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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Nabumetone

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Nabumetone manufacturer with low price

Cas:42924-53-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Nabumetone 42924-53-8 GMP Manufacturer

Cas:42924-53-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nabumetone

Cas:42924-53-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Nabumetone Synonyms: 4-[6-(trideuteriomethoxy)-2-naphthalenyl]-2-butanone;NABUMETONE, EP STANDARD;NABUMETONE, MM(CRM STANDARD);NABUMETONE, IMP. F (EP): 6,6'-DIMETHOXY-2,2'-BINAPHTHALENYL MM(CRM STANDARD);NABUMETONE, IMPURITY

42924-53-8 Nabumetone

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $230.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Nabumetone

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 42924-53-8 with competitive price

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Nabumetone CAS42924-53-8

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Butanone,4-(6-methoxy-2-naphthalenyl)- 42924-53-8

Cas:42924-53-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Nabumetone CAS:42924-53-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Nabumetone CAS:42924-53-8

Cas:42924-53-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Butanone,4-(6-methoxy-2-naphthalenyl)-

Cas:42924-53-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-Butanone,4-(6-methoxy-2-naphthalenyl)-/ LIDE PHARMA- Factory supply / Best price

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Nabumetone CAS: 42924-53-8 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard 2. HPLC-MS: Ensure the mo

Factory supply Nabumetone

Cas:42924-53-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Butanone,4-(6-methoxy-2-naphthalenyl)-

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Nabumetone

Cas:42924-53-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Nabumetone cas 42924-53-8 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Nabumetone cas 42924-53-8

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Nabumetone CAS 42924-53-8 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pr

Nabumetone CAS 42924-53-8

Cas:42924-53-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Nabumetone

Cas:42924-53-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Nabumetone

Cas:42924-53-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Nabumetone

Cas:42924-53-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Other

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Nabumetone

Cas:42924-53-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Nabumetone

Cas:42924-53-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Nabumetone

Cas:42924-53-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:shenzhen/shanghai

Nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

nabumetone

Cas:42924-53-8

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

4-(2-methoxynaphthalene-6-yl)but-3-en-2-one
127053-22-9, 56600-90-9

4-(2-methoxynaphthalene-6-yl)but-3-en-2-one

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With hydrogen In toluene at 50℃; under 3750.38 Torr; for 1h; Catalytic behavior; Temperature; Pressure; Inert atmosphere; Schlenk technique; Autoclave;99%
With 1% Pd on activated carbon; hydrogen In water at 45℃; under 760.051 Torr; for 15h; Reagent/catalyst; Green chemistry; chemoselective reaction;95%
With hydrogen In N,N-dimethyl-formamide at 100℃;90%
methyl vinyl ketone
78-94-4

methyl vinyl ketone

tris(6-methoxy-2-naphthyl)stibine

tris(6-methoxy-2-naphthyl)stibine

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With palladium diacetate; silver(I) acetate; acetic acid at 25℃; for 24h;99%
4-(6-methoxy-2-naphthalenyl)-4-hydroxybut-3-en-2-one
73356-31-7

4-(6-methoxy-2-naphthalenyl)-4-hydroxybut-3-en-2-one

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
palladium on charcoal catalyst In acetic acid93%
Multi-step reaction with 3 steps
1: acetic acid; hydrogen; palladium on activated charcoal / 20 °C
2: sulfuric acid
3: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon; sulfuric acid / ethyl acetate
2: sulfuric acid
3: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
6-methoxynaphthalene-2-carbaldehyde
3453-33-6

6-methoxynaphthalene-2-carbaldehyde

acetone
67-64-1

acetone

A

C18H22O2

C18H22O2

B

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With hydrogen; Pd/Mg-Al hydrotalcite at 74.84℃; under 3750.38 Torr; for 1.25h;A 11 % Chromat.
B 89%
2-Bromo-6-methoxynaphthalene
5111-65-9

2-Bromo-6-methoxynaphthalene

methyl vinyl ketone
78-94-4

methyl vinyl ketone

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; nickel dibromide In pyridine; N,N-dimethyl-formamide at 70℃; Electrochemical reaction;85%
Stage #1: methyl vinyl ketone With [2,2]bipyridinyl; water; cobalt(II) bromide In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 2-Bromo-6-methoxynaphthalene With pyridine; trifluoroacetic acid; lithium bromide; zinc In N,N-dimethyl-formamide at 80℃; for 0.333333h;
50%
2-hydroxy-3-butene
598-32-3

2-hydroxy-3-butene

2-Bromo-6-methoxynaphthalene
5111-65-9

2-Bromo-6-methoxynaphthalene

A

nabumetone
42924-53-8

nabumetone

B

4-(6-methoxy-2-naphthyl)-3-butene-2-ol
127053-21-8

4-(6-methoxy-2-naphthyl)-3-butene-2-ol

Conditions
ConditionsYield
Stage #1: 2-hydroxy-3-butene With dicyclohexylmethylamine; tetrabutylammomium bromide In N,N-dimethyl acetamide; water at 20℃; for 0.25h; Heck reaction;
Stage #2: 2-Bromo-6-methoxynaphthalene; 4'-hydroxyacetophenone oxime palladacycle catalyst In N,N-dimethyl acetamide; water at 120℃; for 9h; Heck reaction; Further stages.;
A 82%
B n/a
With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride In various solvent(s) at 140℃; for 5h; Yield given;A n/a
B 9%
4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With sodium hydroxide; sodium acetate; sodium acetate trihydrate; palladium In methanol; water; hydrogen; toluene79.7%
With sodium hydroxide; sodium acetate; sodium acetate trihydrate; palladium In methanol; water; hydrogen; toluene79.7%
sodium metabisulfite

sodium metabisulfite

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene78.5%
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene78.5%
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene74.8%
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene74.8%
2-hydroxy-3-butene
598-32-3

2-hydroxy-3-butene

2-Bromo-6-methoxynaphthalene
5111-65-9

2-Bromo-6-methoxynaphthalene

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium formate; sodium hydrogencarbonate; Pd-benzothiazole carbene at 130℃; for 3h; Heck reaction;75%
With tetrabutylammomium bromide; sodium hydrogencarbonate; palladium dichloride at 120℃; for 6h; Heck coupling;74%
Stage #1: 2-hydroxy-3-butene With dicyclohexylmethylamine; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 0.25h; Heck reaction;
Stage #2: 2-Bromo-6-methoxynaphthalene; 4'-hydroxyacetophenone oxime palladacycle catalyst In N,N-dimethyl acetamide at 120℃; for 24h; Heck reaction; Further stages.;
90 % Spectr.
With Fe3O4@chitosan nanoparticles/Pd In ethanol at 140℃; for 24h;
6-methoxynaphthalene-2-carbaldehyde
3453-33-6

6-methoxynaphthalene-2-carbaldehyde

acetone
67-64-1

acetone

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; carbon monoxide In neat (no solvent) at 200℃; for 72h; Temperature; Autoclave;75%
With hydrogen; magnesium oxide; palladium at 59.84℃; under 3750.38 Torr; for 1h;98 % Chromat.
6-methoxynaphthalene-2-carbaldehyde
3453-33-6

6-methoxynaphthalene-2-carbaldehyde

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
67%
Multi-step reaction with 2 steps
1: aq. NaOH
2: H2 / Pd-C / ethyl acetate
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 210 °C / Continuous flow
2: hydrogen / N,N-dimethyl-formamide / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 0.12 h / 70 °C / Microwave irradiation; Continuous flow
2: hydrogen / N,N-dimethyl-formamide / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 4 h
2: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
4-(6-methoxy-2-naphthalenyl)-4-hydroxybut-3-en-2-one
73356-31-7

4-(6-methoxy-2-naphthalenyl)-4-hydroxybut-3-en-2-one

A

4-(6-methoxynaphthalen-2-yl)butan-2-ol
65726-24-1

4-(6-methoxynaphthalen-2-yl)butan-2-ol

B

nabumetone
42924-53-8

nabumetone

C

(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone
220786-56-1, 98386-83-5

(±)-4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone

Conditions
ConditionsYield
With sulfuric acid; palladium 10% on activated carbon; hydrogen In ethyl acetateA 5%
B 65%
C 5%
2-(2-iodoethyl)-6-methoxynaphthalene

2-(2-iodoethyl)-6-methoxynaphthalene

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

methyl iodide
74-88-4

methyl iodide

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With [2,2]bipyridinyl; chloro-trimethyl-silane; nickel(II) bromide 2-methoxyethyl ether complex; zinc In tetrahydrofuran; N,N-dimethyl acetamide at 40℃; for 1h; Sealed tube; Inert atmosphere;54%
sodium acetate monohydrate

sodium acetate monohydrate

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With sodium hydroxide; sodium acetate; sodium hydrogensulfite; palladium In methanol; water; hydrogen; N,N-dimethyl-formamide; isopropyl alcohol52.8%
With sodium hydroxide; sodium acetate; sodium hydrogensulfite; palladium In methanol; water; hydrogen; N,N-dimethyl-formamide; isopropyl alcohol52.8%
methyl 3-(6-methoxynaphthalen-2-yl)propanoate
136579-95-8

methyl 3-(6-methoxynaphthalen-2-yl)propanoate

methyl magnesium iodide
917-64-6

methyl magnesium iodide

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
In tetrahydrofuran at -55℃;51%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

2-Methoxynaphthalen-6-propionitril
42924-52-7

2-Methoxynaphthalen-6-propionitril

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
In diethyl ether Heating;
ethyl 2-acetyl-3-(6-methoxy-2-naphthyl) propionate

ethyl 2-acetyl-3-(6-methoxy-2-naphthyl) propionate

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With potassium hydroxide In water for 6h; Heating;4 g
2-(Bromomethyl)-6-methoxynaphthalene
73022-40-9

2-(Bromomethyl)-6-methoxynaphthalene

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / acetone / 3 h / Heating
2: 4 g / KOH / H2O / 6 h / Heating
View Scheme
2-(2-bromoethyl)-6-methoxynaphthalene
42924-51-6

2-(2-bromoethyl)-6-methoxynaphthalene

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. ethanol / Heating
2: diethyl ether / Heating
View Scheme
2-<1-hydroxyethyl>-6-methoxynaphthalene
32725-05-6, 56523-40-1

2-<1-hydroxyethyl>-6-methoxynaphthalene

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PBr3 / benzene / Heating
2: aq. ethanol / Heating
3: diethyl ether / Heating
View Scheme
Multi-step reaction with 2 steps
1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 20 °C
2: [2,2]bipyridinyl; nickel(II) bromide 2-methoxyethyl ether complex; zinc; chloro-trimethyl-silane / N,N-dimethyl acetamide; tetrahydrofuran / 1 h / 40 °C / Sealed tube; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: (2-(dimethylamino)-N-(quinolin-8-yl)acetamido)nickel(II) chloride; manganese / N,N-dimethyl-formamide / 16 h / 20 °C / Sealed tube
View Scheme
methyl 6-methoxy-2-naphthylacetate
23981-48-8

methyl 6-methoxy-2-naphthylacetate

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: LiAlH4 / diethyl ether / Heating
2: PBr3 / benzene / Heating
3: aq. ethanol / Heating
4: diethyl ether / Heating
View Scheme
2-hydroxy-3-butene
598-32-3

2-hydroxy-3-butene

2-Bromo-6-methoxynaphthalene
5111-65-9

2-Bromo-6-methoxynaphthalene

A

C15H16O2

C15H16O2

B

nabumetone
42924-53-8

nabumetone

C

3-(6-methoxy-2-naphthyl)-2-butanone
56600-77-2

3-(6-methoxy-2-naphthyl)-2-butanone

Conditions
ConditionsYield
Stage #1: 2-hydroxy-3-butene With dicyclohexylmethylamine; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 0.25h; Heck reaction;
Stage #2: 2-Bromo-6-methoxynaphthalene; Kaiser oxime-derived complex on resin base In N,N-dimethyl acetamide at 120℃; for 24h; Heck reaction; Further stages. Title compound not separated from byproducts.;
2-hydroxy-3-butene
598-32-3

2-hydroxy-3-butene

2-Bromo-6-methoxynaphthalene
5111-65-9

2-Bromo-6-methoxynaphthalene

A

nabumetone
42924-53-8

nabumetone

B

3-(6-methoxy-2-naphthyl)-2-butanone
56600-77-2

3-(6-methoxy-2-naphthyl)-2-butanone

Conditions
ConditionsYield
Stage #1: 2-hydroxy-3-butene With dicyclohexylmethylamine; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 0.25h; Heck reaction;
Stage #2: 2-Bromo-6-methoxynaphthalene; Kaiser oxime-derived complex on resin base In N,N-dimethyl acetamide at 120℃; for 14h; Heck reaction; Further stages. Title compound not separated from byproducts.;
ethyl-5-(6-methoxy-2-naphthyl)-β-keto-pentanoate
1250259-21-2

ethyl-5-(6-methoxy-2-naphthyl)-β-keto-pentanoate

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
With water; potassium hydroxide In ethanol Conversion of starting material;
β-naphthol
135-19-3

β-naphthol

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic acid; bromine / 0.5 h / 30 - 35 °C
2.1: acetic acid; tin / 3 h / 100 - 120 °C
3.1: potassium carbonate / acetone; water / 4 h / 10 - 50 °C / Cooling
4.1: magnesium; iodine / tetrahydrofuran / 5 h / Reflux
4.2: 1.75 h / 10 - 90 °C
4.3: 1 h / 20 °C
5.1: sodium hydroxide / water / 4 h
6.1: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
1,6-dibromo-2-naphthol
16239-18-2

1,6-dibromo-2-naphthol

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic acid; tin / 3 h / 100 - 120 °C
2.1: potassium carbonate / acetone; water / 4 h / 10 - 50 °C / Cooling
3.1: magnesium; iodine / tetrahydrofuran / 5 h / Reflux
3.2: 1.75 h / 10 - 90 °C
3.3: 1 h / 20 °C
4.1: sodium hydroxide / water / 4 h
5.1: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
6-bromo-naphthalen-2-ol
15231-91-1

6-bromo-naphthalen-2-ol

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone; water / 4 h / 10 - 50 °C / Cooling
2.1: magnesium; iodine / tetrahydrofuran / 5 h / Reflux
2.2: 1.75 h / 10 - 90 °C
2.3: 1 h / 20 °C
3.1: sodium hydroxide / water / 4 h
4.1: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
2-Bromo-6-methoxynaphthalene
5111-65-9

2-Bromo-6-methoxynaphthalene

nabumetone
42924-53-8

nabumetone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 5 h / Reflux
1.2: 1.75 h / 10 - 90 °C
1.3: 1 h / 20 °C
2.1: sodium hydroxide / water / 4 h
3.1: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
1.2: 1.42 h / Inert atmosphere
2.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 20 °C
3.1: [2,2]bipyridinyl; nickel(II) bromide 2-methoxyethyl ether complex; zinc; chloro-trimethyl-silane / N,N-dimethyl acetamide; tetrahydrofuran / 1 h / 40 °C / Sealed tube; Inert atmosphere
View Scheme
nabumetone
42924-53-8

nabumetone

C15H11(2)H5O2

C15H11(2)H5O2

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; water-d2 In tetrahydrofuran at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; regioselective reaction;99%
nabumetone
42924-53-8

nabumetone

4-(5-iodo-6-methoxynaphthalen-2-yl)butan-2-one
1225055-49-1

4-(5-iodo-6-methoxynaphthalen-2-yl)butan-2-one

Conditions
ConditionsYield
With indium(III) triflate; N-iodo-succinimide In acetonitrile at 23℃; for 8h; Inert atmosphere; Darkness;97%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

p-butoxybenzaldehyde
5736-88-9

p-butoxybenzaldehyde

1-(4-butoxyphenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1363178-37-3

1-(4-butoxyphenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; p-butoxybenzaldehyde In ethanol at 25℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 25℃; for 22h; pH=4 - 5; Mannich reaction;
97%
nabumetone
42924-53-8

nabumetone

4-(6-methoxynaphthalen-2-yl)butan-2-ol
65726-24-1

4-(6-methoxynaphthalen-2-yl)butan-2-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at -10 - 20℃; for 4h;95%
With sodium tetrahydroborate In ethanol
With sodium tetrahydroborate In ethanol at -10℃; for 3h; Inert atmosphere;
With sodium tetrahydroborate In ethanol at 0 - 20℃; for 3h; Schlenk technique; Inert atmosphere;
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

5-(6-methoxynaphthalen-2-yl)-1-p-tolyl-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1363178-36-2

5-(6-methoxynaphthalen-2-yl)-1-p-tolyl-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; 4-methyl-benzaldehyde In ethanol at 20℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 20℃; for 26h; pH=4 - 5; Mannich reaction;
95%
nabumetone
42924-53-8

nabumetone

Nabumetone hydroxyimine
68427-21-4

Nabumetone hydroxyimine

Conditions
ConditionsYield
With pyridine; hydroxylamine hydrochloride In ethanol Heating;94%
With hydroxylamine hydrochloride
nabumetone
42924-53-8

nabumetone

C15H19NO

C15H19NO

Conditions
ConditionsYield
With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine In 2,2,2-trifluoroethanol at 120℃; for 24h; chemoselective reaction;91%
With ammonia; hydrogen In tetrahydrofuran at 120℃; for 15h;90%
With N,N'-bis(salicylidene)-1,2-phenylene-diaminocobalt(II); ammonia; hydrogen In tetrahydrofuran; water at 130℃; for 24h; Autoclave;82%
With ammonium hydroxide; hydrogen at 140℃; under 48754.9 Torr; for 20h;
nabumetone
42924-53-8

nabumetone

4-Diazo-2,6-dibromo-2,5-cyclohexadienone
38676-25-4

4-Diazo-2,6-dibromo-2,5-cyclohexadienone

4-(5-(3,5-dibromo-4-hydroxyphenyl)-6-methoxynaphthalen-2-yl)butan-2-one

4-(5-(3,5-dibromo-4-hydroxyphenyl)-6-methoxynaphthalen-2-yl)butan-2-one

Conditions
ConditionsYield
With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} at 20℃; for 16h; Inert atmosphere; Schlenk technique; Molecular sieve;91%
nabumetone
42924-53-8

nabumetone

2,6-dichloro-4-diazocyclohexa-2,5-dien-1-one
31862-15-4

2,6-dichloro-4-diazocyclohexa-2,5-dien-1-one

4-(5-(3,5-dichloro-4-hydroxyphenyl)-6-methoxynaphthalen-2-yl)butan-2-one

4-(5-(3,5-dichloro-4-hydroxyphenyl)-6-methoxynaphthalen-2-yl)butan-2-one

Conditions
ConditionsYield
With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} at 20℃; for 16h; Inert atmosphere; Schlenk technique; Molecular sieve;90%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

1-(4-bromophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1363178-35-1

1-(4-bromophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; 4-bromo-benzaldehyde In ethanol at 25℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 25℃; for 24h; pH=4 - 5; Mannich reaction;
89%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

3,4-dichlorobenzaldehyde
6287-38-3

3,4-dichlorobenzaldehyde

1-(3,4-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1206182-19-5

1-(3,4-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; 3,4-dichlorobenzaldehyde In ethanol at 30℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 30℃; for 29h; pH=4 - 5; Mannich reaction;
89%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

5-(6-methoxynaphthalen-2-yl)-1-m-tolyl-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1206182-16-2

5-(6-methoxynaphthalen-2-yl)-1-m-tolyl-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; m-tolyl aldehyde In ethanol at 31℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 31℃; for 23h; pH=4 - 5; Mannich reaction;
89%
nabumetone
42924-53-8

nabumetone

methyl 3-diazo-6-oxocyclohexa-1,4-diene-1-carboxylate

methyl 3-diazo-6-oxocyclohexa-1,4-diene-1-carboxylate

methyl 2-hydroxy-5-(2-methoxy-6-(3-oxobutyl)naphthalen-1-yl)benzoate

methyl 2-hydroxy-5-(2-methoxy-6-(3-oxobutyl)naphthalen-1-yl)benzoate

Conditions
ConditionsYield
With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} In 1,2-dichloro-ethane at 50℃; for 16h; Inert atmosphere; Schlenk technique; Molecular sieve;89%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

1-(4-hydroxyphenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1363178-38-4

1-(4-hydroxyphenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; 4-hydroxy-benzaldehyde In ethanol at 20℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 20℃; for 25h; pH=3 - 4; Mannich reaction;
88%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

5-(6-methoxynaphthalen-2-yl)-1-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1206182-20-8

5-(6-methoxynaphthalen-2-yl)-1-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; 4-methoxy-benzaldehyde In ethanol at 32℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 32℃; for 28h; pH=3 - 4; Mannich reaction;
87%
nabumetone
42924-53-8

nabumetone

C15H19NO*(x)ClH

C15H19NO*(x)ClH

Conditions
ConditionsYield
Stage #1: nabumetone With ammonium hydroxide; hydrogen at 60℃; under 7500.75 Torr; for 20h; Autoclave;
Stage #2: With hydrogenchloride In diethyl ether
87%
triphenylmethyl alcohol
76-84-6

triphenylmethyl alcohol

nabumetone
42924-53-8

nabumetone

4-(6-methoxynaphthalen-2-yl)-2-phenylbutan-2-ol

4-(6-methoxynaphthalen-2-yl)-2-phenylbutan-2-ol

Conditions
ConditionsYield
Stage #1: triphenylmethyl alcohol; nabumetone With potassium phosphate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium tert-butylate; C69H57N2O2(1+)*BF4(1-)*H(1+) In toluene at 125℃; for 24h; Sealed tube;
Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
86%
nabumetone
42924-53-8

nabumetone

sulfamethoxazole
723-46-6

sulfamethoxazole

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

C32H30N4O7S

C32H30N4O7S

Conditions
ConditionsYield
With hydrogenchloride In ethanol; chloroform; water at 20 - 32℃; for 27h;85%
nabumetone
42924-53-8

nabumetone

benzaldehyde
100-52-7

benzaldehyde

(E)-5-(2-methoxynaphthyl)-1-phenylpenta-1-en-3-one

(E)-5-(2-methoxynaphthyl)-1-phenylpenta-1-en-3-one

Conditions
ConditionsYield
Stage #1: nabumetone With sodium hydroxide In methanol at 20℃; for 0.0833333h;
Stage #2: benzaldehyde In methanol at 20℃; for 16h;
82%
2,4-thiazolidinedion
2295-31-0

2,4-thiazolidinedion

nabumetone
42924-53-8

nabumetone

5-[3-(6-Methoxy-naphthalen-2-yl)-1-methyl-prop-(E)-ylidene]-thiazolidine-2,4-dione

5-[3-(6-Methoxy-naphthalen-2-yl)-1-methyl-prop-(E)-ylidene]-thiazolidine-2,4-dione

Conditions
ConditionsYield
With piperidine; benzoic acid In toluene Heating;80%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

1-(3-fluorophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1363178-31-7

1-(3-fluorophenyl)-5-(6-methoxynaphthalen-2-yl)-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; 3-Fluorobenzaldehyde In ethanol at 13℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 13℃; for 23h; pH=4 - 5; Mannich reaction;
80%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

nabumetone
42924-53-8

nabumetone

benzaldehyde
100-52-7

benzaldehyde

5-(6-methoxynaphthalen-2-yl)-1-phenyl-1-(4-(trifluoromethyl)phenylamino)pentan-3-one
1236218-15-7

5-(6-methoxynaphthalen-2-yl)-1-phenyl-1-(4-(trifluoromethyl)phenylamino)pentan-3-one

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylphenylamine; benzaldehyde In ethanol at 31℃; for 0.333333h; Mannich reaction;
Stage #2: nabumetone With hydrogenchloride In ethanol; chloroform; water at 31℃; for 25h; pH=4 - 5; Mannich reaction;
79%

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