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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-(Trifluoromethyl)pyridine Manufacturer/High quality/Best price/In stock

Cas:368-48-9

Min.Order:1 Kilogram

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-(Trifluoromethyl)Pyridine supplier in China

Cas:368-48-9

Min.Order:1 Metric Ton

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

2-(Trifluoromethyl)pyridine manufacturer with low price

Cas:368-48-9

Min.Order:1 Gram

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-(Trifluoromethyl)Pyridine

Cas:368-48-9

Min.Order:1

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Trifluoromethylpyridine

Cas:368-48-9

Min.Order:1 Metric Ton

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(Trifluoromethyl)-pyridine

Cas:368-48-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

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Henan Tianfu Chemical Co., Ltd.

Product Name: 2-(Trifluoromethyl)pyridine Synonyms: Pyridine, 2-(trifluoromethyl)-;ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE;2-(TRIFLUOROMETHYL)PYRIDINE;à,à,à-trifluoro-2-picoline;α,α,α-trifluoro-2-picolin

368-48-9 2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:1 Kilogram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 368-48-9 with fast shipping

Cas:368-48-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pyridine,2-(trifluoromethyl)- 368-48-9

Cas:368-48-9

Min.Order:1 Kilogram

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Shanghai Minstar Chemical Co., Ltd

Product Name: 2-(Trifluoromethyl)pyridine Synonyms: Pyridine, 2-(trifluoromethyl)-;ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE;à,à,à-trifluoro-2-picoline;α,α,α-trifluoro-2-picoline;2-(TRIFLUOROMETHYL)PYRIDINE;2

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:1 Gram

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Qingdao Beluga Import and Export Co., LTD

2-(Trifluoromethyl)pyridine CAS 368-48-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

2-(Trifluoromethyl)pyridine CAS 368-48-9

Cas:368-48-9

Min.Order:1 Gram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:368-48-9

Cas:368-48-9

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

2-(Trifluoromethyl)pyridine CAS 368-48-9

Cas:368-48-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting2-(Trifluoromethyl)pyridine;6-trifluoromethylpyridine;CAS: 368-48-9 , Please contact us by email freely. We are leading exporter in China.

2-(Trifluoromethyl)pyridine;6-trifluoromethylpyridine;CAS: 368-48-9 from FandaChem

Cas:368-48-9

Min.Order:1 Metric Ton

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-(Trifluoromethyl)Pyridine

Cas:368-48-9

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:0 Metric Ton

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(Trifluoromethyl)pyridine

Cas:368-48-9

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:10 Gram

FOB Price: $100.0

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:brown liquids Storage:In Room Temperature Package:25kg/drum, or as per your request. Application:For medicine , pesticide intermediates Transportation:as per your request. Port:S

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:1 Kilogram

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:1 Metric Ton

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:0

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Nanjing Fred Technology Co.,Ltd.

Taizhou FredChem Co. Ltd. is a high-tech enterprise located in China Medical City specializing in R&D, manufacturing, sales of new APIS, pharmaceutical intermediates and fine chemicals. All of our company is committed to provide high quality ch

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:1 Gram

Negotiable

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-(trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:0

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Trifluoromethyl pyridine

Cas:368-48-9

Min.Order:1 Kilogram

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Type:Other

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Trifluoromethylpyridine cas no. 368-48-9 97%

Cas:368-48-9

Min.Order:0

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:0

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Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-(TrifluoroMethyl)pyridine

Cas:368-48-9

Min.Order:0

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:0

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Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-(Trifluoromethyl)pyridine

Cas:368-48-9

Min.Order:0

Negotiable

Type:Manufacturers

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Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-(Trifluoromethyl)Pyridine

Cas:368-48-9

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Synthetic route

2-bromo-pyridine
109-04-6

2-bromo-pyridine

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: (trifluoromethyl)trimethylsilane With silver fluoride In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: With copper In N,N-dimethyl-formamide for 4h;
Stage #3: 2-bromo-pyridine In N,N-dimethyl-formamide at 90℃; for 5h;
79%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

Umemoto's reagent
129946-88-9

Umemoto's reagent

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper In N,N-dimethyl-formamide at 0 - 80℃; for 4h; Inert atmosphere;96%
2-iodopyridine
5029-67-4

2-iodopyridine

N-methyl-2-phenyl-2-trifluoromethylbenzimidazoline

N-methyl-2-phenyl-2-trifluoromethylbenzimidazoline

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate; copper(l) chloride at 60℃; for 48h; Inert atmosphere;57%
With copper(l) iodide; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate In benzonitrile at 90℃; for 48h;80 %Spectr.
2-bromo-pyridine
109-04-6

2-bromo-pyridine

trifluoroacetic acid-methyl ester
431-47-0

trifluoroacetic acid-methyl ester

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With cesium fluoride; copper(l) iodide In N,N-dimethyl-formamide at 180℃; for 8h;45%
2-iodopyridine
5029-67-4

2-iodopyridine

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium fluoride; copper(l) iodide In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 25℃; for 6h;68%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

methyl 3-oxa-ω-fluorosulfonylperfluoropentanoate
88986-32-7

methyl 3-oxa-ω-fluorosulfonylperfluoropentanoate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper(l) iodide In N,N-dimethyl-formamide at 120℃; for 8h;70%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

trifluoromethylcopper(I)
77152-08-0

trifluoromethylcopper(I)

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With triethylamine tris(hydrogen fluoride) In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;90 %Spectr.
With triethylamine tris(hydrogen fluoride) In N,N-dimethyl-formamide at 80℃; for 20h;57 %Spectr.
2-chloropyridine
109-09-1

2-chloropyridine

methyl 3-oxa-ω-fluorosulfonylperfluoropentanoate
88986-32-7

methyl 3-oxa-ω-fluorosulfonylperfluoropentanoate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper(l) iodide In N,N-dimethyl-formamide at 120℃; for 8h;64%
2-chloro-6-trifluoromethylpyridine
39890-95-4

2-chloro-6-trifluoromethylpyridine

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With N,N-dimethyl-ethanamine; hydrogen; palladium on activated charcoal In acetic acid methyl ester for 1.5h;
2-bromo-pyridine
109-04-6

2-bromo-pyridine

Potassium; difluoro-(1,1,2,2-tetrafluoro-2-fluorosulfonyl-ethoxy)-acetate

Potassium; difluoro-(1,1,2,2-tetrafluoro-2-fluorosulfonyl-ethoxy)-acetate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper(l) iodide In N,N-dimethyl-formamide at 45℃; for 8h;52%
2-chloro-6-trifluoromethylpyridine
39890-95-4

2-chloro-6-trifluoromethylpyridine

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

A

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

B

2-<2-(6-trifluoromethylpyridyl)>-2-methylmalonic acid diethylester

2-<2-(6-trifluoromethylpyridyl)>-2-methylmalonic acid diethylester

Conditions
ConditionsYield
With potassium tert-butylate In ammonia at -78℃; for 4h; Irradiation;A n/a
B 44%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

2,8-difluoro-5-(trifluoromethyl)-5Hdibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate

2,8-difluoro-5-(trifluoromethyl)-5Hdibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper In N,N-dimethyl-formamide Inert atmosphere;99%
6,6,6-trifluoro-1-ethoxy-1,3-hexadien-5-one
126247-93-6, 126247-97-0

6,6,6-trifluoro-1-ethoxy-1,3-hexadien-5-one

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ammonium carbonate at 90 - 130℃;62%
2-iodopyridine
5029-67-4

2-iodopyridine

Cu(2+)*2C2F3O4S(1-)

Cu(2+)*2C2F3O4S(1-)

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;80 %Spectr.
2-iodopyridine
5029-67-4

2-iodopyridine

[(1,10-phenanthroline)2Cu][O2CCF2Cl]

[(1,10-phenanthroline)2Cu][O2CCF2Cl]

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With cesium fluoride; sodium hydroxide In N,N-dimethyl-formamide at 75℃; for 3h; Inert atmosphere; Sealed tube;97 %Spectr.
2-bromo-pyridine
109-04-6

2-bromo-pyridine

sodium 2,2,2-trifluoroacetate
2923-18-4

sodium 2,2,2-trifluoroacetate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper(l) iodide In various solvent(s) at 60℃; for 4h;41 % Chromat.
2-bromo-pyridine
109-04-6

2-bromo-pyridine

(1,10-phenanthroline)(trifluoromethyl)copper (I)

(1,10-phenanthroline)(trifluoromethyl)copper (I)

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 8h; Sealed tube; Inert atmosphere;94 %Spectr.
2-trifluoromethyl-pyridine-5-diazonium tetrafluoroborate

2-trifluoromethyl-pyridine-5-diazonium tetrafluoroborate

3,4-(methylenedioxy)-benzeneboronic acid
94839-07-3

3,4-(methylenedioxy)-benzeneboronic acid

A

5-(3',4'-methylenedioxyphenyl)-2-trifluoromethyl-pyridine

5-(3',4'-methylenedioxyphenyl)-2-trifluoromethyl-pyridine

B

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With palladium diacetate In ethanol at 30℃; for 24h; Inert atmosphere;A 7%
B n/a
2-(methylthio)propionic acid
58809-73-7

2-(methylthio)propionic acid

5-bromo-2(trifluoromethyl)pyridine
436799-32-5

5-bromo-2(trifluoromethyl)pyridine

A

(±)5-(1-(methylthio)ethyl)-2-trifluoromethyl pyridine

(±)5-(1-(methylthio)ethyl)-2-trifluoromethyl pyridine

B

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

C

C7H6F3NS

C7H6F3NS

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide for 17h; Solvent; Reagent/catalyst; Inert atmosphere; Sealed tube; Irradiation;A 70%
B n/a
C n/a
2-iodopyridine
5029-67-4

2-iodopyridine

bis(trifluoromethyl)mercury
371-76-6

bis(trifluoromethyl)mercury

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ISOPROPYLAMIDE; copper74%
2-chloropyridine
109-09-1

2-chloropyridine

dibromodifluoromethane
75-61-6

dibromodifluoromethane

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With copper In N,N-dimethyl acetamide at 100℃; for 8h;13 % Chromat.
2-iodopyridine
5029-67-4

2-iodopyridine

tris(triphenylphosphane)(trifluoromethyl)copper(I)
325810-07-9

tris(triphenylphosphane)(trifluoromethyl)copper(I)

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With 4,4'-di-tert-butyl-2,2'-bipyridine In toluene at 80℃;75 %Spectr.
2-bromo-pyridine
109-04-6

2-bromo-pyridine

trifluoromethan
75-46-7

trifluoromethan

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: trifluoromethan With fluorobenzene; potassium tert-butylate; copper(l) chloride In N,N-dimethyl-formamide for 0.25h; Inert atmosphere;
Stage #2: With triethylamine tris(hydrogen fluoride) In N,N-dimethyl-formamide Inert atmosphere;
Stage #3: 2-bromo-pyridine In N,N-dimethyl-formamide at 50℃; for 16h; Inert atmosphere;
30 %Spectr.
2-iodopyridine
5029-67-4

2-iodopyridine

trifluoromethan
75-46-7

trifluoromethan

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: trifluoromethan With fluorobenzene; potassium tert-butylate; copper(l) chloride In N,N-dimethyl-formamide for 0.25h; Inert atmosphere;
Stage #2: With triethylamine tris(hydrogen fluoride) In N,N-dimethyl-formamide Inert atmosphere;
Stage #3: 2-iodopyridine In N,N-dimethyl-formamide at 50℃; for 16h; Inert atmosphere;
99 %Spectr.
2-iodopyridine
5029-67-4

2-iodopyridine

(1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone)2Zn(CF3)2

(1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone)2Zn(CF3)2

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(l) iodide at 50℃; for 24h; Inert atmosphere;85 %Spectr.
2-iodopyridine
5029-67-4

2-iodopyridine

iodotrifluoromethane
2314-97-8

iodotrifluoromethane

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: iodotrifluoromethane; zinc With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone at 20℃; for 2h; Inert atmosphere;
Stage #2: 2-iodopyridine With copper(l) iodide at 50℃; for 24h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; chemoselective reaction;
96 %Spectr.
trifluoroacetonitrile
353-85-5

trifluoroacetonitrile

buta-1,3-diene
106-99-0

buta-1,3-diene

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
at 475℃;
at 400℃;
at 350 - 520℃; Kinetics; in der Gasphase;
2-chloropyridine
109-09-1

2-chloropyridine

dibromodifluoromethane
75-61-6

dibromodifluoromethane

A

2-heptafluoropropyl-pyridine
1743-97-1

2-heptafluoropropyl-pyridine

B

2-(pentafluoroethyl)pyridine
1744-46-3

2-(pentafluoroethyl)pyridine

C

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ISOPROPYLAMIDE; copper at 100℃; for 8h;A n/a
B 23%
C 13%
2-iodopyridine
5029-67-4

2-iodopyridine

trifluoromethylcopper(I)
77152-08-0

trifluoromethylcopper(I)

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃; for 24h;93 %Spectr.
pyridine
110-86-1

pyridine

Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

A

4-trifluoromethylpyridine
3796-24-5

4-trifluoromethylpyridine

B

3-(trifluoromethyl)pyridine
3796-23-4

3-(trifluoromethyl)pyridine

C

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; sodium dithionite In water at 65℃; under 2250.2 - 3750.3 Torr; for 2h;A 5%
B 1%
C 4%
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

3-hydroxy-2-trifluoromethylpyridine
1063697-17-5

3-hydroxy-2-trifluoromethylpyridine

Conditions
ConditionsYield
Stage #1: 2-(trifluoromethyl)pyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 16h;
Stage #2: With Trimethyl borate In tetrahydrofuran; hexane for 2h;
Stage #3: With peracetic acid In tetrahydrofuran; hexane; water; acetic acid at 0℃; for 1h;
72%
Stage #1: 2-(trifluoromethyl)pyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 16h; Inert atmosphere;
Stage #2: With Trimethyl borate In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;
Stage #3: With peracetic acid In tetrahydrofuran; hexane; acetic acid at -78 - 0℃; for 1h; Inert atmosphere; regioselective reaction;
72%
Stage #1: 2-(trifluoromethyl)pyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran at -78 - -70℃; for 2h;
Stage #2: With Trimethyl borate In tetrahydrofuran at -70℃; for 2h;
Stage #3: With dihydrogen peroxide In tetrahydrofuran at -70 - 0℃; for 1h;
67%
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

2-(trifluoro-methyl)pyridine 1-oxide
22253-71-0

2-(trifluoro-methyl)pyridine 1-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 72h;47%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 24h;47%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 24℃; for 12h; Inert atmosphere;41%
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

3-iodo-2-(trifluoromethyl)pyridine
590371-71-4

3-iodo-2-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; iodine In tetrahydrofuran; hexane at -75℃; for 2h;89%
Stage #1: 2-(trifluoromethyl)pyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Cooling with acetone-dry ice;
Stage #2: With iodine In tetrahydrofuran; hexane at -78 - 20℃;
68%
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate
1055306-64-3

tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

tert-butyl {3,3-difluoro-2-methylene-4-oxo-4-[2-(trifluoromethyl)pyridin-3-yl]butyl}carbamate
1055306-66-5

tert-butyl {3,3-difluoro-2-methylene-4-oxo-4-[2-(trifluoromethyl)pyridin-3-yl]butyl}carbamate

Conditions
ConditionsYield
Stage #1: 2-(trifluoromethyl)pyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2.75h;
Stage #2: tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate In tetrahydrofuran; hexane at -78℃; for 2h;
Stage #3: With water; ammonium chloride In tetrahydrofuran; hexane
87%
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

2-(trifluoromethyl)piperidine hydrochloride

2-(trifluoromethyl)piperidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; platinum(IV) oxide In water; acetic acid under 2068.65 Torr; for 72h;
With hydrogenchloride; hydrogen; platinum(IV) oxide In water; acetic acid under 2068.65 Torr; for 72h;
With hydrogenchloride; hydrogen; platinum(IV) oxide In water; acetic acid under 2068.65 Torr; for 72h;
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

(+/-)-2-(trifluoromethyl)piperidine

(+/-)-2-(trifluoromethyl)piperidine

Conditions
ConditionsYield
With [Rh(cod)(CI)(CAACMe2)]; hydrogen In hexane at 40℃; for 24h; Molecular sieve; diastereoselective reaction;70%
With [Rh(cod)(CI)(CAACMe2)]; hydrogen In hexane at 50℃; under 45004.5 Torr; for 24h; Molecular sieve;
With methanesulfonic acid; hydrogen; [(E)-4-methoxy-N-(1-(4-methoxyphenyl)ethylidene)aniline]iridium(III) mesylate In isopropyl alcohol at 50℃; under 37503.8 Torr; for 16h; Autoclave;
carbon dioxide
124-38-9

carbon dioxide

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

6-(trifluoromethyl)pyridine-2-carboxylic acid
131747-42-7

6-(trifluoromethyl)pyridine-2-carboxylic acid

Conditions
ConditionsYield
With n-butyllithium; 2-(N,N-dimethylamino)ethanol In diethyl ether; hexane at -75℃; for 2h;71%
Stage #1: 2-(trifluoromethyl)pyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol In diethyl ether; hexane at -65℃; Inert atmosphere;
Stage #2: carbon dioxide In diethyl ether; hexane at -65 - 50℃; Inert atmosphere;
Stage #1: 2-(trifluoromethyl)pyridine With n-butyllithium In diethyl ether; hexane at -65℃; Inert atmosphere;
Stage #2: carbon dioxide In diethyl ether; hexane at 0 - 5℃;
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

3‐(methoxycarbonyl)bicyclo[1.1.1]pentane‐1‐carboxylic acid
83249-10-9

3‐(methoxycarbonyl)bicyclo[1.1.1]pentane‐1‐carboxylic acid

methyl 3-(6-(trifluoromethyl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxylate

methyl 3-(6-(trifluoromethyl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxylate

Conditions
ConditionsYield
With sodium persulfate; sulfuric acid; silver nitrate In water; acetonitrile at 80℃; for 2h;5%
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

trimethylsilyl bis(trifluoromethanesulfonyl)imide
82113-66-4

trimethylsilyl bis(trifluoromethanesulfonyl)imide

tris-(o-tolyl)phosphine
6163-58-2

tris-(o-tolyl)phosphine

C27H25F2NP(1+)*C2F6NO4S2(1-)

C27H25F2NP(1+)*C2F6NO4S2(1-)

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate In 1,2-dichloro-benzene at 150℃; for 40h; Inert atmosphere;64%
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

6-(trifluoromethyl)pyridine-2-carboxylic acid
131747-42-7

6-(trifluoromethyl)pyridine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-(N,N-dimethylamino)ethanol With n-butyllithium In diethyl ether; hexane at -75 - -65℃; for 0.166667h; Inert atmosphere;
Stage #2: 2-(trifluoromethyl)pyridine In diethyl ether; hexane at -65℃; Inert atmosphere;
Triisopropyl borate
5419-55-6

Triisopropyl borate

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

isopropyl alcohol
67-63-0

isopropyl alcohol

C15H24BF3NO3(1-)*Li(1+)

C15H24BF3NO3(1-)*Li(1+)

Conditions
ConditionsYield
Stage #1: 2-(trifluoromethyl)pyridine With n-butyllithium In diethyl ether; hexane; toluene at -100℃; for 0.7h; Inert atmosphere;
Stage #2: Triisopropyl borate In diethyl ether; hexane; toluene at -70℃; for 4h; Inert atmosphere;
Stage #3: isopropyl alcohol In diethyl ether; hexane; toluene for 2.5h; Inert atmosphere;
carbon dioxide
124-38-9

carbon dioxide

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

2-(trifluoromethyl)nicotinic acid
131747-43-8

2-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With 2,2,6,6-tetramethylpiperidinyl-lithium at -78℃; for 6h; Large scale reaction;77%
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -75℃; for 6h;73%
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

2-(trifluoromethyl)pyridin-4-amine
147149-98-2

2-(trifluoromethyl)pyridin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O2, acetic acid
2: 89 percent / H2 / 10percent Pd/C / aq. ethanol / 0.75 h / 1810.02 Torr
View Scheme
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 25 °C
2: sulfuric acid; nitric acid / 4 h / 0 - 125 °C
3: hydrogen / palladium 10% on activated carbon / 12 h
View Scheme
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; acetic acid / water / 12 h / 20 - 70 °C
1.2: pH 7
2.1: sulfuric acid; nitric acid / 2 h / 0 - 130 °C
2.2: pH 7
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C / 1551.49 Torr / Inert atmosphere
View Scheme
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

mesitylenesulfonylhydroxylamine
36016-40-7

mesitylenesulfonylhydroxylamine

1-amino-2-trifluoromethylpyridinium mesitylenesulfonate
895636-79-0

1-amino-2-trifluoromethylpyridinium mesitylenesulfonate

Conditions
ConditionsYield
In chloroform at 20℃; for 108h;
homoalylic alcohol
627-27-0

homoalylic alcohol

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

5,5-difluoro-5-(pyridin-2-yl)pentan-1-ol

5,5-difluoro-5-(pyridin-2-yl)pentan-1-ol

Conditions
ConditionsYield
With Cyclohexanethiol; 10-(naphthalen-1-yl)-10H-phenothiazine; sodium formate In water; dimethyl sulfoxide at 23℃; for 24h; Irradiation; Inert atmosphere; Sealed tube; Schlenk technique;47%
With 3,7-di([1,1′-biphenyl]-4-yl)-10-(naphthalen-1-yl)-10H-phenoxazine; potassium formate; thiophenol In dimethyl sulfoxide at 23℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;43%
styrene
292638-84-7

styrene

(dimethoxy)methylsilane
16881-77-9

(dimethoxy)methylsilane

2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

(S)-1-(dimethoxy(methyl)silyl)-4-(1-phenylethyl)-2-(trifluoromethyl)-1,4-dihydropyridine

(S)-1-(dimethoxy(methyl)silyl)-4-(1-phenylethyl)-2-(trifluoromethyl)-1,4-dihydropyridine

1-(dimethoxy(methyl)silyl)-4-(1-phenylethyl)-2-(trifluoromethyl)-1,4-dihydropyridine

1-(dimethoxy(methyl)silyl)-4-(1-phenylethyl)-2-(trifluoromethyl)-1,4-dihydropyridine

Conditions
ConditionsYield
Stage #1: styrene; (dimethoxy)methylsilane With copper diacetate; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane In tetrahydrofuran-d8 at 20℃; Glovebox; Sealed tube;
Stage #2: 2-(trifluoromethyl)pyridine In tetrahydrofuran-d8 at 20℃; for 23.5h; Glovebox; Sealed tube; Overall yield = 12 percentSpectr.; Optical yield = 33.333 percent de; diastereoselective reaction;
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

dithiocarbonic acid O-ethyl S-(2-(trifluoromethyl)pyridin-4-yl) diester
147149-99-3

dithiocarbonic acid O-ethyl S-(2-(trifluoromethyl)pyridin-4-yl) diester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2O2, acetic acid
2: 89 percent / H2 / 10percent Pd/C / aq. ethanol / 0.75 h / 1810.02 Torr
3: 1.) NaNO2, conc. H2SO4 / 1.) H2O, 0 deg C, 5 min, 2.) H2O, from 5 deg C to RT
View Scheme
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

2,6-Dimethyl-5-(2-trifluoromethyl-pyridin-4-ylsulfanyl)-3H-quinazolin-4-one

2,6-Dimethyl-5-(2-trifluoromethyl-pyridin-4-ylsulfanyl)-3H-quinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2O2, acetic acid
2: 89 percent / H2 / 10percent Pd/C / aq. ethanol / 0.75 h / 1810.02 Torr
3: 1.) NaNO2, conc. H2SO4 / 1.) H2O, 0 deg C, 5 min, 2.) H2O, from 5 deg C to RT
4: 1.) 1 N KOH, 2.) CuBr, Cu2O / 1.) MeOH, 90 min, 2.) DMA, 90 deg C, 6 h
View Scheme
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

2-Amino-6-methyl-5-(2-trifluoromethyl-pyridin-4-ylsulfanyl)-3H-quinazolin-4-one

2-Amino-6-methyl-5-(2-trifluoromethyl-pyridin-4-ylsulfanyl)-3H-quinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2O2, acetic acid
2: 89 percent / H2 / 10percent Pd/C / aq. ethanol / 0.75 h / 1810.02 Torr
3: 1.) NaNO2, conc. H2SO4 / 1.) H2O, 0 deg C, 5 min, 2.) H2O, from 5 deg C to RT
4: 1.) 1 N KOH, 2.) CuBr, Cu2O / 1.) MeOH, 90 min, 2.) DMA, 90 deg C, 6 h
View Scheme
2-(trifluoromethyl)pyridine
368-48-9

2-(trifluoromethyl)pyridine

A

2-(difluoromethyl)pyridine
114468-01-8

2-(difluoromethyl)pyridine

B

2-(fluoromethyl)pyridine

2-(fluoromethyl)pyridine

Conditions
ConditionsYield
With 3,7-di([1,1′-biphenyl]-4-yl)-10-(naphthalen-1-yl)-10H-phenoxazine; cesium formate In dimethyl sulfoxide at 23℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Sealed tube;A 58%
B n/a

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