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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-BROMOBENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Bromobenzo[b]thiophene

Cas:5118-13-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Shanghai Scochem Technology Co., Ltd.

Shanghai Sikuo Chemical Technology Co., Ltd. was established in 2012 and is a chemical supplier that integrates research and development, production, and sales. Dedicated to providing basic chemical, fine chemical, pesticide, and pharmaceutical inter

4-bromo-benzo[b]thiophene

Cas:5118-13-8

Min.Order:25 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 4-Bromobenzo[b]thiophene CAS No. 5118-

4-Bromobenzo[b]thiophene

Cas:5118-13-8

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Factory price 4-Bromobenzo[b]thiophene Cas 5118-13-8 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Fe

Factory price 4-Bromobenzo[b]thiophene Cas 5118-13-8 with fast delivery

Cas:5118-13-8

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-bromo-1-benzothiophene

Cas:5118-13-8

Min.Order:1

Negotiable

Type:Other

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Bromobenzo[b]thiophene

Cas:5118-13-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

4-BROMO-BENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromothionaphthene

Cas:5118-13-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of

4-BROMO-BENZO[B]THIOPHENE MANUFACTURER

Cas:5118-13-8

Min.Order:1 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-BROMO-BENZO[B]THIOPHENE 5118-13-8

Cas:5118-13-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Brexpiprazole intermediate/4-BROMO-BENZO[B]THIOPHENE CAS 5118-13-8

Cas:5118-13-8

Min.Order:25 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 5118-13-8 with fast shipping

Cas:5118-13-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Brexpiprazole Powder CAS 5118-13-8

Cas:5118-13-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzo[b]thiophene,4-bromo-

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4-BROMO-BENZO[B]THIOPHENE CAS:5118-13-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

4-BROMO-BENZO[B]THIOPHENE CAS:5118-13-8

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

4-BROMOBENZO[B]THIOPHENE CAS NO.5118-13-8

Cas:5118-13-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzo[b]thiophene,4-bromo-

Cas:5118-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzo[b]thiophene,4-bromo-

Cas:5118-13-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

4-Bromobenzo[b]thiophene

Cas:5118-13-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5118-13-8

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-bromo-1-benzothiophene

Cas:5118-13-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzo[b]thiophene,4-bromo-

Cas:5118-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

4-BROMO-BENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

4-Bromobenzo[b]thiophene CAS 5118-13-8

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

4-BROMO-BENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

CAS5118-13-8 4-BROMO-BENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-BROMO-BENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Bromobenzo[b]thiophene CAS No.:5118-13-8 Molecule Formula:C8H5BrS Molecule Weight:213.09 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard

Best Quality 4-Bromobenzo[b]thiophene

Cas:5118-13-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

4-BROMO-BENZO[B]THIOPHENE Basic information Product Name: 4-BROMO-BENZO[B]THIOPHENE Synonyms: 4-BROMO-BENZO[B]THIOPHENE;4-Bromobenzothiophene;4-BROMO-1-BENZOTHIOPHENE;4-Bromothianaphthene;5-cyanobenzothiophene;4-bromo-thiophene;Benzo[b]thiophe

4-BROMO-BENZO[B]THIOPHENE

Cas:5118-13-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Benzo[b]thiophene
95-15-8

Benzo[b]thiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Stage #1: Benzo[b]thiophene With dihydrogen peroxide; acetic acid at 78℃; for 0.5h; Inert atmosphere;
Stage #2: With tetrabutylammomium bromide; sodium bromide In water at 120℃; under 7220.48 Torr; for 20h;
98.8%
4-bromo-benzo[b]thiophene-2-carboxylic acid
5194-37-6

4-bromo-benzo[b]thiophene-2-carboxylic acid

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With acetic acid; silver carbonate In dimethyl sulfoxide at 120℃; Further stages;95%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 200℃; for 1h; microwave irradiation;91%
With triethylenediamine at 120 - 180℃; for 6h;91.7%
4,7-dibromobenzo[b]thiophene
1391908-40-9

4,7-dibromobenzo[b]thiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Stage #1: 4,7-dibromobenzo[b]thiophene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: With methanol In tetrahydrofuran; hexane at -78℃;
53%
1-bromo-3-[(2,2-dimethoxyethyl)sulfanyl]benzene
19296-69-6

1-bromo-3-[(2,2-dimethoxyethyl)sulfanyl]benzene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
In chlorobenzene14%
benzo[B]thiophen-4-ylamine
17402-83-4

benzo[B]thiophen-4-ylamine

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With hydrogen bromide; sodium nitrite Behandeln der Reaktionsloesung mit Kupfer(I)-bromid;
4-bromo-5-aminobenzothiophene
4965-27-9

4-bromo-5-aminobenzothiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite Behandeln des Diazoniumsalzes mit wss. Hypophosphorigsaeure ;
1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene
17347-29-4

1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Stage #1: 1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene With PPA In chlorobenzene at 130℃; for 1h;
Stage #2: With sodium hydroxide In water; chlorobenzene at 20℃;
4-nitrobenzene[b]thiophene
10133-34-3

4-nitrobenzene[b]thiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium/charcoal; ethanol / Hydrogenation
2: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid
View Scheme
benzo[b]thiophen-5-yl-acetamide
18044-91-2

benzo[b]thiophen-5-yl-acetamide

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: nitric acid
2: aq.-ethanolic NaOH-solution
3: aqueous sulfuric acid; sodium nitrite / Behandeln der Reaktionsloesung mit wss. Hypophosphorigsaeure
4: palladium/charcoal; ethanol / Hydrogenation
5: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid
View Scheme
4-nitro-benzo[b]thiophen-5-ylamine
127491-04-7

4-nitro-benzo[b]thiophen-5-ylamine

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous sulfuric acid; sodium nitrite / Behandeln der Reaktionsloesung mit wss. Hypophosphorigsaeure
2: palladium/charcoal; ethanol / Hydrogenation
3: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid
View Scheme
N-(4-nitro-benzo[b]thiophen-5-yl)-acetamide
857473-95-1

N-(4-nitro-benzo[b]thiophen-5-yl)-acetamide

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aq.-ethanolic NaOH-solution
2: aqueous sulfuric acid; sodium nitrite / Behandeln der Reaktionsloesung mit wss. Hypophosphorigsaeure
3: palladium/charcoal; ethanol / Hydrogenation
4: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid
View Scheme
3-Bromothiophenol
6320-01-0

3-Bromothiophenol

Bromoacetaldehyde diethyl acetal
2032-35-1

Bromoacetaldehyde diethyl acetal

A

6-bromobenzothiophene
17347-32-9

6-bromobenzothiophene

B

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Stage #1: 3-Bromothiophenol; Bromoacetaldehyde diethyl acetal With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 24h;
Stage #2: With PPA In 1,2-dichloro-ethane for 1h; Heating / reflux;
1-bromo-3-[(2,2-dimethoxyethyl)sulfanyl]benzene
19296-69-6

1-bromo-3-[(2,2-dimethoxyethyl)sulfanyl]benzene

A

6-bromobenzothiophene
17347-32-9

6-bromobenzothiophene

B

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With poliphosphoric acid In chlorobenzene for 2h; Product distribution / selectivity; Heating / reflux;
With PPA at 130℃; for 4.5 - 5.5h; Heating / reflux;
With PPA In chlorobenzene at 130℃; for 4.5 - 5.5h; Heating / reflux;
With PPA In chlorobenzene at 140℃; for 5.5h; Heating / reflux;
With phenylpropanol amine In chlorobenzene for 12h; Reflux; Overall yield = 91 %; Overall yield = 7 g;
1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene
17347-29-4

1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene

A

6-bromobenzothiophene
17347-32-9

6-bromobenzothiophene

B

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With PPA In 1,2-dichloro-ethane for 1h; Heating / reflux;
With sodium carbonate In dichloromethane for 4h; Reflux; Overall yield = 58 %; Overall yield = 0.33 g;
3,6-dibromo-2-fluorobenzaldehyde
870703-68-7

3,6-dibromo-2-fluorobenzaldehyde

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 7 h / -30 °C / Inert atmosphere
2.1: potassium carbonate / methanol / 2 h / 0 - 20 °C / Inert atmosphere
3.1: gold(I) chloride / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.2: -78 °C
View Scheme
3,6-dibromo-2-(t-butylsulfanyl)(ethynyl)benzene
1391908-38-5

3,6-dibromo-2-(t-butylsulfanyl)(ethynyl)benzene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: gold(I) chloride / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: -78 °C
View Scheme
3,6-dibromo-2-(t-butylsulfanyl)benzaldehyde
1391908-37-4

3,6-dibromo-2-(t-butylsulfanyl)benzaldehyde

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / methanol / 2 h / 0 - 20 °C / Inert atmosphere
2.1: gold(I) chloride / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: -78 °C
View Scheme
3-Bromothiophenol
6320-01-0

3-Bromothiophenol

A

6-bromobenzothiophene
17347-32-9

6-bromobenzothiophene

B

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
1.2: 2 h / 20 °C
2.1: phenylpropanol amine / chlorobenzene / 12 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2: sodium carbonate / dichloromethane / 4 h / Reflux
View Scheme
3-Bromothiophenol
6320-01-0

3-Bromothiophenol

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / dimethyl sulfoxide; water
2: chlorobenzene
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide / water; dimethyl sulfoxide / 120 h / 20 °C
2.1: PPA / chlorobenzene / 1 h / 130 °C
2.2: 20 °C
View Scheme
2,6-dibromobenzaldehyde
67713-23-9

2,6-dibromobenzaldehyde

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: copper
View Scheme
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere
1.2: 0.33 h / -78 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere
3.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C
4.1: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere
3.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C
4.1: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C
View Scheme
2-bromo-6-fluorobenzaldehyde
360575-28-6

2-bromo-6-fluorobenzaldehyde

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere
2: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C
3: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 4 h / 30 - 35 °C
2: toluene / 4 h / 110 °C
3: sodium hydride / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 10 - 15 °C
2: toluene / 4 h / 110 °C
3: sodium hydride / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere
View Scheme
4-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester
93103-82-3

4-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C
2: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C
View Scheme
C8H6BrClOS

C8H6BrClOS

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 4 h / 110 °C
2: sodium hydride / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere
View Scheme
C26H21BrOPS(1+)*Cl(1-)

C26H21BrOPS(1+)*Cl(1-)

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20 - 30℃; for 2h; Solvent; Wittig Olefination; Inert atmosphere;
5-bromobenzo[b]thiophene
4923-87-9

5-bromobenzo[b]thiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

Conditions
ConditionsYield
With phosphazene base-P4-tert-butyl In 1,4-dioxane at 80℃; for 21h;6 %Spectr.
piperazine
110-85-0

piperazine

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In toluene at 100℃; for 24h; Solvent; Reagent/catalyst; Inert atmosphere;97.2%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

7-bromo-2-trimethylsilyl-benzothiophene
324769-04-2

7-bromo-2-trimethylsilyl-benzothiophene

Conditions
ConditionsYield
Stage #1: 4-bromobenzo[b]thiophene; chloro-trimethyl-silane With lithium diisopropyl amide In tetrahydrofuran; n-heptane at -70℃; for 1.53333h;
Stage #2: With hydrogenchloride In tetrahydrofuran; n-heptane at -70℃; for 1.5h;
95%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

4-tolyl iodide
624-31-7

4-tolyl iodide

4-bromo-2-(p-tolyl)benzo[b]thiophene

4-bromo-2-(p-tolyl)benzo[b]thiophene

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; sodium acetate; palladium diacetate; silver(l) oxide at 30℃; for 16h; regioselective reaction;86%
methanol
67-56-1

methanol

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

carbon monoxide
201230-82-2

carbon monoxide

methyl benzothiophen-4-carboxylate
100590-43-0

methyl benzothiophen-4-carboxylate

Conditions
ConditionsYield
With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate In dimethyl sulfoxide at 80℃; for 24h;84%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine at 120℃; Inert atmosphere;44%
piperazine
110-85-0

piperazine

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

1-benzo[b]thiophen-4-ylpiperazine hydrochloride

1-benzo[b]thiophen-4-ylpiperazine hydrochloride

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; L-proline In N,N-dimethyl-formamide at 110℃; for 10h; Reagent/catalyst; Solvent; Inert atmosphere;80.54%
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl In toluene for 1h; Heating / reflux;
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

N-thiocyanatodibenzenesulfonimide

N-thiocyanatodibenzenesulfonimide

4-bromo-3-thiocyanatobenzo[b]thiophene

4-bromo-3-thiocyanatobenzo[b]thiophene

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In acetonitrile at 60℃; for 12h;80%
piperazine
110-85-0

piperazine

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

Conditions
ConditionsYield
Stage #1: piperazine; 4-bromobenzo[b]thiophene With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 1h; Reflux; Inert atmosphere;
Stage #2: With hydrogenchloride In methanol
79.79%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

7-(4-(piperazin-1-yl)butoxy)quinolin-2(1H)-one

7-(4-(piperazin-1-yl)butoxy)quinolin-2(1H)-one

Brexpiprazole
913611-97-9

Brexpiprazole

Conditions
ConditionsYield
Stage #1: 7-[4-(piperazin-1-yl)butoxy]-2(1H)-quinolinone With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) In dichloromethane; dimethyl sulfoxide at 25 - 35℃; for 0.25h; Inert atmosphere;
Stage #2: 4-bromobenzo[b]thiophene In dichloromethane; dimethyl sulfoxide at 140 - 150℃;
77.8%
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 1,4-dioxane at 25 - 115℃; for 15h; Temperature; Inert atmosphere;40 g
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

2-methyl-1-(trimethylsilyloxy)-1-propene
6651-34-9

2-methyl-1-(trimethylsilyloxy)-1-propene

2-(benzo[b]thiophen-4-yl)-2-methylpropanal

2-(benzo[b]thiophen-4-yl)-2-methylpropanal

Conditions
ConditionsYield
With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide; toluene at 85℃; for 18h; Sealed tube; Inert atmosphere;75%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

carbon dioxide
124-38-9

carbon dioxide

benzothiophen-4-carboxic acid
10134-95-9

benzothiophen-4-carboxic acid

Conditions
ConditionsYield
Stage #1: 4-bromobenzo[b]thiophene With iodine; magnesium In tetrahydrofuran at 50 - 55℃; for 1.5h;
Stage #2: carbon dioxide In tetrahydrofuran at 23℃; for 0.25 - 0.333333h;
Stage #3: With hydrogenchloride; water In tetrahydrofuran at 0℃;
74%
With manganese; 2.9-dimethyl-1,10-phenanthroline; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;62%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

benzo[b]thiophene-4-carbonitrile
17347-34-1

benzo[b]thiophene-4-carbonitrile

Conditions
ConditionsYield
With [2,2]bipyridinyl; aluminum (III) chloride; nickel(II) acetylacetonate; zinc(II) oxide In 1,2-dimethoxyethane at 145℃; for 12h;72%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

(3‑methylbenzyl)(4‑methylphenyl) sulfide
887078-94-6

(3‑methylbenzyl)(4‑methylphenyl) sulfide

4-bromo-2-(4-methyl-2-(p-tolylthiomethyl)phenyl)benzo[b]thiophene

4-bromo-2-(4-methyl-2-(p-tolylthiomethyl)phenyl)benzo[b]thiophene

Conditions
ConditionsYield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(l) oxide; Trimethylacetic acid In dichloromethane at 100℃; for 24h; Inert atmosphere; Schlenk technique;72%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

methyl iodide
74-88-4

methyl iodide

4-bromo-2-methylbenzo[b]thiophene

4-bromo-2-methylbenzo[b]thiophene

Conditions
ConditionsYield
Stage #1: 4-bromobenzo[b]thiophene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran at -78℃; for 1h;
71%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

(benzo[b]thien-4-yl)acetonitrile

(benzo[b]thien-4-yl)acetonitrile

Conditions
ConditionsYield
Stage #1: 4-bromobenzo[b]thiophene; ethyl 2-cyanoacetate With potassium phosphate; N-(2-methylnaphthalen-1-yl)-N’-(pyridin-2-ylmethyl)oxalamide; copper(l) chloride In ethanol at 80℃; for 24h; Schlenk technique; Inert atmosphere;
Stage #2: With water In ethanol at 80℃; Schlenk technique; Inert atmosphere; Cooling;
71%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

4-bromo-3-iodobenzo[b]thiophene
1376607-97-4

4-bromo-3-iodobenzo[b]thiophene

Conditions
ConditionsYield
With iodine In nitromethane at 120℃; for 1h; Sealed tube; regioselective reaction;69%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-(benzo[b]thiophen-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(benzo[b]thiophen-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In diethylene glycol dimethyl ether at 80℃; Inert atmosphere; Sealed tube;60%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

1-benzo[b]thiophen-4-ylpiperazine hydrochloride

1-benzo[b]thiophen-4-ylpiperazine hydrochloride

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate In N,N-dimethyl-formamide at 110℃; for 14h; Reagent/catalyst; Solvent; Inert atmosphere;55.37%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

benzo[b]thiophen-4-ylboronic acid
177735-30-7

benzo[b]thiophen-4-ylboronic acid

Conditions
ConditionsYield
With n-butyllithium; Triisopropyl borate In tetrahydrofuran at -78℃;49%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

C12H10O2S

C12H10O2S

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate In N,N-dimethyl-formamide at 100℃; Inert atmosphere;49%
6-bromobenzothiophene
17347-32-9

6-bromobenzothiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

dicyanozinc
557-21-1

dicyanozinc

A

benzo[b]thiophene-6-carbonitrile
154650-81-4

benzo[b]thiophene-6-carbonitrile

B

benzo[b]thiophene-4-carbonitrile
17347-34-1

benzo[b]thiophene-4-carbonitrile

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 90 - 100℃; for 3h;A 46.2%
B 23%
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 90 - 100℃; for 3h;A 46.2%
B 23%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

1-(tert-butoxycarbonyl)-4-hydroxy-4-(benzothien-4-yl)piperidine
324769-47-3

1-(tert-butoxycarbonyl)-4-hydroxy-4-(benzothien-4-yl)piperidine

Conditions
ConditionsYield
Stage #1: 4-bromobenzo[b]thiophene With magnesium In tetrahydrofuran at 60℃; for 0.0833333h; Inert atmosphere;
Stage #2: N-tert-butyloxycarbonylpiperidin-4-one In tetrahydrofuran at 20℃; for 1h; Further stages;
44%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

(2-oxo-2-phenylethyl)triphenylphosphonium trifluoroacetate
55161-38-1

(2-oxo-2-phenylethyl)triphenylphosphonium trifluoroacetate

(8,11-dibromobenzo[de]benzo[4,5]thieno[3,2-b]benzo[4,5]thieno[2,3-g]chromen-10-yl)triphenylphosphonium trifluoroacetate

(8,11-dibromobenzo[de]benzo[4,5]thieno[3,2-b]benzo[4,5]thieno[2,3-g]chromen-10-yl)triphenylphosphonium trifluoroacetate

Conditions
ConditionsYield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; silver(l) oxide In 2,2,2-trifluoroethanol at 120℃; for 24h; Schlenk technique; Inert atmosphere;42%
6-bromobenzothiophene
17347-32-9

6-bromobenzothiophene

4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

copper(I) cyanide
544-92-3

copper(I) cyanide

A

benzo[b]thiophene-6-carbonitrile
154650-81-4

benzo[b]thiophene-6-carbonitrile

B

benzo[b]thiophene-4-carbonitrile
17347-34-1

benzo[b]thiophene-4-carbonitrile

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide for 20h; Product distribution / selectivity; Heating / reflux;A 41%
B 39%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

benzimidic acid ethyl ester
825-60-5

benzimidic acid ethyl ester

2-(4-bromobenzo[b]thiophen-2-yl)benzonitrile

2-(4-bromobenzo[b]thiophen-2-yl)benzonitrile

Conditions
ConditionsYield
With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; potassium acetate; silver fluoride In tert-butyl alcohol at 100℃; for 24h; Schlenk technique;37%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

methyl (2a,7b)-cis-7-bromo-1,2,2a,7b-tetrahydrobenzo[b]cyclobuta[d]thiophene-1-carboxylate

methyl (2a,7b)-cis-7-bromo-1,2,2a,7b-tetrahydrobenzo[b]cyclobuta[d]thiophene-1-carboxylate

Conditions
ConditionsYield
With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate In water; acetonitrile at 50℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; diastereoselective reaction;35%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

N-(3-chloro-4-fluorophenyl)benzo[b]thiophene-4-carboxamide

N-(3-chloro-4-fluorophenyl)benzo[b]thiophene-4-carboxamide

Conditions
ConditionsYield
With palladium diacetate; sodium carbonate; tri tert-butylphosphoniumtetrafluoroborate In acetonitrile at 70℃; for 1h; Inert atmosphere; Microwave irradiation;32%
4-bromobenzo[b]thiophene
5118-13-8

4-bromobenzo[b]thiophene

2,5-dibromo-terephthalic acid diethyl ester
18013-97-3

2,5-dibromo-terephthalic acid diethyl ester

tributyltin chloride
1461-22-9

tributyltin chloride

tris-(o-tolyl)phosphine
6163-58-2

tris-(o-tolyl)phosphine

diethyl 2,5-di(benzo[b]thiophen-4-yl)terephthalate

diethyl 2,5-di(benzo[b]thiophen-4-yl)terephthalate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide31%

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