Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol Heating; | 100% |
5,5-diphenyl-2-thioxoimidazolidin-4-one
phenythoin
Conditions | Yield |
---|---|
With dihydrogen peroxide; sodium hydrogencarbonate at 24℃; for 0.5h; | 100% |
With tetrabromoglycoluril In ethanol at 40℃; for 0.166667h; Reagent/catalyst; Green chemistry; | 99% |
With dihydrogen peroxide; acetic acid In water; N,N-dimethyl-formamide at 20℃; for 24h; | 92% |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 20℃; for 0.05h; Sonication; | 98% |
With chitosan decorated Fe3O4 magnetic nanoparticles In ethanol; water at 60℃; for 0.133333h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Green chemistry; | 98% |
With dmap; potassium hydroxide In water; butan-1-ol at 119℃; for 0.666667h; Temperature; | 98.2% |
Conditions | Yield |
---|---|
With sodium hydroxide for 0.0333333h; Microwave irradiation; neat (no solvent); | A 1.6% B 98% |
With potassium hydroxide In ethanol at 40℃; for 2h; Ultrasound irradiation; | A 75% B 14% |
With potassium hydroxide In methanol at 64.84℃; for 24h; | A n/a B 61% |
phenythoin
Conditions | Yield |
---|---|
With hydrogenchloride for 2h; Heating; | 93% |
Multi-step reaction with 3 steps 1: 55 percent / 4 h / Heating 2: 71 percent / conc. aq. NH3 / ethanol / 24 h / Ambient temperature 3: 63 percent / 2percent aq. HCl / ethanol / 50 h / Heating View Scheme |
Conditions | Yield |
---|---|
With urea; sodium hydroxide In ethanol; water at 80℃; for 3h; Temperature; Large scale; | 91.4% |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid at 100℃; for 2h; | 87% |
ethyl 3-(5,5-diphenylhydantoin) formate
A
3-amino-5,5-diphenylimidazolidine-2,4-dione
B
phenythoin
Conditions | Yield |
---|---|
With hydrazine hydrate at 130 - 140℃; for 4h; | A 9% B 86% |
Conditions | Yield |
---|---|
In ethanol; water Heating; | 85% |
With iron(III) oxide In neat (no solvent) at 70℃; for 0.9h; Bucherer-Bergs Reaction; | 85% |
In ethanol; water for 0.166667h; Time; Bucherer-Bergs Reaction; Microwave irradiation; | 84% |
In ethanol at 60℃; for 15h; |
trimethylsilyl isocyanate
α,α-diphenylglycine methyl ester hydrochloride
phenythoin
Conditions | Yield |
---|---|
Stage #1: trimethylsilyl isocyanate; α,α-diphenylglycine methyl ester hydrochloride In water for 8h; Milling; Green chemistry; Stage #2: With caesium carbonate In water Milling; Green chemistry; | 84% |
Conditions | Yield |
---|---|
With potassium hydroxide In water; dimethyl sulfoxide for 0.5h; Biltz reaction; microwave irradiation; | A n/a B 80% |
With sodium hydroxide In water; dimethyl sulfoxide at 70℃; for 2h; | A 3.76% B 61.75% |
With potassium hydroxide | |
With potassium hydroxide |
phenythoin
Conditions | Yield |
---|---|
With methanesulfonic acid In dichloromethane at 60℃; for 24h; Sealed tube; | 72% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 100℃; for 1h; Temperature; | 70% |
With potassium bromate; sodium hydroxide | |
With sodium hydroxide; potassium chlorate |
benzil
urea
A
4,5-Dihydroxy-4,5-diphenylimidazolidin-2-on
B
phenythoin
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol at 50 - 60℃; for 2h; | A n/a B 66% |
phenythoin
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 2h; Heating; | 65% |
2-(4,5-dihydro-5-oxo-4,4-diphenyl-1H-imidazol-2-ylthio)acetic acid
phenythoin
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 2h; Heating; | 65% |
Conditions | Yield |
---|---|
With tungsten hexacarbonyl; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 35℃; under 60804.1 Torr; for 24h; Inert atmosphere; | 64% |
Conditions | Yield |
---|---|
With tungsten hexacarbonyl; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 45℃; for 36h; | 64% |
1-(Acetamidoacetyl)-5,5-diphenylimidazolidine-2,4-dione
phenythoin
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 50h; Heating; | 63% |
4-(2-AMINOETHYL)MORPHOLINE
ethyl 3-(5,5-diphenylhydantoin) formate
A
3-N-(2-morpholinoethyl)-5,5-diphenylhydantoin
B
phenythoin
Conditions | Yield |
---|---|
for 4h; Heating; | A 33% B 26% |
2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one
chromium(lll) acetate
phenythoin
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With hydrogenchloride | |
Multi-step reaction with 2 steps 1: aqueous acetic acid 2: aq.-ethanolic HCl View Scheme |
Conditions | Yield |
---|---|
at 230 - 240℃; |
Conditions | Yield |
---|---|
at 150 - 170℃; |
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 50℃; Rate constant; |
3-(hydroxymethyl)-5,5-diphenylhydantoin N,N-dimethylglycine ester, monomethanesulfonate salt
phenythoin
Conditions | Yield |
---|---|
With acetate buffer In water at 25℃; Rate constant; Mechanism; pH dependence; |
C57H56N4O4(2+)*2Br(1-)
A
formaldehyd
B
1,1-diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol
C
phenythoin
Conditions | Yield |
---|---|
With buffer; pH 8.74 In water at 37℃; Rate constant; other pH; |
phenythoin
Conditions | Yield |
---|---|
With acetate buffer In methanol; water at 70℃; Rate constant; Mechanism; pH dependence; | |
With 6-O-(sulfobutyl)-β-cyclodextrin sodium salt In various solvent(s) at 25℃; pH=7.4; Equilibrium constant; Activation energy; Kinetics; Further Variations:; pH-values; Reagents; Elimination; |
methyl 9-bromononanoate
phenythoin
methyl 2,5-dioxo-4,4-diphenylimidazolidine-1-nonanoate
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 110℃; for 0.25h; | 100% |
phenythoin
[(2)H10]phenytoin
Conditions | Yield |
---|---|
With platinum on carbon; hydrogen; water-d2 at 180℃; for 24h; | 100% |
formaldehyd
phenythoin
3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With potassium carbonate In water at 20℃; for 24h; | 98% |
With potassium carbonate In water for 24h; Ambient temperature; | 92% |
With potassium carbonate In water for 24h; Ambient temperature; |
Conditions | Yield |
---|---|
With copper(I) oxide In N,N-dimethyl-formamide at 150℃; for 14h; Inert atmosphere; regioselective reaction; | 98% |
phenythoin
sodium phenytoin
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 42℃; for 0.25h; Temperature; | 97% |
With sodium hydroxide In water at 45℃; pH=12; Temperature; Large scale; | 96.3% |
With sodium hydroxide; sodium chloride In water at 5 - 30℃; for 1h; Product distribution / selectivity; | 85% |
With sodium hydroxide In water at 5 - 30℃; for 1h; Product distribution / selectivity; | 66.2% |
phenythoin
ethyl bromoacetate
ethyl 2-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)acetate
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; for 24h; | 97% |
With potassium carbonate In acetonitrile Heating; |
phenythoin
ethyl bromoacetate
A
ethyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)acetate
B
sodium ethanolate
Conditions | Yield |
---|---|
In ethanol | A 96% B n/a |
Conditions | Yield |
---|---|
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h; Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone at 20℃; for 24.33h; | 96% |
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: 2-Chloro-4'-fluoroacetophenone In acetone at 20℃; for 24h; | 45% |
With potassium carbonate In acetone at 20℃; for 24h; |
Conditions | Yield |
---|---|
With TiO2 blended Fe3O4 coated with phosphotungstic acid at 70℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Sonication; Green chemistry; | 96% |
phenythoin
1,3-dichloro-5,5-diphenylhydantoin
Conditions | Yield |
---|---|
With trichloroisocyanuric acid In acetonitrile at 20℃; for 0.5h; | 95% |
With sodium hypochlorite Ambient temperature; | 31% |
With sodium hypochlorite for 3h; | 25% |
With hydrogenchloride; sodium hypochlorite for 4h; Ambient temperature; | 4.7% |
With sodium hypochlorite |
phenythoin
propargyl bromide
5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 36h; | 95% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; | 87% |
With potassium hydroxide In ethanol for 4h; Heating; | 76% |
Conditions | Yield |
---|---|
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h; Stage #2: p-chlorophenacyl chloride In acetone at 20℃; for 24.33h; | 95% |
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: p-chlorophenacyl chloride In acetone at 20℃; for 24h; | 43% |
Conditions | Yield |
---|---|
With TiO2 blended Fe3O4 coated with phosphotungstic acid at 70℃; for 0.2h; Sonication; Green chemistry; | 94% |
Conditions | Yield |
---|---|
for 16h; Heating; | 93.7% |
phenythoin
trityl chloride
5,5-diphenyl-3-tritylimidazolidine-2,4-dione
Conditions | Yield |
---|---|
Stage #1: phenythoin With triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: trityl chloride In dichloromethane | 93% |
With triethylamine In dichloromethane at 20℃; for 30h; | 58% |
Conditions | Yield |
---|---|
With TiO2 blended Fe3O4 coated with phosphotungstic acid at 70℃; for 0.166667h; Sonication; Green chemistry; | 93% |
phenythoin
3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With formaldehyd; potassium carbonate; phosphorus pentaoxide In water | 92% |
phenythoin
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; | 92% |
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction; | 92% |
Conditions | Yield |
---|---|
Stage #1: phenythoin With tetrabutylammomium bromide; sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Metallation; Stage #2: ethyl bromofluoroacetate In tetrahydrofuran at 20℃; for 12h; Substitution; Gabriel reaction; | 91% |
phenythoin
potassium carbonate
3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With formaldehyd In water | 91% |
With formaldehyd In water | 91% |
With formaldehyd In water | 91% |
With formaldehyd In water |
Conditions | Yield |
---|---|
Stage #1: phenythoin With potassium carbonate In acetone at 20℃; for 0.333333h; Stage #2: 1-chloroacetophenone In acetone at 20℃; for 24.33h; | 91% |
With potassium carbonate In acetone at 20℃; for 24h; |
Conditions | Yield |
---|---|
With pyridine for 4h; Heating; | 90% |
2-(2-bromoethyl)isoindoline-1,3-dione
phenythoin
3-(2'-phthalimidoethyl)-5,5-diphenylhydantoin
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 2h; Heating; | 90% |
With potassium carbonate In N,N-dimethyl-formamide |
1. | dnd-esc 50 µmol/L | MUREAV Mutation Research. 89 (1981),95. | ||
2. | dni-hmn:lym 360 µmol/L | TXAPA9 Toxicology and Applied Pharmacology. 33 (1975),38. | ||
3. | mnt-mus-ivn 500 µg/kg | MUREAV Mutation Research. 141 (1984),183. | ||
4. | orl-wmn TDLo:1620 mg/kg (female 1-39W post):CAR,TER | JAMAAP JAMA, Journal of the American Medical Association. 244 (1980),1464. | ||
5. | orl-wmn TDLo:730 mg/kg/1Y-C:CAR,BLD | NKGZAE Nippon Ketsueki Gakkai Zasshi. Journal of Japan Haematological Society. 46 (1983),1. | ||
6. | unr-wmn TDLo:1620 mg/kg (female 1-39W post):CAR,TER | JAMAAP JAMA, Journal of the American Medical Association. 244 (1980),1464. | ||
7. | unr-wmn TDLo:1620 mg/kg (female 1-39W post):CAR,TER | LANCAO Lancet. 2 (1980),481. | ||
8. | orl-wmn TD:730 mg/kg/1Y-C:CAR,BLD | NKGZAE Nippon Ketsueki Gakkai Zasshi. Journal of Japan Haematological Society. 43 (1980),711. | ||
9. | orl-chd TD:6023 mg/kg/1Y-C:NEO,BLD,SKN | AJDEBP Australasian Journal of Dermatology. 22 (1981),28. | ||
10. | orl-chd TDLo:3 mg/kg/3W:SKN | CLPTAT &n |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View