DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryAnalysis Specification Results Appearance White powder White powder Purity By HPLC ≥
Cas:913611-97-9
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryBrexpiprazole Product Name: Brexpiprazole Synonyms: 7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one;Brexpiprazole impurity a;CS-1678;OPC 34712; OPC34712; OPC-34712;Brexpiprazole(OPC34712);7-{4-[4-(1-Benzothiophen-4-yl)p
Cas:913611-97-9
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryBrexpiprazole CAS No.:913611-97-9 Name: Brexpiprazole Synonyms: 7-[4-(4-(Benzo[b]thien-4-yl)-piperazin-1-yl)butoxy]-1H-quinolin-2-one; OPC 34712
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:913611-97-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiry英文名 Brexpiprazole 别名 7-[4-(4-(Benzo[b]thien-4-yl)-piperazin-1-yl)butoxy]-1H-quinolin-2-one; OPC 34712 产品名称 Brexpiprazole 分子结构
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $5.0 / 10.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:913611-97-9
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:913611-97-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Cas:913611-97-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryName: Brexpiprazole CAS:913611-97-9 MF: C25H27N3O2S Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25KG Application:APIS Transportation:By sea or by air Port:Qingdao Port
Appearance:White to off- white crystalline powder Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china
Cas:913611-97-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr
Cas:913611-97-9
Min.Order:100 Gram
Negotiable
Type:Other
inquiryBrexpiprazole Basic information Description References Product Name: Brexpiprazole Synonyms: 7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one;Brexpiprazole impurity a;CS-1678;OPC 34712; OPC34712; OPC-34712;Brexpiprazole(O
Cas:913611-97-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Brexpiprazole CAS:913611-97-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
Cas:913611-97-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d
Cas:913611-97-9
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:913611-97-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: Brexpiprazole Synonyms: Brexpiprazole(OPC34712);7-{4-[4-(1-Benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one;Brexpiprazole;OPC-34712;7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl)butoxy]- 2(1H)-Quinolinone;7-[4-[4-(1-Benzothio
Cas:913611-97-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se
Cas:913611-97-9
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:913611-97-9
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:913611-97-9
Min.Order:5 Gram
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:913611-97-9
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:913611-97-9
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Fine Chemical Brexpiprazole with Good Price (CAS: 913611-97-9)Appearance:powder Storage:store in a cool dry place and keep away from strong Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx
Cas:913611-97-9
Min.Order:1 Gram
Negotiable
Type:Other
inquiryBrexpiprazole
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 20 - 80℃; for 2h; | 96.1% |
Brexpiprazole
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane; water for 2h; | 96% |
Stage #1: 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one hydrochloride In ethanol; water Reflux; Stage #2: With pyrographite In ethanol; water for 0.5h; Reflux; Stage #3: With sodium hydride In ethanol; water for 0.5h; Reflux; | 3.76 kg |
With pyrographite In ethanol; water for 0.5h; Reflux; Large scale; | 3.76 kg |
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride With sodium carbonate In methanol; water at 50℃; for 0.5h; Stage #2: 7-(4-chlorobutoxy)quinoline-2(1H)-one In methanol; water at 70℃; for 16h; | 95.5% |
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 70℃; for 10h; | 84% |
With potassium carbonate In ethanol; water at 40 - 50℃; | 82.3% |
4-chlorobenzothiophene
Brexpiprazole
Conditions | Yield |
---|---|
With C48H55ClN2Pd; sodium t-butanolate In 1,2-dimethoxyethane at 20℃; for 16h; Inert atmosphere; Sealed tube; | 95% |
4-bromo-1,3-benzothiazole
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[d]thiazole With isopropylmagnesium chloride In tetrahydrofuran at -5℃; for 2h; Stage #2: 7-(4-(piperazin-1-yl)butoxy)quinolin-2(1H)-one dihydrochloride In tetrahydrofuran for 3h; | 91.5% |
4-chlorobenzothiophene
Brexpiprazole
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux; | 90% |
benzo[B]thiophen-4-ylamine
Brexpiprazole
Conditions | Yield |
---|---|
In butan-1-ol at 25 - 125℃; | 90% |
With potassium carbonate; potassium iodide In 5,5-dimethyl-1,3-cyclohexadiene at 130 - 140℃; | 78.5% |
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile for 23h; Reflux; | 88.3% |
7–(4-bromobutoxy)quinolin-2(1H)-one
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine dihydrochloride With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 7–(4-bromobutoxy)quinolin-2(1H)-one With potassium iodide In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere; | 85% |
benzo[b]thiophen-4-ylboronic acid
Brexpiprazole
Conditions | Yield |
---|---|
With copper diacetate; triethylamine In dichloromethane at 0 - 35℃; Reagent/catalyst; Solvent; Temperature; | 83.3% |
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 1.5h; Temperature; | 83.1% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 130 - 135℃; Reagent/catalyst; Temperature; | 82% |
benzo[B]thiophen-4-ylamine
Brexpiprazole
Conditions | Yield |
---|---|
With potassium tert-butylate In toluene at 25 - 35℃; | 78.5% |
4-bromobenzo[b]thiophene
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 7-[4-(piperazin-1-yl)butoxy]-2(1H)-quinolinone With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) In dichloromethane; dimethyl sulfoxide at 25 - 35℃; for 0.25h; Inert atmosphere; Stage #2: 4-bromobenzo[b]thiophene In dichloromethane; dimethyl sulfoxide at 140 - 150℃; | 77.8% |
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 1,4-dioxane at 25 - 115℃; for 15h; Temperature; Inert atmosphere; | 40 g |
Brexpiprazole
Conditions | Yield |
---|---|
With aluminum (III) chloride In chlorobenzene at 0 - 135℃; | 70.8% |
With aluminum (III) chloride In chlorobenzene at 125 - 135℃; | 70.8% |
Brexpiprazole
Conditions | Yield |
---|---|
With 4-methyl-morpholine In ethanol; water for 10h; Reagent/catalyst; Reflux; | 70.4% |
Stage #1: 1-benzo[b]thiophen-4-ylpiperazine hydrochloride With potassium carbonate In N,N-dimethyl-formamide at 25 - 50℃; for 0.5h; Stage #2: 7-(4-chlorobutoxy)quinoline-2(1H)-one With potassium iodide In N,N-dimethyl-formamide at 10 - 95℃; Temperature; | 63.98% |
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide | |
With potassium carbonate In ethanol; water at 80 - 85℃; for 15h; Solvent; Inert atmosphere; | 987 g |
With sodium carbonate In ethanol for 12h; Solvent; Reflux; |
Brexpiprazole
Conditions | Yield |
---|---|
With sodium acetate; sodium tris(acetoxy)borohydride In isopropyl alcohol at 65 - 68℃; for 0.666667h; Reagent/catalyst; Solvent; Temperature; | 51% |
Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride; 4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butanal With sodium tris(acetoxy)borohydride In dimethyl sulfoxide at 20 - 40℃; for 1h; Stage #2: With sodium hydroxide In water; dimethyl sulfoxide at 20 - 65℃; for 2h; pH=> 10; |
Brexpiprazole
Conditions | Yield |
---|---|
With sodium persulfate; iron(III) chloride hexahydrate In water; acetonitrile at 80℃; for 24h; | 35% |
7-hydroxy-1H-quinolin-2-one
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / water; N,N-dimethyl-formamide / 0.25 h / 30 - 40 °C 1.2: 5 h / 40 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 30 - 40 °C 2.2: 2 h / 90 - 100 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / methanol / 8 h / 10 °C / Reflux 2.1: potassium carbonate / water; ethanol / 9 h / 50 °C / Reflux 2.2: 1 h / Reflux 2.3: 1 h / 7 °C / Reflux 3.1: water; ethanol / Reflux 3.2: 0.5 h / Reflux 3.3: 0.5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide / ethanol / 5 h / Reflux 2.1: hydrogenchloride / methanol; water / 0.5 h / 30 °C / Cooling with ice; Large scale 2.2: 20 - 65 °C / Large scale 3.1: palladium diacetate; triphenylphosphine; potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Inert atmosphere; Reflux View Scheme |
4-hydroxybenzothiophene
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydride / toluene / 6 h / 90 - 100 °C 2: sodium hydride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / toluene / 3 h / 90 - 100 °C 3: hydrogenchloride / water / 3 h / 90 - 100 °C / Reflux 4: potassium carbonate / butan-1-ol / 24 h / Reflux 5: sodium carbonate / acetonitrile / 23 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 2.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; XPhos; caesium carbonate / toluene / 8 h / 100 °C / Inert atmosphere 3.1: hydrogenchloride / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 4.2: 4 h / 100 °C / Inert atmosphere View Scheme |
2-(1-benzo[b]thiophen-4-yloxy)-2-methylpropanamide
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / toluene / 3 h / 90 - 100 °C 2: hydrogenchloride / water / 3 h / 90 - 100 °C / Reflux 3: potassium carbonate / butan-1-ol / 24 h / Reflux 4: sodium carbonate / acetonitrile / 23 h / Reflux View Scheme |
N-(1-benzo[b]thiophen-4-yl)-2-hydroxy-2-methylpropanamide
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 3 h / 90 - 100 °C / Reflux 2: potassium carbonate / butan-1-ol / 24 h / Reflux 3: sodium carbonate / acetonitrile / 23 h / Reflux View Scheme |
benzo[B]thiophen-4-ylamine
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / butan-1-ol / 24 h / Reflux 2: sodium carbonate / acetonitrile / 23 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonamide / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / 120 - 150 °C 2.1: sodium carbonate / water; methanol / 0.5 h / 50 °C 2.2: 16 h / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium carbonate / butan-1-ol / 6 h / Reflux 1.2: pH 12 2.1: sodium carbonate / ethanol / 12 h / Reflux View Scheme |
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper(I) oxide / N,N-dimethyl-formamide / 2 h / 120 °C 2: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C View Scheme |
2-bromo-6-fluorobenzaldehyde
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium carbonate / toluene / 4 h / 110 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 100 °C 2.2: 1 h / 40 °C 3.1: lithium hydroxide monohydrate; water / methanol / 3 h / 0 - 50 °C 4.1: copper(I) oxide / N,N-dimethyl-formamide / 2 h / 120 °C 5.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C View Scheme |
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 - 100 °C 1.2: 1 h / 40 °C 2.1: lithium hydroxide monohydrate; water / methanol / 3 h / 0 - 50 °C 3.1: copper(I) oxide / N,N-dimethyl-formamide / 2 h / 120 °C 4.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C View Scheme |
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium hydroxide monohydrate; water / methanol / 3 h / 0 - 50 °C 2: copper(I) oxide / N,N-dimethyl-formamide / 2 h / 120 °C 3: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C View Scheme |
7–(4-bromobutoxy)quinolin-2(1H)-one
Brexpiprazole
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetonitrile Reflux; | 21 g |
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium iodide; potassium carbonate / acetonitrile / 24 h / Reflux 2.1: ammonia / methanol / 2 h / 150 °C 2.2: 24 h / 20 °C / Inert atmosphere 3.1: bromine; sodium acetate / acetic acid; water / 24 h / 80 °C View Scheme |
Brexpiprazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ammonia / methanol / 2 h / 150 °C 1.2: 24 h / 20 °C / Inert atmosphere 2.1: bromine; sodium acetate / acetic acid; water / 24 h / 80 °C View Scheme |
Brexpiprazole
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 1h; Reflux; | 90% |
With hydrogenchloride In ethanol; acetic acid at 10 - 76℃; for 1h; | 800 g |
With boron tribromide In methanol; dichloromethane; water | |
With hydrogenchloride; acetic acid In ethanol at 10℃; for 1h; Reflux; |
Conditions | Yield |
---|---|
In dichloromethane at 0 - 10℃; for 2h; | 88.5% |
Brexpiprazole
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 120℃; for 6h; Temperature; | 84.35% |
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; O,O'-(R)-(1,1'-dinaphthyl-2,2'-diyl)-N,N'-di-(R,R)-[phenylethylphosphoramidite]; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; enantioselective reaction; | 75% |
Brexpiprazole
chloromethyl cyclohexyl carbonate
carbonic acid 7-[4-(4-benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy]-2-oxo-2H-quinolin-1-ylmethyl ester cyclohexyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: Brexpiprazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 1h; Stage #2: chloromethyl cyclohexyl carbonate In tetrahydrofuran; mineral oil at 0 - 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water; mineral oil | 42% |
Stage #1: Brexpiprazole With sodium hydride In tetrahydrofuran at 50℃; for 1h; Stage #2: chloromethyl cyclohexyl carbonate In tetrahydrofuran at 0 - 20℃; | 42% |
Brexpiprazole
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 1h; | A 30% B 37% |
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: Brexpiprazole; 2-(benzyloxy)-7-(4-chlorobutoxy)quinoline With caesium carbonate In N,N-dimethyl-formamide at 110℃; for 6h; Stage #2: With hydrogen bromide In water at 60℃; for 5h; | A 19% B 14% |
Brexpiprazole
toluene-4-sulfonic acid
Conditions | Yield |
---|---|
In methanol; dichloromethane |
Brexpiprazole
maleic acid
Conditions | Yield |
---|---|
In methanol; dichloromethane |
Brexpiprazole
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In methanol; dichloromethane |
Brexpiprazole
citric acid
Conditions | Yield |
---|---|
In methanol; dichloromethane |
Brexpiprazole
Conditions | Yield |
---|---|
With sulfuric acid In methanol; dichloromethane |
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