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Cas:50-55-5
Min.Order:1 Kilogram
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inquiryHebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ
Pharmaceutical Rauwolfia Extract 98% Reserpine powder Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal
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inquiryName: Reserpine English Name: Reserpine CAS:50-55-5 Molecular formula: C33H40N2O9 Molecular weight: 608.69 Packaging Specification: 25kg/drum high purity 99%min stock Hubei DiBo Chemical Co., Ltd. was founded in 2009, is a high-tech indus
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Reserpine Product Description .Basic info.: Name: Reserpine Cas No.: 50-55-5 Apperance: White fine powder Purity: 8%,20%,40%,98%,4:1, 5:1 ,10:1
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Min.Order:1 Kilogram
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inquiryAppearance:off-white crystalline powder Storage:Room temperature Package:25kg/drum Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china
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inquiryReserpine Basic information Overview Indications Mode of action Adverse reactions Warning and precautions References Product Name: Reserpine CAS: 50-55-5 MF: C33H40N2O9 MW: 608.69 EINECS: 200-047-9 Mol File: 50-55-5.mol Reserpine
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Min.Order:1 Kilogram
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inquiryReserpine CAS: 50-55-5 Specification Item Standard Identification A.H-NMR:Comply with the structure B.LC-MS:Comply with the structure C.The IR spectrum of sample
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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reserpine
Conditions | Yield |
---|---|
With acetic acid; zinc |
reserpine
Conditions | Yield |
---|---|
With perchloric acid; zinc |
Conditions | Yield |
---|---|
With acetic acid; zinc for 12h; Heating; | A 195 mg B 70 mg C 22 mg |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane Ambient temperature; Yield given; | |
With pyridine at 20℃; for 96h; |
reserpine
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid |
(1S,2R,3S,4S,7S)-3-(Fluoro-dimethyl-silanyl)-7-hydroxymethyl-5-oxo-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: pyridine; 4-dimethylaminopyridine / CH2Cl2 / 10 h / Heating 2: m-chloroperbenzoic acid; Na2PO4 / CH2Cl2 / 15 h / 20 °C 3: Ag2O; CaSO4 / 20 h 4: diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C 5: MgSO4 / acetonitrile / 1 h 6: aq. HCl / tetrahydrofuran / 30 h / 20 °C 7: pyridine / 96 h / 20 °C View Scheme |
(1R,5S,6S,7R,9S)-7-Methoxy-3-oxo-9-(toluene-4-sulfonyloxymethyl)-2-oxa-bicyclo[3.2.2]nonane-6-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C 2: MgSO4 / acetonitrile / 1 h 3: aq. HCl / tetrahydrofuran / 30 h / 20 °C 4: pyridine / 96 h / 20 °C View Scheme |
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: MgSO4 / acetonitrile / 1 h 2: aq. HCl / tetrahydrofuran / 30 h / 20 °C 3: pyridine / 96 h / 20 °C View Scheme |
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Ag2O; CaSO4 / 20 h 2: diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C 3: MgSO4 / acetonitrile / 1 h 4: aq. HCl / tetrahydrofuran / 30 h / 20 °C 5: pyridine / 96 h / 20 °C View Scheme |
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: H2 / Pd/C / ethyl acetate / 30 h / 760 Torr 2: pyridine; 4-dimethylaminopyridine / CH2Cl2 / 10 h / Heating 3: m-chloroperbenzoic acid; Na2PO4 / CH2Cl2 / 15 h / 20 °C 4: Ag2O; CaSO4 / 20 h 5: diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C 6: MgSO4 / acetonitrile / 1 h 7: aq. HCl / tetrahydrofuran / 30 h / 20 °C 8: pyridine / 96 h / 20 °C View Scheme |
(1S,2R,3S,4S,7S)-7-Benzyloxymethyl-3-(furan-2-yl-dimethyl-silanyl)-5-oxo-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: tetrabutylammonium fluoride / tetrahydrofuran / 0.03 h / 20 °C 2: H2 / Pd/C / ethyl acetate / 30 h / 760 Torr 3: pyridine; 4-dimethylaminopyridine / CH2Cl2 / 10 h / Heating 4: m-chloroperbenzoic acid; Na2PO4 / CH2Cl2 / 15 h / 20 °C 5: Ag2O; CaSO4 / 20 h 6: diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C 7: MgSO4 / acetonitrile / 1 h 8: aq. HCl / tetrahydrofuran / 30 h / 20 °C 9: pyridine / 96 h / 20 °C View Scheme |
(1S,2R,3S,4S,7S)-3-(Fluoro-dimethyl-silanyl)-5-oxo-7-(toluene-4-sulfonyloxymethyl)-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: m-chloroperbenzoic acid; Na2PO4 / CH2Cl2 / 15 h / 20 °C 2: Ag2O; CaSO4 / 20 h 3: diisobutylaluminum hydride / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C 4: MgSO4 / acetonitrile / 1 h 5: aq. HCl / tetrahydrofuran / 30 h / 20 °C 6: pyridine / 96 h / 20 °C View Scheme |
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HCl / tetrahydrofuran / 30 h / 20 °C 2: pyridine / 96 h / 20 °C View Scheme |
(3aS,4S,6R,7S,7aS)-6-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-7-methoxy-hexahydro-benzofuran-4,7a-dicarboxylic acid dimethyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: pivalic acid / benzene / Heating 2: pivalic acid / toluene / Heating 3: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 4: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 5: aq. HF / acetonitrile / 0.5 h / Ambient temperature 6: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 7: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 8: aq. HF / acetonitrile / 3 h / Ambient temperature 9: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme | |
Multi-step reaction with 8 steps 1: 56 mg / pivalic acid / toluene / 0.83 h / Heating 2: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 3: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 4: aq. HF / acetonitrile / 0.5 h / Ambient temperature 5: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 6: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 7: aq. HF / acetonitrile / 3 h / Ambient temperature 8: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(3aS,4S,6R,7S,7aS)-6-(tert-Butyl-dimethyl-silanyloxy)-7-methoxy-2-oxo-hexahydro-benzofuran-4,7a-dicarboxylic acid dimethyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 98 percent / disiamylborane / tetrahydrofuran / 4 h / Ambient temperature 2: pivalic acid / benzene / Heating 3: pivalic acid / toluene / Heating 4: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 5: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 6: aq. HF / acetonitrile / 0.5 h / Ambient temperature 7: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 8: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 9: aq. HF / acetonitrile / 3 h / Ambient temperature 10: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme | |
Multi-step reaction with 9 steps 1: 98 percent / disiamylborane / tetrahydrofuran / 4 h / Ambient temperature 2: 56 mg / pivalic acid / toluene / 0.83 h / Heating 3: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 4: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 5: aq. HF / acetonitrile / 0.5 h / Ambient temperature 6: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 7: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 8: aq. HF / acetonitrile / 3 h / Ambient temperature 9: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(3aS,4S,6R,7S,7aS)-6-(tert-Butyl-dimethyl-silanyloxy)-7-methoxy-2-oxo-hexahydro-benzofuran-4,7a-dicarboxylic acid 4-methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: diethyl ether / 0.08 h / 0 °C 2: 98 percent / disiamylborane / tetrahydrofuran / 4 h / Ambient temperature 3: pivalic acid / benzene / Heating 4: pivalic acid / toluene / Heating 5: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 6: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 7: aq. HF / acetonitrile / 0.5 h / Ambient temperature 8: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 9: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 10: aq. HF / acetonitrile / 3 h / Ambient temperature 11: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme | |
Multi-step reaction with 10 steps 1: diethyl ether / 0.08 h / 0 °C 2: 98 percent / disiamylborane / tetrahydrofuran / 4 h / Ambient temperature 3: 56 mg / pivalic acid / toluene / 0.83 h / Heating 4: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 5: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 6: aq. HF / acetonitrile / 0.5 h / Ambient temperature 7: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 8: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 9: aq. HF / acetonitrile / 3 h / Ambient temperature 10: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(1S,2R,3R,4aS,13bR,14aS)-3-(tert-Butyl-dimethyl-silanyloxy)-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HF / acetonitrile / 3 h / Ambient temperature 2: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(1S,2S,3R,4aS,13bR,14aS)-3-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 2: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 3: aq. HF / acetonitrile / 3 h / Ambient temperature 4: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: pivalic acid / toluene / Heating 2: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 3: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 4: aq. HF / acetonitrile / 0.5 h / Ambient temperature 5: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 6: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 7: aq. HF / acetonitrile / 3 h / Ambient temperature 8: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(1S,2S,3R,4aS,13bR,14aS)-3-(tert-Butyl-dimethyl-silanyloxy)-2,11-dimethoxy-1-trimethylsilanyloxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aq. HF / acetonitrile / 0.5 h / Ambient temperature 2: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 3: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 4: aq. HF / acetonitrile / 3 h / Ambient temperature 5: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(1S,2S,3R,4aS,13bR,14aS)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 2: aq. HF / acetonitrile / 3 h / Ambient temperature 3: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(1S,2S,3R,4aS,13bR,14aS)-3-(tert-Butyl-dimethyl-silanyloxy)-2,11-dimethoxy-5-oxo-1-trimethylsilanyloxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 2: aq. HF / acetonitrile / 0.5 h / Ambient temperature 3: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 4: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 5: aq. HF / acetonitrile / 3 h / Ambient temperature 6: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
(1S,2S,3R,4aS,13bR,14aS)-3-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-2,11-dimethoxy-5-oxo-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
reserpine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 100 percent / 2,6-lutidine / CH2Cl2 / 4 h / Ambient temperature 2: 1.) BH3*THF, 2.) ethylene glycol / 1.) THF, room temperature, 6 h, 2.) THF, HMPA, overnight 3: aq. HF / acetonitrile / 0.5 h / Ambient temperature 4: 2,6-lutidine / CH2Cl2 / 0.17 h / 0 °C 5: ethylene glycol, SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h 6: aq. HF / acetonitrile / 3 h / Ambient temperature 7: Et3N, DMAP / CH2Cl2 / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
With methanol; sodium methylate for 4h; Reflux; | 97% |
With potassium hydroxide Hydrolysis; | |
With sodium methylate Hydrolysis; | |
Stage #1: reserpine With methanol; sodium methylate for 1h; Heating / reflux; Stage #2: With hydrogenchloride; methanol; water pH=1; Stage #3: With ammonia; water Product distribution / selectivity; | |
With sodium methylate In methanol for 1h; Heating / reflux; |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide for 2h; | 83% |
reserpine
(1S,4R,5aS,14bR,15aS,16R)-12,16-dimethoxy-4,5,5a,6,8,9,14,14b,15,15a-decahydro-1,4-methanoindolo[2,3-a]-oxepino[4,5-g]quinolizin-2(1H)-one
Conditions | Yield |
---|---|
With aluminum isopropoxide In xylene for 6h; Heating; | 81% |
With aluminum isopropoxide In xylene for 6h; Product distribution / selectivity; Heating / reflux; | 81% |
With aluminum isopropoxide; xylene |
reserpine
Conditions | Yield |
---|---|
With aluminum isopropoxide In xylene for 6h; Product distribution / selectivity; Heating / reflux; | 81% |
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 80℃; Inert atmosphere; Schlenk technique; | 66% |
Conditions | Yield |
---|---|
Stage #1: reserpine With sodium hydride In N,N-dimethyl-formamide; mineral oil at -20℃; for 0.25h; Stage #2: propargyl bromide In N,N-dimethyl-formamide; toluene; mineral oil at -20℃; for 1h; | A 30% B 63% |
reserpine
dioxyreserpine
Conditions | Yield |
---|---|
With oxygen; 1,5-Dichloroanthraquinone In acetonitrile at 20℃; for 2.5h; Sealed tube; Inert atmosphere; Irradiation; | 63% |
reserpine
11,17-dimethoxy-4-oxy-18-(3,4,5-trimethoxy-benzoyloxy)-yohimbane-16-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With dihydrogen peroxide In acetone at 50℃; for 24h; | 60% |
With monoperoxyphthalic acid | |
With Perbenzoic acid |
Conditions | Yield |
---|---|
Stage #1: allyl methyl carbonate With tris(dibenzylideneacetone)dipalladium (0); trifuran-2-yl-phosphane In dichloromethane at 20℃; Inert atmosphere; Stage #2: reserpine In dichloromethane at 20℃; Inert atmosphere; | 60% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 56% B 17% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 16% B 56% C 3% |
reserpine
Conditions | Yield |
---|---|
With sodium cyanoborohydride In trifluoroacetic acid for 1h; Ambient temperature; | 55% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 55% B 16% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 2% B 55% C 18% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 54% B 14% C 2% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 51% B 18% C 4% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; Friedel-Crafts acylation; | A 18% B 50% C 2% |
reserpine
methyl (1R,15S,17R,18R,19S,20S)-17-[(4-hydroxy-3,5-dimethoxyphenyl)carbonyloxy]-6,18-dimethoxy-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate
Conditions | Yield |
---|---|
Stage #1: reserpine With aluminum (III) chloride In dichloromethane for 2h; Stage #2: With hydrogenchloride In dichloromethane; water for 0.0833333h; Product distribution / selectivity; | 47.1% |
Stage #1: reserpine With aluminum (III) chloride In acetonitrile at 25℃; for 2h; Stage #2: With hydrogenchloride In water; acetonitrile for 0.0833333h; Product distribution / selectivity; | 22.4% |
Stage #1: reserpine With aluminum tri-bromide In dichloromethane at 25℃; for 2h; Stage #2: With hydrogenchloride In dichloromethane; water for 0.0833333h; Product distribution / selectivity; | 22.4% |
Conditions | Yield |
---|---|
With oxygen In acetonitrile for 2.5h; Irradiation; Inert atmosphere; | A n/a B n/a C 46% |
Conditions | Yield |
---|---|
With sodium cyanoborohydride; trifluoroacetic acid In water at -5 - 20℃; for 0.75h; Mechanism; other indole alkaloids like tetraphylline, epireserpine, and reserpine; also AcOH as reagent; var. temp. and time; | 44.5% |
With sodium cyanoborohydride; trifluoroacetic acid In water a) -5 deg C, 15 min, b) RT, 30 min; | 44.5% |
Conditions | Yield |
---|---|
With trifluoroacetic acid-d1; sodium cyanoborohydride In water at 0℃; for 0.5h; | 42% |
reserpine
di-tert-butyl dicarbonate
N-(tert-butyloxycarbonyl)reserpine
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; for 12h; | 38% |
reserpine
A
Isoreserpin
B
(6aS,8R,9R,10S,10aS,11aS)-2-(2-Amino-4-methoxy-phenyl)-9-methoxy-8-(3,4,5-trimethoxy-benzoyloxy)-3,6,6a,7,8,9,10,10a,11,11a-decahydro-4H-pyrido[1,2-b]isoquinoline-10-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With trifluoroacetic acid; zinc for 4h; Reduction; Heating; | A 10% B 15% C 35% |
Conditions | Yield |
---|---|
In benzene at 85℃; for 16h; Diels-Alder Cycloaddition; Sealed tube; regioselective reaction; | 35% |
Conditions | Yield |
---|---|
With oxygen In chloroform for 360h; Mechanism; Ambient temperature; Irradiation; also with deuterated substrate; | A 5.8% B 28.1% |
With oxygen In chloroform for 15h; Ambient temperature; Irradiation; | A 5.8% B 28.1% |
With oxygen In chloroform for 2.5h; Inert atmosphere; Irradiation; |
reserpine
Conditions | Yield |
---|---|
Stage #1: reserpine With lead acetate In dichloromethane at 0℃; for 1.33333h; Inert atmosphere; Irradiation; Stage #2: With sodium methylate In methanol at 0℃; for 2.5h; Inert atmosphere; Irradiation; | 9% |
Conditions | Yield |
---|---|
With acetic anhydride | |
With acetic acid; trichloroacetic acid | |
With trifluoroacetic acid epimerization; Heating; | |
With hydrogenchloride In methanol at 68℃; for 12h; Mechanism; | 280 mg |
With hydrogenchloride In methanol for 72h; Heating; | 18 g |
reserpine
Conditions | Yield |
---|---|
With mercury(II) diacetate | |
With sodium nitrite |
reserpine
ent-11,17β-dimethoxy-16α-methoxycarbonyl-18α-(3,4,5-trimethoxy-benzoyloxy)-15β-yohimba-3,5-dienium; chloride
Conditions | Yield |
---|---|
With lead(IV) acetate; acetic acid Behandeln des Reaktionsprodukts mit wss.HCl; |
reserpine
Conditions | Yield |
---|---|
With methanol; palladium; maleic acid Behandeln der Reaktionsloesung mit HClO4; |
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