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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

Cas:3130-75-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2H-Isoindole-2-butanoicacid, 1,3-dihydro-1,3-dioxo-

Cas:3130-75-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-Isoindole-2-butanoicacid, 1,3-dihydro-1,3-dioxo-

Cas:3130-75-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-Isoindole-2-butanoicacid, 1,3-dihydro-1,3-dioxo-

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

product name :4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid CAS:3130-75-4 Appearance:off-white powder Storage:sealed in container ,room temperature. Package:on the requirement of client Application:vilazodone intermediate Transportation:

4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

Cas:3130-75-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3130-75-4 CAS NO.3130-75-4

Cas:3130-75-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-(1,3-Dioxo-1,3-dihydro-2H-Isoindol-2-yl)butanoic Acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Other

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)Butanoic Acid

Cas:3130-75-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

2H-Isoindole-2-butanoicacid, 1,3-dihydro-1,3-dioxo-

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2H-Isoindole-2-butanoicacid, 1,3-dihydro-1,3-dioxo-

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid cas 3130-75-4Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

3130-75-4

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

3130-75-4

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

4-(1,3-Dioxo-1,3-dihydro-2H-Isoindol-2-yl)butanoic Acid 3130-75-4

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

4-(1,3-Dioxo-1,3-dihydro-2H-Isoindol-2-yl)butanoic Acid 3130-75-4

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

4-phthalimidobutyric acid

Cas:3130-75-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

Cas:3130-75-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

3130-75-4 CAS NO.3130-75-4

Cas:3130-75-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Cas:3130-75-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

phthalic anhydride
85-44-9

phthalic anhydride

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
at 170℃; for 6h;100%
at 180℃;94%
In neat (no solvent) at 170℃; for 3h; Inert atmosphere; Schlenk technique;94%
potassium phtalimide
1074-82-4

potassium phtalimide

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
at 180℃; for 0.5h;96%
benzene-1,2-dicarboxylic acid
88-99-3

benzene-1,2-dicarboxylic acid

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With propionic acid for 4h; Heating;90%
phthalimide
136918-14-4

phthalimide

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
In toluene for 3h; Product distribution / selectivity; Heating / reflux;81%
With acetic acid for 3h;
N-ethoxycarbonylphthalimide
22509-74-6

N-ethoxycarbonylphthalimide

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With sodium carbonate In water for 5h; Ambient temperature;80%
With sodium carbonate for 1h;48%
With sodium carbonate In water for 6h;36%
With sodium carbonate In water at 20℃; for 3h;21%
γ-chlorobutyric acid
627-00-9

γ-chlorobutyric acid

potassium phtalimide
1074-82-4

potassium phtalimide

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide80%
In water; N,N-dimethyl-formamide80%
N-phthaloyl-L-glutamic acid
340-90-9

N-phthaloyl-L-glutamic acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
In acetonitrile for 30h; Decarboxylation; Irradiation;70%
In acetone at 20℃; for 12h; Irradiation;
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

N-phthaloyl-L-glutamic acid
340-90-9

N-phthaloyl-L-glutamic acid

A

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

3-(2-carboxy-ethyl)-9b-hydroxy-5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-a]isoindole-1-carboxylic acid methyl ester

3-(2-carboxy-ethyl)-9b-hydroxy-5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-a]isoindole-1-carboxylic acid methyl ester

3-(2-carboxy-ethyl)-9b-hydroxy-5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-a]isoindole-1-carboxylic acid methyl ester

3-(2-carboxy-ethyl)-9b-hydroxy-5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-a]isoindole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
In acetonitrile for 30h; Cycloaddition; Irradiation;A 5%
B 20%
C 41%
4-butanolide
96-48-0

4-butanolide

potassium phtalimide
1074-82-4

potassium phtalimide

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
at 200℃;
With N,N-dimethyl-formamide
4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester
39739-03-2

4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With sulfuric acid; water
With hydrogenchloride; water; acetic acid
(Z)-4-phthalimidocrotonic acid
16011-10-2

(Z)-4-phthalimidocrotonic acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With ethanol; platinum Hydrogenation;
(E)-4-(1,3-dioxoisoindolin-2-yl)but-2-enoic acid
16011-09-9

(E)-4-(1,3-dioxoisoindolin-2-yl)but-2-enoic acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With ethanol; platinum Hydrogenation;
4-phthalimidobutylguanidine sulfate

4-phthalimidobutylguanidine sulfate

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With potassium permanganate; sulfuric acid for 1h; Ambient temperature;13 mg
N-phthaloyl-L-glutamic anhydride
25830-77-7

N-phthaloyl-L-glutamic anhydride

A

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

B

(S)-2-(1,3-dioxoisoindolin-2-yl)butanoic acid
5203-11-2

(S)-2-(1,3-dioxoisoindolin-2-yl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride; [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) 1.) THF, reflux, 2.5h.; Yield given. Multistep reaction. Yields of byproduct given;
With hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine 1.) THF, reflux, 2.5h.; Yield given. Multistep reaction. Yields of byproduct given;
γ-phthalimido-butyric acid nitrile

γ-phthalimido-butyric acid nitrile

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With sulfuric acid beim Versetzen der abgekuehlten Loesung mit Wasser und Erhitzen des Reaktionsgemisches auf 120-130grad.;
γ-phthalimido-ethylmalonic acid

γ-phthalimido-ethylmalonic acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

N-ethoxycarbonylphthalimide
22509-74-6

N-ethoxycarbonylphthalimide

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 225 mg / sodium bicarbonate / H2O / 1 h / Ambient temperature
2: 13 mg / potassium permanganate, sulfuric acid (1 N) / 1 h / Ambient temperature
View Scheme
N-phthalimidyl-2-aminoacetaldehyde
2913-97-5

N-phthalimidyl-2-aminoacetaldehyde

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 100 °C
2: platinum; ethanol / Hydrogenation
View Scheme
Multi-step reaction with 2 steps
1: pyridine / 100 °C
2: platinum; ethanol / Hydrogenation
View Scheme
2-(4-diazo-3-oxobutyl)isoindoline-1,3-dione
7504-49-6

2-(4-diazo-3-oxobutyl)isoindoline-1,3-dione

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver oxide
2: hydrochloric acid; acetic acid; water
View Scheme
phthalic anhydride
85-44-9

phthalic anhydride

γ-pyrrolidone

γ-pyrrolidone

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
In nitrogen; water116.2 g (99.6%)
phthalic anhydride
85-44-9

phthalic anhydride

5-aminopentanoic acid
660-88-8

5-aminopentanoic acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With triethylamine In toluene Reflux;
3-phthalimido-1-propene
5428-09-1

3-phthalimido-1-propene

benzene 1,3,5-triyl triformate

benzene 1,3,5-triyl triformate

A

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

B

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid
35340-62-6

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

C

3-(1,3-dioxoisoindolin-2-yl)-2-methylpropanoic acid
24431-49-0

3-(1,3-dioxoisoindolin-2-yl)-2-methylpropanoic acid

Conditions
ConditionsYield
With formic acid; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; Inert atmosphere; Sealed tube; Overall yield = 53 %; Overall yield = 61.2 mg;
3-amino propanoic acid
107-95-9

3-amino propanoic acid

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 0.5h;0.92 g
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

4-phthalimidobutyryl chloride
10314-06-4

4-phthalimidobutyryl chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane for 6h; Heating;100%
With thionyl chloride92%
With thionyl chloride In dichloromethane for 5h; Heating;92%
oxalyl dichloride
79-37-8

oxalyl dichloride

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

N,N-bis(n-butylcarbamoyloxyethyl)-N-(4-phthalimidobutyryl) amine

N,N-bis(n-butylcarbamoyloxyethyl)-N-(4-phthalimidobutyryl) amine

Conditions
ConditionsYield
With hydrogenchloride In N,N-bis(n-butylcarbamoyloxyethyl) amine; dichloromethane; triethylamine97.1%
With hydrogenchloride In N,N-bis(n-butylcarbamoyloxyethyl) amine; dichloromethane; triethylamine
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

thiourea
17356-08-0

thiourea

2-amino-4-(3-phthalimidopropyl)thiazole
92166-54-6

2-amino-4-(3-phthalimidopropyl)thiazole

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid; thiourea In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With water; potassium carbonate
97%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid
35197-64-9

2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Conditions
ConditionsYield
With phosphorus; bromine In tetrachloromethane Heating; 6-8 h;96%
With phosphorus; bromine In tetrachloromethane 80 deg C, 30 min, reflux 8 h;80%
Stage #1: 4-phthalimidobutyric acid With thionyl chloride for 2h; Heating / reflux;
Stage #2: With bromine for 52h; Product distribution / selectivity; Heating / reflux;
58%
O-2-tetrahydro-2H-pyranhydroxylamine
6723-30-4

O-2-tetrahydro-2H-pyranhydroxylamine

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

4-(1,3-dioxoisoindolin-2-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
1356930-35-2

4-(1,3-dioxoisoindolin-2-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 20℃;94%
methanol
67-56-1

methanol

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester
39739-03-2

4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 4h;93%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

4-phthalimidoperbutanoic acid

4-phthalimidoperbutanoic acid

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide90%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

9b-hydroxy-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-a]isoindol-5-one

9b-hydroxy-1,2,3,9b-tetrahydro-5H-pyrrolo[2,1-a]isoindol-5-one

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid With potassium carbonate In water Sonication;
Stage #2: In water; acetonitrile for 2.78h; Inert atmosphere; Flow reactor; UV-irradiation;
88%
With potassium carbonate In water; acetone at 15℃; Irradiation;75%
With potassium carbonate In acetone Irradiation;75%
Multi-step reaction with 2 steps
1: acetone; water / 0.25 h / Inert atmosphere
2: acetone; water / Irradiation; Inert atmosphere
View Scheme
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

topiramate
97240-79-4

topiramate

C24H30N2O11S

C24H30N2O11S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;88%
N-methylcyclohexylamine
100-60-7

N-methylcyclohexylamine

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

N-cyclohexyl-N-methyl-4-(1,3-dioxoisoindolin-2-yl)butanamide

N-cyclohexyl-N-methyl-4-(1,3-dioxoisoindolin-2-yl)butanamide

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: N-methylcyclohexylamine In dichloromethane at 20℃; for 17h; Inert atmosphere;
87%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

4-phthalimidobutanal
3598-60-5

4-phthalimidobutanal

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid With 2,6-dimethylpyridine; nickel(II) bromide trihydrate; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc; dimethyl dicarbonate In ethyl acetate for 0.25h; Inert atmosphere; Green chemistry;
Stage #2: With diphenylsilane In ethyl acetate at 60℃; for 16h; Inert atmosphere; Green chemistry;
86%
Multi-step reaction with 2 steps
1: thionyl chloride / DMFA / 30 - 70 °C
2: 100 percent / H2 / Pd/BaSO4 / xylene / 6 h / Heating; catalyst poison
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride
2: palladium/barium sulfate; xylene / 140 °C / Hydrogenation
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride / dichloromethane / 8 h
2: palladium 10% on activated carbon; hydrogen; 2,6-dimethylpyridine / tetrahydrofuran / 6 h / 22 °C / 775.74 Torr
View Scheme
4-(1,3-diacetoxypropan-2-yloxy)indoline
927812-49-5

4-(1,3-diacetoxypropan-2-yloxy)indoline

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

1-(4-phthalimidobutanoyl)-4-(1,3-diacetoxypropan-2-yloxy)indoline
952595-60-7

1-(4-phthalimidobutanoyl)-4-(1,3-diacetoxypropan-2-yloxy)indoline

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃;85%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

5-oxo-3,5-dihydro-2H-pyrrolo[2,1-a]isoindole-1-carboxylic acid

5-oxo-3,5-dihydro-2H-pyrrolo[2,1-a]isoindole-1-carboxylic acid

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid With t-butyldimethylsiyl triflate; triethylamine In chloroform for 3h;
Stage #2: With potassium carbonate In methanol Further stages.;
85%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione
41306-64-3

2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1h;
Stage #2: diazomethane In diethyl ether; dichloromethane at 0℃; for 1.5h;
Stage #3: With hydrogen bromide In diethyl ether; dichloromethane; water
84%
Stage #1: 4-phthalimidobutyric acid With sulfuryl dichloride
Stage #2: diazomethane In diethyl ether
Stage #3: With hydrogen bromide In tetrahydrofuran
N-(7-chloroquinolin-4-yl)ethylenediamine
5407-57-8

N-(7-chloroquinolin-4-yl)ethylenediamine

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

N-(2-((7-chloroquinolin-4-yl)amino)ethyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide

N-(2-((7-chloroquinolin-4-yl)amino)ethyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide

Conditions
ConditionsYield
Stage #1: 4-phthalimidobutyric acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: N-(7-chloroquinolin-4-yl)ethylenediamine In N,N-dimethyl-formamide at 20℃; for 3h;
83%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;83%
1,2-dimethoxybenzene
91-16-7

1,2-dimethoxybenzene

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

1-(3,4-dimethoxyphenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butan-1-one
76356-13-3

1-(3,4-dimethoxyphenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butan-1-one

Conditions
ConditionsYield
With PPA at 80 - 90℃; for 1h;82%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

epichlorohydrin
106-89-8

epichlorohydrin

N-(3-carboxypropyl)phthalimide glycidyl ester
97663-53-1

N-(3-carboxypropyl)phthalimide glycidyl ester

Conditions
ConditionsYield
benzyltrimethylammonium chloride for 0.25h; Heating;81%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

L-alanyl-D-isoglutamine benzyl ester hydrochloride
59524-62-8

L-alanyl-D-isoglutamine benzyl ester hydrochloride

benzyl N-(4-phthalimidobutanoyl)-L-alanyl-D-isoglutaminate

benzyl N-(4-phthalimidobutanoyl)-L-alanyl-D-isoglutaminate

Conditions
ConditionsYield
With diphenylphosphoranyl azide; triethylamine In N,N-dimethyl-formamide 1.) 0 deg C, 1 h, 2.) r.t., 24 h;81%
1,3-Dimethyllumazine
13401-18-8

1,3-Dimethyllumazine

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

7-[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-1,3-dimethyl-1H-pteridine-2,4-dione
121485-74-3

7-[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-1,3-dimethyl-1H-pteridine-2,4-dione

Conditions
ConditionsYield
With ammonium peroxydisulfate; silver nitrate In water; acetonitrile for 5.5h; Heating;80%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

magnesium monomethyl malonate

magnesium monomethyl malonate

6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-hexanoic acid methyl ester
213820-50-9

6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-hexanoic acid methyl ester

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In tetrahydrofuran for 24h;80%
L-Alanine methyl ester
10065-72-2

L-Alanine methyl ester

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

methyl 2-(4-(phthalimido-2-yl)butanamido)propanoate

methyl 2-(4-(phthalimido-2-yl)butanamido)propanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetonitrile at 0 - 23℃; for 18h;80%
L-threonine methyl ester
3373-59-9

L-threonine methyl ester

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

methyl 2-(4-(phthalimido-2-yl)butanamido)-3-hydroxybutanoate

methyl 2-(4-(phthalimido-2-yl)butanamido)-3-hydroxybutanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetonitrile at 0 - 23℃; for 18h;80%
sulfure de methyle et de 2-chloroethyle
542-81-4

sulfure de methyle et de 2-chloroethyle

4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

4-phthalimidobutyric acid 2-(methylthio)ethyl ester

4-phthalimidobutyric acid 2-(methylthio)ethyl ester

Conditions
ConditionsYield
With triethylamine In ethyl acetate for 72h; Heating;79%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

2-(3-fluoropentyl)isoindoline-1,3-dione

2-(3-fluoropentyl)isoindoline-1,3-dione

Conditions
ConditionsYield
With disodium hydrogenphosphate; Ir[dF(CF3)ppy]2(dtbbpy)PF6; Selectfluor In water; acetonitrile for 12h; Inert atmosphere; Microwave irradiation;79%

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