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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

METHYL 4-((4-METHYLPIPERAZIN-1-YL)METHYL)BENZOATE

Cas:314268-40-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 314268-40-1 with competitive price

Cas:314268-40-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-, methyl ester

Cas:314268-40-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-, methyl ester

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-, methyl ester

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE Basic information Product Name: METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE Synonyms: METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE;METHYL 4-[(4-METHYL-1-PIPERAZINYL)METHYL]BENZOATE;MA

METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE

Cas:314268-40-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

314268-40-1

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Methyl 4-((4-Methylpiperazin-1-yl)Methyl)benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-, methyl ester

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-, methyl ester

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate Application:methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Other

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Hangzhou Fandachem Co.,Ltd

Methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoateAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Other

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

314268-40-1

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoateAppearance:white powder Storage:Shading, sealed, dry place. Package:aluminous bag Application:API Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to ai

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

314268-40-1

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

methyl 4-((4-methylpiperazin-1-yl)methyl)benzoate

Cas:314268-40-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

314268-40-1 CAS NO.314268-40-1

Cas:314268-40-1

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

1-methyl-piperazine
109-01-3

1-methyl-piperazine

methyl 4-formylbenzoate
1571-08-0

methyl 4-formylbenzoate

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; acetic acid In chloroform at 0 - 20℃; for 13h;99%
With sodium tetrahydroborate; acetic acid In chloroform at 0 - 20℃;98%
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 1.5h;98%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

Methyl 4-(bromomethyl)benzoate
2417-72-3

Methyl 4-(bromomethyl)benzoate

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 100℃; Cooling with ice; Microwave irradiation;97%
With potassium carbonate In acetonitrile at 20℃; for 7h;93%
With triethylamine In dichloromethane at 20℃;93%
methanol
67-56-1

methanol

4-(4-methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7

4-(4-methylpiperazin-1-ylmethyl)benzoic acid

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 48h; Heating;85%
1-methyl-4-((trifluoro-λ4-boranyl)methyl)piperazine potassium
1015484-22-6

1-methyl-4-((trifluoro-λ4-boranyl)methyl)piperazine potassium

4-methoxycarbonylphenyl bromide
619-42-1

4-methoxycarbonylphenyl bromide

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
With C52H67ClFeNPPd; caesium carbonate In tetrahydrofuran; water at 80℃; for 12h; Suzuki-Miyaura cross-coupling;83%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

methyl 4-formylbenzoate
1571-08-0

methyl 4-formylbenzoate

A

1-formyl-4-methylpiperidine
7556-55-0

1-formyl-4-methylpiperidine

B

4-(methoxycarbonyl)benzyl alcohol
6908-41-4

4-(methoxycarbonyl)benzyl alcohol

C

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: 1-methyl-piperazine With formic acid for 0.25h; cooling;
Stage #2: methyl 4-formylbenzoate at 180 - 200℃; for 8h; Leuckart-Wallach reaction; Further stages.;
A n/a
B n/a
C 70%
4-(4-methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7

4-(4-methylpiperazin-1-ylmethyl)benzoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
In methanol; diethyl ether; toluene at 20℃; for 21.1667h;44.2%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

p-methyloxycarbonylbenzyl chloride
34040-64-7

p-methyloxycarbonylbenzyl chloride

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

Conditions
ConditionsYield
With sodium iodide In acetone at 60℃; for 10.5h;
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

4-(4-methylpiperazin-1-ylmethyl)benzoic acid
106261-48-7

4-(4-methylpiperazin-1-ylmethyl)benzoic acid

Conditions
ConditionsYield
With water; lithium hydroxide In tetrahydrofuran for 4h; Reflux;100%
With water; lithium hydroxide In tetrahydrofuran for 4h; Reflux;100%
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

4-((4-methylpiperazin-1-yl)methyl)benzoic acid dihydrochloride

4-((4-methylpiperazin-1-yl)methyl)benzoic acid dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 100℃; for 3h;98%
With hydrogenchloride In water Reflux;96%
With hydrogenchloride; water for 10h; Reflux;286 mg
6-methyl-N-phenylbenzene-1,3-diamine
41131-23-1

6-methyl-N-phenylbenzene-1,3-diamine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-methyl-3-(phenylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-methyl-3-(phenylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
With [m-(1,4-diazabicyclo[2.2.2]octanekN1:kN4)]hexamethyldialuminum In toluene for 1h; Schlenk technique; Reflux;98%
N,N-(4-methyl-3-aminophenyl)[4-(pyridin-3-yl)-pyrimidin-2-yl]amine
571187-03-6

N,N-(4-methyl-3-aminophenyl)[4-(pyridin-3-yl)-pyrimidin-2-yl]amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran; methanol Product distribution / selectivity; Reflux;91%
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran at 70℃;91%
With trimethylaluminum In toluene at 40℃; for 0.5h; Inert atmosphere;
4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine
34801-14-4

4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-(5-bromothiophen-2-yl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-(5-bromothiophen-2-yl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(5-bromothiophen-2-yl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux;
91%
4-(4-bromophenyl)-1,3-thiazol-2-amine
2103-94-8

4-(4-bromophenyl)-1,3-thiazol-2-amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-(3-bromophenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-(3-bromophenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(4-bromophenyl)-1,3-thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux;
86%
N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine
660837-08-1

N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

masitinib
790299-79-5

masitinib

Conditions
ConditionsYield
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine With trimethylaluminum In hexane; dichloromethane at 5 - 15℃; for 2h;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In hexane; dichloromethane at 20℃; for 21.1667h; Heating / reflux;
Stage #3: With sodium hydroxide; water In hexane; dichloromethane at 20℃; for 3h; Product distribution / selectivity;
78%
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine With trimethylaluminum In dichloromethane; toluene at 0 - 20℃; for 0.5h;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In dichloromethane; toluene for 5h; Heating / reflux;
72%
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine With trimethylaluminum In dichloromethane; toluene at 0 - 20℃; for 0.5h;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In dichloromethane; toluene for 5h; Heating / reflux;
72%
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

(4-((4-methylpiperazin-1-yl)methyl)phenyl)methanol
622381-65-1

(4-((4-methylpiperazin-1-yl)methyl)phenyl)methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Cooling with ice;77%
Stage #1: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With sodium hydroxide; water In tetrahydrofuran
73%
With lithium aluminium tetrahydride In tetrahydrofuran Reduction;
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere;
aniline
62-53-3

aniline

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

4-(4-methylpiperazinomethyl) N-phenylbenzamide

4-(4-methylpiperazinomethyl) N-phenylbenzamide

Conditions
ConditionsYield
With sodium methylate In toluene for 6h; Heating;75%
4-methylbenzene-1,3-diamine
95-80-7

4-methylbenzene-1,3-diamine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(3-amino-4-methylphenyl)-4-((4-methyl-1-piperazinyl)methyl)benzamide

N-(3-amino-4-methylphenyl)-4-((4-methyl-1-piperazinyl)methyl)benzamide

Conditions
ConditionsYield
With aluminum (III) chloride In toluene; acetonitrile at 40℃; for 8.5h; Inert atmosphere;75%
cyclohexylamine
108-91-8

cyclohexylamine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

4-(4-methylpiperazinomethyl) N-cyclohexylbenzamide

4-(4-methylpiperazinomethyl) N-cyclohexylbenzamide

Conditions
ConditionsYield
With sodium ethanolate In toluene for 6h; Heating;70%
3-bromo-4-methylaniline
7745-91-7

3-bromo-4-methylaniline

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide
581076-59-7

N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 17h; Inert atmosphere;65%
With trimethylaluminum In toluene at 40℃; for 1h; Inert atmosphere;4.69 g
4-(4-bromo-3-chlorophenyl)thiazol-2-amine

4-(4-bromo-3-chlorophenyl)thiazol-2-amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-(4-bromo-3-chlorophenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-(4-bromo-3-chlorophenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(4-bromo-3-chlorophenyl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux;
64%
4-(3-bromo-4-methylphenyl)thiazol-2-amine

4-(3-bromo-4-methylphenyl)thiazol-2-amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-(3-bromo-4-methylphenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-(3-bromo-4-methylphenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(3-bromo-4-methylphenyl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux;
60%
4-(4-bromo-3-methylphenyl)thiazol-2-amine

4-(4-bromo-3-methylphenyl)thiazol-2-amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-(4-bromo-3-methylphenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-(4-bromo-3-methylphenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(4-bromo-3-methylphenyl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux;
59%
4-(4-bromophenyl)-1,3-thiazol-2-amine
2103-94-8

4-(4-bromophenyl)-1,3-thiazol-2-amine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-(4-(4-bromophenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4-(4-bromophenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(4-bromophenyl)-1,3-thiazol-2-amine With trimethylaluminum In toluene at 50℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In toluene Reflux;
48%
tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate
1035270-66-6

tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide
1035269-80-7

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide

Conditions
ConditionsYield
Stage #1: tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate; 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester With sodium hexamethyldisilazane In tetrahydrofuran for 0.166667h;
Stage #2: With sodium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; for 61.5h;
5.19%
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

2,2-dimethyl-propionic acid 4-(4-methyl-piperazin-1-ylmethyl)-benzyl ester

2,2-dimethyl-propionic acid 4-(4-methyl-piperazin-1-ylmethyl)-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran
2: DCCD; DMAP; pyridine / CH2Cl2
View Scheme
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

3,4-dimethoxy-benzoic acid 4-(4-methyl-piperazin-1-ylmethyl)-benzyl ester

3,4-dimethoxy-benzoic acid 4-(4-methyl-piperazin-1-ylmethyl)-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran
2: DCCD; DMAP; pyridine / CH2Cl2
View Scheme
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

4-(4-methylpiperazin-1-ylmethyl)benzoic acid methyl ester hydrochloride
728936-43-4

4-(4-methylpiperazin-1-ylmethyl)benzoic acid methyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; ethyl acetate for 1h;
6-[2-(4-fluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine

6-[2-(4-fluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

N-{6-[2-(4-fluorophenyl)chroman-6-yloxy]-pyridin-3-yl}-4-(4-methyl-piperazin-1-ylmethyl)benzamide

N-{6-[2-(4-fluorophenyl)chroman-6-yloxy]-pyridin-3-yl}-4-(4-methyl-piperazin-1-ylmethyl)benzamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 7h;
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
314268-40-1

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

C13H20N4O
1236355-89-7

C13H20N4O

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 1h; Reflux;

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