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Hangzhou ZeErRui Chemical Co., Ltd.

CAS No. 40665-68-7 Molecular formula C11H15O5P Molecular weight 258.20800 Accurate mass 258.06600 Density: 1.209g/cm 3 Boiling point: 369.8ºC at 760 mmHg Flash point: 191.1 ºC Refra

Dimethyl (2-oxo-3-phenoxypropyl)phosphonate manufature

Cas:40665-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Dimethyl (3-phenoxy-2-oxopropyl)phosphonate Manufacturer/High quality/Best price/In stock

Cas:40665-68-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply DiMethyl (2-Oxo-3-phenoxypropyl)phosphonate CAS 40665-68-7 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical &am

Manufacturer supply DiMethyl (2-Oxo-3-phenoxypropyl)phosphonate CAS 40665-68-7 with attractive price

Cas:40665-68-7

Min.Order:10 Gram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

1-dimethoxyphosphoryl-3-phenoxypropan-2-one

Cas:40665-68-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dimethyl (3-phenoxyacetonyl)-phosphonate

Cas:40665-68-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM--DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 40665-68-7 with best quality

Cas:40665-68-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 40665-68-7 ,DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE Synonyms: Dimethyl(2-oxo-3-phenoxypropyl)phosphonate;Dimethyl[(3-phenoxyacetyl)methyl]phosphonate;(2-OXO-3-PHENOXY-PROPYL)-PHOSPHONIC ACID DIMETHYL E

Dimethyl(3-phenoxy-2-oxopropyl)phosphonate CAS: 40665-68-7

Cas:40665-68-7

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P-(2-oxo-3-phenoxypropyl)-, dimethyl ester 40665-68-7

Cas:40665-68-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE CAS:40665-68-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE CAS:40665-68-7

Cas:40665-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphonic acid,P-(2-oxo-3-phenoxypropyl)-, dimethyl ester

Cas:40665-68-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Phosphonic acid,P-(2-oxo-3-phenoxypropyl)-, dimethyl ester

Cas:40665-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Phosphonic acid,P-(2-oxo-3-phenoxypropyl)-, dimethyl ester

Cas:40665-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-dimethoxyphosphoryl-3-phenoxypropan-2-one

Cas:40665-68-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

1-dimethoxyphosphoryl-3-phenoxypropan-2-one supplier in ChinaAppearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:according to customers' requirements Application:It is an important raw mater

1-dimethoxyphosphoryl-3-phenoxypropan-2-one supplier in China

Cas:40665-68-7

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Dimethyl(3-phenoxy-2-oxopropyl)phosphonate, min. 90 %

Cas:40665-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Dimethyl(2-oxo-3-phenoxypropyl)phosphonate

Cas:40665-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Cas:40665-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name: ETP Dimethyl (3-phenoxy-2-oxopropyl)phosphonate CAS No.: 40665-68-7 Other name: DIMETHYL(3-PHENOXYACETONYL)PHOSPHONATE;Dimethyl(2-oxo-3-phenoxypropyl)phosphonate;Dimethyl[(3-phenoxyacetyl)methyl]phosphonate;(2-OXO-3-PHENOXY-PROPYL)-

ETP Dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Cas:40665-68-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE

Cas:40665-68-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-Dimethoxyphosphoryl-3-phenoxypropan-2-one cas no. 40665-68-7 98%

Cas:40665-68-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

methyl 2-phenoxyacetate
2065-23-8

methyl 2-phenoxyacetate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: methyl 2-phenoxyacetate In tetrahydrofuran at -78 - 20℃; for 2.5h; Inert atmosphere;
83%
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: methyl 2-phenoxyacetate In tetrahydrofuran at 25℃;
25%
With n-butyllithium 1.) THF, hexane, -78 deg C, 5 min, 2.) -78 deg C, 2 h; Yield given. Multistep reaction;
With n-butyllithium In tetrahydrofuran; hexane; water
methyl 2-phenoxyacetate
2065-23-8

methyl 2-phenoxyacetate

dimethyl lithiomethylphosphonate
34939-91-8, 58648-56-9

dimethyl lithiomethylphosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
In tetrahydrofuran at -78℃;
bis-tetrahydropyran-2-yl ether
709-84-2

bis-tetrahydropyran-2-yl ether

n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

Phenoxyacetyl chloride
701-99-5

Phenoxyacetyl chloride

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
In tetrahydrofuran; hexane; water
phenoxyacetic acid ethyl ester
2555-49-9

phenoxyacetic acid ethyl ester

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane
With n-butyllithium In tetrahydrofuran; hexane
Phenoxyacetyl chloride
701-99-5

Phenoxyacetyl chloride

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
In tetrahydrofuran; hexane
In tetrahydrofuran; hexane
methyl 9α-acetoxy-11α-(2-tetrahydropyranyloxy)-15α-hdroxy-16-phenoxy-17,18,19,20-tetranorprosta-cis-5,trans-13-dienoate

methyl 9α-acetoxy-11α-(2-tetrahydropyranyloxy)-15α-hdroxy-16-phenoxy-17,18,19,20-tetranorprosta-cis-5,trans-13-dienoate

phenoxyacetic acid ethyl ester
2555-49-9

phenoxyacetic acid ethyl ester

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane
phenol
108-95-2

phenol

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 16 h / 25 - 56 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 2.5 h / -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 0.67 h / 25 °C
1.2: 16 h / 30 - 35 °C
2.1: zinc(II) chloride / toluene / 6 h / 65 - 70 °C / Inert atmosphere
3.1: Jones reagent / acetone / 7 h / Cooling with ice
View Scheme
Phenyl glycidyl ether
122-60-1

Phenyl glycidyl ether

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: zinc(II) chloride / toluene / 6 h / 65 - 70 °C / Inert atmosphere
2: Jones reagent / acetone / 7 h / Cooling with ice
View Scheme
2-hydroxy-3-phenoxypropyldimethylphosphonate

2-hydroxy-3-phenoxypropyldimethylphosphonate

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Conditions
ConditionsYield
With Jones reagent In acetone for 7h; Cooling with ice;92.8 g
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

(1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one
39746-01-5

(1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one

(3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate
51638-91-6

(3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate

Conditions
ConditionsYield
With sodium hydride Horner-Emmons reaction;90%
Stage #1: dimethyl (3-phenoxy-2-oxopropyl)phosphonate With sodium hydride; zinc(II) chloride In tetrahydrofuran; mineral oil at 25 - 35℃; for 0.416667h; Inert atmosphere;
Stage #2: (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one In tetrahydrofuran; dichloromethane; mineral oil at 25 - 40℃; for 2.08333h; Inert atmosphere;
61%
Stage #1: dimethyl (3-phenoxy-2-oxopropyl)phosphonate With sodium hydroxide; zinc(II) chloride In tetrahydrofuran at 27℃; Inert atmosphere;
Stage #2: (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one In tetrahydrofuran at 27℃; for 15h; Inert atmosphere;
50%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-formyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate

isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-formyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate

isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-((E)-3-oxo-4-phenoxybut-1-en-1-yl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate

isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-((E)-3-oxo-4-phenoxybut-1-en-1-yl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate

Conditions
ConditionsYield
Stage #1: dimethyl (3-phenoxy-2-oxopropyl)phosphonate With n-butyllithium; tetrabutylammomium bromide In dichloromethane at 20 - 30℃; for 1h; Horner-Wadsworth-Emmons Olefination;
Stage #2: isopropyl (Z)-7-((1R,2R,3R,5S)-5-acetoxy-2-formyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate In dichloromethane at 20℃; for 15h; Reagent/catalyst; Solvent; Temperature; Horner-Wadsworth-Emmons Olefination;
85.4%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

2α-(6-methoxycarbonylhexyl)-3β-formyloxycyclopent-1-one
38698-56-5, 61659-10-7, 62769-46-4

2α-(6-methoxycarbonylhexyl)-3β-formyloxycyclopent-1-one

methyl 9,15-dioxo-16-phenoxy-13-trans-17,18,19,20-tetranorprostenoate
122437-70-1, 129444-27-5

methyl 9,15-dioxo-16-phenoxy-13-trans-17,18,19,20-tetranorprostenoate

Conditions
ConditionsYield
With potassium hydroxide In dichloromethane for 1h; Ambient temperature;68%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

(Z)-4-formyl-5-(7-isopropoxy-7-oxohept-2-enyl)cyclopentane-1,3-diyl dibenzoate

(Z)-4-formyl-5-(7-isopropoxy-7-oxohept-2-enyl)cyclopentane-1,3-diyl dibenzoate

4-((Z)-7-isopropoxy-7-oxohept-2-enyl)-5-((E)-3-oxo-4-phenoxybut-1-enyl)cyclopentane-1,3-diyl dibenzoate

4-((Z)-7-isopropoxy-7-oxohept-2-enyl)-5-((E)-3-oxo-4-phenoxybut-1-enyl)cyclopentane-1,3-diyl dibenzoate

Conditions
ConditionsYield
Stage #1: dimethyl (3-phenoxy-2-oxopropyl)phosphonate With sodium hydride In 1,2-dimethoxyethane at -5 - 25℃; for 1.25h; Horner-Wadsworth-Emmons olefination; Inert atmosphere;
Stage #2: (Z)-4-formyl-5-(7-isopropoxy-7-oxohept-2-enyl)cyclopentane-1,3-diyl dibenzoate In 1,2-dimethoxyethane at -5 - 25℃; for 2h; Horner-Wadsworth-Emmons olefination; Inert atmosphere;
60%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

C21H29NO6S

C21H29NO6S

isopropyl 2-[(2R,4aR,5R,6R,7aS)-5-[(1E)-3-oxo-4-phenoxy-1-buten-1-yl]-6-(tetrahydro-2H-pyran-2-yloxy)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylate

isopropyl 2-[(2R,4aR,5R,6R,7aS)-5-[(1E)-3-oxo-4-phenoxy-1-buten-1-yl]-6-(tetrahydro-2H-pyran-2-yloxy)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylate

Conditions
ConditionsYield
With triethylamine; lithium chloride In tetrahydrofuran at 20℃; for 16h;52%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

11-((1S,2R)-2-Formyl-5-oxo-cyclopentyl)-undecanoic acid methyl ester
129367-74-4

11-((1S,2R)-2-Formyl-5-oxo-cyclopentyl)-undecanoic acid methyl ester

11-[(1S,5S)-2-Oxo-5-((E)-3-oxo-4-phenoxy-but-1-enyl)-cyclopentyl]-undecanoic acid methyl ester
129367-85-7

11-[(1S,5S)-2-Oxo-5-((E)-3-oxo-4-phenoxy-but-1-enyl)-cyclopentyl]-undecanoic acid methyl ester

Conditions
ConditionsYield
With potassium hydroxide In dichloromethane for 1h; Ambient temperature;50%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Biphenyl-4-carboxylic acid (3aS,5S,6aR)-4-formyl-2-oxo-octahydro-cyclopenta[b]pyrrol-5-yl ester
78845-62-2, 111900-95-9

Biphenyl-4-carboxylic acid (3aS,5S,6aR)-4-formyl-2-oxo-octahydro-cyclopenta[b]pyrrol-5-yl ester

Biphenyl-4-carboxylic acid (3aS,5S,6aR)-2-oxo-4-((E)-3-oxo-4-phenoxy-but-1-enyl)-octahydro-cyclopenta[b]pyrrol-5-yl ester
111803-58-8

Biphenyl-4-carboxylic acid (3aS,5S,6aR)-2-oxo-4-((E)-3-oxo-4-phenoxy-but-1-enyl)-octahydro-cyclopenta[b]pyrrol-5-yl ester

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane Ambient temperature; 1.) 0.5 h 2.) 3 h;19%
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

Corey aldehyde
62961-72-2

Corey aldehyde

7α-hydroxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one
871669-32-8

7α-hydroxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one

Conditions
ConditionsYield
With potassium carbonate at 20℃; for 5h; Yield given;
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

7α-trimethylsilyloxy-6β-formyl-2-oxabicyclo<3.3.0>octan-3-one
122517-79-7

7α-trimethylsilyloxy-6β-formyl-2-oxabicyclo<3.3.0>octan-3-one

7α-trimethylsilyloxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one
871669-30-6

7α-trimethylsilyloxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one

Conditions
ConditionsYield
With potassium hydroxide In dichloromethane for 0.333333h; Ambient temperature; Yield given;
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

methyl <1α,2α(Z),3α,4α>-7-<3-formyl-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoate
104596-33-0

methyl <1α,2α(Z),3α,4α>-7-<3-formyl-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoate

(Z)-7-[(1S,2R,3S,4R)-3-((E)-3-Oxo-4-phenoxy-but-1-enyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester
87929-54-2

(Z)-7-[(1S,2R,3S,4R)-3-((E)-3-Oxo-4-phenoxy-but-1-enyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

Conditions
ConditionsYield
With sodium hydride 1.) DME, 2.) 23 deg C; Multistep reaction;
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

2α-(7-methoxycarbonyl-4Z-heptenyl)-3β-formylcyclopentanone
88736-15-6

2α-(7-methoxycarbonyl-4Z-heptenyl)-3β-formylcyclopentanone

methyl 1-homo-3,4-cis-didehydro-9,15-diketo-16-phenoxy-17,18,19,20-tetranorprostenoate
131846-19-0

methyl 1-homo-3,4-cis-didehydro-9,15-diketo-16-phenoxy-17,18,19,20-tetranorprostenoate

Conditions
ConditionsYield
With sodium hydride 1.) THF, RT, 1.5 h, 2.) THF, RT, 30 min; Yield given. Multistep reaction;
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

7-(4-Formyl-furan-3-yl)-heptanoic acid methyl ester
78932-40-8

7-(4-Formyl-furan-3-yl)-heptanoic acid methyl ester

7-[4-((E)-3-Oxo-4-phenoxy-but-1-enyl)-furan-3-yl]-heptanoic acid methyl ester

7-[4-((E)-3-Oxo-4-phenoxy-but-1-enyl)-furan-3-yl]-heptanoic acid methyl ester

dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

methyl (Z)-7-[(1R,2R,3R,5S)-5-acetoxy-2-formyl-3-(2-tetrahydropyranyloxy)cyclopentyl]-5-heptenate
61218-06-2

methyl (Z)-7-[(1R,2R,3R,5S)-5-acetoxy-2-formyl-3-(2-tetrahydropyranyloxy)cyclopentyl]-5-heptenate

16-phenoxy-17,18,19,20-tetranor-15-dehydroprostaglandin F2α 9-acetate methyl ester 11-(tetrahydropyran-2-yl ether)
62561-47-1

16-phenoxy-17,18,19,20-tetranor-15-dehydroprostaglandin F2α 9-acetate methyl ester 11-(tetrahydropyran-2-yl ether)

Conditions
ConditionsYield
With sodium hydride 1.) THF, 25 deg C, 20 min, 2.) THF, from 25 deg C to 60 deg C, 4.5 h; Yield given. Multistep reaction;
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

C64H110O17Si3
141242-63-9

C64H110O17Si3

C73H118O18Si3
141242-73-1

C73H118O18Si3

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile Ambient temperature; Yield given;
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate
38754-71-1

(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate

Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxy-but-1-enyl)-hexahydro-cyclopenta[b]furan-5-yl ester
79171-99-6

Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxy-but-1-enyl)-hexahydro-cyclopenta[b]furan-5-yl ester

Conditions
ConditionsYield
With sodium hydride 1.) THF, 90 min, 2.) THF, 30 min; Yield given. Multistep reaction;
Stage #1: dimethyl (3-phenoxy-2-oxopropyl)phosphonate; (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate With water; lithium hydroxide In dichloromethane at 5 - 22℃; for 19.5h;
Stage #2: With citric acid In dichloromethane at 22℃; pH=1-2; Reagent/catalyst;
8.7 g
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

7α-hydroxy-6β-(3'-hydroxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one
51638-93-8, 60761-96-8, 63324-34-5, 103616-92-8, 127760-07-0

7α-hydroxy-6β-(3'-hydroxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / 5 h / 20 °C
2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
View Scheme
Multi-step reaction with 3 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
3: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

7α-hydroxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one
871669-32-8

7α-hydroxy-6β-(3'-oxo-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol
127718-28-9

7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: K2CO3 / 5 h / 20 °C
2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
3: 85 percent / pyridine / 2 h / 5 °C
4: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
View Scheme
Multi-step reaction with 5 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
3: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
4: 85 percent / pyridine / 2 h / 5 °C
5: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one
127702-12-9

7α-trimethylsilyloxy-6β-(3'α-trimethylsilyloxy-4'-phenoxy-1'E-butenyl)-2-oxabicyclo<3.3.0>octan-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3 / 5 h / 20 °C
2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
3: 85 percent / pyridine / 2 h / 5 °C
View Scheme
Multi-step reaction with 4 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
3: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
4: 85 percent / pyridine / 2 h / 5 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

N-(methanesulfonyl)-16-phenox-ω-tetranor-PGF2α-carboxamide
79172-00-2

N-(methanesulfonyl)-16-phenox-ω-tetranor-PGF2α-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: K2CO3 / 5 h / 20 °C
2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
3: 85 percent / pyridine / 2 h / 5 °C
4: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
5: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min
View Scheme
Multi-step reaction with 6 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
3: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
4: 85 percent / pyridine / 2 h / 5 °C
5: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
6: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) THF, 90 min, 2.) THF, 30 min
2: 25 percent / lithium triethylborohydride / tetrahydrofuran / 0.5 h
3: potassium carbonate / methanol; tetrahydrofuran / 2.5 h
4: 95 percent / p-toluenesulfonic acid / CH2Cl2 / 0.5 h
5: 79 percent / diisobutylaluminum hydride / toluene; hexane / 0.33 h
6: 1.) sodium methylsulfinylcarbanide / 1.) Me2SO, 2.) Me2SO, 2 h
7: 40 percent / 65percent aq. acetic acid / 14 h
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

N-{(Z)-7-[(1R,2R,3R)-5-Oxo-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

N-{(Z)-7-[(1R,2R,3R)-5-Oxo-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: K2CO3 / 5 h / 20 °C
2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
3: 85 percent / pyridine / 2 h / 5 °C
4: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
5: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min
6: 90 percent / acetone / 1.5 h / -45 °C
7: CrO3/pyridine / CH2Cl2
View Scheme
Multi-step reaction with 8 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
3: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
4: 85 percent / pyridine / 2 h / 5 °C
5: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
6: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min
7: 90 percent / acetone / 1.5 h / -45 °C
8: CrO3/pyridine / CH2Cl2
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide
127718-29-0

N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: K2CO3 / 5 h / 20 °C
2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
3: 85 percent / pyridine / 2 h / 5 °C
4: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
5: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min
6: 90 percent / acetone / 1.5 h / -45 °C
View Scheme
Multi-step reaction with 7 steps
1: KOH / CH2Cl2 / 0.33 h / Ambient temperature
2: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C
3: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH2Cl2 / 0.5 h / -78 °C
4: 85 percent / pyridine / 2 h / 5 °C
5: 0.24 g / i-Bu2AlH / CH2Cl2 / 1 h / -78 °C
6: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min
7: 90 percent / acetone / 1.5 h / -45 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one
209861-01-8

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 90 percent / NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 72 h / 20 °C
3: potassium carbonate / methanol / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium hydroxide; water / dichloromethane / 19.5 h / 5 - 22 °C
1.2: 22 °C / pH 1-2
2.1: diethylamino-sulfur trifluoride / dichloromethane / 94 h / 5 - 30 °C / Inert atmosphere
3.1: potassium carbonate / methanol / 2 h / 20 °C
3.2: 1 h / 0 °C / Acidic conditions
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol
209861-02-9

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
4: 83 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 1 h / -78 °C
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
4: 83 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 1 h / -78 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride; zinc(II) chloride / mineral oil; tetrahydrofuran / 0.42 h / 25 - 35 °C / Inert atmosphere
1.2: 2.08 h / 25 - 40 °C / Inert atmosphere
2.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 0 - 35 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / toluene / 3.25 h / -65 - -61 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 72 h / 20 °C
3: potassium carbonate / methanol / 1.5 h / 20 °C
4: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / -70 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybutan-1-en-1-yl)-hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl benzoate
209861-00-7

(3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybutan-1-en-1-yl)-hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride; zinc(II) chloride / mineral oil; tetrahydrofuran / 0.42 h / 25 - 35 °C / Inert atmosphere
1.2: 2.08 h / 25 - 40 °C / Inert atmosphere
2.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 0 - 35 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 72 h / 20 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

AFP-172
209860-88-8

AFP-172

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
4: 83 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 1 h / -78 °C
5: NaN(SiMe3)2 / tetrahydrofuran / 3 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: 90 percent / NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
4: 83 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 1 h / -78 °C
5: NaN(SiMe3)2 / tetrahydrofuran / 3 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride; zinc(II) chloride / mineral oil; tetrahydrofuran / 0.42 h / 25 - 35 °C / Inert atmosphere
1.2: 2.08 h / 25 - 40 °C / Inert atmosphere
2.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 0 - 35 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / toluene / 3.25 h / -65 - -61 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 5 °C / Inert atmosphere
4.2: 2 h / 0 - 3 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 20 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 72 h / 20 °C
3: potassium carbonate / methanol / 1.5 h / 20 °C
4: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / -70 °C
5: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 10 °C
View Scheme
dimethyl (3-phenoxy-2-oxopropyl)phosphonate
40665-68-7

dimethyl (3-phenoxy-2-oxopropyl)phosphonate

tafluprost

tafluprost

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
4: 83 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 1 h / -78 °C
5: NaN(SiMe3)2 / tetrahydrofuran / 3 h / 0 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 16 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: 90 percent / NaH
2: morpholinosulfur trifluoride / CHCl3 / 82 h / 30 - 40 °C
3: K2CO3 / methanol / 3 h / 20 °C
4: 83 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 1 h / -78 °C
5: NaN(SiMe3)2 / tetrahydrofuran / 3 h / 0 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 16 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydride; zinc(II) chloride / mineral oil; tetrahydrofuran / 0.42 h / 25 - 35 °C / Inert atmosphere
1.2: 2.08 h / 25 - 40 °C / Inert atmosphere
2.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 0 - 35 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / toluene / 3.25 h / -65 - -61 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 5 °C / Inert atmosphere
4.2: 2 h / 0 - 3 °C
5.1: acetone / 20 °C
6.1: sulfuric acid / ethyl acetate
6.2: 20 h / 30 °C
View Scheme

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