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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5,5-Diphenylhydantoin Manufacturer/High quality/Best price/In stock

Cas:57-41-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Phenytoin CAS 57-41-0 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the p

Phenytoin CAS 57-41-0

Cas:57-41-0

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Phenytoin

Cas:57-41-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 5,5-Diphenylhydantoin 57-41-0 GMP Manufacturer

Cas:57-41-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

5,5-Diphenylhydantoin Basic information Product Name: 5,5-Diphenylhydantoin Synonyms: PHENYTOIN BASE;PHENYTION;PHENYTOIN;5,5-DIPHENYLHYDANTHOIN;5,5-DIPHENYLHYDANTOIN;5,5-DIPHENYL-2,4-IMI

TIANFU-CHEM CAS:57-41-0 5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 57-41-0 with best quality

Cas:57-41-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

5,5-Diphenylhydantoin/ LIDE PHARMA- Factory supply / Best price

Cas:57-41-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4-Imidazolidinedione,5,5-diphenyl- 57-41-0

Cas:57-41-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:25 Gram

FOB Price: $45.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

5,5-Diphenylhydantoin CAS:57-41-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

5,5-Diphenylhydantoin CAS:57-41-0

Cas:57-41-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,4-Imidazolidinedione,5,5-diphenyl-

Cas:57-41-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2,4-Imidazolidinedione,5,5-diphenyl-

Cas:57-41-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Phenytoin

Cas:57-41-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Phenytoin

Cas:57-41-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery Appearance:white crystals or powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Reduces incidence of gran

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

57-41-0 5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

57-41-0 5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

57-41-0 5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

2,4-Imidazolidinedione,5,5-diphenyl-

Cas:57-41-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Phenytoin

Cas:57-41-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

57-41-0 5,5-Diphenylhydantoin

Cas:57-41-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

PHENYTION

Cas:57-41-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

ethyl 3-(5,5-diphenylhydantoin) formate
1097-57-0

ethyl 3-(5,5-diphenylhydantoin) formate

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrazine hydrate In ethanol Heating;100%
5,5-diphenyl-2-thioxoimidazolidin-4-one
21083-47-6

5,5-diphenyl-2-thioxoimidazolidin-4-one

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With dihydrogen peroxide; sodium hydrogencarbonate at 24℃; for 0.5h;100%
With tetrabromoglycoluril In ethanol at 40℃; for 0.166667h; Reagent/catalyst; Green chemistry;99%
With dihydrogen peroxide; acetic acid In water; N,N-dimethyl-formamide at 20℃; for 24h;92%
benzil
134-81-6

benzil

urea
57-13-6

urea

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 0.05h; Sonication;98%
With chitosan decorated Fe3O4 magnetic nanoparticles In ethanol; water at 60℃; for 0.133333h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Green chemistry;98%
With dmap; potassium hydroxide In water; butan-1-ol at 119℃; for 0.666667h; Temperature;98.2%
benzil
134-81-6

benzil

urea
57-13-6

urea

A

3a,6a-diphenylglycoluril
5157-15-3

3a,6a-diphenylglycoluril

B

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With sodium hydroxide for 0.0333333h; Microwave irradiation; neat (no solvent);A 1.6%
B 98%
With potassium hydroxide In ethanol at 40℃; for 2h; Ultrasound irradiation;A 75%
B 14%
With potassium hydroxide In methanol at 64.84℃; for 24h;A n/a
B 61%
1-(Aminoacetyl)-5,5-diphenylimidazolidine-2,4-dione hydrochloride

1-(Aminoacetyl)-5,5-diphenylimidazolidine-2,4-dione hydrochloride

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride for 2h; Heating;93%
Multi-step reaction with 3 steps
1: 55 percent / 4 h / Heating
2: 71 percent / conc. aq. NH3 / ethanol / 24 h / Ambient temperature
3: 63 percent / 2percent aq. HCl / ethanol / 50 h / Heating
View Scheme
benzil
134-81-6

benzil

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With urea; sodium hydroxide In ethanol; water at 80℃; for 3h; Temperature; Large scale;91.4%
parabanic acid
120-89-8

parabanic acid

benzene
71-43-2

benzene

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With trifluorormethanesulfonic acid at 100℃; for 2h;87%
ethyl 3-(5,5-diphenylhydantoin) formate
1097-57-0

ethyl 3-(5,5-diphenylhydantoin) formate

A

3-amino-5,5-diphenylimidazolidine-2,4-dione
1224-08-4

3-amino-5,5-diphenylimidazolidine-2,4-dione

B

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrazine hydrate at 130 - 140℃; for 4h;A 9%
B 86%
potassium cyanide

potassium cyanide

benzophenone
119-61-9

benzophenone

ammonium carbonate
506-87-6

ammonium carbonate

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
In ethanol; water Heating;85%
With iron(III) oxide In neat (no solvent) at 70℃; for 0.9h; Bucherer-Bergs Reaction;85%
In ethanol; water for 0.166667h; Time; Bucherer-Bergs Reaction; Microwave irradiation;84%
In ethanol at 60℃; for 15h;
trimethylsilyl isocyanate
1118-02-1

trimethylsilyl isocyanate

α,α-diphenylglycine methyl ester hydrochloride
93504-24-6

α,α-diphenylglycine methyl ester hydrochloride

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
Stage #1: trimethylsilyl isocyanate; α,α-diphenylglycine methyl ester hydrochloride In water for 8h; Milling; Green chemistry;
Stage #2: With caesium carbonate In water Milling; Green chemistry;
84%
benzil
134-81-6

benzil

urea
57-13-6

urea

A

3a,6a-diphenylglycoluril
101241-21-8

3a,6a-diphenylglycoluril

B

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With potassium hydroxide In water; dimethyl sulfoxide for 0.5h; Biltz reaction; microwave irradiation;A n/a
B 80%
With sodium hydroxide In water; dimethyl sulfoxide at 70℃; for 2h;A 3.76%
B 61.75%
With potassium hydroxide
With potassium hydroxide
3-(tert-butyl)-1-(4-methoxybenzyl)-5,5-diphenylimidazolidine-2,4-dione

3-(tert-butyl)-1-(4-methoxybenzyl)-5,5-diphenylimidazolidine-2,4-dione

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With methanesulfonic acid In dichloromethane at 60℃; for 24h; Sealed tube;72%
2-hydroxy-2-phenylacetophenone
119-53-9

2-hydroxy-2-phenylacetophenone

urea
57-13-6

urea

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 100℃; for 1h; Temperature;70%
With potassium bromate; sodium hydroxide
With sodium hydroxide; potassium chlorate
benzil
134-81-6

benzil

urea
57-13-6

urea

A

4,5-Dihydroxy-4,5-diphenylimidazolidin-2-on
5157-13-1

4,5-Dihydroxy-4,5-diphenylimidazolidin-2-on

B

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 50 - 60℃; for 2h;A n/a
B 66%
ethyl 2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2-ylthio)acetate

ethyl 2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2-ylthio)acetate

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Heating;65%
2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2-ylthio)acetic acid
122180-35-2

2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2-ylthio)acetic acid

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Heating;65%
carbon monoxide
201230-82-2

carbon monoxide

α-amino-α,α-diphenylacetamide
15427-81-3

α-amino-α,α-diphenylacetamide

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With tungsten hexacarbonyl; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 35℃; under 60804.1 Torr; for 24h; Inert atmosphere;64%
carbon monoxide
201230-82-2

carbon monoxide

2,2-diphenylglycine
3060-50-2

2,2-diphenylglycine

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With tungsten hexacarbonyl; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 45℃; for 36h;64%
1-(Acetamidoacetyl)-5,5-diphenylimidazolidine-2,4-dione
170700-20-6

1-(Acetamidoacetyl)-5,5-diphenylimidazolidine-2,4-dione

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 50h; Heating;63%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

ethyl 3-(5,5-diphenylhydantoin) formate
1097-57-0

ethyl 3-(5,5-diphenylhydantoin) formate

A

3-N-(2-morpholinoethyl)-5,5-diphenylhydantoin
20000-16-2

3-N-(2-morpholinoethyl)-5,5-diphenylhydantoin

B

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
for 4h; Heating;A 33%
B 26%
2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one
24133-90-2

2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one

chromium(lll) acetate
1066-30-4

chromium(lll) acetate

phenythoin
57-41-0

phenythoin

4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazol-2-one
2032-16-8

4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazol-2-one

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride
2,5-bis-methylsulfanyl-4,4-diphenyl-4H-imidazole
2032-17-9

2,5-bis-methylsulfanyl-4,4-diphenyl-4H-imidazole

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride
Multi-step reaction with 2 steps
1: aqueous acetic acid
2: aq.-ethanolic HCl
View Scheme
ethanol
64-17-5

ethanol

1,3-dichloro-5,5-diphenylhydantoin
100965-46-6

1,3-dichloro-5,5-diphenylhydantoin

phenythoin
57-41-0

phenythoin

Benzilic acid
76-93-7

Benzilic acid

urea
57-13-6

urea

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
at 230 - 240℃;
bromo-diphenyl-acetic acid
7494-95-3

bromo-diphenyl-acetic acid

urea
57-13-6

urea

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
at 150 - 170℃;
2.2-Diphenylhydantoinsaeure
6802-95-5

2.2-Diphenylhydantoinsaeure

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; Rate constant;
3-(hydroxymethyl)-5,5-diphenylhydantoin N,N-dimethylglycine ester, monomethanesulfonate salt
71919-15-8

3-(hydroxymethyl)-5,5-diphenylhydantoin N,N-dimethylglycine ester, monomethanesulfonate salt

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With acetate buffer In water at 25℃; Rate constant; Mechanism; pH dependence;
C57H56N4O4(2+)*2Br(1-)
80381-85-7

C57H56N4O4(2+)*2Br(1-)

A

formaldehyd
50-00-0

formaldehyd

B

1,1-diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol
968-63-8

1,1-diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol

C

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With buffer; pH 8.74 In water at 37℃; Rate constant; other pH;
Fosphenytoin

Fosphenytoin

phenythoin
57-41-0

phenythoin

Conditions
ConditionsYield
With acetate buffer In methanol; water at 70℃; Rate constant; Mechanism; pH dependence;
With 6-O-(sulfobutyl)-β-cyclodextrin sodium salt In various solvent(s) at 25℃; pH=7.4; Equilibrium constant; Activation energy; Kinetics; Further Variations:; pH-values; Reagents; Elimination;
methyl 9-bromononanoate
67878-15-3

methyl 9-bromononanoate

phenythoin
57-41-0

phenythoin

methyl 2,5-dioxo-4,4-diphenylimidazolidine-1-nonanoate
143547-58-4

methyl 2,5-dioxo-4,4-diphenylimidazolidine-1-nonanoate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 110℃; for 0.25h;100%
phenythoin
57-41-0

phenythoin

[(2)H10]phenytoin
65854-97-9

[(2)H10]phenytoin

Conditions
ConditionsYield
With platinum on carbon; hydrogen; water-d2 at 180℃; for 24h;100%
formaldehyd
50-00-0

formaldehyd

phenythoin
57-41-0

phenythoin

3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione
21616-46-6

3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione

Conditions
ConditionsYield
With potassium carbonate In water at 20℃; for 24h;98%
With potassium carbonate In water for 24h; Ambient temperature;92%
With potassium carbonate In water for 24h; Ambient temperature;
iodobenzene
591-50-4

iodobenzene

phenythoin
57-41-0

phenythoin

3,5,5-triphenylimidazolidine-2,4-dione
52461-02-6

3,5,5-triphenylimidazolidine-2,4-dione

Conditions
ConditionsYield
With copper(I) oxide In N,N-dimethyl-formamide at 150℃; for 14h; Inert atmosphere; regioselective reaction;98%
phenythoin
57-41-0

phenythoin

sodium phenytoin
630-93-3, 64915-84-0

sodium phenytoin

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 42℃; for 0.25h; Temperature;97%
With sodium hydroxide In water at 45℃; pH=12; Temperature; Large scale;96.3%
With sodium hydroxide; sodium chloride In water at 5 - 30℃; for 1h; Product distribution / selectivity;85%
With sodium hydroxide In water at 5 - 30℃; for 1h; Product distribution / selectivity;66.2%
phenythoin
57-41-0

phenythoin

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)acetate
99702-70-2

ethyl 2-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;97%
With potassium carbonate In acetonitrile Heating;
phenythoin
57-41-0

phenythoin

ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

ethyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)acetate
976-85-2

ethyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)acetate

B

sodium ethanolate
141-52-6

sodium ethanolate

Conditions
ConditionsYield
In ethanolA 96%
B n/a
phenythoin
57-41-0

phenythoin

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

3-(2-(4-fluorophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

3-(2-(4-fluorophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h;
Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone at 20℃; for 24.33h;
96%
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.5h;
Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone at 20℃; for 24h;
45%
With potassium carbonate In acetone at 20℃; for 24h;
phenythoin
57-41-0

phenythoin

p-toluidine
106-49-0

p-toluidine

dimedone
126-81-8

dimedone

(p-tolyl)spiro[acridine-9,20-imidazolidine]-trione

(p-tolyl)spiro[acridine-9,20-imidazolidine]-trione

Conditions
ConditionsYield
With TiO2 blended Fe3O4 coated with phosphotungstic acid at 70℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Sonication; Green chemistry;96%
phenythoin
57-41-0

phenythoin

1,3-dichloro-5,5-diphenylhydantoin
100965-46-6

1,3-dichloro-5,5-diphenylhydantoin

Conditions
ConditionsYield
With trichloroisocyanuric acid In acetonitrile at 20℃; for 0.5h;95%
With sodium hypochlorite Ambient temperature;31%
With sodium hypochlorite for 3h;25%
With hydrogenchloride; sodium hypochlorite for 4h; Ambient temperature;4.7%
With sodium hypochlorite
phenythoin
57-41-0

phenythoin

propargyl bromide
106-96-7

propargyl bromide

5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione
2718-07-2

5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 36h;95%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;87%
With potassium hydroxide In ethanol for 4h; Heating;76%
phenythoin
57-41-0

phenythoin

p-chlorophenacyl chloride
937-20-2

p-chlorophenacyl chloride

3-(2-(4-chlorophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

3-(2-(4-chlorophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h;
Stage #2: p-chlorophenacyl chloride In acetone at 20℃; for 24.33h;
95%
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.5h;
Stage #2: p-chlorophenacyl chloride In acetone at 20℃; for 24h;
43%
phenythoin
57-41-0

phenythoin

dimedone
126-81-8

dimedone

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

(4-aminophenyl)spiro[acridine-9,20-imidazolidine]-trione

(4-aminophenyl)spiro[acridine-9,20-imidazolidine]-trione

Conditions
ConditionsYield
With TiO2 blended Fe3O4 coated with phosphotungstic acid at 70℃; for 0.2h; Sonication; Green chemistry;94%
phenythoin
57-41-0

phenythoin

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

5,5-diphenyl-3-methylthiomethylhydantoin
66503-15-9

5,5-diphenyl-3-methylthiomethylhydantoin

Conditions
ConditionsYield
for 16h; Heating;93.7%
phenythoin
57-41-0

phenythoin

trityl chloride
76-83-5

trityl chloride

5,5-diphenyl-3-tritylimidazolidine-2,4-dione
1272010-17-9

5,5-diphenyl-3-tritylimidazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: phenythoin With triethylamine In dichloromethane at 20℃; for 0.25h;
Stage #2: trityl chloride In dichloromethane
93%
With triethylamine In dichloromethane at 20℃; for 30h;58%
phenythoin
57-41-0

phenythoin

4-amino-phenol
123-30-8

4-amino-phenol

dimedone
126-81-8

dimedone

(4-hydroxyphenyl)spiro[acridine-9,20-imidazolidine]-trione

(4-hydroxyphenyl)spiro[acridine-9,20-imidazolidine]-trione

Conditions
ConditionsYield
With TiO2 blended Fe3O4 coated with phosphotungstic acid at 70℃; for 0.166667h; Sonication; Green chemistry;93%
phenythoin
57-41-0

phenythoin

3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione
21616-46-6

3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione

Conditions
ConditionsYield
With formaldehyd; potassium carbonate; phosphorus pentaoxide In water92%
phenythoin
57-41-0

phenythoin

3-chloro-N-(4-fluorophenyl)propionamide

3-chloro-N-(4-fluorophenyl)propionamide

3-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)-N-(4-fluorophenyl)propanamide

3-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)-N-(4-fluorophenyl)propanamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h;92%
fluoroiodomethane
373-53-5

fluoroiodomethane

phenythoin
57-41-0

phenythoin

1,3-bis(fluoromethyl)-5,5-diphenyl-2,4-imidazolidinone

1,3-bis(fluoromethyl)-5,5-diphenyl-2,4-imidazolidinone

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction;92%
ethyl bromofluoroacetate
401-55-8

ethyl bromofluoroacetate

phenythoin
57-41-0

phenythoin

(2,5-dioxo-4,4-diphenyl-imidazolidin-1-yl)-fluoro-acetic acid ethyl ester

(2,5-dioxo-4,4-diphenyl-imidazolidin-1-yl)-fluoro-acetic acid ethyl ester

Conditions
ConditionsYield
Stage #1: phenythoin With tetrabutylammomium bromide; sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Metallation;
Stage #2: ethyl bromofluoroacetate In tetrahydrofuran at 20℃; for 12h; Substitution; Gabriel reaction;
91%
phenythoin
57-41-0

phenythoin

potassium carbonate
584-08-7

potassium carbonate

3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione
21616-46-6

3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione

Conditions
ConditionsYield
With formaldehyd In water91%
With formaldehyd In water91%
With formaldehyd In water91%
With formaldehyd In water
phenythoin
57-41-0

phenythoin

1-chloroacetophenone
532-27-4

1-chloroacetophenone

3-(2-oxo-2-phenylethyl)-5,5-diphenylimidazolidine-2,4-dione

3-(2-oxo-2-phenylethyl)-5,5-diphenylimidazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h;
Stage #2: 1-chloroacetophenone In acetone at 20℃; for 24.33h;
91%
With potassium carbonate In acetone at 20℃; for 24h;
phenythoin
57-41-0

phenythoin

acetic anhydride
108-24-7

acetic anhydride

1-Acetyl-5,5-diphenylhydantoin
4635-21-6

1-Acetyl-5,5-diphenylhydantoin

Conditions
ConditionsYield
With pyridine for 4h; Heating;90%
2-(2-bromoethyl)isoindoline-1,3-dione
574-98-1

2-(2-bromoethyl)isoindoline-1,3-dione

phenythoin
57-41-0

phenythoin

3-(2'-phthalimidoethyl)-5,5-diphenylhydantoin
20000-09-3

3-(2'-phthalimidoethyl)-5,5-diphenylhydantoin

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 2h; Heating;90%
With potassium carbonate In N,N-dimethyl-formamide

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