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Greenutra Resource Inc

radix scutellariae extract powder Product Name: baical skullcap root extract Botanical Name: scutellaria baicalensis Part Used:Root Sepcification: Baicalin 80% 85% 90% CAS No. 491-67-8 Molecular formula: C15H10O5 Molecular Weight:270.2

radix scutellariae extract powder

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $20.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Baicalein Manufacturer/High quality/Best price/In stock

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Light cream yellow powder Complies Odor Characteristic

High purity Baicalein with high quality cas:491-67-8

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $250.0 / 500.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Baicalein powder 491-67-8

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Baicalin supplier in China

Cas:491-67-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Specifications Type: Herbal Extract Variety: Baicalein Form: Powder Part: Other Extraction Type: Solvent Extraction Pac

Scutellaria Baicalensis Extract 98% Baicalein 80%-85% Baicalin

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $400.0 / 500.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Baicalin 98% CAS NO.491-67-8

Cas:491-67-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Xi'an Quanao Biotech Co., Ltd.

Company profile Xi’an Quanao Biotech Co., Ltd. with 10 years experience in plant extract filed. Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Med

Free Sample Natural Herbal Supplement 10:1 Scutellaria Baicalensis Root Extract Powder

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $14.0 / 20.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Baicalin

Cas:491-67-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% Baicalein 491-67-8 HACCP Manufacturer

Cas:491-67-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

Baicalein CAS: 491-67-8;27462-75-5 Molecular Formula: C15H10O5 Home Product Category Organic raw materials Ketones 491-67-8 491-67-8 - Names and Identifiers Name Baicalein Synonyms Noroxylin Baicalein Baicele

Top Quality Natural Baicalein

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $35.0 / 49.0

Type:Lab/Research institutions

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Baicalein

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Shanxi Zorui Biotechnology Co.Ltd.

Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ

Natural HPLC Baicalein Scutellaria Baicalensis Extract Powder CAS 491-67-8

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Baicalein

Cas:491-67-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name: Baicalein CAS no. : 491-67-8 Molecular formula: C15H10O5 Molecular weight: 270.24 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Baicalein /CAS :491-67-8/raw material

Cas:491-67-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Baicalein

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 491-67-8 Scutellaria Baicalensis Extract 98% Baicalein

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 491-67-8 with competitive price

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High purity Baicalein with high quality cas:491-67-8

Cas:491-67-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl- 491-67-8

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

Natural Pure baicalein herbal extract 98% baicalein with best price 491-67-8

Cas:491-67-8

Min.Order:1 Kilogram

FOB Price: $40.0 / 300.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical

scutellaria baicalensis extract powder/491-67-8

Cas:491-67-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl-

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl-

Cas:491-67-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Baicalein

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:yellow crystalline solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:An inhibitor of 12-lipoxygenase, leukotriene

4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl-

Cas:491-67-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Baicalein

Cas:491-67-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Baicalein NanoEmulsion, Water-Soluble Baicalein, Liposomal Baicalein

Cas:491-67-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Baicalein

Cas:491-67-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Baicalein

Cas:491-67-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

baicalin
21967-41-9

baicalin

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With sulfuric acid; water at 20℃; for 0.166667h;93%
With sulfuric acid In water at 90℃; for 0.0833333h;71.9%
With sulfuric acid at 90℃; for 0.166667h;29.3%
Baicalin methyl ester
82475-03-4

Baicalin methyl ester

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With sulfuric acid In ethanol; water at 95℃; for 8.5h; Inert atmosphere;97%
With hydrogenchloride In ethanol at 85℃; for 12h; Temperature; Reagent/catalyst; Inert atmosphere;91.8%
5,7-dimethoxy-6-hydroxyflavone
119892-40-9

5,7-dimethoxy-6-hydroxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogen bromide at 120 - 130℃; Reagent/catalyst; Temperature; Reflux;91%
With hydrogen bromide at 120℃; Reagent/catalyst; Temperature; Inert atmosphere;88%
Multi-step reaction with 2 steps
1: potassium carbonate; acetone
2: aqueous hydriodic acid; acetic acid anhydride / 140 °C
View Scheme
5,6,7-trimethoxyflavone
973-67-1

5,6,7-trimethoxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 130℃;92%
With hydrogen bromide; acetic acid for 18h; Heating;89%
With pyridine hydrochloride at 190℃; for 6.5h; Inert atmosphere;85%
5,6-dihydroxy-7-methoxyflavone
29550-13-8

5,6-dihydroxy-7-methoxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With water; hydrogen bromide; acetic acid for 18h; Reflux;85%
With water; hydrogen bromide; Aliquat 336 at 105℃; for 8h; Catalytic behavior;80%
With hydrogen iodide; acetic anhydride
4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate
67047-05-6

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Stage #1: 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate With sodium hydroxide In water; acetone at 0℃; for 1h;
Stage #2: With hydrogenchloride In water; acetone pH=6 - 7;
66.7%
oroxylin A
480-11-5

oroxylin A

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With water; hydrogen bromide; Aliquat 336 at 105℃; for 7h; Catalytic behavior;84%
With hydrogen bromide; acetic acid for 12h; Heating;81%
2',4',5',6'-tetrahydroxyflavone
671791-94-9

2',4',5',6'-tetrahydroxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogenchloride; lithium hydroxide; sulfuric acid In tetrahydrofuran; acetic acid
C15H12O6

C15H12O6

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With sulfuric acid; acetic acid for 1h; Reflux;
baicalein 6-O-β-D-glucopyranoside
28279-72-3

baicalein 6-O-β-D-glucopyranoside

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogenchloride In methanol at 90℃; for 0.5h;
baicalein 7-O-β-(6''-O-malonylglycoside)

baicalein 7-O-β-(6''-O-malonylglycoside)

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogenchloride In methanol at 90℃; for 0.5h;
cinnamoyl chloride
102-92-1

cinnamoyl chloride

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / BF3-Et2O / 0.25 h / Heating
2: 87 percent / I2; DMSO / 2 h / Heating
3: 89 percent / HBr; glacial AcOH / 18 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / BF3-Et2O / 0.25 h / Heating
2: 87 percent / I2; DMSO / 2 h / Heating
3: 88 percent / HBr; glacial AcOH / 2 h / Heating
4: 81 percent / HBr; glacial AcOH / 12 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / BF3-Et2O / 0.25 h / Heating
2: 91 percent / HBr; glacial AcOH / 2 h / Heating
3: 46 percent / I2; DMSO / Heating
4: 81 percent / HBr; glacial AcOH / 12 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / toluene
2: iodine / dimethyl sulfoxide
3: hydrogen bromide; acetic acid / 130 °C
View Scheme
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / dichloromethane / 0.17 h / Reflux
2: iodine / dimethyl sulfoxide / 3 h / Reflux
3: hydrogen bromide; acetic acid / 48 h
View Scheme
6,7-dihydroxy-5-methoxyflavone
150036-33-2

6,7-dihydroxy-5-methoxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogenchloride
3,4,5-trimethoxyphenol
642-71-7

3,4,5-trimethoxyphenol

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: BF3-Et2O / 0.25 h
2: KOH / ethanol
3: 87 percent / I2; DMSO / 2 h / Heating
4: 89 percent / HBr; glacial AcOH / 18 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: BF3-Et2O / 0.25 h
2: KOH / ethanol
3: 87 percent / I2; DMSO / 2 h / Heating
4: 88 percent / HBr; glacial AcOH / 2 h / Heating
5: 81 percent / HBr; glacial AcOH / 12 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: BF3-Et2O / 0.25 h
2: KOH / ethanol
3: 91 percent / HBr; glacial AcOH / 2 h / Heating
4: 46 percent / I2; DMSO / Heating
5: 81 percent / HBr; glacial AcOH / 12 h / Heating
View Scheme
7-hydroxy-5-methoxy-4-oxo-2-phenyl-4H-chromene-6-carbaldehyde
412027-80-6

7-hydroxy-5-methoxy-4-oxo-2-phenyl-4H-chromene-6-carbaldehyde

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH solution; aqueous hydrogen peroxide
2: aqueous hydrochloric acid
View Scheme
6-hydroxy-2,3,4-trimethoxyacetophenone
22248-14-2

6-hydroxy-2,3,4-trimethoxyacetophenone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KOH / ethanol
2: 87 percent / I2; DMSO / 2 h / Heating
3: 89 percent / HBr; glacial AcOH / 18 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: KOH / ethanol
2: 87 percent / I2; DMSO / 2 h / Heating
3: 88 percent / HBr; glacial AcOH / 2 h / Heating
4: 81 percent / HBr; glacial AcOH / 12 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: KOH / ethanol
2: 91 percent / HBr; glacial AcOH / 2 h / Heating
3: 46 percent / I2; DMSO / Heating
4: 81 percent / HBr; glacial AcOH / 12 h / Heating
View Scheme
3,6-dihydroxy-2,4-dimethoxyacetophenone
6962-57-8

3,6-dihydroxy-2,4-dimethoxyacetophenone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium benzoate / 180 °C / Unter vermindertem Druck und anschliessend Erwaermen mit wss.-aethanol. Kalilauge
2: potassium carbonate; acetone
3: aqueous hydriodic acid; acetic acid anhydride / 140 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride; sodium hydroxide / water / 48 h / 20 °C / Inert atmosphere
2: iodine; sodium hydrogensulfite / dimethylsulfoxide-d6 / 48 h / 120 °C / Cooling with ice
3: hydrogen bromide / 120 °C / Inert atmosphere
View Scheme
6′-hydroxy-2′,3′,4′-trimethoxychalcone
70185-52-3, 74064-14-5

6′-hydroxy-2′,3′,4′-trimethoxychalcone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iodine / dimethyl sulfoxide
2: hydrogen bromide; acetic acid / 130 °C
View Scheme
Multi-step reaction with 2 steps
1: iodine / dimethyl sulfoxide / 3 h / Reflux
2: hydrogen bromide; acetic acid / 48 h
View Scheme
Cinnamic acid
621-82-9

Cinnamic acid

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / benzene / Reflux
2: boron trifluoride diethyl etherate / toluene
3: iodine / dimethyl sulfoxide
4: hydrogen bromide; acetic acid / 130 °C
View Scheme
Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Cooling with ice
2: boron trifluoride diethyl etherate / dichloromethane / 0.17 h / Reflux
3: iodine / dimethyl sulfoxide / 3 h / Reflux
4: hydrogen bromide; acetic acid / 48 h
View Scheme
(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Cooling with ice
2: boron trifluoride diethyl etherate / 0.17 h / Reflux
3: iodine / dimethyl sulfoxide / 3 h / Reflux
4: hydrogen bromide; acetic acid / 48 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate; acetic anhydride / 1,2-dichloro-ethane; methanol / 8 h / 90 °C / Reflux
2: iodine / dimethyl sulfoxide / 6 h / 180 °C
3: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
phenol
108-95-2

phenol

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic acid; sulfuric acid; sodium bromide; dihydrogen peroxide / 20 - 45 °C
2.1: copper(l) chloride / methanol; N,N-dimethyl-formamide / 100 - 110 °C
3.1: boron trifluoride diethyl etherate / chloroform / 36 h / 20 - 60 °C
3.2: 120 °C / Reflux
4.1: iodine / dimethyl sulfoxide / 6 h / 180 °C
5.1: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1: acetic acid; sulfuric acid; sodium bromide; dihydrogen peroxide / 20 - 45 °C
2: copper(l) chloride / methanol; N,N-dimethyl-formamide / 100 - 110 °C
3: boron trifluoride diethyl etherate; acetic anhydride / 1,2-dichloro-ethane; methanol / 8 h / 90 °C / Reflux
4: iodine / dimethyl sulfoxide / 6 h / 180 °C
5: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1: acetic acid; sulfuric acid; sodium bromide; dihydrogen peroxide / 20 - 45 °C
2: copper(l) chloride / methanol; N,N-dimethyl-formamide / 100 - 110 °C
3: boron trifluoride diethyl etherate / chloroform / 10 h / 20 - 60 °C
4: boron trifluoride diethyl etherate; acetic anhydride / chloroform / 36 h / 60 °C / Reflux
5: iodine / dimethyl sulfoxide / 6 h / 180 °C
6: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
2,4,6-tribromophenol
118-79-6

2,4,6-tribromophenol

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: copper(l) chloride / methanol; N,N-dimethyl-formamide / 100 - 110 °C
2.1: boron trifluoride diethyl etherate / chloroform / 36 h / 20 - 60 °C
2.2: 120 °C / Reflux
3.1: iodine / dimethyl sulfoxide / 6 h / 180 °C
4.1: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1: copper(l) chloride / methanol; N,N-dimethyl-formamide / 100 - 110 °C
2: boron trifluoride diethyl etherate; acetic anhydride / 1,2-dichloro-ethane; methanol / 8 h / 90 °C / Reflux
3: iodine / dimethyl sulfoxide / 6 h / 180 °C
4: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1: copper(l) chloride / methanol; N,N-dimethyl-formamide / 100 - 110 °C
2: boron trifluoride diethyl etherate / chloroform / 10 h / 20 - 60 °C
3: boron trifluoride diethyl etherate; acetic anhydride / chloroform / 36 h / 60 °C / Reflux
4: iodine / dimethyl sulfoxide / 6 h / 180 °C
5: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
2,4,6-trimethoxyphenol
20491-92-3

2,4,6-trimethoxyphenol

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / chloroform / 36 h / 20 - 60 °C
1.2: 120 °C / Reflux
2.1: iodine / dimethyl sulfoxide / 6 h / 180 °C
3.1: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate; acetic anhydride / 1,2-dichloro-ethane; methanol / 8 h / 90 °C / Reflux
2: iodine / dimethyl sulfoxide / 6 h / 180 °C
3: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / chloroform / 10 h / 20 - 60 °C
2: boron trifluoride diethyl etherate; acetic anhydride / chloroform / 36 h / 60 °C / Reflux
3: iodine / dimethyl sulfoxide / 6 h / 180 °C
4: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
wogonin
632-85-9

wogonin

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogen iodide; acetic anhydride at 150℃;
7-hydroxy-5,8-dimethoxyflavone
3316-54-9

7-hydroxy-5,8-dimethoxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With hydrogen iodide; acetic anhydride at 150℃;
Cinnamoyl chloride
102-92-1

Cinnamoyl chloride

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / 0.17 h / Reflux
2: iodine / dimethyl sulfoxide / 3 h / Reflux
3: hydrogen bromide; acetic acid / 48 h / Reflux
View Scheme
5-hydroxy-2,4,6-trimethoxyacetophenone
103777-45-3

5-hydroxy-2,4,6-trimethoxyacetophenone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate; acetic anhydride / chloroform / 36 h / 60 °C / Reflux
2: iodine / dimethyl sulfoxide / 6 h / 180 °C
3: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
benzaldehyde
100-52-7

benzaldehyde

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / chloroform / 36 h / 20 - 60 °C
1.2: 120 °C / Reflux
2.1: iodine / dimethyl sulfoxide / 6 h / 180 °C
3.1: hydrogen bromide / 120 - 130 °C / Reflux
View Scheme
2,6-dimethoxy-p-quinone
530-55-2

2,6-dimethoxy-p-quinone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium dithionite / water / 3 h / 20 °C
2: boron trifluoride diethyl etherate / chloroform / 10 h / 20 - 90 °C
3: hydrogenchloride; sodium hydroxide / water / 48 h / 20 °C / Inert atmosphere
4: iodine; sodium hydrogensulfite / dimethylsulfoxide-d6 / 48 h / 120 °C / Cooling with ice
5: hydrogen bromide / 120 °C / Inert atmosphere
View Scheme
2,6-dimethoxy-1,4-hydroquinone
15233-65-5

2,6-dimethoxy-1,4-hydroquinone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / chloroform / 10 h / 20 - 90 °C
2: hydrogenchloride; sodium hydroxide / water / 48 h / 20 °C / Inert atmosphere
3: iodine; sodium hydrogensulfite / dimethylsulfoxide-d6 / 48 h / 120 °C / Cooling with ice
4: hydrogen bromide / 120 °C / Inert atmosphere
View Scheme
benzaldehyde dimethyl acetal
1125-88-8

benzaldehyde dimethyl acetal

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

C22H14O5

C22H14O5

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water for 2h;100%
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

methyl iodide
74-88-4

methyl iodide

5,6,7-trimethoxyflavone
973-67-1

5,6,7-trimethoxyflavone

Conditions
ConditionsYield
With pyridine; potassium carbonate; potassium iodide In acetone at 60℃; for 8h; Reflux;95%
With potassium carbonate In acetone for 8h; Heating;82%
With potassium carbonate; acetone
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

acetic anhydride
108-24-7

acetic anhydride

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate
67047-05-6

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate

Conditions
ConditionsYield
With pyridine at 70℃; for 6h;94%
With sodium acetate at 80℃; for 2h;92%
With sodium acetate at 75℃;91.1%
morpholine
110-91-8

morpholine

formaldehyd
50-00-0

formaldehyd

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

8-morpholinemethylene baicalein
852333-36-9

8-morpholinemethylene baicalein

Conditions
ConditionsYield
In methanol at 55℃;93.5%
In methanol; water at 20℃; for 2h; Mannich reaction;69%
pyrrolidine
123-75-1

pyrrolidine

formaldehyd
50-00-0

formaldehyd

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

5,6,7-trihydroxy-2-phenyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one
1060171-73-4

5,6,7-trihydroxy-2-phenyl-8-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one

Conditions
ConditionsYield
In methanol at 45℃;92.5%
In methanol; water at 20℃; for 2h; Mannich reaction;71%
In methanol; water at 70℃; for 8h; Mannich Aminomethylation;
formaldehyd
50-00-0

formaldehyd

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

di-n-propylamine
142-84-7

di-n-propylamine

8-dipropylaminemethylene baicalein

8-dipropylaminemethylene baicalein

Conditions
ConditionsYield
In methanol at 45℃;92.5%
methoxypolyethylene glycol carboxylic acid

methoxypolyethylene glycol carboxylic acid

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

conjugate of methoxy-polyethylene glycol and baicalein

conjugate of methoxy-polyethylene glycol and baicalein

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;92%
Dichlorodiphenylmethane
2051-90-3

Dichlorodiphenylmethane

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

6,7-(diphenylmethylenedioxy)-5-methoxyflavone

6,7-(diphenylmethylenedioxy)-5-methoxyflavone

Conditions
ConditionsYield
Stage #1: Dichlorodiphenylmethane; 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one at 170℃; for 1h;
Stage #2: diazomethyl-trimethyl-silane In tetrahydrofuran; methanol; hexane at 20℃; for 24h;
90%
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

(R,R)-1,2-diphenylethylenediamine
35132-20-8

(R,R)-1,2-diphenylethylenediamine

(2R,3R)-5-hydroxy-2,3,8-triphenyl-3,4-dihydro-1H-pyrano[3,2-f]quinoxalin-10(2H)-one

(2R,3R)-5-hydroxy-2,3,8-triphenyl-3,4-dihydro-1H-pyrano[3,2-f]quinoxalin-10(2H)-one

Conditions
ConditionsYield
In ethanol at 20℃; for 168h;90%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

formaldehyd
50-00-0

formaldehyd

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

5,6,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-2-phenyl-4H-chromen-4-one
1060171-92-7

5,6,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
In methanol at 50℃;89.5%
In methanol; water at 20℃; for 2h; Mannich reaction;72.2%
In methanol at 55℃; for 4h;
amyl iodide
628-17-1

amyl iodide

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

5-hydroxy-6,7-(dipentyloxy)flavone

5-hydroxy-6,7-(dipentyloxy)flavone

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Heating;87%
With potassium carbonate In acetone for 24h; Heating / reflux;87%
formaldehyd
50-00-0

formaldehyd

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

bis(5,6,7-trihydroxyflavon-8-yl)methane

bis(5,6,7-trihydroxyflavon-8-yl)methane

Conditions
ConditionsYield
In ethanol; water at 90℃; for 8h; Condensation;85%
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

β-D-galactopyranosyl-(1->4)-α-D-glucopyranosyl fluoride
7584-85-2, 7792-96-3, 30048-41-0, 66701-54-0, 71328-30-8, 103531-01-7, 149342-82-5

β-D-galactopyranosyl-(1->4)-α-D-glucopyranosyl fluoride

6-O-β-lactosyl-baicalein

6-O-β-lactosyl-baicalein

Conditions
ConditionsYield
With Tris buffer at 37℃; pH=7.0;84%
With Tris-HCl buffer at 25℃; pH=7.8; Enzyme kinetics;
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

acetic anhydride
108-24-7

acetic anhydride

5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6,7-diyl diacetate
731817-58-6

5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6,7-diyl diacetate

Conditions
ConditionsYield
With pyridine; sodium acetate at 120℃; for 8h;84%
With pyridine; dmap for 24h;
1-chloro-2,4-dinitro-6-trifluoromethylbenzene
392-95-0

1-chloro-2,4-dinitro-6-trifluoromethylbenzene

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

7-(2,4-dinitro-6-(trifluoromethyl)phenoxy)-5,6-dihydroxy-2-phenyl-4H-chromen-4-one

7-(2,4-dinitro-6-(trifluoromethyl)phenoxy)-5,6-dihydroxy-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃;83%
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

C15H6(2)H4O5

C15H6(2)H4O5

Conditions
ConditionsYield
Stage #1: 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one With [D]-sodium hydroxide; platinum on activated charcoal; water-d2 at 130℃; for 12h; Inert atmosphere;
Stage #2: With formic acid at 130℃; for 12h; Temperature; Inert atmosphere;
83%
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

L-proline
147-85-3

L-proline

baicalein L-proline cocrystals (1:1)

baicalein L-proline cocrystals (1:1)

Conditions
ConditionsYield
In ethanol; ethyl acetate at 20 - 50℃;82.6%
1-Iodooctane
629-27-6

1-Iodooctane

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

5-hydroxy-6,7-(dioctyloxy)flavone

5-hydroxy-6,7-(dioctyloxy)flavone

Conditions
ConditionsYield
With potassium carbonate In acetone for 30h; Heating;82%
With potassium carbonate In acetone for 30h; Heating / reflux;82%
1-bromo-hexane
111-25-1

1-bromo-hexane

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

6,7-(dihexyloxy)-5-hydroxyflavone

6,7-(dihexyloxy)-5-hydroxyflavone

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Heating;82%
With potassium carbonate In acetone for 24h; Heating / reflux;82%
Dichlorodiphenylmethane
2051-90-3

Dichlorodiphenylmethane

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

9-hydroxy-2,2,6-triphenyl-[1,3]dioxolo[4,5-g]chromen-8-one

9-hydroxy-2,2,6-triphenyl-[1,3]dioxolo[4,5-g]chromen-8-one

Conditions
ConditionsYield
at 170℃; for 1h;81%
caffeic acid
331-39-5

caffeic acid

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

C23H18O7
1266114-33-3

C23H18O7

Conditions
ConditionsYield
With cerium(III) chloride heptahydrate; sodium iodide In ethanol; acetonitrile for 0.2h; Reflux;80%
formaldehyd
50-00-0

formaldehyd

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

dimethyl amine
124-40-3

dimethyl amine

8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
516484-10-9

8-((dimethylamino)methyl)-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
In methanol; water at 20℃; for 2h; Mannich reaction;79%
In methanol at 20℃; for 1.5h; Mannich Aminomethylation;10.5%
4-chloro-3,5-dinitrobenzotrifluoride
393-75-9

4-chloro-3,5-dinitrobenzotrifluoride

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
491-67-8

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

6,7-bis(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

6,7-bis(2,6-dinitro-4-(trifluoromethyl)phenoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃;78%

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