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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications tert-butyl (2,6-dioxopiperidin-3-yl)carbamate CAS:31140-42-8

Cas:31140-42-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Boc-Amino-2,6-Dioxopiperidine

Cas:31140-42-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 31140-42-8 with best quality

Cas:31140-42-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 31140-42-8 3-BOC-AMINO-2,6-DIOXOPIPERIDINE with best price

Cas:31140-42-8

Min.Order:10 Gram

Negotiable

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Model NO. CAS 31140-42-8 Powder Yes Customized Customized Certification GMP, ISO 9001 Suitable for Adult State Solid Purity >99% Trademark cooperate-pharm Transport Package Foil Bag Specification white powder Origin China Hebe

3-Boc-Amino-2, 6-Dioxopiperidine

Cas:31140-42-8

Min.Order:1 Kilogram

FOB Price: $60.0 / 80.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-BOC-AMINO-2,6-DIOXOPIPERIDINE CAS:31140-42-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o

3-BOC-AMINO-2,6-DIOXOPIPERIDINE CAS:31140-42-8

Cas:31140-42-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU-CHEM - 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU-CHEM - 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU-CHEM - 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFU-CHEM - 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

tert-butyl (2,6-dioxopiperidin-3-yl)carbamate

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-Boc-Amino-2,6-Dioxopiperidine

Cas:31140-42-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

3-Boc-Amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Trading Company

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3-BOC-AMINO-2,6-DIOXOPIPERIDINE CAS No.31140-42-8

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

3-BOC-AMINO-2,6-DIOXOPIPERIDINEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-Boc-amino-2,6-dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

31140-42-8

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

stock,low price,high quality,high purity,good sevice Application:R&D

3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

TIANFU-CHEM - 3-BOC-AMINO-2,6-DIOXOPIPERIDINEAppearance:Solid Storage:In Room Temperature Package:IN 25kg drums Application:Organic synthesis Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airpor

TIANFU-CHEM - 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Boc-Amino-2,6-Dioxopiperidine

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Other

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Cas:31140-42-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid
85535-45-1

5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 80℃;99%
With dmap; triethylamine; 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 72h;90%
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 16h; Reflux;88%
1-[(tert-butoxy)-carbonyl-amino]propane-1,3-dicarboxylic acid
120341-33-5

1-[(tert-butoxy)-carbonyl-amino]propane-1,3-dicarboxylic acid

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 2,2,2-trifluoroacetamide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine at 20℃;95%
With 2,2,2-trifluoroacetamide; TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

rac-α-aminoglutarimide hydrochloride
24666-56-6

rac-α-aminoglutarimide hydrochloride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: rac-α-aminoglutarimide hydrochloride With triethylamine In dichloromethane at 50℃; for 0.5h; Sealed tube; Microwave irradiation;
Stage #2: di-tert-butyl dicarbonate In dichloromethane at 0℃; for 0.5h;
87%
Boc-Gln-OH
13726-85-7

Boc-Gln-OH

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 17h; Heating;76%
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 24h; Heating;76%
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; Inert atmosphere; Reflux;76%
Boc-glutamine methyl ester

Boc-glutamine methyl ester

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide In tetrahydrofuran for 48h; Reflux;66.2%
(S)-methyl 5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoate
4976-88-9

(S)-methyl 5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoate

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 48h; Reflux;64%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-aminopiperidine-2,6-dione hydrochloric acid salt

3-aminopiperidine-2,6-dione hydrochloric acid salt

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 8h;58%
glutamine methyl ester
1218991-05-9

glutamine methyl ester

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / water; methanol / 15 h / 20 °C
2: diisopropyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / tetrahydrofuran / 48 h / Reflux
View Scheme
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / 8 h / 0 °C / Reflux
2: sodium hydrogencarbonate / water; methanol / 15 h / 20 °C
3: diisopropyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / tetrahydrofuran / 48 h / Reflux
View Scheme
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

Conditions
ConditionsYield
at 20℃; for 0.5h;100%
In dichloromethane at 25℃;99%
In dichloromethane at 20℃; for 4h;98%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 4h;99%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

rac-α-aminoglutarimide hydrochloride
24666-56-6

rac-α-aminoglutarimide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 2h;99%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

(+/-)-α-aminoglutarimide
2353-44-8

(+/-)-α-aminoglutarimide

Conditions
ConditionsYield
With water; sodium chloride for 4h; Time; Reflux;98%
With trifluoroacetic acid In dichloromethane
With trifluoroacetic acid In dichloromethane at 0 - 20℃;
With trifluoroacetic acid In dichloromethane at 20℃;
With hydrogenchloride In tert-butyl methyl ether; water at 0℃; for 0.333333h;9.5 g
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

3-aminopiperidine-2,6-dione hydrobromide
90802-45-2

3-aminopiperidine-2,6-dione hydrobromide

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 20℃; for 0.5h;98%
With hydrogen bromide; acetic acid at 20℃; for 0.5h;98%
3-nitrophthalic acid anhydride
641-70-3

3-nitrophthalic acid anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;95%
With sodium acetate; acetic acid for 6h; Reflux;
5-norbornene-2,3-dicarboxylic anhydride
826-62-0, 85081-15-8, 85081-16-9

5-norbornene-2,3-dicarboxylic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

2-(2,6-dioxopiperidin-3-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
14166-22-4, 14166-24-6

2-(2,6-dioxopiperidin-3-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;94%
4-hydroxyphthalic anhydride
27550-59-0

4-hydroxyphthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

5-Hydroxythalidomide
64567-60-8

5-Hydroxythalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;91%
phthalic anhydride
85-44-9

phthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Reagent/catalyst; Microwave irradiation;91%
In 2,2,2-trifluoroethanol at 150℃; for 2h; Solvent;91%
With sodium acetate; acetic acid for 6h; Reflux;
3-fluorophthalic anhydride
652-39-1

3-fluorophthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

2‐(2,6‐dioxopiperidin‐3‐yl)‐4‐fluoroisoindoline‐1,3‐dione

2‐(2,6‐dioxopiperidin‐3‐yl)‐4‐fluoroisoindoline‐1,3‐dione

Conditions
ConditionsYield
With sodium acetate In acetic acid for 6h; Reflux;89%
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;69%
With sodium acetate; acetic acid for 6h; Reflux;
3-hydroxyphthalic anhydride
37418-88-5

3-hydroxyphthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

4-Hydroxythalidomide
5054-59-1

4-Hydroxythalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;86%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

1,2-Cyclohexanedicarboxylic acid-anhydride
85-42-7

1,2-Cyclohexanedicarboxylic acid-anhydride

cis-2-(2,6-dioxopiperidin-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione
14166-19-9

cis-2-(2,6-dioxopiperidin-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;86%
phthalic anhydride
85-44-9

phthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

2-(2,6-dioxopiperidin-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione

2-(2,6-dioxopiperidin-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
In 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation;86%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

methyl iodide
74-88-4

methyl iodide

tert-butyl N-(1-methyl-2,6-dioxopiperidin-3-yl)carbamate

tert-butyl N-(1-methyl-2,6-dioxopiperidin-3-yl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 3h;84%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1.5h;71%
Stage #1: (RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.583333h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 2h;
66%
4-tert-butylphthalic anhydride
32703-79-0

4-tert-butylphthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

5-(tert-butyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

5-(tert-butyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;83%
1,8-Naphthalic anhydride
81-84-5

1,8-Naphthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

2-(2,6-dioxopiperidin-3-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
14656-93-0

2-(2,6-dioxopiperidin-3-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 6h; Microwave irradiation; Sealed tube;80%
3-aminophthalic anhydride
17395-99-2

3-aminophthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

pomalidomide
19171-19-8

pomalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;80%
4-bromophthalic anhydride
86-90-8

4-bromophthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

5-bromo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
26166-92-7

5-bromo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;75%
4-methylphthalic anhydride
19438-61-0

4-methylphthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione
40313-92-6

2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;74%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

1,2,3,6-Tetrahydrophthalic anhydride
85-43-8

1,2,3,6-Tetrahydrophthalic anhydride

2-(2,6-dioxopiperidin-3-yl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
14166-18-8

2-(2,6-dioxopiperidin-3-yl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;73%
formaldehyd
50-00-0

formaldehyd

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

1-hydroxymethyl-3-(tert-butoxycarbonylamino)-2,6-dioxopiperidine
1320352-96-2

1-hydroxymethyl-3-(tert-butoxycarbonylamino)-2,6-dioxopiperidine

Conditions
ConditionsYield
In water for 0.5h; Inert atmosphere; Reflux;72.9%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

trimellitic Anhydride
552-30-7

trimellitic Anhydride

2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid

2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; Sealed tube;66%
(2-trimethylethylsilylethoxy)methyl chloride
76513-69-4

(2-trimethylethylsilylethoxy)methyl chloride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

tert-butyl (2,6-dioxo-1-((2-(trimethylsilyl)ethoxy)methyl)piperidin-3-yl)carbamate

tert-butyl (2,6-dioxo-1-((2-(trimethylsilyl)ethoxy)methyl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
Stage #1: (RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide at 20℃; for 1h;
65%
Stage #1: (RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
65%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

benzene-1,2-dicarboxylic acid
88-99-3

benzene-1,2-dicarboxylic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation;62%

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