tetrahydrofuran / 3 h / 10 - 20 °C 3.1: t-BuOK / 1 h / 50 °C 3.2: 56 percent / tetrahydrofuran / 48 h / 150 °C 4.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C 4.2: hexane; tetrahydrofuran / 0.5 h / 20 °C 5.1: K2CO3 / acetone / 120 h / 20 °C View Scheme |
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