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Zhejiang Zhengshuo Biotechnology Co., Ltd.

Zhejiang Zhengshuo Biotechnology Co., Ltd. is a vigorous and fast-growing green biosynthesis company, specializing in the R&D, production and sales of functional active substances, daily chemical raw materials, pharmaceutical chemicals, intermedi

Tetrahydrocurcumin 36062-04-1

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $539.0 / 639.0

Type:Lab/Research institutions

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Wuhan ZeShanCheng Biomedical Technology Co., Ltd.

tetrahydrocurcumin CAS No.: 36062-04-1 Molecular formula: C21H24O6 Molecular weight: three hundred and seventy-two point four one five Chemical properties: quasi white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solve

tetrahydrocurcumin

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Natural Tetrahydrocurcumin 99%

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Our company SINOWAY advantages : 1) ISO 9001:2015 & SGS audited supplier 2) Established in 1987, exported 34 years in pharmaceutical /cosmetic raw materials and health care products. 3) We are members of SINOSURE ,we can do better payment te

Natural Turmeric Tetrahydrocurcumin 95% powder

Cas:36062-04-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Tetrahydrocurcumin supplier in China

Cas:36062-04-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications 1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione CAS:36062-04-1

Cas:36062-04-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Light yellow to white flowing powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:cosmetic ra

Manufacturer high quality Tetrahydrocurcumin Cas 36062-04-1 with good price

Cas:36062-04-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Cosmetic Grade Skin Whitening 36062-04-1 Curcumin Extract 98% Tetrahydrocurcumin Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food

Cosmetic Grade Skin Whitening 36062-04-1 Curcumin Extract 98% Tetrahydrocurcumin

Cas:36062-04-1

Min.Order:100 Gram

FOB Price: $0.75 / 0.79

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exporting

Manufacturer Tetrahydrocurcumin CAS NO.:36062-04-1 supplie from china

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Cas:36062-04-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Tetrahydrocurcumin 36062-04-1 GMP Manufacturer

Cas:36062-04-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

CAS: 36062-04-1 Molecular Formula: C21H24O6 Home Product Category Biochemistry natural product 36062-04-1 36062-04-1 - Names and Identifiers Name 1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione Synonyms Tetrahyd

Top Quality Natural Tetrahydrocurcumin

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $35.0 / 49.0

Type:Lab/Research institutions

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Tetrahydrocurcumin

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Tetrahydrocurcumin powder

Cas:36062-04-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Shanxi Zorui Biotechnology Co.Ltd.

Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ

Tetrahydrocurcumin/ Turmeric Root Extract Powder CAS 36062-04-1

Cas:36062-04-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Tetrahydro curcumin

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

Chengdu yancey Co., LTD. specializing in the production of research and development of pharmaceutical intermediates, 4 CDC cec \ U47700 \ \ 4 hexen \ bkedbp \ dibutylone \ appp, this kind of products with high quality price concessions, welcomed t

Nanoactive tetrahydrocurcuminoids THC

Cas:36062-04-1

Min.Order:10 Gram

FOB Price: $0.1 / 1.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tetrahydrocurcumin

Cas:36062-04-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Kono Chem Co.,Ltd

This product is a natural functional whitening ingredients. Because has potent activity of tyrosinase, the product of the whitening effect is better than arbutin. Can effectively restrain the oxygen free radicals (oxygen free radicals) generation a

tetrahydrocurcuminoids

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $480.0 / 500.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Tetrahydrocurcumin cas 36062-04-1 C21H24O6

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Name: 1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione CAS No.: 36062-04-1 Molecular Fomula: C21H24O6 Molecular weight: 372.415 Appearance:Off-white powder Storage:Store in cool and dry place, away from sun light. Package:25KG Applicat

1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 36062-04-1 with competitive price

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Tetrahydrocurcumin SabiWhite- Manufacturer 36062-04-1 For Flavors And Spices

Cas:36062-04-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Tetrahydrocurcumin CAS36062-04-1

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Off-white powder Storage:ln stock Package:25kg/Carton drum Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

Tetrahydrocurcumin

Cas:36062-04-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

SabiWhite- Manufacturer 36062-04-1 For Flavors And Spices

Cas:36062-04-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Top Quality Tetrahydrocurcumin/ THC

Cas:36062-04-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

Tetrahydrocurcumin CAS:36062-04-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

Tetrahydrocurcumin CAS:36062-04-1

Cas:36062-04-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Cas:36062-04-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1,7-bis(4’-acetoxy-3’-methoxyphenyl)-3,5-heptadione
52199-86-7

1,7-bis(4’-acetoxy-3’-methoxyphenyl)-3,5-heptadione

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
With water; sodium carbonate; sodium hydroxide In methanol; ethanol at 100℃; for 1h; Temperature; Reagent/catalyst; Solvent;95%
curcumin
458-37-7

curcumin

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
With platinum-iron-nickel hydroxide composite nanoparticle catalyst In ethanol at 24℃; for 1h;92.9%
With palladium on activated charcoal; hydrogen In ethanol under 103.432 Torr; for 4h;91.8%
With hydrogen; palladium on activated charcoal In ethyl acetate at 20℃; for 2h;80%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
With 1,4-dihydropyridine; palladium on activated charcoal In ethanol for 8h; Reflux;86%
With NADPH-dependent curcumin/dihydrocurcumin reductase from Escherichia coli DH10B; NADPH at 28℃; for 0.5h; Enzymatic reaction;
With platinum(IV) oxide
curcumin
458-37-7

curcumin

B

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
With palladium on activated charcoalA 18%
B 68%
curcumin
458-37-7

curcumin

B

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

C

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
36062-07-4, 112494-41-4, 135413-63-7

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 4h;A 20%
B 64%
C 15%
With 5% palladium on activated carbon; hydrogen In ethanol
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In chloroform; ethyl acetate at 100℃; under 38000 Torr;60.5%

B

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

C

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
36062-07-4, 112494-41-4, 135413-63-7

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 760 Torr; for 4h;A 9%
B 14%
C 5%
With hydrogen; palladium on activated charcoal In methanol for 20h; Ambient temperature;A 0.6 g
B 1.8 g
C 2.4 g
With hydrogen; palladium on activated charcoal In ethyl acetate under 2327.17 Torr;
vanillin
121-33-5

vanillin

5-fluoro-2-trifluoromethylbenzyl halide

5-fluoro-2-trifluoromethylbenzyl halide

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: B2O3; B(OC4H9)3; n-BuNH2 / ethyl acetate
2: H2 / Pd-C / ethyl acetate
View Scheme
acetylacetone
123-54-6

acetylacetone

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: B2O3; B(OC4H9)3; n-BuNH2 / ethyl acetate
2: H2 / Pd-C / ethyl acetate
View Scheme
glucose
115945-70-5

glucose

curcumin
458-37-7

curcumin

A

4,4'-di-O-(β-D-glucopyranosyl)curcumin

4,4'-di-O-(β-D-glucopyranosyl)curcumin

B

curcumin 4'-O-β-D-glucoside
387818-26-0

curcumin 4'-O-β-D-glucoside

C

dihydrocurcumin-O-glucoside
1352455-17-4

dihydrocurcumin-O-glucoside

D

octahydrocurcumin-O-glucoside
1352455-15-2

octahydrocurcumin-O-glucoside

E

hexahydrocurcumin-O-glucoside

hexahydrocurcumin-O-glucoside

G

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

H

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
36062-07-4, 112494-41-4, 135413-63-7

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

I

(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione

(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione

J

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-diol

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-diol

Conditions
ConditionsYield
With Rhizopus chinensis IFFI 3043 at 25℃; for 24h; Microbiological reaction;

A

dihydrocurcumin
917909-26-3

dihydrocurcumin

B

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
With NADPH-dependent curcumin/dihydrocurcumin reductase from Escherichia coli DH10B; NADPH at 28℃; Kinetics; Concentration; Time; Enzymatic reaction;
curcumin
458-37-7

curcumin

A

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

B

(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione

(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione

Conditions
ConditionsYield
With recombinant Vibrio vulnificus curcumin reductase; NADPH In aq. phosphate buffer; ethanol at 35℃; pH=6; Kinetics; Enzymatic reaction;
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 5%-palladium/activated carbon; hydrogen / dichloromethane; methanol / 16 h / 2585.81 Torr
2.1: sodium hydroxide / water / 16 h / 20 °C / Cooling
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
4.2: 18 h / 20 °C
5.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
5.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 5%-palladium/activated carbon; hydrogen / dichloromethane; methanol / 16 h / 2585.81 Torr
2.1: sodium hydroxide / water / 16 h / 20 °C / Cooling
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C
4.1: triethylamine; magnesium chloride / acetonitrile / 1 h / 0 °C
4.2: 18 h / 20 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
5.2: 18 h / 20 °C
6.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
6.2: 3 h / 20 °C
View Scheme
3-(4-hydroxy-3-methoxyphenyl)propionic acid
1135-23-5

3-(4-hydroxy-3-methoxyphenyl)propionic acid

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 16 h / 20 °C / Cooling
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
3.2: 18 h / 20 °C
4.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
4.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 16 h / 20 °C / Cooling
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C
3.1: triethylamine; magnesium chloride / acetonitrile / 1 h / 0 °C
3.2: 18 h / 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
4.2: 18 h / 20 °C
5.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
5.2: 3 h / 20 °C
View Scheme
C17H16O5

C17H16O5

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
2.2: 18 h / 20 °C
3.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
3.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C
2.1: triethylamine; magnesium chloride / acetonitrile / 1 h / 0 °C
2.2: 18 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
3.2: 18 h / 20 °C
4.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
4.2: 3 h / 20 °C
View Scheme
C17H15ClO4

C17H15ClO4

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; magnesium chloride / acetonitrile / 1 h / 0 °C
1.2: 18 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
2.2: 18 h / 20 °C
3.1: sodium chloride; water / dimethyl sulfoxide / 3 h / 150 °C
3.2: 3 h / 20 °C
View Scheme
C38H36O10

C38H36O10

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

Conditions
ConditionsYield
Stage #1: C38H36O10 With water; sodium chloride In dimethyl sulfoxide at 150℃; for 3h;
Stage #2: With sodium methylate In methanol at 20℃; for 3h;
0.44 g
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

4,4'-((3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

4,4'-((3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;97.5%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4-Chloro-1,2-phenylenediamine
95-83-0

4-Chloro-1,2-phenylenediamine

4,4'-((7-chloro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

4,4'-((7-chloro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;96.1%
4,5-Dichloro-1,2-phenylenediamine
5348-42-5

4,5-Dichloro-1,2-phenylenediamine

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4,4’-((7,8-dichloro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

4,4’-((7,8-dichloro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;96.1%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

1-(6-chloro-2-(4-hydroxy-3-methoxyphenethyl)-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one
1408335-44-3

1-(6-chloro-2-(4-hydroxy-3-methoxyphenethyl)-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 0.666667h;95%
C19H13Cl2NO

C19H13Cl2NO

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

1-(6-chloro-4-(2-chlorophenyl)-2-(4-hydroxy-3-methoxyphenethyl)quinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

1-(6-chloro-4-(2-chlorophenyl)-2-(4-hydroxy-3-methoxyphenethyl)quinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 1h;95%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

(2-aminophenyl)(phenyl)methanone
2835-77-0

(2-aminophenyl)(phenyl)methanone

1-(2-(4-hydroxy-3-methoxyphenethyl)-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one
1408335-42-1

1-(2-(4-hydroxy-3-methoxyphenethyl)-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 0.5h;93%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4-Bromo-benzene-1,2-diamine
1575-37-7

4-Bromo-benzene-1,2-diamine

4,4'-((7-bromo-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

4,4'-((7-bromo-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;90.7%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
36062-07-4, 112494-41-4, 135413-63-7

1,7-bis-(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran at 20℃; for 5h;89%
With sodium tetrahydroborate In 1,4-dioxane; water at 20℃; for 1h;73.7%
4-fluoro-1,2-phenylenediamine
367-31-7

4-fluoro-1,2-phenylenediamine

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4,4'-((7-fluoro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

4,4'-((7-fluoro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;88.8%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

C28H28N2O8

C28H28N2O8

Conditions
ConditionsYield
Stage #1: 4-amino-benzoic acid With sodium nitrite In water at 3 - 5℃; for 0.25h;
Stage #2: With hydrogenchloride In water for 0.0833333h;
Stage #3: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione With sodium hydroxide In water at 25℃; for 0.5h; pH=10;
85.1%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

ethylenediamine
107-15-3

ethylenediamine

4,4’-((3,6-dihydro-2H-1,4-diazepine 5,7-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

4,4’-((3,6-dihydro-2H-1,4-diazepine 5,7-diyl)bis(ethane-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃; for 2h;85%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

2-aminoacetophenone
551-93-9

2-aminoacetophenone

1-(2-(4-hydroxy-3-methoxyphenethyl)-4-methylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one
1408335-41-0

1-(2-(4-hydroxy-3-methoxyphenethyl)-4-methylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 0.666667h;84%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

(Z)-5-amino-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one

(Z)-5-amino-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one

Conditions
ConditionsYield
With ammonium acetate; toluene-4-sulfonic acid In ethanol for 2h;80%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

methyl iodide
74-88-4

methyl iodide

1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylheptane-3,5-dione
1537182-88-9

1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylheptane-3,5-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;79%
p-Aminohippuric acid
61-78-9

p-Aminohippuric acid

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

C30H31N3O9

C30H31N3O9

Conditions
ConditionsYield
Stage #1: p-Aminohippuric acid With sodium nitrite In water at 3 - 5℃; for 0.25h;
Stage #2: With hydrogenchloride In water for 0.0833333h;
Stage #3: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione With sodium hydroxide In water at 25℃; for 0.5h; pH=10;
78.23%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

benzaldehyde
100-52-7

benzaldehyde

urea
57-13-6

urea

6-(4-hydroxy-3-methoxyphenethyl)-5-(3-(4-hydroxy-3-methoxyphenyl)propanoyl)-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
1432038-10-2

6-(4-hydroxy-3-methoxyphenethyl)-5-(3-(4-hydroxy-3-methoxyphenyl)propanoyl)-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
Stage #1: benzaldehyde; urea With copper(ll) sulfate pentahydrate In ethanol at 80℃; for 0.25h; Biginelli Pyrimidone Synthesis;
Stage #2: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione In ethanol at 80℃; for 24h; Biginelli Pyrimidone Synthesis;
74%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

C21H25NO6

C21H25NO6

Conditions
ConditionsYield
With pyridine; hydroxylamine hydrochloride at 20℃; for 1h;70%
2,5-diaminobenzophenone
18330-94-4

2,5-diaminobenzophenone

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

1-(6-amino-2-(4-hydroxy-3-methoxyphenethyl)-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one
1408335-45-4

1-(6-amino-2-(4-hydroxy-3-methoxyphenethyl)-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 1.5h;70%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

urea
57-13-6

urea

C29H29N3O8
1432038-14-6

C29H29N3O8

Conditions
ConditionsYield
Stage #1: 4-nitrobenzaldehdye; urea With copper(ll) sulfate pentahydrate In ethanol at 80℃; for 0.25h; Biginelli Pyrimidone Synthesis;
Stage #2: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione In ethanol at 80℃; for 24h; Biginelli Pyrimidone Synthesis;
67%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

3,5-bis<β-(4-hydroxy-3-methoxyphenyl)ethyl>pyrazole
113464-93-0

3,5-bis<β-(4-hydroxy-3-methoxyphenyl)ethyl>pyrazole

Conditions
ConditionsYield
With hydrazine hydrate; acetic acid In ethanol; butan-1-ol at 60℃; for 24h;65%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

2-amino-5-nitrobenzophenone
1775-95-7

2-amino-5-nitrobenzophenone

1-(2-(4-hydroxy-3-methoxyphenethyl)-6-nitro-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one
1408335-43-2

1-(2-(4-hydroxy-3-methoxyphenethyl)-6-nitro-4-phenylquinolin-3-yl)-3-(4-hydroxy-3-methoxyphenyl)propan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 2h;65%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

urea
57-13-6

urea

C29H29N3O8
1432038-13-5

C29H29N3O8

Conditions
ConditionsYield
Stage #1: 3-nitro-benzaldehyde; urea With copper(ll) sulfate pentahydrate In ethanol at 80℃; for 0.25h; Biginelli Pyrimidone Synthesis;
Stage #2: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione In ethanol at 80℃; for 24h; Biginelli Pyrimidone Synthesis;
59%
1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

A

1,1'-(2,6-bis(4-hydroxy-3-methoxyphenethyl)-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-diyl)bis-(3-(4-hydroxy-3-methoxyphenyl)propan-1-one)

1,1'-(2,6-bis(4-hydroxy-3-methoxyphenethyl)-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-diyl)bis-(3-(4-hydroxy-3-methoxyphenyl)propan-1-one)

B

(Z)-5-amino-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one

(Z)-5-amino-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one

Conditions
ConditionsYield
Stage #1: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione; 4-methoxy-benzaldehyde With toluene-4-sulfonic acid In ethanol at 80℃; for 0.333333h; Hantzsch Dihydropyridine Synthesis; Molecular sieve;
Stage #2: With ammonium acetate In ethanol at 80℃; for 24h; Hantzsch Dihydropyridine Synthesis; Molecular sieve;
A 10%
B 54%
[iridium(III)(μ-chloro)(2-phenylpyridine)2]2

[iridium(III)(μ-chloro)(2-phenylpyridine)2]2

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione
36062-04-1

1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione

C43H39IrN2O6

C43H39IrN2O6

Conditions
ConditionsYield
Stage #1: 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-dione With sodium methylate In methanol at 0℃; for 1h;
Stage #2: [iridium(III)(μ-chloro)(2-phenylpyridine)2]2 In methanol for 24h; Reflux;
54%

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