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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 3-hydroxy-phthalicanhydrid(37418-88-5)

Cas:37418-88-5

Min.Order:100 Gram

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Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity 3-hydroxyphthalic anhydride CAS:37418-88-5

Cas:37418-88-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name 3-hydroxyphthalic anhydride CAS number 37418-88-5 Assay ≥98% Appearance White to off-white powder Capacity 200mt/year Application Pharmaceut

3-hydroxyphthalic anhydride

Cas:37418-88-5

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Hydroxyphthalic anhydride

Cas:37418-88-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Hydroxyphthalic anhydride

Cas:37418-88-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

3-HYDROXYPHTHALIC ANHYDRIDE

Cas:37418-88-5

Min.Order:1 Kilogram

FOB Price: $0.96 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 3-HYDROXYPHTHALIC ANHYDRIDE

Cas:37418-88-5

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 37418-88-5 with competitive price

Cas:37418-88-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 37418-88-5 3-HYDROXYPHTHALIC ANHYDRIDE with best price

Cas:37418-88-5

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,3-Isobenzofurandione, 4-hydroxy- 37418-88-5

Cas:37418-88-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3-HYDROXYPHTHALIC ANHYDRIDE

Cas:37418-88-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 10.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-HYDROXYPHTHALIC ANHYDRIDE CAS:37418-88-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

3-HYDROXYPHTHALIC ANHYDRIDE CAS:37418-88-5

Cas:37418-88-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,3-Isobenzofurandione, 4-hydroxy-

Cas:37418-88-5

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:37418-88-5

Cas:37418-88-5

Min.Order:0

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

3-hydroxyphthalic anhydride

Cas:37418-88-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-hydroxyisobenzofuran-1,3-dione CAS NO.37418-88-5

Cas:37418-88-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-hydroxy-1,3-dihydro-2-benzofuran-1,3-dione

Cas:37418-88-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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JINING XINHE CHEMICAL CO., LTD

Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit

Raw Material 3-hydroxy-phthalicanhydrid

Cas:37418-88-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-HYDROXYPHTHALIC ANHYDRIDE

Cas:37418-88-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity 3-hydroxyphthalic anhydride

Cas:37418-88-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Trimethylsulfoxonium bromide

Cas:37418-88-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-Hydroxyphthalicanhydride

Cas:37418-88-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 3-Hydroxyphthalic Anhydride CAS No.:37418-88-5 Molecule Formula:C8H4O4 Molecule Weight:164.12 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTIN

High Quality 3-Hydroxyphthalic Anhydride

Cas:37418-88-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

37418-88-5

Cas:37418-88-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-hydroxyisobenzofuran-1,3-dione CAS NO.37418-88-5

Cas:37418-88-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1,3-Isobenzofurandione, 4-hydroxy-

Cas:37418-88-5

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1,3-Isobenzofurandione, 4-hydroxy-

Cas:37418-88-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-hydroxyisobenzofuran-1,3-dione CAS NO.37418-88-5

Cas:37418-88-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Hydroxy-2-benzofuran-1,3-dione

Cas:37418-88-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

3-Hydroxyphthalic anhydride

Cas:37418-88-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

3-hydroxyphthalic acid
601-97-8

3-hydroxyphthalic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
at 300℃; Green chemistry;90%
In acetic anhydride at 80℃; for 2h; Temperature;80.1%
With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 150℃; for 1h; Solvent; Temperature; Reagent/catalyst;79.72%
1-(2,2-dimethylpropanoyloxy-3,5)-dioxo-exo-10-oxatricyclo<5.2.1.02.6>dec-8-ene
100921-73-1, 135414-50-5

1-(2,2-dimethylpropanoyloxy-3,5)-dioxo-exo-10-oxatricyclo<5.2.1.02.6>dec-8-ene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
With sulfuric acid for 0.0833333h;90%
3-fluorophthalic acid
1583-67-1

3-fluorophthalic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Stage #1: 3-fluorophthalic acid With copper(l) iodide; potassium hydroxide In N,N-dimethyl-formamide at 100℃; for 6h;
Stage #2: With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃; for 2h; Reagent/catalyst; Solvent; Temperature;
88.2%
1-(2,2-dimethylpropionyl)-4,10-dioxatricyclo[5.2.1.02,6]-dec-8-ene-3,5-dione

1-(2,2-dimethylpropionyl)-4,10-dioxatricyclo[5.2.1.02,6]-dec-8-ene-3,5-dione

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
With sulfuric acid at -15℃; for 0.0833333h;73%
1,3-dioxo-3,3a,7,7a-tetrahydro-4,7-epoxy-2-benzofuran-4(1H)-yl 2,2-dimethyl-propanoate
135414-50-5

1,3-dioxo-3,3a,7,7a-tetrahydro-4,7-epoxy-2-benzofuran-4(1H)-yl 2,2-dimethyl-propanoate

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
With sulfuric acid at 0 - 15℃; for 0.0833333h;73%
With sulfuric acid at -30℃; for 0.0833333h;73%
With sulfuric acid at -15℃; for 0.25h;
1-methoxy-7-oxa-norborn-5-ene-2,3-dicarboxylic acid-anhydride
78136-34-2

1-methoxy-7-oxa-norborn-5-ene-2,3-dicarboxylic acid-anhydride

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

acetic acid
64-19-7

acetic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

5-methoxynaphthalen-1-ol
3588-80-5

5-methoxynaphthalen-1-ol

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KMnO4; diluted NaOH-solution
2: diluted sulfuric acid; KMnO4 / 0 °C
3: potash / beim Schmelzen
4: 150 °C
View Scheme
1,5-dihydroxynaphthalene
83-56-7

1,5-dihydroxynaphthalene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaOH-solution
2: KMnO4; diluted NaOH-solution
3: diluted sulfuric acid; KMnO4 / 0 °C
4: potash / beim Schmelzen
5: 150 °C
View Scheme
3-methoxyphthalic acid
14963-97-4

3-methoxyphthalic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potash / beim Schmelzen
2: 150 °C
View Scheme
Multi-step reaction with 2 steps
1: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
2: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
(2-carboxy-3-methoxy-phenyl)-glyoxylic acid
17802-94-7

(2-carboxy-3-methoxy-phenyl)-glyoxylic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diluted sulfuric acid; KMnO4 / 0 °C
2: potash / beim Schmelzen
3: 150 °C
View Scheme
3-nitrophthalic acid anhydride
641-70-3

3-nitrophthalic acid anhydride

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium sulfate; palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
2.1: sulfuric acid / 1 h / 0 °C
2.2: 2 h / 0 - 80 °C
3.1: 135 - 140 °C / 0.04 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen; magnesium sulfate / 50 °C / 3102.97 Torr
2.1: sulfuric acid / 1 h / 0 °C
2.2: 5 - 80 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen; magnesium sulfate / acetone / 50 °C / 3102.97 Torr
2.1: sulfuric acid / 1 h / 0 °C
2.2: 0.5 h / 5 - 80 °C
View Scheme
3-aminophthalic anhydride
17395-99-2

3-aminophthalic anhydride

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / 1 h / 0 °C
1.2: 2 h / 0 - 80 °C
2.1: 135 - 140 °C / 0.04 Torr
View Scheme
Stage #1: 3-aminophthalic anhydride With sulfuric acid at 0℃; for 1h;
Stage #2: With sodium nitrite at 5 - 80℃;
Stage #1: 3-aminophthalic anhydride With sulfuric acid at 0℃; for 1h;
Stage #2: With sodium nitrite In water at 5 - 80℃; for 0.5h;
3-chlorobenzene-1,2-dicarboxylic acid
27563-65-1

3-chlorobenzene-1,2-dicarboxylic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Stage #1: 3-chlorobenzene-1,2-dicarboxylic acid With copper(l) iodide; potassium hydroxide In N,N-dimethyl-formamide at 80℃; for 8h;
Stage #2: With phosphoric acid In N,N-dimethyl-formamide at 100℃; for 7.5h;
172.0 g
3-chlorophthalic acid dimethyl ester
61539-35-3

3-chlorophthalic acid dimethyl ester

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Stage #1: 3-chlorophthalic acid dimethyl ester With copper(I) bromide; sodium hydroxide In dimethyl sulfoxide at 100℃; for 5h;
Stage #2: With phosphorus pentoxide In dimethyl sulfoxide at 120℃; for 2h;
188.9 g
3-bromophthalic acid
116-69-8

3-bromophthalic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Stage #1: 3-bromophthalic acid With copper(I) oxide; sodium t-butanolate In tetrahydrofuran at 130℃; for 1.5h;
Stage #2: With dicyclohexyl-carbodiimide In tetrahydrofuran at 130℃; for 3.5h;
230.9 g
Reaxys ID: 30570620

Reaxys ID: 30570620

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

3-iodophthalic acid
6937-34-4

3-iodophthalic acid

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Stage #1: 3-iodophthalic acid With sodium ethanolate; copper(II) bis(trifluoromethanesulfonate) In dimethyl sulfoxide at 120℃; for 3h;
Stage #2: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dimethyl sulfoxide at 130℃; for 4.5h; Reagent/catalyst; Temperature; Solvent;
247.9 g
3-fluorophthalic acid diethyl ester

3-fluorophthalic acid diethyl ester

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Stage #1: 3-fluorophthalic acid diethyl ester With copper(l) iodide; potassium tert-butylate In dimethyl sulfoxide at 120℃; for 4h;
Stage #2: With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 130℃; for 2.5h;
210.2 g
3-nitrobenzene-1,2-dicarbonitrile
51762-67-5

3-nitrobenzene-1,2-dicarbonitrile

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium nitrite; potassium carbonate / dimethyl sulfoxide / 3 h / 160 °C
1.2: pH 3
2.1: water; potassium hydroxide / 90 h / 130 °C
3.1: 300 °C / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; sodium nitrite / dimethyl sulfoxide / 20 - 160 °C
2: water / Cooling with ice
3: neat (no solvent) / 1 h
View Scheme
3-hydroxylphthalonitrile
116039-49-7

3-hydroxylphthalonitrile

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; potassium hydroxide / 90 h / 130 °C
2: 300 °C / Green chemistry
View Scheme
Multi-step reaction with 2 steps
1: water / Cooling with ice
2: neat (no solvent) / 1 h
View Scheme
1-methoxy-2-ethyl-3-methylbenzene
6161-63-3

1-methoxy-2-ethyl-3-methylbenzene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cetyltrimethylammonim bromide; potassium permanganate / water / 6.5 h / 80 - 90 °C
2: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
3: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
5-methoxy-1,2,3,4-tetrahydro-naphthalene
1008-19-1

5-methoxy-1,2,3,4-tetrahydro-naphthalene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cetyltrimethylammonim bromide; potassium permanganate / dimethyl sulfoxide / 3.17 h / 75 - 90 °C
2: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
3: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
1-methoxy-2-propyl-3-ethylbenzene

1-methoxy-2-propyl-3-ethylbenzene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cetyltrimethylammonim bromide; potassium permanganate / water / 8.5 h / 70 - 90 °C
2: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
3: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
4-methoxy-2,3-dihydro-1H-indene
21573-42-2

4-methoxy-2,3-dihydro-1H-indene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cetyltrimethylammonim bromide; potassium permanganate / water / 7.5 h / 70 - 90 °C
2: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
3: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
1-methoxy-2,3-dipropylbenzene

1-methoxy-2,3-dipropylbenzene

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cetyltrimethylammonim bromide; potassium permanganate / N,N-dimethyl-formamide / 4.5 h / 70 - 90 °C
2: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
3: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
2,3-dimethylanisole
2944-49-2

2,3-dimethylanisole

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cetyltrimethylammonim bromide; potassium permanganate / N,N-dimethyl-formamide / 4.5 h / 70 - 90 °C
2: boron tribromide / dichloromethane / 5 h / 10 - 15 °C
3: dicyclohexyl-carbodiimide / dimethyl sulfoxide / 1 h / 150 °C
View Scheme
C13H14O6

C13H14O6

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
With sulfuric acid at -15 - -10℃; for 0.33h;
3-chlorophthalic anhydride
117-21-5

3-chlorophthalic anhydride

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide; copper(l) chloride / water; N,N-dimethyl-formamide / 12 h / 105 °C
2: acetic anhydride / 2 h / 80 °C
View Scheme
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

3-methoxymethyloxyphthalic acid anhydride
330192-57-9

3-methoxymethyloxyphthalic acid anhydride

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane99%
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane99%
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane99%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

ethanol
64-17-5

ethanol

diethyl 3-hydroxyphthalate
24736-82-1

diethyl 3-hydroxyphthalate

Conditions
ConditionsYield
With sulfuric acid Reflux;98.7%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

(3-hydroxy-1,2-phenylene)dimethanol
7369-27-9

(3-hydroxy-1,2-phenylene)dimethanol

Conditions
ConditionsYield
With borane tetrahydrofuran In tetrahydrofuran for 18h; Heating / reflux;98%
With lithium aluminium tetrahydride In tetrahydrofuran at -78℃; Reflux;86%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

[(R)-4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester
944256-13-7

[(R)-4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester

C25H30N2O7
944256-14-8

C25H30N2O7

Conditions
ConditionsYield
With triethylamine In toluene for 24h; Heating / reflux;98%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

[4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester
944256-06-8

[4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester

[4-(3,4-dimethoxyphenyl)-4-(4-hydroxy-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl]carbamic acid tert-butyl ester
1190089-46-3

[4-(3,4-dimethoxyphenyl)-4-(4-hydroxy-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In toluene for 24h; Reflux;98%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

3,4-dimethoxybenzylamine
5763-61-1

3,4-dimethoxybenzylamine

4-hydroxy-2-(3,4-dimethoxybenzyl)-2,3-dihydro-1H-isoindole-1,3-dione
944255-95-2

4-hydroxy-2-(3,4-dimethoxybenzyl)-2,3-dihydro-1H-isoindole-1,3-dione

Conditions
ConditionsYield
With triethylamine In toluene for 24h; Reflux;96%
With triethylamine In toluene for 24h; Heating / reflux;96%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

rac-α-aminoglutarimide hydrochloride
24666-56-6

rac-α-aminoglutarimide hydrochloride

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
With potassium acetate In acetic acid for 24h; Reflux;96%
With sodium acetate; acetic acid at 100℃; for 2h;96%
With pyridine at 110℃;93%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

3-phenoxypropanamine
7617-76-7

3-phenoxypropanamine

4-hydroxy-2-(3-phenoxypropyl)isoindole-1,3-dione

4-hydroxy-2-(3-phenoxypropyl)isoindole-1,3-dione

Conditions
ConditionsYield
In toluene for 16h; Heating;94%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

(+/-)-α-aminoglutarimide
2353-44-8

(+/-)-α-aminoglutarimide

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
With triethylamine In toluene at 110℃; for 12h;92%
With triethylamine In toluene at 110℃; for 12h;92%
With sodium acetate; acetic acid for 6h; Reflux;80%
tyrosamine
51-67-2

tyrosamine

3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

4-hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione
1639899-90-3

4-hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione

Conditions
ConditionsYield
With acetic acid In water at 85℃;90%
With acetic acid In water Reflux;
With acetic acid In water at 85℃;
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

4-Bromophenethylamine
73918-56-6

4-Bromophenethylamine

3-hydroxy-N-(p-bromo-phenethyl) phthalimide

3-hydroxy-N-(p-bromo-phenethyl) phthalimide

Conditions
ConditionsYield
With acetic acid In water at 85℃;90%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

6-amino-1-hexanol
4048-33-3

6-amino-1-hexanol

C14H17NO4

C14H17NO4

Conditions
ConditionsYield
In toluene at 80 - 135℃;90%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

3-aminopiperidine-2,6-dione hydrochloric acid salt

3-aminopiperidine-2,6-dione hydrochloric acid salt

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
With pyridine at 110℃; for 14h;88%
With sodium acetate; acetic acid at 110℃; for 10h;85%
With potassium acetate; acetic acid at 100℃; for 15h; Reagent/catalyst; Temperature;78.06%
With sodium acetate; acetic acid at 120℃; for 12h;21%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

tert-butyl N-(1-methyl-2,6-dioxopiperidin-3-yl)carbamate

tert-butyl N-(1-methyl-2,6-dioxopiperidin-3-yl)carbamate

4-hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

4-hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;88%
Stage #1: tert-butyl N-(1-methyl-2,6-dioxopiperidin-3-yl)carbamate With trifluoroacetic acid In dichloromethane at 25℃; for 1h;
Stage #2: 3-hydroxyphthalic anhydride With acetic anhydride at 140℃; for 6h;
39%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;86%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

3,5-bis-trifluoromethylbenzylamine
85068-29-7

3,5-bis-trifluoromethylbenzylamine

C17H9F6NO3

C17H9F6NO3

Conditions
ConditionsYield
In chlorobenzene for 3h; Heating / reflux;85.2%
In chlorobenzene for 3h; Heating / reflux;85.2%
In chlorobenzene for 3h; Heating / reflux;85.2%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(4-hydroxy-3-oxo-3H-isobenzofuran-1-ylidene)propanedioate

diethyl 2-(4-hydroxy-3-oxo-3H-isobenzofuran-1-ylidene)propanedioate

Conditions
ConditionsYield
With triethylamine In acetic anhydride at 0 - 40℃;84.5%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

2-amino-2,3-dihydro-6,7-dimethoxy-1H-isoindol-1-one
1003849-90-8

2-amino-2,3-dihydro-6,7-dimethoxy-1H-isoindol-1-one

2-[1,3-dihydro-6,7-dimethoxy-1-oxo-2H-isoindol-2-yl]-1H-4-hydroxyisoindole-1,3(2H)-dione
1003851-02-2

2-[1,3-dihydro-6,7-dimethoxy-1-oxo-2H-isoindol-2-yl]-1H-4-hydroxyisoindole-1,3(2H)-dione

Conditions
ConditionsYield
With triethylamine In toluene Heating;83%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

4-hydroxy-2-(4-methoxybenzyl)-1H-isoindole-1,3(2H)-dione
491875-13-9

4-hydroxy-2-(4-methoxybenzyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With acetic acid at 100℃; for 4h;81%
In acetic acid at 100℃; for 4h;81%
With acetic acid at 100℃; for 4h;81%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

1-bromo-octane
111-83-1

1-bromo-octane

C16H22O5
1395236-57-3

C16H22O5

Conditions
ConditionsYield
With water; silver(l) oxide In acetonitrile at 80℃; for 12h;80%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
Stage #1: 3-hydroxyphthalic anhydride; (RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate With triethylamine In tetrahydrofuran for 24h; Inert atmosphere; Reflux;
Stage #2: With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 72h; Reflux; Inert atmosphere;
76%
Stage #1: 3-hydroxyphthalic anhydride; (RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate With triethylamine In tetrahydrofuran for 4h; Reflux; Inert atmosphere;
Stage #2: With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 72h; Reflux;
66%
With potassium acetate; acetic acid Reflux;51%
With pyridine at 20 - 110℃; for 16h;50%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

2,4-Dimethoxybenzylamine
20781-20-8

2,4-Dimethoxybenzylamine

2-(2,4-dimethoxybenzyl)-4-hydroxyisoindole-1,3-dione
912999-90-7

2-(2,4-dimethoxybenzyl)-4-hydroxyisoindole-1,3-dione

Conditions
ConditionsYield
With acetic acid at 80℃; for 24h;73%
In acetic acid at 80℃; for 24h;73%
With acetic acid at 80℃; for 24h;73%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

3-aminopiperidine-2,6-dione hydrobromide
90802-45-2

3-aminopiperidine-2,6-dione hydrobromide

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
Stage #1: 3-hydroxyphthalic anhydride; DL-3-amino-2,6-piperidinone hydrobromide In N,N-dimethyl-formamide at 60℃; for 24h;
Stage #2: With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 63℃; for 54h;
71%
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

7-hydroxy-1 (3H)-isobenzofuranone
3956-91-0

7-hydroxy-1 (3H)-isobenzofuranone

Conditions
ConditionsYield
With sodium tetrahydroborate70%
With hydrogen; Λ(+)-tris(pentane-2,5-dionato)ruthenium; TOP; toluene-4-sulfonic acid In various solvent(s) at 200℃; under 22501.8 Torr; for 2h;60%
Stage #1: 3-hydroxyphthalic anhydride With potassium tri-sec-butyl-borohydride In tetrahydrofuran at -78 - -30℃;
Stage #2: With hydrogenchloride In water; ethyl acetate
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

n-decanoyl chloride
112-13-0

n-decanoyl chloride

C18H22O5
1395236-65-3

C18H22O5

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 15℃;70%

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