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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Chloro-4'-fluoroacetophenone Manufacturer/High quality/Best price/In stock

Cas:456-04-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloro-4'-Fluoroacetophenone supplier in China

Cas:456-04-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply α-chloro-4-fluoroacetophenone

Cas:456-04-2

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 2-Chloro-4'-fluoroacetophenone CAS No. 456-04-2

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 456-04-2 with best quality

Cas:456-04-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

CAS Number 456-04-2 Product Name 2-chloro-4'-fluoroacetophenone Synonyms 4-fluorophenacyl Chloride; Alpha.-chloro-p-fluoroac

2-Chloro-4'-fluoroacetophenone CAS: 456-04-2

Cas:456-04-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanone,2-chloro-1-(4-fluorophenyl)- 456-04-2

Cas:456-04-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe,

2-Chloro-4'-fluoroacetophenone cas 456-04-2 4-Fluorophenacyl Chloride

Cas:456-04-2

Min.Order:1 Kilogram

FOB Price: $135.0 / 150.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanone,2-chloro-1-(4-fluorophenyl)-

Cas:456-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-4'-Fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

2-chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

α-Chloro-4-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 15.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Chloro-4'-fluoroacetophenone Basic information Product Name: 2-Chloro-4'-fluoroacetophenone Synonyms: .alpha.-Chloro-p-Fluoroacetophenone;AKOS BBS-00004073;ALPHA-CHLORO-4-FLUOROACETOPHENONE;LABOTEST-BB LT00233195;2'-CHLORO-4-FLUO

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Chloro-4'-fluoroacetophenone cas no. 456-04-2 98%

Cas:456-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Best price 2-Chloro-4'-Fluoroacetophenone 456-04-2

Cas:456-04-2

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

High quality 2-Chloro-4'-fluoroacetophenone cas NO.: 456-04-2

Cas:456-04-2

Min.Order:0

Negotiable

Type:Other

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

2-Chloro-4'-fluoroacetophenone

Cas:456-04-2

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

fluorobenzene
462-06-6

fluorobenzene

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With C6H11N2(1+)*Cl(1-)*Al0.67Cl2.01 at 20℃; for 0.5h; Reagent/catalyst; Concentration; Temperature;98.1%
aluminium trichloride In carbon disulfide for 2h; Heating;83%
With aluminium trichloride74.9%
methyl 4-flurobenzoate
403-33-8

methyl 4-flurobenzoate

chloroacetic acid
79-11-8

chloroacetic acid

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at -10℃; Flow reactor;98%
1-(chloroethynyl)-4-fluorobenzene
1737-34-4

1-(chloroethynyl)-4-fluorobenzene

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With tetrafluoroboric acid; water In 2,2,2-trifluoroethanol at 80℃; for 10h;92%
fluorobenzene
462-06-6

fluorobenzene

Chloroacetamide
79-07-2

Chloroacetamide

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
Stage #1: Chloroacetamide With tin(ll) chloride In isopropyl alcohol; acetonitrile at 15℃; for 1.16667h;
Stage #2: fluorobenzene In cyclohexane; isopropyl alcohol; acetonitrile at 8 - 45℃; for 9h; Temperature;
91%
1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With N-chloro-succinimide; toluene-4-sulfonic acid In acetonitrile at 80℃; Inert atmosphere;85%
With sodium hypochlorite at 40.8℃; Rate constant; Thermodynamic data; Kinetics; μ=0.025, var. temp. and solvents; or in the presence of α- or β-cyclodextrin in var. conc.; ΔH(excit.), ΔS(excit.);
Multi-step reaction with 2 steps
1: 59 percent / Et3N / dimethylformamide / 48 h / Heating
2: 19 percent / RuCl2(PPh3)3 / benzene / 7 h / 120 °C
View Scheme
1-(4-Fluorophenyl)ethanol
403-41-8

1-(4-Fluorophenyl)ethanol

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid In dichloromethane at 20℃; for 2h; Reagent/catalyst;83%
2-bromo-4'-fluoroacetophenone
403-29-2

2-bromo-4'-fluoroacetophenone

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With S4N4*SbCl5 In toluene for 3.5h; Heating;79%
With sodium chloride In acetonitrile
With N-benzyl-N,N,N-triethylammonium chloride; benzenesulfonyl chloride In water at 20℃; for 2h; Solvent; Green chemistry;
para-fluorostyrene
405-99-2

para-fluorostyrene

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With magnesium(II) chloride hexahydrate; oxygen; lithium perchlorate; manganese(ll) chloride In dichloromethane; acetone at 40℃; for 40h; Electrochemical reaction;68%
With iron(III) chloride; potassium chloride; oxygen; toluene-4-sulfonic acid In tert-butyl methyl ether at 20℃; Irradiation; Green chemistry;67%
With magnesium(II) chloride hexahydrate; cobalt(II) chloride hexahydrate; oxygen; lithium perchlorate In dichloromethane; acetone at 40℃; for 10h; Electrolysis; Sealed tube; chemoselective reaction;62%
1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

A

2,2-dichloro-1-(4-fluorophenyl)-ethan-1-one
5157-58-4

2,2-dichloro-1-(4-fluorophenyl)-ethan-1-one

B

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 60℃; for 48h;A n/a
B 67%
1-ethynyl-4-fluorobenzene
766-98-3

1-ethynyl-4-fluorobenzene

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With hydrogenchloride; iodine In dimethyl sulfoxide at 20℃; for 16h;67%
Trichloromethanesulfonyl chloride
2547-61-7

Trichloromethanesulfonyl chloride

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane
58518-77-7

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

A

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

B

3,3-dichloro-1-(4-fluorophenyl)prop-2-en-1-one

3,3-dichloro-1-(4-fluorophenyl)prop-2-en-1-one

Conditions
ConditionsYield
With ruthenium(II) In benzene at 120℃; for 7h; sealed;A 58%
B 21%
4-fluorobenzylic alcohol
459-56-3

4-fluorobenzylic alcohol

A

4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

B

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

C

1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

D

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With potassium tetrakis-μ-pyrophosphitodiplatinate(II); dichloromethane; tetrabutyl-ammonium chloride In water at 20℃; for 8h; Inert atmosphere; Irradiation;A n/a
B 45%
C n/a
D n/a
trifluoromethane sulfonyl chloride
421-83-0

trifluoromethane sulfonyl chloride

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane
58518-77-7

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

A

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

B

1-(4-fluorophenyl)-3,3,3-trifluoropropane-1-one

1-(4-fluorophenyl)-3,3,3-trifluoropropane-1-one

Conditions
ConditionsYield
With tris(triphenylphosphine)ruthenium(II) chloride In benzene at 120℃; for 7h;A 19%
B 24%
1-ethynyl-4-fluorobenzene
766-98-3

1-ethynyl-4-fluorobenzene

acetic acid
64-19-7

acetic acid

A

1-(chloroethynyl)-4-fluorobenzene
1737-34-4

1-(chloroethynyl)-4-fluorobenzene

B

2,2-dichloro-1-(4-fluorophenyl)-ethan-1-one
5157-58-4

2,2-dichloro-1-(4-fluorophenyl)-ethan-1-one

C

1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

D

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

E

1-((Z)-1,2-Dichloro-vinyl)-4-fluoro-benzene

1-((Z)-1,2-Dichloro-vinyl)-4-fluoro-benzene

F

2-chloro-1-(4-fluorophenyl)butane-1,3-dione
87992-01-6

2-chloro-1-(4-fluorophenyl)butane-1,3-dione

Conditions
ConditionsYield
With perchloric acid at 40℃; Rate constant; Product distribution; Mechanism;A 3 % Chromat.
B 24 % Chromat.
C 8 % Chromat.
D 34 % Chromat.
E 14 % Chromat.
F 9 % Chromat.
3-(5-chloropyrid-2-yl)-4-(4-fluorophenyl)-thiazolidine-2-thione
75130-83-5

3-(5-chloropyrid-2-yl)-4-(4-fluorophenyl)-thiazolidine-2-thione

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
In chloroform; [2-(4-fluorophenyl)-2-oxo]-ethyl 5-chloropyrid-2-yldithiocarbamate; acetonitrile
4-fluoro-2-hydroxy-acetophenone
403-31-6

4-fluoro-2-hydroxy-acetophenone

A

4-(4-fluorophenyl)-5H-[1,2,3]oxathiazole 2,2-dioxide
1025506-04-0

4-(4-fluorophenyl)-5H-[1,2,3]oxathiazole 2,2-dioxide

B

C8H8FNO4S

C8H8FNO4S

C

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With pyridine; formic acid; isocyanate de chlorosulfonyle In acetonitrile at 0 - 10℃; Inert atmosphere;
N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride
343337-74-6

N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With triethylamine In diethyl ether Inert atmosphere;
N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride
343337-74-6

N-trifluoromethylsulfonyl-(4-fluorophenyl)-carboximidoyl chloride

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

A

Trifluoromethanesulfonamide
421-85-2

Trifluoromethanesulfonamide

B

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran Inert atmosphere;
1-[4-(1-naphthyl)butyl]piperazine dihydrochloride

1-[4-(1-naphthyl)butyl]piperazine dihydrochloride

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone
932028-02-9

1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)butyl]piperazin-1-yl}ethanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In chloroform for 3h; Heating;100%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

[R]-1-chloro-2-(4-fluorophenyl)-2-ethanol
126534-43-8

[R]-1-chloro-2-(4-fluorophenyl)-2-ethanol

Conditions
ConditionsYield
Stage #1: 2-Chloro-4'-fluoroacetophenone With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran at 20℃; for 105h; Inert atmosphere;
Stage #2: With methanol In tetrahydrofuran Inert atmosphere;
100%
With Almag CRED A131; NADP; glucose dehydrogenase In water; dimethyl sulfoxide; isopropyl alcohol at 20℃; pH=7; Enzymatic reaction;96%
With formic acid; C25H29N2O3RuS; potassium formate In water; ethyl acetate at 60℃; for 4h; Inert atmosphere; enantioselective reaction;94%
(trimethylsilyl)methylmagnesium chloride
13170-43-9

(trimethylsilyl)methylmagnesium chloride

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

2-(4-fluorophenyl)-2-trimethylsilylmethyloxirane

2-(4-fluorophenyl)-2-trimethylsilylmethyloxirane

Conditions
ConditionsYield
With sodium chloride In N-methyl-acetamide; diethyl ether; hexane; water100%
With sodium chloride In N-methyl-acetamide; diethyl ether; hexane; water100%
2-methyl-1,3,4-oxadiazol-5(4H)-one
3069-67-8

2-methyl-1,3,4-oxadiazol-5(4H)-one

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

3-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-5-methyl-3H-1,3,4-oxadiazol-2-one
1068975-19-8

3-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-5-methyl-3H-1,3,4-oxadiazol-2-one

Conditions
ConditionsYield
Stage #1: 2-methyl-1,3,4-oxadiazol-5(4H)-one With sodium methylate In methanol at 20℃; for 0.166667h;
Stage #2: 2-Chloro-4'-fluoroacetophenone; tetrabutylammomium bromide In chloroform at 20℃; Heating / reflux;
100%
2'-methylbenzaldehyde-thiosemicarbazone
5706-81-0

2'-methylbenzaldehyde-thiosemicarbazone

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-(2-methylbenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine
1011943-68-2

1-(2-methylbenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine

Conditions
ConditionsYield
In isopropyl alcohol Reflux;100%
Boc-D-Trp-OH
5241-64-5

Boc-D-Trp-OH

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

C24H25FN2O5
1411994-50-7

C24H25FN2O5

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;100%
4-(4-chlorophenyl)-4-hydroxypiperidine
39512-49-7

4-(4-chlorophenyl)-4-hydroxypiperidine

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

C19H19ClFNO2

C19H19ClFNO2

Conditions
ConditionsYield
With potassium carbonate In ethanol Inert atmosphere;100%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

(S)-1-chloro-2-hydroxy-2-(p-fluorophenyl)ethane
126534-42-7

(S)-1-chloro-2-hydroxy-2-(p-fluorophenyl)ethane

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; f-amphox; hydrogen; potassium carbonate In ethanol; hexane at 25 - 30℃; under 38002.6 Torr; for 4h; Inert atmosphere; Glovebox; Autoclave; enantioselective reaction;99%
With Almag CRED A161; NADP; glucose dehydrogenase In water; dimethyl sulfoxide; isopropyl alcohol at 20℃; pH=7; Enzymatic reaction;96%
With dimethylsulfide borane complex; C72H66N6O9 In toluene at 30℃; for 2.5h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;95%
4-phenyl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
16629-40-6

4-phenyl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-(4-fluorophenyl)-2-[(4-phenyl-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl)thio]ethanone
325694-00-6

1-(4-fluorophenyl)-2-[(4-phenyl-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl)thio]ethanone

Conditions
ConditionsYield
With potassium carbonate In acetone for 3h; Heating / reflux;99%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

cyclohexylmethylamine
3218-02-8

cyclohexylmethylamine

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

ethyl 1-(cyclohexylmethyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

ethyl 1-(cyclohexylmethyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl acetoacetate With sodium hydride In tetrahydrofuran; paraffin oil at 0℃; for 0.5h;
Stage #2: 2-Chloro-4'-fluoroacetophenone With potassium iodide In tetrahydrofuran; paraffin oil at 20℃; for 2h;
Stage #3: cyclohexylmethylamine In acetic acid at 80℃; for 18h;
97%
phenythoin
57-41-0

phenythoin

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

3-(2-(4-fluorophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

3-(2-(4-fluorophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h;
Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone at 20℃; for 24.33h;
96%
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.5h;
Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone at 20℃; for 24h;
45%
With potassium carbonate In acetone at 20℃; for 24h;
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

4-fluoro-2-hydroxy-acetophenone
403-31-6

4-fluoro-2-hydroxy-acetophenone

Conditions
ConditionsYield
With potassium iodide; sodium hydroxide In dimethyl sulfoxide at 100℃; for 5h;95.5%
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 10 h / 90 °C
2: potassium carbonate; methanol / 2 h / 20 °C
View Scheme
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

3-chloro-2-(4-fluorophenyl)-2-(trimethylsilanyloxy)propionitrile

3-chloro-2-(4-fluorophenyl)-2-(trimethylsilanyloxy)propionitrile

Conditions
ConditionsYield
With tris[N,N-bis(trimethylsilyl)amide]gadolinium(III); (2S,3S,4R)-2-Ph2P(O)CH2-3-OH-4-(2-OH-4,5-F2-C6H2)tetraHpyran; propiononitrile at -30℃; for 3h;95%
2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide
6292-77-9

2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-(3,4-dimethoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine
464881-93-4

1-(3,4-dimethoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine

Conditions
ConditionsYield
In isopropyl alcohol Reflux;95%
1-hydroxy-3-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one
19815-03-3

1-hydroxy-3-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-[2-(4-fluorophenyl)-2-oxoethoxy]-3-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one

1-[2-(4-fluorophenyl)-2-oxoethoxy]-3-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one

Conditions
ConditionsYield
Stage #1: 1-hydroxy-3-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one With potassium carbonate In acetone at 50 - 56℃; Williamson reaction;
Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone for 1h; Williamson reaction; Heating;
94%
3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one
55047-37-5

3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

3-[2-(4-fluorophenyl)-2-oxoethoxy]-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one

3-[2-(4-fluorophenyl)-2-oxoethoxy]-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one

Conditions
ConditionsYield
Stage #1: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one With potassium carbonate In acetone at 50 - 56℃; Williamson reaction;
Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone for 1h; Williamson reaction; Heating;
94%
4-methoxybenzylidene thiosemicarbazone
4334-74-1

4-methoxybenzylidene thiosemicarbazone

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine
364057-81-8

1-(4-methoxybenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine

Conditions
ConditionsYield
In isopropyl alcohol Reflux;94%
5-acetyl-2,4-dimethylthiazole
38205-60-6

5-acetyl-2,4-dimethylthiazole

thiosemicarbazide
79-19-6

thiosemicarbazide

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

2-(4-(4-fluorophenyl)thiazol-2-yl)-1-(1-(2,4-dimethylthiazol-5-yl)ethylidene)hydrazine

2-(4-(4-fluorophenyl)thiazol-2-yl)-1-(1-(2,4-dimethylthiazol-5-yl)ethylidene)hydrazine

Conditions
ConditionsYield
at 20℃; for 0.5h; Solvent;94%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

ethyl 4-[2-(4-fluorophenyl)-2-oxoethyl]piperazine-1-carboxylate
89011-45-0

ethyl 4-[2-(4-fluorophenyl)-2-oxoethyl]piperazine-1-carboxylate

Conditions
ConditionsYield
In chloroform 1)1.5 h at room temperature 2) reflux for 1 h;93%
In chloroform for 3h; Heating;
In chloroform Heating;
In chloroform for 3h; Heating / reflux;
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

2-Chloro-1-(4-fluorophenyl)ethanol
61592-48-1

2-Chloro-1-(4-fluorophenyl)ethanol

Conditions
ConditionsYield
With formic acid; 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; sodium formate In water at 80℃; for 18h; pH=4.5; Inert atmosphere; chemoselective reaction;93%
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.666667h;93%
With sodium tetrahydroborate In methanol at 0 - 20℃;80%
7-hydroxy-6-methyl-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
55047-28-4

7-hydroxy-6-methyl-2,3-dihydrocyclopenta[c]chromen-4(1H)-one

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

7-[2-(4-fluorophenyl)-2-oxoethoxy]-6-methyl-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
307548-96-5

7-[2-(4-fluorophenyl)-2-oxoethoxy]-6-methyl-2,3-dihydrocyclopenta[c]chromen-4(1H)-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 50 - 56℃; Williamson reaction;93%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

7-hydroxy-4-(4-methoxyphenyl)-8-methyl-2H-2-chromenone
370583-62-3

7-hydroxy-4-(4-methoxyphenyl)-8-methyl-2H-2-chromenone

7-[2-(4-fluorophenyl)-2-oxoethoxy]-4-(4-methoxyphenyl)-8-methyl-2H-2-chromenone
376383-09-4

7-[2-(4-fluorophenyl)-2-oxoethoxy]-4-(4-methoxyphenyl)-8-methyl-2H-2-chromenone

Conditions
ConditionsYield
With potassium carbonate In acetone at 50 - 56℃; Williamson reaction;93%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

2-azido-1-(4-fluoro-phenyl)-ethanone
118887-70-0

2-azido-1-(4-fluoro-phenyl)-ethanone

Conditions
ConditionsYield
With sodium azide In glycerol at 25℃; for 3h;93%
With azide on Amberlite(R) IRA 900 In dichloromethane at 30℃; for 0.5h;
fluorobenzene
462-06-6

fluorobenzene

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

4,4'-difluorodeoxybenzoin
366-68-7

4,4'-difluorodeoxybenzoin

Conditions
ConditionsYield
Stage #1: fluorobenzene; 2-Chloro-4'-fluoroacetophenone With aluminum (III) chloride at 20 - 50℃; for 14.25h; Friedel-Crafts Acylation; Cooling with ice; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water
93%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

potassium thioacetate
10387-40-3

potassium thioacetate

S-acetyl-2-mercapto-4’-fluoroacetophenone
181931-41-9

S-acetyl-2-mercapto-4’-fluoroacetophenone

Conditions
ConditionsYield
In ethanol for 24h; Ambient temperature;92%
7-hydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
21260-41-3

7-hydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

7-[2-(4-fluorophenyl)-2-oxoethoxy]-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
307548-75-0

7-[2-(4-fluorophenyl)-2-oxoethoxy]-2,3-dihydrocyclopenta[c]chromen-4(1H)-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 50 - 56℃; Williamson reaction;92%
2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

R-(-)-2-(4-fluorophenyl)oxirane
18511-62-1, 53631-23-5, 134356-74-4, 134356-73-3

R-(-)-2-(4-fluorophenyl)oxirane

Conditions
ConditionsYield
With sodium formate In water at 25℃; enantioselective reaction;92%
Multi-step reaction with 2 steps
1: NaBH4; 2-(3-NO2-Ph)-1,3,2-dioxaborolane-(4R,5R)-dicarboxylic acid / tetrahydrofuran / 25 °C
2: aq. NaOH / tetrahydrofuran / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: 24.4 g / sodium borohydride / methanol / 1.5 h / Ambient temperature
3: 5.7 g / potassium carbonate / methanol; H2O / 3 h / Ambient temperature
View Scheme
4-methylbenzaldehyde thiosemicarbazone
5706-83-2

4-methylbenzaldehyde thiosemicarbazone

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

1-(4-methylbenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine
402584-91-2

1-(4-methylbenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine

Conditions
ConditionsYield
In isopropyl alcohol Reflux;92%

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