Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:5118-13-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:5118-13-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryShanghai Sikuo Chemical Technology Co., Ltd. was established in 2012 and is a chemical supplier that integrates research and development, production, and sales. Dedicated to providing basic chemical, fine chemical, pesticide, and pharmaceutical inter
Cas:5118-13-8
Min.Order:25 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Description Product website: http://www.finerchem.com Product Name 4-Bromobenzo[b]thiophene CAS No. 5118-
Cas:5118-13-8
Min.Order:1 Gram
FOB Price: $45.0
Type:Lab/Research institutions
inquiryFactory price 4-Bromobenzo[b]thiophene Cas 5118-13-8 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Fe
Cas:5118-13-8
Min.Order:10 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:5118-13-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:5118-13-8
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryAdvantage : LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of
Cas:5118-13-8
Min.Order:1 Gram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:5118-13-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:5118-13-8
Min.Order:25 Kilogram
FOB Price: $100.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:5118-13-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:5118-13-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry4-BROMO-BENZO[B]THIOPHENE CAS:5118-13-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:5118-13-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:5118-13-8
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:5118-13-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:5118-13-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:5118-13-8
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:5118-13-8
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:5118-13-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:5118-13-8
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o
Cas:5118-13-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:5118-13-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: 4-Bromobenzo[b]thiophene CAS No.:5118-13-8 Molecule Formula:C8H5BrS Molecule Weight:213.09 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard
Cas:5118-13-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry4-BROMO-BENZO[B]THIOPHENE Basic information Product Name: 4-BROMO-BENZO[B]THIOPHENE Synonyms: 4-BROMO-BENZO[B]THIOPHENE;4-Bromobenzothiophene;4-BROMO-1-BENZOTHIOPHENE;4-Bromothianaphthene;5-cyanobenzothiophene;4-bromo-thiophene;Benzo[b]thiophe
Cas:5118-13-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
Stage #1: Benzo[b]thiophene With dihydrogen peroxide; acetic acid at 78℃; for 0.5h; Inert atmosphere; Stage #2: With tetrabutylammomium bromide; sodium bromide In water at 120℃; under 7220.48 Torr; for 20h; | 98.8% |
Conditions | Yield |
---|---|
With acetic acid; silver carbonate In dimethyl sulfoxide at 120℃; Further stages; | 95% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 200℃; for 1h; microwave irradiation; | 91% |
With triethylenediamine at 120 - 180℃; for 6h; | 91.7% |
4,7-dibromobenzo[b]thiophene
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Stage #1: 4,7-dibromobenzo[b]thiophene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: With methanol In tetrahydrofuran; hexane at -78℃; | 53% |
1-bromo-3-[(2,2-dimethoxyethyl)sulfanyl]benzene
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
In chlorobenzene | 14% |
benzo[B]thiophen-4-ylamine
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
With hydrogen bromide; sodium nitrite Behandeln der Reaktionsloesung mit Kupfer(I)-bromid; |
Conditions | Yield |
---|---|
With sulfuric acid; sodium nitrite Behandeln des Diazoniumsalzes mit wss. Hypophosphorigsaeure ; |
1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Stage #1: 1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene With PPA In chlorobenzene at 130℃; for 1h; Stage #2: With sodium hydroxide In water; chlorobenzene at 20℃; |
4-nitrobenzene[b]thiophene
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium/charcoal; ethanol / Hydrogenation 2: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid View Scheme |
benzo[b]thiophen-5-yl-acetamide
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: nitric acid 2: aq.-ethanolic NaOH-solution 3: aqueous sulfuric acid; sodium nitrite / Behandeln der Reaktionsloesung mit wss. Hypophosphorigsaeure 4: palladium/charcoal; ethanol / Hydrogenation 5: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid View Scheme |
4-nitro-benzo[b]thiophen-5-ylamine
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aqueous sulfuric acid; sodium nitrite / Behandeln der Reaktionsloesung mit wss. Hypophosphorigsaeure 2: palladium/charcoal; ethanol / Hydrogenation 3: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid View Scheme |
N-(4-nitro-benzo[b]thiophen-5-yl)-acetamide
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aq.-ethanolic NaOH-solution 2: aqueous sulfuric acid; sodium nitrite / Behandeln der Reaktionsloesung mit wss. Hypophosphorigsaeure 3: palladium/charcoal; ethanol / Hydrogenation 4: aqueous hydrobromic acid; sodium nitrite / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid View Scheme |
3-Bromothiophenol
Bromoacetaldehyde diethyl acetal
A
6-bromobenzothiophene
B
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Stage #1: 3-Bromothiophenol; Bromoacetaldehyde diethyl acetal With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 24h; Stage #2: With PPA In 1,2-dichloro-ethane for 1h; Heating / reflux; |
1-bromo-3-[(2,2-dimethoxyethyl)sulfanyl]benzene
A
6-bromobenzothiophene
B
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
With poliphosphoric acid In chlorobenzene for 2h; Product distribution / selectivity; Heating / reflux; | |
With PPA at 130℃; for 4.5 - 5.5h; Heating / reflux; | |
With PPA In chlorobenzene at 130℃; for 4.5 - 5.5h; Heating / reflux; | |
With PPA In chlorobenzene at 140℃; for 5.5h; Heating / reflux; | |
With phenylpropanol amine In chlorobenzene for 12h; Reflux; Overall yield = 91 %; Overall yield = 7 g; |
1-bromo-3-(2,2-diethoxy-ethylsulfanyl)benzene
A
6-bromobenzothiophene
B
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
With PPA In 1,2-dichloro-ethane for 1h; Heating / reflux; | |
With sodium carbonate In dichloromethane for 4h; Reflux; Overall yield = 58 %; Overall yield = 0.33 g; |
3,6-dibromo-2-fluorobenzaldehyde
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere 1.2: 7 h / -30 °C / Inert atmosphere 2.1: potassium carbonate / methanol / 2 h / 0 - 20 °C / Inert atmosphere 3.1: gold(I) chloride / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere 4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 4.2: -78 °C View Scheme |
3,6-dibromo-2-(t-butylsulfanyl)(ethynyl)benzene
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: gold(I) chloride / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: -78 °C View Scheme |
3,6-dibromo-2-(t-butylsulfanyl)benzaldehyde
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / methanol / 2 h / 0 - 20 °C / Inert atmosphere 2.1: gold(I) chloride / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 3.2: -78 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C 1.2: 2 h / 20 °C 2.1: phenylpropanol amine / chlorobenzene / 12 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C 2: sodium carbonate / dichloromethane / 4 h / Reflux View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / dimethyl sulfoxide; water 2: chlorobenzene View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium hydroxide / water; dimethyl sulfoxide / 120 h / 20 °C 2.1: PPA / chlorobenzene / 1 h / 130 °C 2.2: 20 °C View Scheme |
2,6-dibromobenzaldehyde
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: copper View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere 1.2: 0.33 h / -78 °C / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere 3.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C 4.1: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere 3.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C 4.1: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C View Scheme |
2-bromo-6-fluorobenzaldehyde
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere 2: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C 3: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 4 h / 30 - 35 °C 2: toluene / 4 h / 110 °C 3: sodium hydride / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 10 - 15 °C 2: toluene / 4 h / 110 °C 3: sodium hydride / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere View Scheme |
4-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water; tetrahydrofuran / 1 h / 70 °C 2: silver carbonate; acetic acid / dimethyl sulfoxide / 120 °C View Scheme |
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 4 h / 110 °C 2: sodium hydride / tetrahydrofuran / 2 h / 20 - 30 °C / Inert atmosphere View Scheme |
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20 - 30℃; for 2h; Solvent; Wittig Olefination; Inert atmosphere; |
Conditions | Yield |
---|---|
With phosphazene base-P4-tert-butyl In 1,4-dioxane at 80℃; for 21h; | 6 %Spectr. |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline In toluene at 100℃; for 24h; Solvent; Reagent/catalyst; Inert atmosphere; | 97.2% |
4-bromobenzo[b]thiophene
chloro-trimethyl-silane
7-bromo-2-trimethylsilyl-benzothiophene
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[b]thiophene; chloro-trimethyl-silane With lithium diisopropyl amide In tetrahydrofuran; n-heptane at -70℃; for 1.53333h; Stage #2: With hydrogenchloride In tetrahydrofuran; n-heptane at -70℃; for 1.5h; | 95% |
Conditions | Yield |
---|---|
With 1,1,1,3',3',3'-hexafluoro-propanol; sodium acetate; palladium diacetate; silver(l) oxide at 30℃; for 16h; regioselective reaction; | 86% |
methanol
4-bromobenzo[b]thiophene
carbon monoxide
methyl benzothiophen-4-carboxylate
Conditions | Yield |
---|---|
With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate In dimethyl sulfoxide at 80℃; for 24h; | 84% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine at 120℃; Inert atmosphere; | 44% |
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; L-proline In N,N-dimethyl-formamide at 110℃; for 10h; Reagent/catalyst; Solvent; Inert atmosphere; | 80.54% |
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl In toluene for 1h; Heating / reflux; | |
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate |
4-bromobenzo[b]thiophene
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In acetonitrile at 60℃; for 12h; | 80% |
Conditions | Yield |
---|---|
Stage #1: piperazine; 4-bromobenzo[b]thiophene With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 1h; Reflux; Inert atmosphere; Stage #2: With hydrogenchloride In methanol | 79.79% |
4-bromobenzo[b]thiophene
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 7-[4-(piperazin-1-yl)butoxy]-2(1H)-quinolinone With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) In dichloromethane; dimethyl sulfoxide at 25 - 35℃; for 0.25h; Inert atmosphere; Stage #2: 4-bromobenzo[b]thiophene In dichloromethane; dimethyl sulfoxide at 140 - 150℃; | 77.8% |
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 1,4-dioxane at 25 - 115℃; for 15h; Temperature; Inert atmosphere; | 40 g |
Conditions | Yield |
---|---|
With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide; toluene at 85℃; for 18h; Sealed tube; Inert atmosphere; | 75% |
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[b]thiophene With iodine; magnesium In tetrahydrofuran at 50 - 55℃; for 1.5h; Stage #2: carbon dioxide In tetrahydrofuran at 23℃; for 0.25 - 0.333333h; Stage #3: With hydrogenchloride; water In tetrahydrofuran at 0℃; | 74% |
With manganese; 2.9-dimethyl-1,10-phenanthroline; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique; | 62% |
4-bromobenzo[b]thiophene
formamide
benzo[b]thiophene-4-carbonitrile
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; aluminum (III) chloride; nickel(II) acetylacetonate; zinc(II) oxide In 1,2-dimethoxyethane at 145℃; for 12h; | 72% |
4-bromobenzo[b]thiophene
(3‑methylbenzyl)(4‑methylphenyl) sulfide
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(l) oxide; Trimethylacetic acid In dichloromethane at 100℃; for 24h; Inert atmosphere; Schlenk technique; | 72% |
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[b]thiophene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran at -78℃; for 1h; | 71% |
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[b]thiophene; ethyl 2-cyanoacetate With potassium phosphate; N-(2-methylnaphthalen-1-yl)-N’-(pyridin-2-ylmethyl)oxalamide; copper(l) chloride In ethanol at 80℃; for 24h; Schlenk technique; Inert atmosphere; Stage #2: With water In ethanol at 80℃; Schlenk technique; Inert atmosphere; Cooling; | 71% |
4-bromobenzo[b]thiophene
4-bromo-3-iodobenzo[b]thiophene
Conditions | Yield |
---|---|
With iodine In nitromethane at 120℃; for 1h; Sealed tube; regioselective reaction; | 69% |
4-bromobenzo[b]thiophene
bis(pinacol)diborane
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In diethylene glycol dimethyl ether at 80℃; Inert atmosphere; Sealed tube; | 60% |
4-bromobenzo[b]thiophene
1-t-Butoxycarbonylpiperazine
Conditions | Yield |
---|---|
With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate In N,N-dimethyl-formamide at 110℃; for 14h; Reagent/catalyst; Solvent; Inert atmosphere; | 55.37% |
4-bromobenzo[b]thiophene
benzo[b]thiophen-4-ylboronic acid
Conditions | Yield |
---|---|
With n-butyllithium; Triisopropyl borate In tetrahydrofuran at -78℃; | 49% |
Conditions | Yield |
---|---|
With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate In N,N-dimethyl-formamide at 100℃; Inert atmosphere; | 49% |
6-bromobenzothiophene
4-bromobenzo[b]thiophene
dicyanozinc
A
benzo[b]thiophene-6-carbonitrile
B
benzo[b]thiophene-4-carbonitrile
Conditions | Yield |
---|---|
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 90 - 100℃; for 3h; | A 46.2% B 23% |
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 90 - 100℃; for 3h; | A 46.2% B 23% |
4-bromobenzo[b]thiophene
N-tert-butyloxycarbonylpiperidin-4-one
1-(tert-butoxycarbonyl)-4-hydroxy-4-(benzothien-4-yl)piperidine
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[b]thiophene With magnesium In tetrahydrofuran at 60℃; for 0.0833333h; Inert atmosphere; Stage #2: N-tert-butyloxycarbonylpiperidin-4-one In tetrahydrofuran at 20℃; for 1h; Further stages; | 44% |
4-bromobenzo[b]thiophene
(2-oxo-2-phenylethyl)triphenylphosphonium trifluoroacetate
Conditions | Yield |
---|---|
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; silver(l) oxide In 2,2,2-trifluoroethanol at 120℃; for 24h; Schlenk technique; Inert atmosphere; | 42% |
6-bromobenzothiophene
4-bromobenzo[b]thiophene
copper(I) cyanide
A
benzo[b]thiophene-6-carbonitrile
B
benzo[b]thiophene-4-carbonitrile
Conditions | Yield |
---|---|
With pyridine In N,N-dimethyl-formamide for 20h; Product distribution / selectivity; Heating / reflux; | A 41% B 39% |
Conditions | Yield |
---|---|
With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; potassium acetate; silver fluoride In tert-butyl alcohol at 100℃; for 24h; Schlenk technique; | 37% |
4-bromobenzo[b]thiophene
acrylic acid methyl ester
Conditions | Yield |
---|---|
With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate In water; acetonitrile at 50℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; diastereoselective reaction; | 35% |
4-bromobenzo[b]thiophene
3-chloro-4-fluorophenylamine
molybdenum hexacarbonyl
Conditions | Yield |
---|---|
With palladium diacetate; sodium carbonate; tri tert-butylphosphoniumtetrafluoroborate In acetonitrile at 70℃; for 1h; Inert atmosphere; Microwave irradiation; | 32% |
4-bromobenzo[b]thiophene
2,5-dibromo-terephthalic acid diethyl ester
tributyltin chloride
tris-(o-tolyl)phosphine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide | 31% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View