We are the manufacuter of this item in China and produced this item for more than 10 years.Appearance:A White or almost white crystalline powder Storage:normal Package:25kgs net carton drums Application:API Transportation:normal
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:50-35-1
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Thalidomide The alias:(+-)-THALIDOMIDE >98% IMMUNOSUPPRESSIVE, SE;α-Phthalimidoglutarimide CAS NO:50-35-1 Molecular formula:C13H10N2O4 Molecular weight:258.2295 Product Quality 12 years of chemical raw materials Mature opera
Cas:50-35-1
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:50-35-1
Min.Order:1 Gram
FOB Price: $6.0 / 9.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:50-35-1
Min.Order:1 Metric Ton
FOB Price: $500.0
Type:Lab/Research institutions
inquiryPackage : 25kg/carton, or at customer's requirements Storage: Store in a cool, dry place and keep away from direct strong light. Shelf Life :2 years Appearance:Yellow crystalline or yellow crystal powder. Storage:Stored in dry
Appearance:White?to?off-white?powder Storage:R.T Package:25kg/Barrel Application:It has the effects of sedation, anti-inflammatory, immune regulation and anti-tumor angiogenesis. Transportation:Express/Sea/Air Port:Any port in China
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $100.0 / 680.0
Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $76.0 / 84.0
Type:Trading Company
inquiryThalidomide CAS: 50-35-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:50-35-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:50-35-1
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:50-35-1
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $60.0 / 80.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:50-35-1
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:50-35-1
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:50-35-1
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:50-35-1
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With acetic acid; triethylamine for 3h; Temperature; Reagent/catalyst; Concentration; Reflux; | 95% |
Conditions | Yield |
---|---|
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 16h; Reflux; Inert atmosphere; | 91% |
phthalic anhydride
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
thalidomide
Conditions | Yield |
---|---|
With 2,2,2-trifluoroethanol at 150℃; for 2h; Reagent/catalyst; Microwave irradiation; | 91% |
In 2,2,2-trifluoroethanol at 150℃; for 2h; Solvent; | 91% |
With sodium acetate; acetic acid for 6h; Reflux; |
Conditions | Yield |
---|---|
With Glutamic acid; ammonium acetate at 150℃; for 0.166667h; Reagent/catalyst; Microwave irradiation; Sealed tube; Green chemistry; | A 90% B 7% |
carbon monoxide
(+/-)-α-aminoglutarimide
1,2-dibromobenzene
thalidomide
Conditions | Yield |
---|---|
With palladium diacetate; triethylamine; catacxium A In N,N-dimethyl acetamide at 100℃; under 22502.3 Torr; for 30h; Autoclave; Inert atmosphere; | 87% |
Conditions | Yield |
---|---|
With dmap; ammonium chloride at 150℃; for 0.166667h; Microwave irradiation; Sealed tube; Green chemistry; | 86% |
Conditions | Yield |
---|---|
With thiourea for 0.25h; Microwave irradiation; | 85% |
Conditions | Yield |
---|---|
With urea at 170 - 180℃; for 0.75h; | 75% |
With urea at 180℃; | 70% |
Stage #1: N-phthaloylglutamic acid anhydride With ammonia In N,N-dimethyl-formamide at 25℃; for 14h; Stage #2: With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 100℃; for 1h; | 68.3% |
2-[2,6-dioxo-5-(toluene-4-sulfonyl)-piperidin-3-yl]-isoindole-1,3-dione
thalidomide
Conditions | Yield |
---|---|
With sodium amalgam at 20℃; for 4h; | 72% |
Conditions | Yield |
---|---|
Stage #1: L-glutamine; phthalic acid dimethyl ester With pyridine at 20 - 85℃; for 6h; Stage #2: With 1,1'-carbonyldiimidazole at 40℃; for 2h; Stage #3: With hydrogenchloride In ethanol; water at 5 - 25℃; for 4h; pH=7; Product distribution / selectivity; | 72% |
Conditions | Yield |
---|---|
Stage #1: phthalic anhydride; L-glutamine In ISOPROPYLAMIDE at 20 - 80℃; for 6h; Stage #2: With 1,1'-carbonyldiimidazole In ISOPROPYLAMIDE at 20 - 90℃; for 4h; Product distribution / selectivity; | 71% |
Stage #1: phthalic anhydride; L-glutamine In 1-methyl-pyrrolidin-2-one at 20 - 80℃; for 6h; Stage #2: With 1,1'-carbonyldiimidazole In 1-methyl-pyrrolidin-2-one at 20 - 90℃; for 4h; Product distribution / selectivity; | 65% |
Stage #1: phthalic anhydride; L-glutamine In DMF (N,N-dimethyl-formamide) at 20 - 80℃; for 6h; Stage #2: With 1,1'-carbonyldiimidazole In DMF (N,N-dimethyl-formamide) at 20 - 90℃; for 4h; Product distribution / selectivity; | 63% |
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In ISOPROPYLAMIDE at 20 - 90℃; for 4h; Product distribution / selectivity; | 71% |
With 1,1'-carbonyldiimidazole In 1-methyl-pyrrolidin-2-one at 20 - 90℃; for 4h; Product distribution / selectivity; | 65% |
With 1,1'-carbonyldiimidazole In dimethyl sulfoxide at 20 - 90℃; for 4h; Product distribution / selectivity; | 62% |
Conditions | Yield |
---|---|
With ammonium acetate In diphenylether at 170 - 175℃; for 0.75h; Reagent/catalyst; Solvent; Temperature; | 65.57% |
With urea In 5,5-dimethyl-1,3-cyclohexadiene for 12h; Solvent; Temperature; Reflux; | 42.5% |
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester
benzene-1,2-dicarboxylic acid
thalidomide
Conditions | Yield |
---|---|
With 2,2,2-trifluoroethanol at 150℃; for 2h; Microwave irradiation; | 62% |
Conditions | Yield |
---|---|
Stage #1: L-glutamine; Phthaloyl dichloride With pyridine at 10 - 15℃; for 4h; Stage #2: With 1,1'-carbonyldiimidazole at 20℃; for 4h; Stage #3: With hydrogenchloride In water at 5 - 20℃; for 4h; pH=7; Product distribution / selectivity; | 58% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 80℃; for 24h; | 55% |
With triethylamine In tetrahydrofuran for 48h; Heating / reflux; | 54% |
Conditions | Yield |
---|---|
at 170 - 180℃; |
Conditions | Yield |
---|---|
for 0.316667h; Microwave irradiation; |
Conditions | Yield |
---|---|
With phosphate buffer In water at 37℃; pH=7.4; Kinetics; |
Conditions | Yield |
---|---|
With phosphate buffer In water at 37℃; pH=7.4; Kinetics; |
Conditions | Yield |
---|---|
With phosphate buffer In water at 37℃; pH=7.4; Kinetics; |
2-[1-(4-methoxybenzyl)-2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione
thalidomide
Conditions | Yield |
---|---|
With ammonium cerium(IV) nitrate In acetonitrile at 20℃; for 5h; | 34 mg |
With ammonium cerium(IV) nitrate In water; acetonitrile for 5h; | 34 mg |
ethyl 2-(1,3-dioxoisoindolin-2-yl)acrylate
thalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 72 percent / Na/Hg / 4 h / 20 °C View Scheme |
phthalimide
thalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triphenylphosphine; sodium acetate / toluene / 0.17 h / Heating 1.2: 78 percent / acetic acid / toluene / 18 h / Heating 2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 2.2: 58 percent / tetrahydrofuran / 0.33 h / Heating 3.1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C 4.1: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h View Scheme |
methyl 2-phthalimidoacrylate
thalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 1.2: 58 percent / tetrahydrofuran / 0.33 h / Heating 2.1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C 3.1: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h View Scheme |
1-p-methoxybenzyl-3-phthalimido-5-(p-toluenesulfonyl)piperidine-2,6-dione
thalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C 2: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h View Scheme | |
Multi-step reaction with 2 steps 1: Na2HPO4; 6 percent sodium amalgam / methanol / 1 h / 20 °C 2: 34 mg / aq. ceric ammonium nitrate / acetonitrile / 5 h / 20 °C View Scheme |
3-amino-1-(4-methoxy-benzyl)-5-(toluene-4-sulfonyl)-piperidine-2,6-dione
thalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 450 mg / Et3N; 4 A molecular sieves / tetrahydrofuran / 2 h / Heating 2: Na2HPO4; 6 percent sodium amalgam / methanol / 1 h / 20 °C 3: 34 mg / aq. ceric ammonium nitrate / acetonitrile / 5 h / 20 °C View Scheme |
1-p-methoxybenzyl-3-tert-butoxycarbonylamino-5-(p-toluenesulfonyl)-piperidine-2,6-dione
thalidomide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: TFA / CH2Cl2 / 0.5 h / 20 °C 2: 450 mg / Et3N; 4 A molecular sieves / tetrahydrofuran / 2 h / Heating 3: Na2HPO4; 6 percent sodium amalgam / methanol / 1 h / 20 °C 4: 34 mg / aq. ceric ammonium nitrate / acetonitrile / 5 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With triethylamine In chloroform at 0 - 20℃; | 98% |
Conditions | Yield |
---|---|
With potassium carbonate at 80℃; for 12h; Inert atmosphere; Schlenk technique; | 98% |
Conditions | Yield |
---|---|
With 2C8H8N5O2(1-)*Cu(2+) In acetonitrile at 25℃; Resolution of racemate; | A 96% B 78% |
With N-[(S)-1-phenylethyl]carbamoyl-derivatized cyclofructan-6 column In ethanol; n-heptane; trifluoroacetic acid at 20℃; Resolution of racemate; | |
With chiral Ceramosphere RU-2 In methanol Resolution of racemate; |
thalidomide
tetramethylammonium fluoride
2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 160℃; for 12h; | 92% |
di-tert-butyl dicarbonate
thalidomide
1,3-dioxo-2-(1-tert.-butoxycarbonyl-2,6-dioxopiperidin-3-yl)isoindoline
Conditions | Yield |
---|---|
With dmap In 1,4-dioxane | 90% |
With 2-(Dimethylamino)pyridine In 1,4-dioxane |
thalidomide
3-(1-hydroxy-3-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
Conditions | Yield |
---|---|
With acetic acid; zinc at 90℃; for 0.166667h; | 87% |
With aluminium amalgam; water; acetic acid In ethanol for 3h; Heating; |
Conditions | Yield |
---|---|
Stage #1: thalidomide With potassium carbonate In acetone at 20℃; for 0.166667h; Stage #2: propargyl bromide In acetone; toluene at 20℃; for 48h; | 87% |
thalidomide
tosylethylazide
Conditions | Yield |
---|---|
Stage #1: thalidomide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h; Stage #2: tosylethylazide In N,N-dimethyl-formamide; mineral oil at 60℃; for 18h; | 84% |
Conditions | Yield |
---|---|
Stage #1: thalidomide With sodium hydride In dimethyl sulfoxide; mineral oil for 0.25h; Inert atmosphere; Stage #2: i-pentyl bromide In dimethyl sulfoxide; mineral oil at 20℃; Inert atmosphere; | 84% |
E-styryl iodide
thalidomide
Conditions | Yield |
---|---|
With palladium diacetate; potassium hydrogencarbonate at 100℃; regioselective reaction; | 83% |
Conditions | Yield |
---|---|
Stage #1: thalidomide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Stage #2: (Z)-1-bromohex-4-ene In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; | 79% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h; | 79% |
Conditions | Yield |
---|---|
Stage #1: thalidomide With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 2-fluoroethyl bromide In N,N-dimethyl-formamide at 20℃; for 72h; | 77% |
Conditions | Yield |
---|---|
Stage #1: carbon disulfide; thalidomide In methanol at 0 - 5℃; for 4h; Stage #2: With sodium hydroxide In methanol for 8h; | 74.6% |
chloromethyl n-butyrate
thalidomide
Conditions | Yield |
---|---|
Stage #1: thalidomide With caesium carbonate In DMF (N,N-dimethyl-formamide) Stage #2: chloromethyl n-butyrate In DMF (N,N-dimethyl-formamide) at 20℃; for 20h; | 74% |
thalidomide
(R,S)-2-(1-(hydroxymethyl)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Conditions | Yield |
---|---|
With formaldehyd In water at 25℃; Reflux; | 74% |
thalidomide
Conditions | Yield |
---|---|
With Lawessons reagent In toluene for 12h; Heating / reflux; | 73% |
thalidomide
methyl iodide
2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere; | 72.3% |
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