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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

2,8-Bis(trifluoromethyl)-4-bromoquinoline

Cas:35853-45-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,8-Bis(Trifluoromethyl)-4-Bromoquinoline with high purity

Cas:35853-45-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C11H4BrF6N 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product name 4-Bromo-2,8-bis(trifluoromethyl)quinoline Cas number 35853-45-3 Molecular formula C11H4BrF6N Molecular weight 344.05

4-bromo-2,8-bis(trifluoromethyl)quinoline

Cas:35853-45-3

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Quinoline,4-bromo-2,8-bis(trifluoromethyl)- 35853-45-3

Cas:35853-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE CAS:35853-45-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE CAS:35853-45-3

Cas:35853-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Quinoline,4-bromo-2,8-bis(trifluoromethyl)-

Cas:35853-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Quinoline,4-bromo-2,8-bis(trifluoromethyl)-

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,8-Bis(Trifluoromethyl)-4-Bromoquinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

4-BroMo-2,8-bis(trifluoroMethyl)quinoline

Cas:35853-45-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

C11H4BrF6N 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

CC-PMLSC-DMA-P108 cas 35853-45-3

Cas:35853-45-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-bromo-2,8-bis(trifluoromethyl)quinoline

Cas:35853-45-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,8-bis-(Trifluoromethyl)-4-bromoquinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE

Cas:35853-45-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,8-Bis(Trifluoromethyl)-4-Bromoquinoline

Cas:35853-45-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE

Cas:35853-45-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE Synonyms: 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE;4-BROMO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE;2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLIN;4-Bromo-2,8-bis(trifluoromethyl)quinoline, >=98%;

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

C11H4BrF6N 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE

Cas:35853-45-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

C11H4BrF6N 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

C11H4BrF6N 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2,8-Bis(trifluoromethyl)-4-bromoquinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

C11H4BrF6N 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3

Cas:35853-45-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-BroMo-2,8-bis(trifluoroMethyl)quinoline cas no. 35853-45-3 98%

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-bromo-2,8-bis(trifluoromethyl)quinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-BroMo-2,8-bis(trifluoroMethyl)quinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2,8-bis-(Trifluoromethyl)-4-bromoquinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

2,8-Bis(Trifluoromethyl)-4-Bromoquinoline

Cas:35853-45-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd a comprehensive enterprise, is located in High-Tech Science Park,Changsha,Chia . Specializing in R&D, manufacture and marketing, we provide a wide range of products and the most professional services to meet the

4-Bromo-2,8-bis(trifluoromethyl)quinoline

Cas:35853-45-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2,8-bis(trifluoromethyl)quinolin-4-ol
35853-41-9

2,8-bis(trifluoromethyl)quinolin-4-ol

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

Conditions
ConditionsYield
With phosphorus(V) oxybromide99%
With phosphorus(V) oxybromide at 120℃; for 5h; Inert atmosphere;98%
With phosphorus(V) oxybromide at 140℃; Inert atmosphere;98%
2,8-bis(trifluoromethyl)quinolin-4-yl 4-methylbenzenesulfonate
150785-70-9

2,8-bis(trifluoromethyl)quinolin-4-yl 4-methylbenzenesulfonate

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

Conditions
ConditionsYield
With phosphorus; bromine In acetic acid at 25℃; for 4h;80%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

N-benzhydryl 3-azetidinone
40320-60-3

N-benzhydryl 3-azetidinone

3-(2,8-bis(trifluoromethyl)-4-quinolinyl)-1-diphenylmethyl-3-azetidinol
260972-91-6

3-(2,8-bis(trifluoromethyl)-4-quinolinyl)-1-diphenylmethyl-3-azetidinol

Conditions
ConditionsYield
With n-butyllithium In water100%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

para-thiocresol
106-45-6

para-thiocresol

2,8-bis(trifluoromethyl)-4-quinolyl p-tolylsulphide
177092-30-7

2,8-bis(trifluoromethyl)-4-quinolyl p-tolylsulphide

Conditions
ConditionsYield
With potassium hydroxide In methanol; ethanol at 60℃; for 2h;95%
ferrocenecarboxaldehyde
12093-10-6

ferrocenecarboxaldehyde

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

[2,8-bis(trifluoromethyl)quinolin-4-yl]ferrocenemethanol

[2,8-bis(trifluoromethyl)quinolin-4-yl]ferrocenemethanol

Conditions
ConditionsYield
Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.333333h; Inert atmosphere; Schlenk technique;
Stage #2: ferrocenecarboxaldehyde In diethyl ether; hexane at -78℃; for 2h; Inert atmosphere; Schlenk technique;
94%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

sodium vinyl trifluoroborate

sodium vinyl trifluoroborate

2,8-bis(trifluoromethyl)-4-vinylquinoline
1031928-53-6

2,8-bis(trifluoromethyl)-4-vinylquinoline

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 Suzuki Coupling;94%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

copper(I) cyanide
544-92-3

copper(I) cyanide

2,8-bis(trifluoromethyl)quinoline-4-carbonitrile

2,8-bis(trifluoromethyl)quinoline-4-carbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide Substitution; Heating;93%
piperazine
110-85-0

piperazine

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

4-(piperazin-1-yl)-2,8-bis(trifluoromethyl)quinoline

4-(piperazin-1-yl)-2,8-bis(trifluoromethyl)quinoline

Conditions
ConditionsYield
With potassium carbonate; triethylamine at 135℃; for 4h;92%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

1-acetoxy-1'-(1,3-dioxan-2-yl)ferrocene
1241848-96-3

1-acetoxy-1'-(1,3-dioxan-2-yl)ferrocene

1-(1,3-dioxan-2-yl)-1'-(2,8-bis(trifluoromethyl)quinolin-4-yloxy)-ferrocene
1381984-20-8

1-(1,3-dioxan-2-yl)-1'-(2,8-bis(trifluoromethyl)quinolin-4-yloxy)-ferrocene

Conditions
ConditionsYield
Stage #1: 1-acetoxy-1'-(1,3-dioxan-2-yl)ferrocene With sodium methylate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Schlenk technique;
Stage #2: (2,8-bis-trifluoromethyl)-4-bromoquinoline In N,N-dimethyl-formamide at 150℃; for 6h; Inert atmosphere; Schlenk technique;
92%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

carbon dioxide
124-38-9

carbon dioxide

2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid
35853-50-0

2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid

Conditions
ConditionsYield
With n-butyllithium In diethyl ether at -35℃; for 0.333333h;86%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

4-azido-2,8-bis(trifluoromethyl)quinoline
1258291-33-6

4-azido-2,8-bis(trifluoromethyl)quinoline

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 90℃; for 1h;85%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

vinylboronic acid dibutyl ester
6336-45-4

vinylboronic acid dibutyl ester

2,8-bis(trifluoromethyl)-4-vinylquinoline
1031928-53-6

2,8-bis(trifluoromethyl)-4-vinylquinoline

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium hydroxide In water; toluene for 24h; Suzuki-Miyaura coupling; Inert atmosphere; Reflux;82%
With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 24h; Suzuki-Miyaura cross-coupling reaction; Inert atmosphere; Reflux;82%
With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 24h; Suzuki-Miyaura cross-coupling reaction; Inert atmosphere; Reflux;82%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

propargyl alcohol
107-19-7

propargyl alcohol

3-(2,8-bis(trifluoromethyl)quinolin-4-yl)prop-2-yn-1-ol

3-(2,8-bis(trifluoromethyl)quinolin-4-yl)prop-2-yn-1-ol

Conditions
ConditionsYield
Stage #1: propargyl alcohol With triethylamine for 0.0833333h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: (2,8-bis-trifluoromethyl)-4-bromoquinoline With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide for 4h; Reflux;
80%
3-hydroxypiperazine
6859-99-0

3-hydroxypiperazine

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

4-(3-hydroxypiperidine-1-yl)-2,8-bis(trifluoromethyl)quinoline
1092355-84-4

4-(3-hydroxypiperidine-1-yl)-2,8-bis(trifluoromethyl)quinoline

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 2h;78%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

ruthenocene carboxylaldheyde
66507-25-3

ruthenocene carboxylaldheyde

[2,8-bis(trifluoromethyl)quinolin-4-yl]ruthenocenemethanol

[2,8-bis(trifluoromethyl)quinolin-4-yl]ruthenocenemethanol

Conditions
ConditionsYield
Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.333333h; Inert atmosphere; Schlenk technique;
Stage #2: ruthenocene carboxylaldheyde In diethyl ether; hexane at -78℃; for 2h; Inert atmosphere; Schlenk technique;
78%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

(E)-2-(6-(4,4,5,5-tetramethylmethyl-1,3,2-dioxaborolan-2-yl)-hex-5-en-1-yl)isoindoline-1,3-dione

(E)-2-(6-(4,4,5,5-tetramethylmethyl-1,3,2-dioxaborolan-2-yl)-hex-5-en-1-yl)isoindoline-1,3-dione

(E)-2-(6-(2,8-bis(trifluoromethyl)quinolin-4-yl)hex-5-en-1-yl)isoindoline-1,3-dione

(E)-2-(6-(2,8-bis(trifluoromethyl)quinolin-4-yl)hex-5-en-1-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; XPhos In tetrahydrofuran; water for 5h; Suzuki Coupling; Reflux; Inert atmosphere;77%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

C20H26BNO4

C20H26BNO4

C25H18F6N2O2

C25H18F6N2O2

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; XPhos In tetrahydrofuran; water Reflux;77%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

bis(2,8-bis-trifluoromethyl quinolyl) disulphide
736147-22-1

bis(2,8-bis-trifluoromethyl quinolyl) disulphide

Conditions
ConditionsYield
With potassium ethyldithiocarbamate In DMF (N,N-dimethyl-formamide) at 20℃; for 10h;75%
With potassium ethyldithiocarbamate In DMF (N,N-dimethyl-formamide) at 20℃; for 10h;75%
pyrrolidin-3-ol
40499-83-0

pyrrolidin-3-ol

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

4-(3-hydroxypyrrolidin-1-yl)-2,8-bis(trifluoromethyl)quinoline
1092355-83-3

4-(3-hydroxypyrrolidin-1-yl)-2,8-bis(trifluoromethyl)quinoline

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 2h;75%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

tri-n-butyl(vinyl)tin
7486-35-3

tri-n-butyl(vinyl)tin

2,8-bis(trifluoromethyl)-4-vinylquinoline
1031928-53-6

2,8-bis(trifluoromethyl)-4-vinylquinoline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate In acetonitrile at 90℃; for 4h; Stille coupling; Inert atmosphere; Sealed tube;75%
With tetrabutylammomium bromide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 90℃; for 4h; Product distribution / selectivity; Stille Coupling; Inert atmosphere; Sealed tube;75%
With tetrabutylammomium bromide; potassium carbonate; bis(triphenylphosphine)palladium(II) dichloride In acetonitrile at 90℃; for 4h; Product distribution / selectivity; Stille Coupling reaction; Inert atmosphere;75%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

potassium vinyltrifluoroborate

potassium vinyltrifluoroborate

2,8-bis(trifluoromethyl)-4-vinylquinoline
1031928-53-6

2,8-bis(trifluoromethyl)-4-vinylquinoline

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In tetrahydrofuran; water for 24h; Suzuki-Miyaura coupling; Inert atmosphere; Reflux;71%
With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran; water for 24h; Inert atmosphere; Reflux;71%
With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran; water for 24h; Product distribution / selectivity; Stille Coupling reaction; Inert atmosphere; Reflux;71%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

N-(5-hexenyl)phthalimide
52898-33-6

N-(5-hexenyl)phthalimide

C25H19F6N3O2

C25H19F6N3O2

Conditions
ConditionsYield
With 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene; palladium diacetate; triethylamine In N,N-dimethyl-formamide at 110℃; Reagent/catalyst;68%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

N-(5-hexenyl)phthalimide
52898-33-6

N-(5-hexenyl)phthalimide

(E)-2-(6-(2,8-bis(trifluoromethyl)quinolin-4-yl)hex-5-en-1-yl)isoindoline-1,3-dione

(E)-2-(6-(2,8-bis(trifluoromethyl)quinolin-4-yl)hex-5-en-1-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With AD-mix-β; palladium diacetate; triethylamine; 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene In N,N-dimethyl-formamide at 110℃; Reagent/catalyst; Inert atmosphere;68%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

benzofuran-2-boronic acid
98437-24-2

benzofuran-2-boronic acid

4-(2-Benzofuranyl)-2,8-bis(trifluoromethyl)quinoline
260972-85-8

4-(2-Benzofuranyl)-2,8-bis(trifluoromethyl)quinoline

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water64%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,8-bis(trifluoromethyl)-4-quinoline carboxaldehyde
57120-56-6

2,8-bis(trifluoromethyl)-4-quinoline carboxaldehyde

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78℃;64%
Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h;
Stage #2: N,N-dimethyl-formamide In diethyl ether; hexane at -78℃; for 3h;
37%
Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium In diethyl ether at -78℃;
Stage #2: N,N-dimethyl-formamide In diethyl ether at -78℃;
29%
With n-butyllithium at -78℃; Inert atmosphere;
Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium at -78℃; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide Inert atmosphere;
10 g
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

(S)-1-N-Boc-piperidine-2-al
150521-32-7

(S)-1-N-Boc-piperidine-2-al

(S)-tert-butyl 2-((R)-(2,8-bis(trifluoromethyl)quinolin-4-yl)(hydroxy)methyl)piperidine-1-carboxylate
1309854-88-3

(S)-tert-butyl 2-((R)-(2,8-bis(trifluoromethyl)quinolin-4-yl)(hydroxy)methyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: (2,8-bis-trifluoromethyl)-4-bromoquinoline With n-butyllithium In diethyl ether at -78℃; for 1h; Inert atmosphere; Schlenk technique;
Stage #2: (S)-1-N-Boc-piperidine-2-al In diethyl ether at -78℃; for 0.333333h; Inert atmosphere; Schlenk technique; stereoselective reaction;
58%
1-phenyl-6-tributylstannyl-3,4-dihydropyrrolo[1,2-a]pyrazine

1-phenyl-6-tributylstannyl-3,4-dihydropyrrolo[1,2-a]pyrazine

(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

1-phenyl-6-(2,8-bis(trifluoromethyl)quinolin-4-yl)-3,4-dihydropyrrolo[1,2-a]pyrazine

1-phenyl-6-(2,8-bis(trifluoromethyl)quinolin-4-yl)-3,4-dihydropyrrolo[1,2-a]pyrazine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); lithium chloride In tetrahydrofuran for 20h; Stille coupling; Heating;56%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

Propargylamine
2450-71-7

Propargylamine

N-(2-propyn-1-yl)-[2,8-bis(trifluoromethyl)]-4-quinolinylamine
1257629-75-6

N-(2-propyn-1-yl)-[2,8-bis(trifluoromethyl)]-4-quinolinylamine

Conditions
ConditionsYield
In 1,4-dioxane Reflux;45%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

4-allyl-1-benzoylpiperidine
155269-97-9

4-allyl-1-benzoylpiperidine

1-benzoyl-4-<(E)-3-<2,8-bis(trifluoromethyl)-4-quinolinyl>allyl>piperidine
155269-98-0

1-benzoyl-4-<(E)-3-<2,8-bis(trifluoromethyl)-4-quinolinyl>allyl>piperidine

Conditions
ConditionsYield
With palladium diacetate; copper(l) iodide; tributyl-amine; triphenyl-o-tolylphosphine In N,N,N,N,N,N-hexamethylphosphoric triamide at 120℃; for 20h;42%
(2,8-bis-trifluoromethyl)-4-bromoquinoline
35853-45-3

(2,8-bis-trifluoromethyl)-4-bromoquinoline

(S,S,p-S)-(-)-1-acetoxy-2-(4-methoxymethyl-1,3-dioxan-2-yl)ferrocene

(S,S,p-S)-(-)-1-acetoxy-2-(4-methoxymethyl-1,3-dioxan-2-yl)ferrocene

(2S,4S)-1-(2,8-bis(trifluoromethyl)quinolin-4-yloxy)-2-(4-methoxymethyl-1,3-dioxan-2-yl)ferrocene

(2S,4S)-1-(2,8-bis(trifluoromethyl)quinolin-4-yloxy)-2-(4-methoxymethyl-1,3-dioxan-2-yl)ferrocene

Conditions
ConditionsYield
Stage #1: (S,S,p-S)-(-)-1-acetoxy-2-(4-methoxymethyl-1,3-dioxan-2-yl)ferrocene With sodium methylate In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;
Stage #2: (2,8-bis-trifluoromethyl)-4-bromoquinoline In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere;
32%

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