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CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are the manufacuter of this item in China and produced this item for more than 10 years.Appearance:A White or almost white crystalline powder Storage:normal Package:25kgs net carton drums Application:API Transportation:normal

Thalidomide

Cas:50-35-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Thalidomide Manufacturer/High quality/Best price/In stock

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Thalidomide 50-35-1 ISO Manufacturer

Cas:50-35-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Thalidomide

Cas:50-35-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Thalidomide The alias:(+-)-THALIDOMIDE >98% IMMUNOSUPPRESSIVE, SE;α-Phthalimidoglutarimide CAS NO:50-35-1 Molecular formula:C13H10N2O4 Molecular weight:258.2295 Product Quality 12 years of chemical raw materials Mature opera

Thalidomide/CAS:50-35-1/High quality

Cas:50-35-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 50-35-1 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione

Cas:50-35-1

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Thalidomide 50-35-1

Cas:50-35-1

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Package : 25kg/carton, or at customer's requirements Storage: Store in a cool, dry place and keep away from direct strong light. Shelf Life :2 years Appearance:Yellow crystalline or yellow crystal powder. Storage:Stored in dry

Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White?to?off-white?powder Storage:R.T Package:25kg/Barrel Application:It has the effects of sedation, anti-inflammatory, immune regulation and anti-tumor angiogenesis. Transportation:Express/Sea/Air Port:Any port in China

Good supplier Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 680.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Top quality Thalidomide raw powder best price CAS 50-35-1 Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed

Top Quality Thalidomide 99% with low price

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Animal Pharmaceuticals, Thalidomide CAS:50-35-1

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $76.0 / 84.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Thalidomide CAS: 50-35-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Thalidomide CAS: 50-35-1

Cas:50-35-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Thalidomide/ LIDE PHARMA- Factory supply / Best price

Cas:50-35-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Thalidomide manufacturer with low price

Cas:50-35-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Thalidomide

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $60.0 / 80.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Thalidomide

Cas:50-35-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Top Quality Thalidomide 99% with low price CAS NO.50-35-1

Cas:50-35-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Thalidomide 50-35-1

Cas:50-35-1

Min.Order:50 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Thalidomide CAS 50-35-1

Cas:50-35-1

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Thalidomide

Cas:50-35-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Thalidomide

Cas:50-35-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Thalidomide

Cas:50-35-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(+/-)-Thalidomide

Cas:50-35-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply thalidomide

Cas:50-35-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

thalidomide

Cas:50-35-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Thalidomide

Cas:50-35-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

phthalic anhydride
85-44-9

phthalic anhydride

rac-α-aminoglutarimide hydrochloride
24666-56-6

rac-α-aminoglutarimide hydrochloride

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With acetic acid; triethylamine for 3h; Temperature; Reagent/catalyst; Concentration; Reflux;95%
(S)-2-phthalimidoglutaramic acid
3343-29-1

(S)-2-phthalimidoglutaramic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 16h; Reflux; Inert atmosphere;91%
phthalic anhydride
85-44-9

phthalic anhydride

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Reagent/catalyst; Microwave irradiation;91%
In 2,2,2-trifluoroethanol at 150℃; for 2h; Solvent;91%
With sodium acetate; acetic acid for 6h; Reflux;
phthalic anhydride
85-44-9

phthalic anhydride

A

phthalimide
136918-14-4

phthalimide

B

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With Glutamic acid; ammonium acetate at 150℃; for 0.166667h; Reagent/catalyst; Microwave irradiation; Sealed tube; Green chemistry;A 90%
B 7%
carbon monoxide
201230-82-2

carbon monoxide

(+/-)-α-aminoglutarimide
2353-44-8

(+/-)-α-aminoglutarimide

1,2-dibromobenzene
583-53-9

1,2-dibromobenzene

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With palladium diacetate; triethylamine; catacxium A In N,N-dimethyl acetamide at 100℃; under 22502.3 Torr; for 30h; Autoclave; Inert atmosphere;87%
phthalic anhydride
85-44-9

phthalic anhydride

Glutamic acid
617-65-2

Glutamic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With dmap; ammonium chloride at 150℃; for 0.166667h; Microwave irradiation; Sealed tube; Green chemistry;86%
N-phthaloyl-L-glutamic acid
340-90-9

N-phthaloyl-L-glutamic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With thiourea for 0.25h; Microwave irradiation;85%
N-phthaloylglutamic acid anhydride
3343-28-0

N-phthaloylglutamic acid anhydride

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With urea at 170 - 180℃; for 0.75h;75%
With urea at 180℃;70%
Stage #1: N-phthaloylglutamic acid anhydride With ammonia In N,N-dimethyl-formamide at 25℃; for 14h;
Stage #2: With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 100℃; for 1h;
68.3%
2-[2,6-dioxo-5-(toluene-4-sulfonyl)-piperidin-3-yl]-isoindole-1,3-dione
671787-01-2

2-[2,6-dioxo-5-(toluene-4-sulfonyl)-piperidin-3-yl]-isoindole-1,3-dione

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With sodium amalgam at 20℃; for 4h;72%
L-glutamine
56-85-9

L-glutamine

phthalic acid dimethyl ester
131-11-3

phthalic acid dimethyl ester

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Stage #1: L-glutamine; phthalic acid dimethyl ester With pyridine at 20 - 85℃; for 6h;
Stage #2: With 1,1'-carbonyldiimidazole at 40℃; for 2h;
Stage #3: With hydrogenchloride In ethanol; water at 5 - 25℃; for 4h; pH=7; Product distribution / selectivity;
72%
phthalic anhydride
85-44-9

phthalic anhydride

L-glutamine
56-85-9

L-glutamine

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Stage #1: phthalic anhydride; L-glutamine In ISOPROPYLAMIDE at 20 - 80℃; for 6h;
Stage #2: With 1,1'-carbonyldiimidazole In ISOPROPYLAMIDE at 20 - 90℃; for 4h; Product distribution / selectivity;
71%
Stage #1: phthalic anhydride; L-glutamine In 1-methyl-pyrrolidin-2-one at 20 - 80℃; for 6h;
Stage #2: With 1,1'-carbonyldiimidazole In 1-methyl-pyrrolidin-2-one at 20 - 90℃; for 4h; Product distribution / selectivity;
65%
Stage #1: phthalic anhydride; L-glutamine In DMF (N,N-dimethyl-formamide) at 20 - 80℃; for 6h;
Stage #2: With 1,1'-carbonyldiimidazole In DMF (N,N-dimethyl-formamide) at 20 - 90℃; for 4h; Product distribution / selectivity;
63%
2-phthalimidoglutaramic acid
7607-72-9

2-phthalimidoglutaramic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In ISOPROPYLAMIDE at 20 - 90℃; for 4h; Product distribution / selectivity;71%
With 1,1'-carbonyldiimidazole In 1-methyl-pyrrolidin-2-one at 20 - 90℃; for 4h; Product distribution / selectivity;65%
With 1,1'-carbonyldiimidazole In dimethyl sulfoxide at 20 - 90℃; for 4h; Product distribution / selectivity;62%
N-phthalylglutamic acid
6349-98-0

N-phthalylglutamic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With ammonium acetate In diphenylether at 170 - 175℃; for 0.75h; Reagent/catalyst; Solvent; Temperature;65.57%
With urea In 5,5-dimethyl-1,3-cyclohexadiene for 12h; Solvent; Temperature; Reflux;42.5%
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
31140-42-8

(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

benzene-1,2-dicarboxylic acid
88-99-3

benzene-1,2-dicarboxylic acid

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation;62%
L-glutamine
56-85-9

L-glutamine

Phthaloyl dichloride
88-95-9

Phthaloyl dichloride

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Stage #1: L-glutamine; Phthaloyl dichloride With pyridine at 10 - 15℃; for 4h;
Stage #2: With 1,1'-carbonyldiimidazole at 20℃; for 4h;
Stage #3: With hydrogenchloride In water at 5 - 20℃; for 4h; pH=7; Product distribution / selectivity;
58%
phthalic anhydride
85-44-9

phthalic anhydride

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

(RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 80℃; for 24h;55%
With triethylamine In tetrahydrofuran for 48h; Heating / reflux;54%
acetic anhydride
108-24-7

acetic anhydride

2-phthalimidoglutaramic acid
7607-72-9

2-phthalimidoglutaramic acid

thalidomide
50-35-1

thalidomide

urea
57-13-6

urea

N-phthaloylglutamic acid anhydride
3343-28-0

N-phthaloylglutamic acid anhydride

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
at 170 - 180℃;
phthalic anhydride
85-44-9

phthalic anhydride

L-glutamine
56-85-9

L-glutamine

A

thalidomide
50-35-1

thalidomide

B

Pyroglutamic acid
149-87-1

Pyroglutamic acid

Conditions
ConditionsYield
for 0.316667h; Microwave irradiation;
2-aminoacetic acid-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxo-piperidin-1-yl]methyl ester hydrochloride

2-aminoacetic acid-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxo-piperidin-1-yl]methyl ester hydrochloride

A

formaldehyd
50-00-0

formaldehyd

B

glycinate
23297-34-9

glycinate

C

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With phosphate buffer In water at 37℃; pH=7.4; Kinetics;
2-methylamino(propionic acid)-[3-(1,3-dihydro-1,3-dioxo-2H-isoindole-2-yl)-2,6-di-oxo-piperidine-1-yl-methyl]ester hydrochloride

2-methylamino(propionic acid)-[3-(1,3-dihydro-1,3-dioxo-2H-isoindole-2-yl)-2,6-di-oxo-piperidine-1-yl-methyl]ester hydrochloride

A

formaldehyd
50-00-0

formaldehyd

B

thalidomide
50-35-1

thalidomide

C

(S)-2-Methylamino-propionic acid anion

(S)-2-Methylamino-propionic acid anion

Conditions
ConditionsYield
With phosphate buffer In water at 37℃; pH=7.4; Kinetics;
2-amino-3-methylbutyric acid-[3-(1,3-dihydro-1,3-dioxo-2H-isoindole-2-yl)-2,6-dioxo-piperidine-1-yl-methyl]ester hydrochloride

2-amino-3-methylbutyric acid-[3-(1,3-dihydro-1,3-dioxo-2H-isoindole-2-yl)-2,6-dioxo-piperidine-1-yl-methyl]ester hydrochloride

A

formaldehyd
50-00-0

formaldehyd

B

thalidomide
50-35-1

thalidomide

C

L-valinate
17333-21-0

L-valinate

Conditions
ConditionsYield
With phosphate buffer In water at 37℃; pH=7.4; Kinetics;
2-[1-(4-methoxybenzyl)-2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione
222713-07-7

2-[1-(4-methoxybenzyl)-2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate In acetonitrile at 20℃; for 5h;34 mg
With ammonium cerium(IV) nitrate In water; acetonitrile for 5h;34 mg
ethyl 2-(1,3-dioxoisoindolin-2-yl)acrylate
24249-89-6

ethyl 2-(1,3-dioxoisoindolin-2-yl)acrylate

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / Na/Hg / 4 h / 20 °C
View Scheme
phthalimide
136918-14-4

phthalimide

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triphenylphosphine; sodium acetate / toluene / 0.17 h / Heating
1.2: 78 percent / acetic acid / toluene / 18 h / Heating
2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C
2.2: 58 percent / tetrahydrofuran / 0.33 h / Heating
3.1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C
4.1: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h
View Scheme
methyl 2-phthalimidoacrylate
26878-24-0

methyl 2-phthalimidoacrylate

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C
1.2: 58 percent / tetrahydrofuran / 0.33 h / Heating
2.1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C
3.1: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h
View Scheme
1-p-methoxybenzyl-3-phthalimido-5-(p-toluenesulfonyl)piperidine-2,6-dione
485817-55-8

1-p-methoxybenzyl-3-phthalimido-5-(p-toluenesulfonyl)piperidine-2,6-dione

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C
2: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h
View Scheme
Multi-step reaction with 2 steps
1: Na2HPO4; 6 percent sodium amalgam / methanol / 1 h / 20 °C
2: 34 mg / aq. ceric ammonium nitrate / acetonitrile / 5 h / 20 °C
View Scheme
3-amino-1-(4-methoxy-benzyl)-5-(toluene-4-sulfonyl)-piperidine-2,6-dione
485817-54-7

3-amino-1-(4-methoxy-benzyl)-5-(toluene-4-sulfonyl)-piperidine-2,6-dione

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 450 mg / Et3N; 4 A molecular sieves / tetrahydrofuran / 2 h / Heating
2: Na2HPO4; 6 percent sodium amalgam / methanol / 1 h / 20 °C
3: 34 mg / aq. ceric ammonium nitrate / acetonitrile / 5 h / 20 °C
View Scheme
1-p-methoxybenzyl-3-tert-butoxycarbonylamino-5-(p-toluenesulfonyl)-piperidine-2,6-dione
485817-52-5

1-p-methoxybenzyl-3-tert-butoxycarbonylamino-5-(p-toluenesulfonyl)-piperidine-2,6-dione

thalidomide
50-35-1

thalidomide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: TFA / CH2Cl2 / 0.5 h / 20 °C
2: 450 mg / Et3N; 4 A molecular sieves / tetrahydrofuran / 2 h / Heating
3: Na2HPO4; 6 percent sodium amalgam / methanol / 1 h / 20 °C
4: 34 mg / aq. ceric ammonium nitrate / acetonitrile / 5 h / 20 °C
View Scheme
thalidomide
50-35-1

thalidomide

O-acetylsalicyloyl chloride
5538-51-2

O-acetylsalicyloyl chloride

2-acetoxy-N-(2,6-dioxopiperidin-3-yl)benzamide

2-acetoxy-N-(2,6-dioxopiperidin-3-yl)benzamide

Conditions
ConditionsYield
With triethylamine In chloroform at 0 - 20℃;98%
1,4-dioxane
123-91-1

1,4-dioxane

ethyl 2-(2-bromophenyl)-2-diazoacetate
1398179-24-2

ethyl 2-(2-bromophenyl)-2-diazoacetate

thalidomide
50-35-1

thalidomide

ethyl 2-(2-bromophenyl)-2-(2-(2-(3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)ethoxy)ethoxy)acetate

ethyl 2-(2-bromophenyl)-2-(2-(2-(3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)ethoxy)ethoxy)acetate

Conditions
ConditionsYield
With potassium carbonate at 80℃; for 12h; Inert atmosphere; Schlenk technique;98%
thalidomide
50-35-1

thalidomide

A

(R)-thalidomide
2614-06-4

(R)-thalidomide

B

(S)-thalidomide
841-67-8

(S)-thalidomide

Conditions
ConditionsYield
With 2C8H8N5O2(1-)*Cu(2+) In acetonitrile at 25℃; Resolution of racemate;A 96%
B 78%
With N-[(S)-1-phenylethyl]carbamoyl-derivatized cyclofructan-6 column In ethanol; n-heptane; trifluoroacetic acid at 20℃; Resolution of racemate;
With chiral Ceramosphere RU-2 In methanol Resolution of racemate;
thalidomide
50-35-1

thalidomide

tetramethylammonium fluoride
373-68-2

tetramethylammonium fluoride

2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
42472-93-5

2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 160℃; for 12h;92%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

thalidomide
50-35-1

thalidomide

1,3-dioxo-2-(1-tert.-butoxycarbonyl-2,6-dioxopiperidin-3-yl)isoindoline
220460-69-5

1,3-dioxo-2-(1-tert.-butoxycarbonyl-2,6-dioxopiperidin-3-yl)isoindoline

Conditions
ConditionsYield
With dmap In 1,4-dioxane90%
With 2-(Dimethylamino)pyridine In 1,4-dioxane
thalidomide
50-35-1

thalidomide

3-(1-hydroxy-3-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
58585-25-4

3-(1-hydroxy-3-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione

Conditions
ConditionsYield
With acetic acid; zinc at 90℃; for 0.166667h;87%
With aluminium amalgam; water; acetic acid In ethanol for 3h; Heating;
thalidomide
50-35-1

thalidomide

propargyl bromide
106-96-7

propargyl bromide

2-[2,6-dioxo-1-(prop-2-yn-1-yl)piperidin-3-yl]isoindoline-1,3-dione

2-[2,6-dioxo-1-(prop-2-yn-1-yl)piperidin-3-yl]isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: thalidomide With potassium carbonate In acetone at 20℃; for 0.166667h;
Stage #2: propargyl bromide In acetone; toluene at 20℃; for 48h;
87%
thalidomide
50-35-1

thalidomide

tosylethylazide
113738-22-0

tosylethylazide

(±)-2-(1-(2-azidoethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

(±)-2-(1-(2-azidoethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: thalidomide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h;
Stage #2: tosylethylazide In N,N-dimethyl-formamide; mineral oil at 60℃; for 18h;
84%
thalidomide
50-35-1

thalidomide

i-pentyl bromide
107-82-4

i-pentyl bromide

2-(1-(4-methylpentyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

2-(1-(4-methylpentyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: thalidomide With sodium hydride In dimethyl sulfoxide; mineral oil for 0.25h; Inert atmosphere;
Stage #2: i-pentyl bromide In dimethyl sulfoxide; mineral oil at 20℃; Inert atmosphere;
84%
E-styryl iodide
42599-24-6

E-styryl iodide

N-(quinolin-8-yl)but‐3‐enamide

N-(quinolin-8-yl)but‐3‐enamide

thalidomide
50-35-1

thalidomide

(E)-3-((3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methyl)-5-phenyl-N-(quinolin-8-yl)pent-4-enamide

(E)-3-((3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methyl)-5-phenyl-N-(quinolin-8-yl)pent-4-enamide

Conditions
ConditionsYield
With palladium diacetate; potassium hydrogencarbonate at 100℃; regioselective reaction;83%
(Z)-1-bromo-4-hexene
63281-98-1

(Z)-1-bromo-4-hexene

thalidomide
50-35-1

thalidomide

C19H20N2O4

C19H20N2O4

Conditions
ConditionsYield
Stage #1: thalidomide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h;
Stage #2: (Z)-1-bromohex-4-ene In N,N-dimethyl-formamide; mineral oil at 0 - 20℃;
79%
thalidomide
50-35-1

thalidomide

i-pentyl bromide
107-82-4

i-pentyl bromide

2-(1-isopentyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

2-(1-isopentyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h;79%
2-fluoroethyl bromide
762-49-2

2-fluoroethyl bromide

thalidomide
50-35-1

thalidomide

(±)-2-(1-(2-fluoroethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

(±)-2-(1-(2-fluoroethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: thalidomide With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 2-fluoroethyl bromide In N,N-dimethyl-formamide at 20℃; for 72h;
77%
carbon disulfide
75-15-0

carbon disulfide

thalidomide
50-35-1

thalidomide

C14H9N2O4S2(1-)

C14H9N2O4S2(1-)

Conditions
ConditionsYield
Stage #1: carbon disulfide; thalidomide In methanol at 0 - 5℃; for 4h;
Stage #2: With sodium hydroxide In methanol for 8h;
74.6%
chloromethyl n-butyrate
33657-49-7

chloromethyl n-butyrate

thalidomide
50-35-1

thalidomide

2-(1-butyroyloxymethyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

2-(1-butyroyloxymethyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: thalidomide With caesium carbonate In DMF (N,N-dimethyl-formamide)
Stage #2: chloromethyl n-butyrate In DMF (N,N-dimethyl-formamide) at 20℃; for 20h;
74%
thalidomide
50-35-1

thalidomide

(R,S)-2-(1-(hydroxymethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
145945-21-7

(R,S)-2-(1-(hydroxymethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With formaldehyd In water at 25℃; Reflux;74%
thalidomide
50-35-1

thalidomide

1,3-dioxo-2-(2-oxo-6-thioxopiperidin-3-yl)isoindoline

1,3-dioxo-2-(2-oxo-6-thioxopiperidin-3-yl)isoindoline

Conditions
ConditionsYield
With Lawessons reagent In toluene for 12h; Heating / reflux;73%
thalidomide
50-35-1

thalidomide

methyl iodide
74-88-4

methyl iodide

2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
42472-93-5

2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;72.3%
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