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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Hexadecanedioic Acid supplier in China

Cas:505-54-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ------------------------------------------------------------------------------------

High purity Hexadecanedioic acid CAS:505-54-4

Cas:505-54-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Hexadecanedioic acid

Cas:505-54-4

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Hexadecanedioic acid Manufacturer/High quality/Best price/In stock

Cas:505-54-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1,16-Hexadecanedioic acid

Cas:505-54-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---HEXADECANEDIOIC ACID

Cas:505-54-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥95% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

HEXADECANEDIOIC ACID CAS:505-54-4

Cas:505-54-4

Min.Order:1 Gram

FOB Price: $2.0 / 5.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 505-54-4 with best quality

Cas:505-54-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Hexadecandioic acid Molecular formula: C16H30O4 CAS #: 505-54-4 Uses: as perfume, lubrication oil and medical intermediate Product index: total acid single acid moisture

Hexadecandioic acid

Cas:505-54-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Hexadecanedioic acid 505-54-4

Cas:505-54-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: HEXADECANEDIOIC ACID Synonyms: THAPSIC ACID;Hexadecane-1,16-dioic acid;n-Tetradecane-omega,omega'-dicarboxylic acid;Hexadecanedioic acid 96%;16-hexadecanedioic acid;DICARBOXYLIC ACID C16;HEXADECANE DIACID;HEXADECANEDIOIC ACID

HEXADECANEDIOIC ACID

Cas:505-54-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply HEXADECANEDIOIC ACID CAS 505-54-4

Cas:505-54-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate,HEXADECANEDIOIC ACID CAS:505-54-4

Cas:505-54-4

Min.Order:1 Kilogram

FOB Price: $57.4 / 62.3

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

HEXADECANEDIOIC ACID CAS:505-54-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

HEXADECANEDIOIC ACID CAS:505-54-4

Cas:505-54-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Hexadecanedioic acid

Cas:505-54-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:505-54-4

Cas:505-54-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

Hexadecanedioic acid CAS: 505-54-4 Specification Items Standard Result Assay 98%min Welcome to contact us to get complete COA. Shanghai Lonwin Chem

Factory supply Hexadecanedioic acid

Cas:505-54-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--High purity HEXADECANEDIOIC ACID factory price

Cas:505-54-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Hexadecandioic acid

Cas:505-54-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

HEXADECANEDIOIC ACID

Cas:505-54-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

hexadecanedioicacid

Cas:505-54-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Hexadecanedioic acid

Cas:505-54-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Hexadecanedioic Acid

Cas:505-54-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Hexadecanedioic Acid CAS No.: 505-54-4 Molecule Formula:C16H28O4 Molecule Weight:284.39 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price Hexadecanedioic Acid on stock

Cas:505-54-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

In Bulk SupplyHexadecanedioic acid

Cas:505-54-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

HEXADECANEDIOICACID

Cas:505-54-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Hexadecandioic acid

Cas:505-54-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Hexadecanedioic acid

Cas:505-54-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Hexadecanedioic acid

Cas:505-54-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--High purity HEXADECANEDIOIC ACID factory price

Cas:505-54-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

C24H38O8
81393-29-5

C24H38O8

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With hydrogenchloride In water Heating;95%
hexadec-8t-enedioic acid
121626-90-2

hexadec-8t-enedioic acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With methanol; nickel Hydrogenation;
With acetic acid; platinum Hydrogenation;
1,12-dibromododecane
3344-70-5

1,12-dibromododecane

sodium diethylmalonate
996-82-7

sodium diethylmalonate

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
Durch Verseifen und Erhitzen der erhaltenen Tetracarbonsaeure;
16-hydroxyhexadecanoic acid
506-13-8

16-hydroxyhexadecanoic acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
With chromium(VI) oxide
With chromium(VI) oxide; sulfuric acid In acetone
hexadecanediamide
89790-15-8

hexadecanediamide

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With potassium hydroxide
5,12-dioxo-hexadecanedioic acid
408311-05-7

5,12-dioxo-hexadecanedioic acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With potassium hydroxide; hydrazine hydrate; diethylene glycol
With hydrogenchloride; amalgamated zinc; acetic acid
7-semicarbazono-hexadecanedioic acid
109155-87-5

7-semicarbazono-hexadecanedioic acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With potassium hydroxide; hydrazine hydrate; diethylene glycol
cyclohexadecanone
2550-52-9

cyclohexadecanone

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
5,12-dioxo-hexadecanedioic acid bis-methylamide

5,12-dioxo-hexadecanedioic acid bis-methylamide

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With sodium; hydrazine hydrate; ethylene glycol
Hexadecane
544-76-3

Hexadecane

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
(microbiological transformation);
azelaic acid monoethyl ester
1593-55-1

azelaic acid monoethyl ester

9-acetoxy nonanoic acid
30993-88-5

9-acetoxy nonanoic acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
(i) (electrochemical oxidation), aq. K2CO3, (ii) KOH, EtOH; Multistep reaction;
heptadec-16-enoic acid
65119-97-3

heptadec-16-enoic acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With potassium permanganate In acetone
dimethyl hexadecanedioate
19102-90-0

dimethyl hexadecanedioate

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
(saponification);
1,16-hexadecanediol
7735-42-4

1,16-hexadecanediol

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With potassium permanganate In water; acetone at 70℃;
5-Oxohexadecanedioic Acid
3974-28-5

5-Oxohexadecanedioic Acid

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
(i) NaOH, N2H4*H2O, (ii) (heating); Multistep reaction;
6-Oxo-hexadecan-disaeure
93158-51-1

6-Oxo-hexadecan-disaeure

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With potassium hydroxide; hydrazine hydrate In diethylene glycol
4-Oxo-tetradecan-dicarbonsaeure-(1,14)-diethylester
102376-23-8

4-Oxo-tetradecan-dicarbonsaeure-(1,14)-diethylester

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
(i) N2H4*H2O, HOCH2CH2OCH2CH2OH, (ii) KOH, (thermolysis); Multistep reaction;
17-Phenyl-stearinsaeure
3839-45-0

17-Phenyl-stearinsaeure

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With chromium(VI) oxide In acetic acid at 100℃;
4-Oxo-hexadecandisaeure
17204-92-1

4-Oxo-hexadecandisaeure

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
(i) KOH, N(CH2CH2OH)3, (ii) N2H4*H2O, (iii) KOH; Multistep reaction;
β-Propiolactone
57-57-8

β-Propiolactone

1,10-Decandiylbis(magnesiumbromid)
23708-54-5

1,10-Decandiylbis(magnesiumbromid)

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With dilithium tetrachlorocuprate In tetrahydrofuran at 0℃; for 3h;
1-(tert-Butyl-dimethyl-silanyloxy)-cyclooctyl-hydroperoxide
88739-44-0

1-(tert-Butyl-dimethyl-silanyloxy)-cyclooctyl-hydroperoxide

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With sulfuric acid; water; iron(II) sulfate 1.) 0 deg C, methanol 2.) RT; Yield given. Multistep reaction;
2,3,19-Trioxabicyclo<14.2.1>nonadecane

2,3,19-Trioxabicyclo<14.2.1>nonadecane

A

thapsic acid
505-54-4

thapsic acid

B

15-formylpentadecanoic acid
69275-06-5

15-formylpentadecanoic acid

Conditions
ConditionsYield
In benzene-d6 at 80℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
1-methyl-4-nitrosobenzene
623-11-0

1-methyl-4-nitrosobenzene

6-[5-(5-carboxy-[2]thienylmethyl)-[2]thienyl]-hexanoic acid
857979-06-7

6-[5-(5-carboxy-[2]thienylmethyl)-[2]thienyl]-hexanoic acid

nickel-aluminium-alloy

nickel-aluminium-alloy

thapsic acid
505-54-4

thapsic acid

2-thiophenebutyric acid
4653-11-6

2-thiophenebutyric acid

aqueous sodium carbonate-solution

aqueous sodium carbonate-solution

Raney nickel

Raney nickel

A

Octanoic acid
124-07-2

Octanoic acid

B

thapsic acid
505-54-4

thapsic acid

7-oxo-tetradecane-dicarboxylic acid-(1.14)

7-oxo-tetradecane-dicarboxylic acid-(1.14)

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With hydrogenchloride; amalgamated zinc unter Durchleiten von Chlorwasserstoff;
1,14-tetradecanediol
19812-64-7

1,14-tetradecanediol

carbon monoxide

carbon monoxide

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With iodine; tetracarbonyl nickel at 260℃; under 147102 Torr;
zibetan

zibetan

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
With permanganate(VII) ion; benzene
(E)-tert-butyl (cyclooct-1-en-1-yloxy)dimethylsilane
67788-03-8

(E)-tert-butyl (cyclooct-1-en-1-yloxy)dimethylsilane

thapsic acid
505-54-4

thapsic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O2 / trifluoroacetic acid
2: 1.)FeSO4 2.) H2O, H2SO4 / 1.) 0 deg C, methanol 2.) RT
View Scheme
thapsic acid
505-54-4

thapsic acid

1,16-hexadecanediol
7735-42-4

1,16-hexadecanediol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Reflux;96%
With lithium aluminium tetrahydride In tetrahydrofuran for 24h; Reduction; Heating;92%
With lithium aluminium tetrahydride In tetrahydrofuran Ambient temperature;84%
thapsic acid
505-54-4

thapsic acid

1,16-hexadecanedioyl dichloride
34959-19-8

1,16-hexadecanedioyl dichloride

Conditions
ConditionsYield
With thionyl chloride In benzene for 2h; Heating;95%
With thionyl chloride for 3h; Heating;
With thionyl chloride for 1h; Heating;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

thapsic acid
505-54-4

thapsic acid

hexadecanedioic acid bis-(2,5-dioxopyrrolidin-1-yl)ester
191091-30-2

hexadecanedioic acid bis-(2,5-dioxopyrrolidin-1-yl)ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h;95%
thapsic acid
505-54-4

thapsic acid

benzyl alcohol
100-51-6

benzyl alcohol

dibenzyl hexadecanedioate

dibenzyl hexadecanedioate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 120℃; for 24h;95%
With toluene-4-sulfonic acid In toluene for 8h; Heating / reflux;
thapsic acid
505-54-4

thapsic acid

N1-(tert-butoxycarbonyl)-N2-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine
1146622-60-7

N1-(tert-butoxycarbonyl)-N2-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine

N1,N16-bis{(tert-butoxycarbonylamino)[3-(1-trityl-1H-imidazol-4-yl)propylamino]methylene}hexadecanediamide
1356946-87-6

N1,N16-bis{(tert-butoxycarbonylamino)[3-(1-trityl-1H-imidazol-4-yl)propylamino]methylene}hexadecanediamide

Conditions
ConditionsYield
Stage #1: thapsic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.25h; Inert atmosphere;
Stage #2: N1-(tert-butoxycarbonyl)-N2-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine In dichloromethane at 20℃; Inert atmosphere;
88%
thapsic acid
505-54-4

thapsic acid

glycerol
56-81-5

glycerol

hexadecandioic acid bis(2,3-dihydroxypropyl)ester

hexadecandioic acid bis(2,3-dihydroxypropyl)ester

Conditions
ConditionsYield
With mesoporous silica HMS2-SO3H at 110℃; for 6h; Product distribution; Further Variations:; Reagents; reaction times;86%
thapsic acid
505-54-4

thapsic acid

acotinine
302-27-2

acotinine

C48H73NO13

C48H73NO13

Conditions
ConditionsYield
With 2,3,5-trimethyl-pyridine In tetrahydrofuran at 70℃; for 5h;85.5%
thapsic acid
505-54-4

thapsic acid

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

1,14-tetradecyldiammonium ditosylate

1,14-tetradecyldiammonium ditosylate

Conditions
ConditionsYield
Stage #1: thapsic acid With sodium azide; sulfuric acid In chloroform at 50℃; for 2h; Schmidt Reaction;
Stage #2: toluene-4-sulfonic acid
73%
thapsic acid
505-54-4

thapsic acid

11-amino-N-(strychnin-2-yl)undecanoic acid amide

11-amino-N-(strychnin-2-yl)undecanoic acid amide

N1,N16-Bis[N-(strychnine-2-yl)undecanoic Acid Amide-11-yl]hexadecanediamide

N1,N16-Bis[N-(strychnine-2-yl)undecanoic Acid Amide-11-yl]hexadecanediamide

Conditions
ConditionsYield
Stage #1: thapsic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h; Inert atmosphere; Cooling with ice;
Stage #2: 11-amino-N-(strychnin-2-yl)undecanoic acid amide In dichloromethane at 20℃; for 14h; Inert atmosphere; Cooling with ice;
71%
methanol
67-56-1

methanol

thapsic acid
505-54-4

thapsic acid

dimethyl hexadecanedioate
19102-90-0

dimethyl hexadecanedioate

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 4h;69%
With thionyl chloride at 20℃; for 6h;
ethanol
64-17-5

ethanol

thapsic acid
505-54-4

thapsic acid

A

diethyl hexadecanedioate
15786-31-9

diethyl hexadecanedioate

B

hexadecanedioic acid monoethyl ester
18017-66-8

hexadecanedioic acid monoethyl ester

Conditions
ConditionsYield
With sulfuric acid In cyclohexane for 48h;A n/a
B 68%
thapsic acid
505-54-4

thapsic acid

α-bromoacetophenone
70-11-1

α-bromoacetophenone

hexadecanedioic acid mono-(2-oxo-2-phenyl-ethyl) ester
443770-14-7

hexadecanedioic acid mono-(2-oxo-2-phenyl-ethyl) ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 24h;65%
vinyl acetate
108-05-4

vinyl acetate

thapsic acid
505-54-4

thapsic acid

divinyl hexadecanedioate
160907-11-9

divinyl hexadecanedioate

Conditions
ConditionsYield
With sulfuric acid; mercury(II) diacetate for 4h; Reflux; Inert atmosphere;64%
4'-demethyl-4-deoxypodophyllotoxin
3590-93-0, 85440-15-9, 123287-54-7, 123287-57-0

4'-demethyl-4-deoxypodophyllotoxin

thapsic acid
505-54-4

thapsic acid

Hexadecanedioic acid mono-[2,6-dimethoxy-4-((5R,5aR,8aR)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-phenyl] ester

Hexadecanedioic acid mono-[2,6-dimethoxy-4-((5R,5aR,8aR)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-phenyl] ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 2h;63%
thapsic acid
505-54-4

thapsic acid

<3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester
89965-56-0

<3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester

15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid
177334-75-7

15-[(4-Benzyloxycarbonylamino-butyl)-(3-benzyloxycarbonylamino-propyl)-carbamoyl]-pentadecanoic acid

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;62%
thapsic acid
505-54-4

thapsic acid

tert-butyl 5-[3-(2-tert-butoxycarbonylguanidino)propyl]thiazol-2-yl-carbamate
1151467-62-7

tert-butyl 5-[3-(2-tert-butoxycarbonylguanidino)propyl]thiazol-2-yl-carbamate

N1,N16-bis((tert-butoxycarbonylamino){3-[2-(tert-butoxycarbonyl)aminothiazol-5-yl]propylamino}methylene)hexadecanediamide
1356946-78-5

N1,N16-bis((tert-butoxycarbonylamino){3-[2-(tert-butoxycarbonyl)aminothiazol-5-yl]propylamino}methylene)hexadecanediamide

Conditions
ConditionsYield
Stage #1: thapsic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.25h; Inert atmosphere;
Stage #2: tert-butyl 5-[3-(2-tert-butoxycarbonylguanidino)propyl]thiazol-2-yl-carbamate In dichloromethane at 20℃; Inert atmosphere;
62%
thapsic acid
505-54-4

thapsic acid

metronidazole
443-48-1

metronidazole

16-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)-16-oxohexadecanoic acid
848046-35-5

16-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)-16-oxohexadecanoic acid

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;60%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 40℃; for 24h;57.4%
Stage #1: thapsic acid With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 2h;
Stage #2: metronidazole With dmap In tetrahydrofuran
37.2%
Stage #1: thapsic acid With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 2h;
Stage #2: metronidazole With dmap In tetrahydrofuran
37.2%
thapsic acid
505-54-4

thapsic acid

N-trityl-N,N'-bis-[3-(trityl-amino)-propyl]-butane-1,4-diamine
213403-58-8

N-trityl-N,N'-bis-[3-(trityl-amino)-propyl]-butane-1,4-diamine

C150H162N8O2

C150H162N8O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 24h;57%
thapsic acid
505-54-4

thapsic acid

benzyl bromide
100-39-0

benzyl bromide

16-(benzyloxy)-16-oxohexadecanoic acid
146004-98-0

16-(benzyloxy)-16-oxohexadecanoic acid

Conditions
ConditionsYield
With sodium carbonate In 2-methyltetrahydrofuran; water at 75℃; for 22h;55.6%
With tetrabutylammomium bromide; potassium hydroxide In methanol Inert atmosphere;42%
thapsic acid
505-54-4

thapsic acid

ciprofloxacin
85721-33-1

ciprofloxacin

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;55%

tert-butyl 5-[3-(2-tert-butoxycarbonylguanidino)propyl]-4-methylthiazol-2-yl-carbamate

tert-butyl 5-[3-(2-tert-butoxycarbonylguanidino)propyl]-4-methylthiazol-2-yl-carbamate

N1,N16-bis((tert-butoxycarbonylamino){3-[2-(tert-butoxycarbonyl)amino-4-methylthiazol-5-yl]propylamino}methylene)hexadecanediamide
1356946-70-7

N1,N16-bis((tert-butoxycarbonylamino){3-[2-(tert-butoxycarbonyl)amino-4-methylthiazol-5-yl]propylamino}methylene)hexadecanediamide

Conditions
ConditionsYield
Stage #1: thapsic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.25h; Inert atmosphere;
Stage #2: tert-butyl 5-[3-(2-tert-butoxycarbonylguanidino)propyl]-4-methylthiazol-2-yl-carbamate In dichloromethane at 20℃; Inert atmosphere;
54%
thapsic acid
505-54-4

thapsic acid

Dideoxyinosine
69655-05-6

Dideoxyinosine

2',3'-dideoxy-5'-hydrogen hexadecanedioate inosine
879015-25-5

2',3'-dideoxy-5'-hydrogen hexadecanedioate inosine

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃;50.5%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃;50.5%
thapsic acid
505-54-4

thapsic acid

template CS diol
110224-49-2

template CS diol

C67H74O4
124461-68-3

C67H74O4

Conditions
ConditionsYield
With dmap; 4-(dimethylamino)pyridine hydrochloride; dicyclohexyl-carbodiimide In chloroform for 14h; Heating;50%
thapsic acid
505-54-4

thapsic acid

benzyl chloride
100-44-7

benzyl chloride

16-(benzyloxy)-16-oxohexadecanoic acid
146004-98-0

16-(benzyloxy)-16-oxohexadecanoic acid

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 80℃; for 40h;50%
thapsic acid
505-54-4

thapsic acid

N,N-dimethylformamide di-tert-butyl acetal
36805-97-7

N,N-dimethylformamide di-tert-butyl acetal

hexadecanedioic acid mono-tert-butyl ester
843666-27-3

hexadecanedioic acid mono-tert-butyl ester

Conditions
ConditionsYield
In toluene Reflux;49%
In toluene Reflux;47.6%
Stage #1: thapsic acid; N,N-dimethylformamide di-tert-butyl acetal In toluene at 50℃;
Stage #2: With ethyl acetate In dichloromethane for 0.25h;
33%
thapsic acid
505-54-4

thapsic acid

hydroxytyrosol
10597-60-1

hydroxytyrosol

bis(3,4-dihydroxyphenethyl) hexadecanedioate

bis(3,4-dihydroxyphenethyl) hexadecanedioate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran at 75℃;48%
thapsic acid
505-54-4

thapsic acid

butyl 6-O-hexadecanedioyl-α-D-glucopyranoside

butyl 6-O-hexadecanedioyl-α-D-glucopyranoside

Conditions
ConditionsYield
pig pancreatic lipase In acetone at 45℃; for 72h;47%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

thapsic acid
505-54-4

thapsic acid

ω-carboxypentanedecanoic acid monosuccinimidyl ester

ω-carboxypentanedecanoic acid monosuccinimidyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane; ethyl acetate at 20℃; for 12h;45%
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 0.5h;41%
7-[4-(2-chloroacetyl) piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

7-[4-(2-chloroacetyl) piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

thapsic acid
505-54-4

thapsic acid

C54H66F2N6O12
1350462-77-9

C54H66F2N6O12

Conditions
ConditionsYield
Stage #1: thapsic acid With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 1h;
Stage #2: 7-[4-(2-chloroacetyl) piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 50℃; for 72h;
41%

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