2-Amino-4-chloropyrimidine supplier

Name
2-Amino-4-chloropyrimidine
EINECS
CAS No. 3993-78-0
Article Data27
CAS DataBase
Density 1.437g/cm³
Solubility
Melting Point 155-160 °C (dec.)
Formula C₄H₄ClN₃
Boiling Point 314.609 °C at 760 mmHg
Molecular Weight 129.549
Flash Point 144.07 °C
Transport Information
Appearance White solid
Safety 26-36/37/39-36/39
Risk Codes 36/37/38-41-37/38-22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Pyrimidine,2-amino-4-chloro- (6CI,7CI,8CI);(4-Chloropyrimidin-2-yl)amine;4-Chloro-2-pyrimidinamine;NSC 10872;NSC 25184;2-Amino-4-chloridepyrimidine;
PSA 51.80000
LogP 1.29340

Synthetic route

: 97229-11-3
4-chloro-2-methanesulfonylpyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With aq. NH3 In isopropyl alcohol	100%

: 108-53-2
2-amino-4-hydroxypyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent);	95%
With trichlorophosphate for 1.5h; Heating;	52%

: 108-53-2
isocytosine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
Stage #1: isocytosine With chlorosulfonic acid; trichlorophosphate at 20 - 95℃; Inert atmosphere; Stage #2: With ammonium hydroxide In water at 20℃; pH=~ 7; Cooling wit ice;	92%
Stage #1: isocytosine With trichlorophosphate for 1.5h; Reflux; Stage #2: With sodium carbonate In water pH=9; Cooling with ice;	52%

: 108-53-2
isocytosine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With chlorosulfonic acid; trichlorophosphate at -5 - 90℃; for 5h; Inert atmosphere;	73%

: 3934-20-1
2,6-Dichloropyrimidine

A: 7461-50-9
2-chloropyrimidin-4-amine

B: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 20℃;	A 69% B 23%
With ammonium hydroxide at 20℃; for 5h;	A 59% B 37%
With ammonium hydroxide In water at 20℃; for 5h;	A 59% B 37%

: 3934-20-1
2,6-Dichloropyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With ammonia; water
With ammonium hydroxide at 20℃; for 16h;

2-amino-3H-pyrimidin-2-one: 2-amino-3H-pyrimidin-2-one

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With sulfuric acid; trichlorophosphate
With chlorosulphuric acid; trichlorophosphate

4-oxy-2-amino-pyrimidine: 4-oxy-2-amino-pyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate

: 3934-20-1
2,6-Dichloropyrimidine

: 7664-41-7
ammonia

A: 7461-50-9
2-chloropyrimidin-4-amine

B: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
at 100℃;

...Expand

: 2-nitro-3H-4-chloropyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With ammonia	51.3 g

: 3993-78-0
2-amino-4-chloropyrimidine

: 2516-47-4
cyclopropanemethylamine

: 1169699-05-1
N4-(cyclopropylmethyl)pyrimidine-2,4-diamine

Conditions

Conditions	Yield
In ethanol at 100℃; for 16h;	100%

: 552330-61-7
tert-butyl (1S)-2-(3-aminophenoxy)-1-(1H-indol-3-ylmethyl)ethylcarbamate

: 3993-78-0
2-amino-4-chloropyrimidine

: tert-butyl (1S)-2-{3-[(2-aminopyrimidin-4-yl)amino]phenoxy}-1-(1H-indol-3-ylmethyl)ethylcarbamate

Conditions

Conditions	Yield
In ethanol	98%
In ethanol at 80℃; for 13h;	98%

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 3993-78-0
2-amino-4-chloropyrimidine

: 1238077-12-7
4-(2-amino-4-pyrimidinyl)-2-fluorobenzonitrile

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki Coupling; Inert atmosphere;	97%
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki coupling; Inert atmosphere;	83%

: 110-91-8
morpholine

: 3993-78-0
2-amino-4-chloropyrimidine

: 4-morpholin-4-ylpyrimidin-2-ylamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux;	95%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux;	95%
With potassium carbonate In dimethyl sulfoxide at 100℃; for 0.333333h; Microwave irradiation;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 815610-16-3
2-amino-4-iodopyrimidine

Conditions

Conditions	Yield
With hydrogen iodide In water at 0 - 20℃; for 3h;	95%
With hydrogen iodide; sodium iodide In water at 20℃; for 3.5h;	86%

: 3993-78-0
2-amino-4-chloropyrimidine

: 108-42-9
3-chloro-aniline

: N4-(3-chlorophenyl)pyrimidine-2,4-diamine

Conditions

Conditions	Yield
With hydrogenchloride for 2h; Heating;	94%

: 3993-78-0
2-amino-4-chloropyrimidine

: 2835-95-2
amino-4 hydroxy-2 toluene

: 933045-98-8
5-(2-aminopyrimidin-4-ylamino)-2-methylphenol

Conditions

Conditions	Yield
Stage #1: 2-amino-4-chloropyrimidine; amino-4 hydroxy-2 toluene With hydrogenchloride In ethanol; water at 90℃; for 18h; Stage #2: With potassium carbonate In ethanol; water; ethyl acetate Product distribution / selectivity;	94%
With hydrogenchloride In ethanol; water at 80 - 90℃; Product distribution / selectivity;

: 3993-78-0
2-amino-4-chloropyrimidine

: 106103-36-0
6-bromo-5-methoxy-1H-indole

: 4-(6-bromo-5-methoxy-1H-indol-1-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
Stage #1: 6-bromo-5-methoxy-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 15℃; for 0.5h; Stage #2: 2-amino-4-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 80℃; for 18h;	94%

: 1369257-58-8
(4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol

: 3993-78-0
2-amino-4-chloropyrimidine

: 4-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)pyrimidin-2-amine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 13331-27-6
m-nitrobenzene boronic acid

: 4-(3-nitrophenyl)-2-aminopyrimidine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane at 95℃; Inert atmosphere;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 33575-09-6
4-hydrazinylpyrimidin-2-amine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 80 - 100℃; Microwave irradiation;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 17288-40-3
5-methoxy-4-aza-1H-indole

: 4-(5-methoxy-1H-pyrrolo[3,2-b]pyridin-1-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 2h;	92.13%

: 3993-78-0
2-amino-4-chloropyrimidine

: 124-41-4
sodium methylate

: 155-90-8
4-methoxypyrimidin-2-amine

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	92%
With methanol
In methanol at 50℃; for 2.5h;

: 97229-11-3
4-chloro-2-methanesulfonylpyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With aq. NH3 In isopropyl alcohol	100%

: 108-53-2
2-amino-4-hydroxypyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent);	95%
With trichlorophosphate for 1.5h; Heating;	52%

: 108-53-2
isocytosine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
Stage #1: isocytosine With chlorosulfonic acid; trichlorophosphate at 20 - 95℃; Inert atmosphere; Stage #2: With ammonium hydroxide In water at 20℃; pH=~ 7; Cooling wit ice;	92%
Stage #1: isocytosine With trichlorophosphate for 1.5h; Reflux; Stage #2: With sodium carbonate In water pH=9; Cooling with ice;	52%

: 108-53-2
isocytosine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With chlorosulfonic acid; trichlorophosphate at -5 - 90℃; for 5h; Inert atmosphere;	73%

: 3934-20-1
2,6-Dichloropyrimidine

A: 7461-50-9
2-chloropyrimidin-4-amine

B: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 20℃;	A 69% B 23%
With ammonium hydroxide at 20℃; for 5h;	A 59% B 37%
With ammonium hydroxide In water at 20℃; for 5h;	A 59% B 37%

: 3934-20-1
2,6-Dichloropyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With ammonia; water
With ammonium hydroxide at 20℃; for 16h;

2-amino-3H-pyrimidin-2-one: 2-amino-3H-pyrimidin-2-one

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With sulfuric acid; trichlorophosphate
With chlorosulphuric acid; trichlorophosphate

4-oxy-2-amino-pyrimidine: 4-oxy-2-amino-pyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate

: 3934-20-1
2,6-Dichloropyrimidine

: 7664-41-7
ammonia

A: 7461-50-9
2-chloropyrimidin-4-amine

B: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
at 100℃;

...Expand

: 2-nitro-3H-4-chloropyrimidine

: 3993-78-0
2-amino-4-chloropyrimidine

Conditions

Conditions	Yield
With ammonia	51.3 g

: 3993-78-0
2-amino-4-chloropyrimidine

: 2516-47-4
cyclopropanemethylamine

: 1169699-05-1
N4-(cyclopropylmethyl)pyrimidine-2,4-diamine

Conditions

Conditions	Yield
In ethanol at 100℃; for 16h;	100%

: 552330-61-7
tert-butyl (1S)-2-(3-aminophenoxy)-1-(1H-indol-3-ylmethyl)ethylcarbamate

: 3993-78-0
2-amino-4-chloropyrimidine

: tert-butyl (1S)-2-{3-[(2-aminopyrimidin-4-yl)amino]phenoxy}-1-(1H-indol-3-ylmethyl)ethylcarbamate

Conditions

Conditions	Yield
In ethanol	98%
In ethanol at 80℃; for 13h;	98%

: 843663-18-3
(4-cyano-3-fluorophenyl)boronic acid

: 3993-78-0
2-amino-4-chloropyrimidine

: 1238077-12-7
4-(2-amino-4-pyrimidinyl)-2-fluorobenzonitrile

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki Coupling; Inert atmosphere;	97%
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 95℃; for 3h; Suzuki coupling; Inert atmosphere;	83%

: 110-91-8
morpholine

: 3993-78-0
2-amino-4-chloropyrimidine

: 4-morpholin-4-ylpyrimidin-2-ylamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux;	95%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 4h; Reflux;	95%
With potassium carbonate In dimethyl sulfoxide at 100℃; for 0.333333h; Microwave irradiation;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 815610-16-3
2-amino-4-iodopyrimidine

Conditions

Conditions	Yield
With hydrogen iodide In water at 0 - 20℃; for 3h;	95%
With hydrogen iodide; sodium iodide In water at 20℃; for 3.5h;	86%

: 3993-78-0
2-amino-4-chloropyrimidine

: 108-42-9
3-chloro-aniline

: N4-(3-chlorophenyl)pyrimidine-2,4-diamine

Conditions

Conditions	Yield
With hydrogenchloride for 2h; Heating;	94%

: 3993-78-0
2-amino-4-chloropyrimidine

: 2835-95-2
amino-4 hydroxy-2 toluene

: 933045-98-8
5-(2-aminopyrimidin-4-ylamino)-2-methylphenol

Conditions

Conditions	Yield
Stage #1: 2-amino-4-chloropyrimidine; amino-4 hydroxy-2 toluene With hydrogenchloride In ethanol; water at 90℃; for 18h; Stage #2: With potassium carbonate In ethanol; water; ethyl acetate Product distribution / selectivity;	94%
With hydrogenchloride In ethanol; water at 80 - 90℃; Product distribution / selectivity;

: 3993-78-0
2-amino-4-chloropyrimidine

: 106103-36-0
6-bromo-5-methoxy-1H-indole

: 4-(6-bromo-5-methoxy-1H-indol-1-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
Stage #1: 6-bromo-5-methoxy-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 15℃; for 0.5h; Stage #2: 2-amino-4-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 80℃; for 18h;	94%

: 1369257-58-8
(4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol

: 3993-78-0
2-amino-4-chloropyrimidine

: 4-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)pyrimidin-2-amine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 13331-27-6
m-nitrobenzene boronic acid

: 4-(3-nitrophenyl)-2-aminopyrimidine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane at 95℃; Inert atmosphere;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 33575-09-6
4-hydrazinylpyrimidin-2-amine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 80 - 100℃; Microwave irradiation;	93%

: 3993-78-0
2-amino-4-chloropyrimidine

: 17288-40-3
5-methoxy-4-aza-1H-indole

: 4-(5-methoxy-1H-pyrrolo[3,2-b]pyridin-1-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 2h;	92.13%

: 3993-78-0
2-amino-4-chloropyrimidine

: 124-41-4
sodium methylate

: 155-90-8
4-methoxypyrimidin-2-amine

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	92%
With methanol
In methanol at 50℃; for 2.5h;

: 3993-78-0
2-amino-4-chloropyrimidine

: 63839-24-7
6-bromo-indoline

: 1202765-50-1
4-(6-bromoindolin-1-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
In 1,4-dioxane at 90℃; for 21h;	92%
With hydrogenchloride In water at 60℃;	80%

: 3993-78-0
2-amino-4-chloropyrimidine

: N-benzylpiperidine-3-carboxamide

: 1-(2-aminopyrimidin-4-yl)-N-benzylpiperidine-3-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube;	92%

: 1208228-61-8
C7H6IN3

: 3993-78-0
2-amino-4-chloropyrimidine

: 953411-13-7
C11H9IN6

Conditions

Conditions	Yield
In ethanol at 80℃; for 2.5h;	91%

: 3993-78-0
2-amino-4-chloropyrimidine

: 174669-73-9
(2-fluoro-pyridin-3-yl)boronic acid

: 4-(2-fluoropyridin-3-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With bis(di-tert-butylphenylphosphine)palladium(II) dichloride; potassium acetate In water; acetonitrile at 85℃; for 15h; Sealed tube; Inert atmosphere;	91%

: 123-75-1
pyrrolidine

: 3993-78-0
2-amino-4-chloropyrimidine

: 1215986-09-6
4-(pyrrolidin-1-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 20 - 120℃; Inert atmosphere;	89.7%
at 150℃; for 1h; Microwave irradiation;	67%
at 150℃; for 1h; Microwave irradiation; Sealed tube;	67%

: 496-15-1
1-indoline

: 3993-78-0
2-amino-4-chloropyrimidine

: 67-63-0
isopropyl alcohol

: 1401661-20-8
2-amino-4-(indolin-1-yl)pyrimidine

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water	89.6%

...Expand

: 3993-78-0
2-amino-4-chloropyrimidine

: 2-(5-fluorofuran-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 4-(5-fluorofuran-2-yl)pyrimidine-2-amine

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 90℃; for 2h; Inert atmosphere;	89.01%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 90℃; for 2h; Inert atmosphere;	89.01%

: 109-01-3
1-methyl-piperazine

: 3993-78-0
2-amino-4-chloropyrimidine

: 4-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine

Conditions

Conditions	Yield
In ethanol at 150℃; for 0.166667h; Microwave irradiation; Sealed tube;	89%
at 120℃; for 0.166667h; Microwave irradiation;	54%

: 1202765-56-7
6-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]

: 3993-78-0
2-amino-4-chloropyrimidine

: 1202765-64-7
4-(6-bromo-2',3',5',6'-tetrahydrospiro[indole-3,4'-pyran]-1(2H)-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
Stage #1: 6-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]; 2-amino-4-chloropyrimidine With hydrogenchloride In water at 60℃; for 17.5h; Stage #2: With sodium hydroxide In water Cooling;	88.3%

: 867018-12-0
2-[4-(4-amino-2-fluoro-phenoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]-ethanol

: 3993-78-0
2-amino-4-chloropyrimidine

: 2-(4-{4-[(2-aminopyrimidin-4-yl)amino]-2-fluorophenoxy}-1H-pyrrolo[2,3-b]pyridin-4-yl)ethanol

Conditions

Conditions	Yield
Stage #1: 2-[4-(4-amino-2-fluoro-phenoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]-ethanol; 2-amino-4-chloropyrimidine With hydrogenchloride In water Heating / reflux; Stage #2: With sodium hydroxide In water pH=10;	88%

: 3993-78-0
2-amino-4-chloropyrimidine

: C11H12N2S

: N4-((4-methyl-2-phenyl-5-thiazolyl)methyl)pyrimidine-2,4-diamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol at 40℃; for 3h; Inert atmosphere;	88%

: 942070-45-3
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate

: 3993-78-0
2-amino-4-chloropyrimidine

: 289628-76-8
4-(1H-indol-3-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); caesium carbonate In water; isopropyl alcohol at 80℃; for 16h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	87%
With caesium carbonate In methanol at 100℃; for 24h; Suzuki coupling; Inert atmosphere;	73%

: 3993-78-0
2-amino-4-chloropyrimidine

: 5720-06-9
2-Methoxyphenylboronic acid

: 915070-01-8
4-(2-methoxyphenyl)pyrimidin-2-amine

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 100℃; for 2h; Inert atmosphere;	87%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 95℃; for 2h; Suzuki-Miyaura Coupling; Inert atmosphere;	86%

: 3993-78-0
2-amino-4-chloropyrimidine

: 1044767-99-8
2-amino-5-bromo-4-chloropyrimidine

Conditions

Conditions	Yield
With bromine; acetic acid at 20℃; for 2h;	86%
With N-Bromosuccinimide In chloroform at 20℃;	62%
With N-Bromosuccinimide In methanol; acetonitrile at 20℃; for 0.5h;

2-Amino-4-chloropyrimidine Chemical Properties

Empirical Formula: C₄H₄ClN₃
Molecular Weight: 129.5477
Nominal Mass: 129 Da
Average Mass: 129.5477 Da
Monoisotopic Mass: 129.009375 Da
Index of Refraction: 1.617
Molar Refractivity: 31.56 cm³
Molar Volume: 90.1 cm³
Surface Tension: 66.4 dyne/cm
Density: 1.437 g/cm³
Flash Point: 144.1 °C
Enthalpy of Vaporization: 55.58 kJ/mol
Boiling Point: 314.6 °C at 760 mmHg
Vapour Pressure: 0.000461 mmHg at 25 °C
Melting Point: 155-160 °C (dec.)
Appearance: White solid
Structure of 2-Amino-4-chloropyrimidine (CAS NO.3993-78-0):

IUPAC Name: 4-Chloropyrimidin-2-amine
Canonical SMILES: C1=CN=C(N=C1Cl)N
InChI: InChI=1S/C4H4ClN3/c5-3-1-2-7-4(6)8-3/h1-2H,(H2,6,7,8)
InChIKey: DBGFGNCFYUNXLD-UHFFFAOYSA-N
Product Category of 2-Amino-4-chloropyrimidine (CAS NO.3993-78-0): APIs & Intermediate;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Bases & Related Reagents;Heterocycles;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Halogenated Heterocycles;Heterocyclic Building Blocks

2-Amino-4-chloropyrimidine Uses

2-Amino-4-chloropyrimidine (CAS NO.3993-78-0) is usually used for the synthesis of pesticides such as Chlorimuron-ethyl.

2-Amino-4-chloropyrimidine Safety Profile

The Hazard Codes: Irritant Xi, Harmful Xn
The Risk Statements:
22: Harmful if swallowed
41: Risk of serious damage to eyes
36/37/38: Irritating to eyes, respiratory system and skin
37/38: Irritating to respiratory system and skin
The Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
36/39: Wear suitable protective clothing and eye/face protection
Hazard Note: Irritant

2-Amino-4-chloropyrimidine Specification

2-Amino-4-chloropyrimidine , its cas register number is 3993-78-0. It also can be called (4-Chloropyrimidin-2-yl)amine ; 4-Chloro-2-pyrimidinamine ; and 2-Pyrimidinamine,4-chloro- .

Product Name

2-Amino-4-chloropyrimidine

Synthetic route

2-Amino-4-chloropyrimidine Chemical Properties

2-Amino-4-chloropyrimidine Uses

2-Amino-4-chloropyrimidine Safety Profile

2-Amino-4-chloropyrimidine Specification

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