As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryProduct Name: 2-Amino-4-chloropyrimidine Synonyms: AKOS BBS-00005838;4-CHLOROPYRIMIDIN-2-AMINE;2-PYRIMIDINAMINE, 4-CHLORO-;2-AMINO-4-CHLOROPYRIMIDINE;CHLORO-ISO-CYTOSINE;2-Pyrimidinamine, 4-chloro- (9CI);2-
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inquiry2-Amino-4-chloropyrimidine CAS:3993-78-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi
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Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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Cas:3993-78-0
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiry2-Amino-4-chloropyrimidine wih good price and high quality factory supply Appearance:white powder Application:Pharmaceutical intermediate
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Min.Order:2 Kilogram
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:3993-78-0
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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Min.Order:1 Gram
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inquiry2-Amino-4-chloropyrimidine Basic information Product Name: 2-Amino-4-chloropyrimidine Synonyms: AKOS BBS-00005838;4-CHLOROPYRIMIDIN-2-AMINE;2-PYRIMIDINAMINE, 4-CHLORO-;2-AMINO-4-CHLOROPYRIMIDINE;CHLORO-ISO-CYTOSINE;2-Pyrimidinamine, 4-chloro- (
Cas:3993-78-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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Min.Order:1 Kilogram
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Type:Trading Company
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Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:3993-78-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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Min.Order:1 Metric Ton
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Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
4-chloro-2-methanesulfonylpyrimidine
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With aq. NH3 In isopropyl alcohol | 100% |
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent); | 95% |
With trichlorophosphate for 1.5h; Heating; | 52% |
Conditions | Yield |
---|---|
Stage #1: isocytosine With chlorosulfonic acid; trichlorophosphate at 20 - 95℃; Inert atmosphere; Stage #2: With ammonium hydroxide In water at 20℃; pH=~ 7; Cooling wit ice; | 92% |
Stage #1: isocytosine With trichlorophosphate for 1.5h; Reflux; Stage #2: With sodium carbonate In water pH=9; Cooling with ice; | 52% |
Conditions | Yield |
---|---|
With chlorosulfonic acid; trichlorophosphate at -5 - 90℃; for 5h; Inert atmosphere; | 73% |
2,6-Dichloropyrimidine
A
2-chloropyrimidin-4-amine
B
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With ammonium hydroxide In water at 20℃; | A 69% B 23% |
With ammonium hydroxide at 20℃; for 5h; | A 59% B 37% |
With ammonium hydroxide In water at 20℃; for 5h; | A 59% B 37% |
Conditions | Yield |
---|---|
With ammonia; water | |
With ammonium hydroxide at 20℃; for 16h; |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With sulfuric acid; trichlorophosphate | |
With chlorosulphuric acid; trichlorophosphate |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With trichlorophosphate |
2,6-Dichloropyrimidine
ammonia
A
2-chloropyrimidin-4-amine
B
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
at 100℃; |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With ammonia | 51.3 g |
2-amino-4-chloropyrimidine
cyclopropanemethylamine
N4-(cyclopropylmethyl)pyrimidine-2,4-diamine
Conditions | Yield |
---|---|
In ethanol at 100℃; for 16h; | 100% |
tert-butyl (1S)-2-(3-aminophenoxy)-1-(1H-indol-3-ylmethyl)ethylcarbamate
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
In ethanol | 98% |
In ethanol at 80℃; for 13h; | 98% |
(4-cyano-3-fluorophenyl)boronic acid
2-amino-4-chloropyrimidine
4-(2-amino-4-pyrimidinyl)-2-fluorobenzonitrile
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki Coupling; Inert atmosphere; | 97% |
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki coupling; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux; | 95% |
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux; | 95% |
With potassium carbonate In dimethyl sulfoxide at 100℃; for 0.333333h; Microwave irradiation; | 93% |
2-amino-4-chloropyrimidine
2-amino-4-iodopyrimidine
Conditions | Yield |
---|---|
With hydrogen iodide In water at 0 - 20℃; for 3h; | 95% |
With hydrogen iodide; sodium iodide In water at 20℃; for 3.5h; | 86% |
Conditions | Yield |
---|---|
With hydrogenchloride for 2h; Heating; | 94% |
2-amino-4-chloropyrimidine
amino-4 hydroxy-2 toluene
5-(2-aminopyrimidin-4-ylamino)-2-methylphenol
Conditions | Yield |
---|---|
Stage #1: 2-amino-4-chloropyrimidine; amino-4 hydroxy-2 toluene With hydrogenchloride In ethanol; water at 90℃; for 18h; Stage #2: With potassium carbonate In ethanol; water; ethyl acetate Product distribution / selectivity; | 94% |
With hydrogenchloride In ethanol; water at 80 - 90℃; Product distribution / selectivity; |
2-amino-4-chloropyrimidine
6-bromo-5-methoxy-1H-indole
Conditions | Yield |
---|---|
Stage #1: 6-bromo-5-methoxy-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 15℃; for 0.5h; Stage #2: 2-amino-4-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 80℃; for 18h; | 94% |
(4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; | 93% |
2-amino-4-chloropyrimidine
m-nitrobenzene boronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane at 95℃; Inert atmosphere; | 93% |
2-amino-4-chloropyrimidine
4-hydrazinylpyrimidin-2-amine
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 80 - 100℃; Microwave irradiation; | 93% |
2-amino-4-chloropyrimidine
5-methoxy-4-aza-1H-indole
Conditions | Yield |
---|---|
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 2h; | 92.13% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 92% |
With methanol | |
In methanol at 50℃; for 2.5h; |
4-chloro-2-methanesulfonylpyrimidine
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With aq. NH3 In isopropyl alcohol | 100% |
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent); | 95% |
With trichlorophosphate for 1.5h; Heating; | 52% |
Conditions | Yield |
---|---|
Stage #1: isocytosine With chlorosulfonic acid; trichlorophosphate at 20 - 95℃; Inert atmosphere; Stage #2: With ammonium hydroxide In water at 20℃; pH=~ 7; Cooling wit ice; | 92% |
Stage #1: isocytosine With trichlorophosphate for 1.5h; Reflux; Stage #2: With sodium carbonate In water pH=9; Cooling with ice; | 52% |
Conditions | Yield |
---|---|
With chlorosulfonic acid; trichlorophosphate at -5 - 90℃; for 5h; Inert atmosphere; | 73% |
2,6-Dichloropyrimidine
A
2-chloropyrimidin-4-amine
B
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With ammonium hydroxide In water at 20℃; | A 69% B 23% |
With ammonium hydroxide at 20℃; for 5h; | A 59% B 37% |
With ammonium hydroxide In water at 20℃; for 5h; | A 59% B 37% |
Conditions | Yield |
---|---|
With ammonia; water | |
With ammonium hydroxide at 20℃; for 16h; |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With sulfuric acid; trichlorophosphate | |
With chlorosulphuric acid; trichlorophosphate |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With trichlorophosphate |
2,6-Dichloropyrimidine
ammonia
A
2-chloropyrimidin-4-amine
B
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
at 100℃; |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With ammonia | 51.3 g |
2-amino-4-chloropyrimidine
cyclopropanemethylamine
N4-(cyclopropylmethyl)pyrimidine-2,4-diamine
Conditions | Yield |
---|---|
In ethanol at 100℃; for 16h; | 100% |
tert-butyl (1S)-2-(3-aminophenoxy)-1-(1H-indol-3-ylmethyl)ethylcarbamate
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
In ethanol | 98% |
In ethanol at 80℃; for 13h; | 98% |
(4-cyano-3-fluorophenyl)boronic acid
2-amino-4-chloropyrimidine
4-(2-amino-4-pyrimidinyl)-2-fluorobenzonitrile
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki Coupling; Inert atmosphere; | 97% |
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki coupling; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux; | 95% |
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux; | 95% |
With potassium carbonate In dimethyl sulfoxide at 100℃; for 0.333333h; Microwave irradiation; | 93% |
2-amino-4-chloropyrimidine
2-amino-4-iodopyrimidine
Conditions | Yield |
---|---|
With hydrogen iodide In water at 0 - 20℃; for 3h; | 95% |
With hydrogen iodide; sodium iodide In water at 20℃; for 3.5h; | 86% |
Conditions | Yield |
---|---|
With hydrogenchloride for 2h; Heating; | 94% |
2-amino-4-chloropyrimidine
amino-4 hydroxy-2 toluene
5-(2-aminopyrimidin-4-ylamino)-2-methylphenol
Conditions | Yield |
---|---|
Stage #1: 2-amino-4-chloropyrimidine; amino-4 hydroxy-2 toluene With hydrogenchloride In ethanol; water at 90℃; for 18h; Stage #2: With potassium carbonate In ethanol; water; ethyl acetate Product distribution / selectivity; | 94% |
With hydrogenchloride In ethanol; water at 80 - 90℃; Product distribution / selectivity; |
2-amino-4-chloropyrimidine
6-bromo-5-methoxy-1H-indole
Conditions | Yield |
---|---|
Stage #1: 6-bromo-5-methoxy-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 15℃; for 0.5h; Stage #2: 2-amino-4-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 80℃; for 18h; | 94% |
(4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; | 93% |
2-amino-4-chloropyrimidine
m-nitrobenzene boronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane at 95℃; Inert atmosphere; | 93% |
2-amino-4-chloropyrimidine
4-hydrazinylpyrimidin-2-amine
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 80 - 100℃; Microwave irradiation; | 93% |
2-amino-4-chloropyrimidine
5-methoxy-4-aza-1H-indole
Conditions | Yield |
---|---|
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 2h; | 92.13% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 92% |
With methanol | |
In methanol at 50℃; for 2.5h; |
2-amino-4-chloropyrimidine
6-bromo-indoline
4-(6-bromoindolin-1-yl)pyrimidin-2-amine
Conditions | Yield |
---|---|
In 1,4-dioxane at 90℃; for 21h; | 92% |
With hydrogenchloride In water at 60℃; | 80% |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube; | 92% |
Conditions | Yield |
---|---|
In ethanol at 80℃; for 2.5h; | 91% |
2-amino-4-chloropyrimidine
(2-fluoro-pyridin-3-yl)boronic acid
Conditions | Yield |
---|---|
With bis(di-tert-butylphenylphosphine)palladium(II) dichloride; potassium acetate In water; acetonitrile at 85℃; for 15h; Sealed tube; Inert atmosphere; | 91% |
pyrrolidine
2-amino-4-chloropyrimidine
4-(pyrrolidin-1-yl)pyrimidin-2-amine
Conditions | Yield |
---|---|
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 20 - 120℃; Inert atmosphere; | 89.7% |
at 150℃; for 1h; Microwave irradiation; | 67% |
at 150℃; for 1h; Microwave irradiation; Sealed tube; | 67% |
1-indoline
2-amino-4-chloropyrimidine
isopropyl alcohol
2-amino-4-(indolin-1-yl)pyrimidine
Conditions | Yield |
---|---|
With potassium hydroxide In 1,4-dioxane; water | 89.6% |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 90℃; for 2h; Inert atmosphere; | 89.01% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 90℃; for 2h; Inert atmosphere; | 89.01% |
Conditions | Yield |
---|---|
In ethanol at 150℃; for 0.166667h; Microwave irradiation; Sealed tube; | 89% |
at 120℃; for 0.166667h; Microwave irradiation; | 54% |
6-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]
2-amino-4-chloropyrimidine
4-(6-bromo-2',3',5',6'-tetrahydrospiro[indole-3,4'-pyran]-1(2H)-yl)pyrimidin-2-amine
Conditions | Yield |
---|---|
Stage #1: 6-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]; 2-amino-4-chloropyrimidine With hydrogenchloride In water at 60℃; for 17.5h; Stage #2: With sodium hydroxide In water Cooling; | 88.3% |
2-[4-(4-amino-2-fluoro-phenoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]-ethanol
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
Stage #1: 2-[4-(4-amino-2-fluoro-phenoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]-ethanol; 2-amino-4-chloropyrimidine With hydrogenchloride In water Heating / reflux; Stage #2: With sodium hydroxide In water pH=10; | 88% |
2-amino-4-chloropyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In ethanol at 40℃; for 3h; Inert atmosphere; | 88% |
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
2-amino-4-chloropyrimidine
4-(1H-indol-3-yl)pyrimidin-2-amine
Conditions | Yield |
---|---|
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); caesium carbonate In water; isopropyl alcohol at 80℃; for 16h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; | 87% |
With caesium carbonate In methanol at 100℃; for 24h; Suzuki coupling; Inert atmosphere; | 73% |
2-amino-4-chloropyrimidine
2-Methoxyphenylboronic acid
4-(2-methoxyphenyl)pyrimidin-2-amine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 100℃; for 2h; Inert atmosphere; | 87% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 95℃; for 2h; Suzuki-Miyaura Coupling; Inert atmosphere; | 86% |
2-amino-4-chloropyrimidine
2-amino-5-bromo-4-chloropyrimidine
Conditions | Yield |
---|---|
With bromine; acetic acid at 20℃; for 2h; | 86% |
With N-Bromosuccinimide In chloroform at 20℃; | 62% |
With N-Bromosuccinimide In methanol; acetonitrile at 20℃; for 0.5h; |
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