Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMETHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE Basic information Product Name: METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE Synonyms: METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE;METHYL 4-[(4-METHYL-1-PIPERAZINYL)METHYL]BENZOATE;MA
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryWe are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for
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inquirymethyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate Application:methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate
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inquiryMethyl 4-[(4-methylpiperazin-1-yl)methyl]benzoateAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquiry1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
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inquiryHangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri
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inquirymethyl 4-[(4-methylpiperazin-1-yl)methyl]benzoateAppearance:white powder Storage:Shading, sealed, dry place. Package:aluminous bag Application:API Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to ai
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
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inquiryPrice, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
1-methyl-piperazine
methyl 4-formylbenzoate
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sodium tetrahydroborate; acetic acid In chloroform at 0 - 20℃; for 13h; | 99% |
With sodium tetrahydroborate; acetic acid In chloroform at 0 - 20℃; | 98% |
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 1.5h; | 98% |
1-methyl-piperazine
Methyl 4-(bromomethyl)benzoate
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran at 100℃; Cooling with ice; Microwave irradiation; | 97% |
With potassium carbonate In acetonitrile at 20℃; for 7h; | 93% |
With triethylamine In dichloromethane at 20℃; | 93% |
methanol
4-(4-methylpiperazin-1-ylmethyl)benzoic acid
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 48h; Heating; | 85% |
1-methyl-4-((trifluoro-λ4-boranyl)methyl)piperazine potassium
4-methoxycarbonylphenyl bromide
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With C52H67ClFeNPPd; caesium carbonate In tetrahydrofuran; water at 80℃; for 12h; Suzuki-Miyaura cross-coupling; | 83% |
1-methyl-piperazine
methyl 4-formylbenzoate
A
1-formyl-4-methylpiperidine
B
4-(methoxycarbonyl)benzyl alcohol
C
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 1-methyl-piperazine With formic acid for 0.25h; cooling; Stage #2: methyl 4-formylbenzoate at 180 - 200℃; for 8h; Leuckart-Wallach reaction; Further stages.; | A n/a B n/a C 70% |
4-(4-methylpiperazin-1-ylmethyl)benzoic acid
diazomethyl-trimethyl-silane
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
In methanol; diethyl ether; toluene at 20℃; for 21.1667h; | 44.2% |
1-methyl-piperazine
p-methyloxycarbonylbenzyl chloride
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sodium iodide In acetone at 60℃; for 10.5h; |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
4-(4-methylpiperazin-1-ylmethyl)benzoic acid
Conditions | Yield |
---|---|
With water; lithium hydroxide In tetrahydrofuran for 4h; Reflux; | 100% |
With water; lithium hydroxide In tetrahydrofuran for 4h; Reflux; | 100% |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In water at 100℃; for 3h; | 98% |
With hydrogenchloride In water Reflux; | 96% |
With hydrogenchloride; water for 10h; Reflux; | 286 mg |
6-methyl-N-phenylbenzene-1,3-diamine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With [m-(1,4-diazabicyclo[2.2.2]octanekN1:kN4)]hexamethyldialuminum In toluene for 1h; Schlenk technique; Reflux; | 98% |
N,N-(4-methyl-3-aminophenyl)[4-(pyridin-3-yl)-pyrimidin-2-yl]amine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
imatinib
Conditions | Yield |
---|---|
With sodium methylate In tetrahydrofuran; methanol Product distribution / selectivity; Reflux; | 91% |
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
imatinib
Conditions | Yield |
---|---|
With sodium methylate In tetrahydrofuran at 70℃; | 91% |
With trimethylaluminum In toluene at 40℃; for 0.5h; Inert atmosphere; |
4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(5-bromothiophen-2-yl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux; | 91% |
4-(4-bromophenyl)-1,3-thiazol-2-amine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(4-bromophenyl)-1,3-thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux; | 86% |
N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
masitinib
Conditions | Yield |
---|---|
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine With trimethylaluminum In hexane; dichloromethane at 5 - 15℃; for 2h; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In hexane; dichloromethane at 20℃; for 21.1667h; Heating / reflux; Stage #3: With sodium hydroxide; water In hexane; dichloromethane at 20℃; for 3h; Product distribution / selectivity; | 78% |
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine With trimethylaluminum In dichloromethane; toluene at 0 - 20℃; for 0.5h; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In dichloromethane; toluene for 5h; Heating / reflux; | 72% |
Stage #1: N1-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine With trimethylaluminum In dichloromethane; toluene at 0 - 20℃; for 0.5h; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In dichloromethane; toluene for 5h; Heating / reflux; | 72% |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
(4-((4-methylpiperazin-1-yl)methyl)phenyl)methanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Cooling with ice; | 77% |
Stage #1: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Stage #2: With sodium hydroxide; water In tetrahydrofuran | 73% |
With lithium aluminium tetrahydride In tetrahydrofuran Reduction; | |
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere; |
aniline
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sodium methylate In toluene for 6h; Heating; | 75% |
4-methylbenzene-1,3-diamine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With aluminum (III) chloride In toluene; acetonitrile at 40℃; for 8.5h; Inert atmosphere; | 75% |
cyclohexylamine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sodium ethanolate In toluene for 6h; Heating; | 70% |
3-bromo-4-methylaniline
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 20℃; for 17h; Inert atmosphere; | 65% |
With trimethylaluminum In toluene at 40℃; for 1h; Inert atmosphere; | 4.69 g |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(4-bromo-3-chlorophenyl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux; | 64% |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(3-bromo-4-methylphenyl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux; | 60% |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(4-bromo-3-methylphenyl)thiazol-2-amine With trimethylaluminum In n-heptane; toluene at 50℃; for 0.333333h; Inert atmosphere; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In n-heptane; toluene Reflux; | 59% |
4-(4-bromophenyl)-1,3-thiazol-2-amine
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(4-bromophenyl)-1,3-thiazol-2-amine With trimethylaluminum In toluene at 50℃; for 0.333333h; Inert atmosphere; Stage #2: 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester In toluene Reflux; | 48% |
tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide
Conditions | Yield |
---|---|
Stage #1: tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate; 4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester With sodium hexamethyldisilazane In tetrahydrofuran for 0.166667h; Stage #2: With sodium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; for 61.5h; | 5.19% |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiAlH4 / tetrahydrofuran 2: DCCD; DMAP; pyridine / CH2Cl2 View Scheme |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiAlH4 / tetrahydrofuran 2: DCCD; DMAP; pyridine / CH2Cl2 View Scheme |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
4-(4-methylpiperazin-1-ylmethyl)benzoic acid methyl ester hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; ethyl acetate for 1h; |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 7h; |
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester
C13H20N4O
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 1h; Reflux; |
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