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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Hesperetin Manufacturer/High quality/Best price/In stock

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Hesperetin CAS 520-33-2

Cas:520-33-2

Min.Order:100 Gram

FOB Price: $180.0 / 200.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for HESPERETIN Cas 520-33-2 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:2-8°C Package:1kg/foil bag, 25kg/drum or as you required

Factory supply high quality HESPERETIN Cas 520-33-2 with best purity and favorable price

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

Natural Citrus Aurantinum Extract 98% Hesperetin Powder

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $204.8 / 206.3

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Hesperitin HACCP manufacturer

Cas:520-33-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Hesperetin

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Hesperetin

Cas:520-33-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Hesperetin English Name: Hesperetin Plant sources:Citrus,Citrus sinensis,Citrus limon. CAS No.520-33-2 Molecular formula: C16H14O6 Molecular weight: 302.29 Packaging Specification: 25kg/drum high purity 99%min stock Hubei DiBo Chemic

Hesperetin Manufacturer /CAS:520-33-2/Chinese suppliers/Content is 98%

Cas:520-33-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: HESPERETIN Synonyms: (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one;(2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2H-1-benzopyran-4(3H)-one;(S)-3',5,7-Trihydroxy-4'-methoxyflavanone;[S,(

520-33-2 HESPERETIN

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $230.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Neohesperidin are a natural new nutrition sweetener widely existing in plants of dry orange peel, can be derived from extraction. Since the sweetness are 1300-1500 times than sugar, Neohesperidin are widely used in fruit juice, wine, beverage, bakery

Manufacture Supply Natural Extract CAS: 520-33-2 Citrus Aurantium Extract Hesperetin Powder for Food Supplement

Cas:520-33-2

Min.Order:5 Kilogram

FOB Price: $25.0 / 40.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

China factory supplyCAS 520-33-2 with competitive price

Cas:520-33-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

Herbal Extract 95 % Hesperetin Plant Extract Product Name: Hesperetin CAS: 520-33-2 MF: C16H14O6 MW: 302.28 EINECS: 208-290-2 Appearance:white Storage:room Package:drum Application:anti aging Port:Shanghai/Wuhan

Herbal Extract 95 % Hesperetin Plant Extract

Cas:520-33-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Hesperetin CAS520-33-2

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name Hesperidin Chemical Names Hesperidin; 520-26-3; Cirantin; Hesperidoside; Hesper bitabs; Hesperetin-rutinosid Synonym Hesperetin 7-

Hesperetin CAS: 520-33-2

Cas:520-33-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Beige to Light Brown Crystalline Solid Storage:Room temperature Package:25kg/drum Application:Citrus Extract Transportation:Express/Sea/Air Port:Any port in china

Best Quality Hesperetin Natural Citrus Aurantinum Extract

Cas:520-33-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

High Quality Orange Peel Citrus Sinensis Extract 98% Hesperetin CAS 520-33-2

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Hesperetin 520-33-2

Cas:520-33-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

HESPERETIN Fruit Extract Variety: orange Form: Powder Part: peel Extraction Type: Solvent Extraction Packaging: Drum Place of Origin: Fujian, C

HESPERETIN

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $45.0 / 50.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

Antiallergic drugs HESPERETIN with CAS:520-33-2

Cas:520-33-2

Min.Order:10 Gram

FOB Price: $26.0 / 31.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Hesperetin CAS:520-33-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Hesperetin CAS:520-33-2

Cas:520-33-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS Hesperetin Basic information

China Biggest Manufacturer factory sales Hesperitin CAS 520-33-2

Cas:520-33-2

Min.Order:100 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Hesperetin

Cas:520-33-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

We warmly welcome customers from at home and abroad to establish cooperation and create a bright future with us together. And leading the way to make health industries heathier, help more people healthy and happy… Trade Assurance Get full p

Hesperetin CAS 520-33-2 Citrus Aurantium Extract

Cas:520-33-2

Min.Order:1 Kilogram

FOB Price: $140.0

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Hesperetin

Cas:520-33-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

HESPERETIN

Cas:520-33-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Hesperetin

Cas:520-33-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Hesperetin

Cas:520-33-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Hesperetin

Cas:520-33-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Hesperitin

Cas:520-33-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Binbo is engaged in R&D with perfect equipm

High Quality Hesperetin

Cas:520-33-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

hesperidin
520-26-3

hesperidin

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With sulfuric acid; acetic acid In water for 12h; Reflux;98%
With sulfuric acid In water at 121℃; for 4h; High pressure;87%
With sulfuric acid In ethanol for 8h; Reflux;87%
7-hydroxy-4-methyl-chromen-2-one
90-33-5, 79566-13-5

7-hydroxy-4-methyl-chromen-2-one

hesperidin
520-26-3

hesperidin

A

4-methylumbelliferyl-rutinoside
1356391-89-3

4-methylumbelliferyl-rutinoside

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water In dimethyl sulfoxide at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;A 28%
B n/a
hesperidin
520-26-3

hesperidin

A

hesperetin
520-33-2

hesperetin

B

3′,5,7,8-tetrahydroxy-4′-methoxyflavanone

3′,5,7,8-tetrahydroxy-4′-methoxyflavanone

Conditions
ConditionsYield
With Aspergillus saitoi In water; dimethyl sulfoxide at 30℃; pH=5.0;A n/a
B 3.5%
hesperidin
520-26-3

hesperidin

A

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
520-33-2

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With sulfuric acid; ethylene glycol
With sulfuric acid
With methanol; sulfuric acid
hesperidin
520-26-3

hesperidin

A

D-Glucose
2280-44-6

D-Glucose

B

L-rhamnose
73-34-7

L-rhamnose

C

hesperetin 7‐O‐β‐D‐glucopyranoside

hesperetin 7‐O‐β‐D‐glucopyranoside

D

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With sulfuric acid In water at 140℃; for 1h; Kinetics; Product distribution; Further Variations:; pH-values; Reagents; Temperatures; Hydrolysis;
hesperidin
520-26-3

hesperidin

A

hesperetin-7-glucoside

hesperetin-7-glucoside

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
L. acidophilus NCC 3010 crude extract for 4 - 8h; pH=4 - 6; Product distribution / selectivity; Enzymatic reaction;
L. plantarum NCC 1313 crude extract for 4 - 8h; pH=4 - 6; Product distribution / selectivity; Enzymatic reaction;
4G-α-D-glucopyranosyl hesperidin
161713-86-6

4G-α-D-glucopyranosyl hesperidin

A

hesperidin
520-26-3

hesperidin

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With small intestine homogenate of rat at 37℃; for 4h; Title compound not separated from byproducts.;
concentrated H2 SO4

concentrated H2 SO4

hesperidin
520-26-3

hesperidin

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
In methanol; water
(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
520-33-2

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

A

(R)-4'-methoxy-3',5,7-trihydroxyflavanone
24604-97-5

(R)-4'-methoxy-3',5,7-trihydroxyflavanone

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With ammonium acetate In water; isopropyl alcohol pH=5; Resolution of racemate;
With per(4-chloro-3-methyl)phenylcarbamate β-cyclodextrin clicked onto an alkynyl surface modified silica support In ethanol; hexane at 25℃; Resolution of racemate;
methanol
67-56-1

methanol

hesperidin
520-26-3

hesperidin

A

C13H24O10
184239-14-3

C13H24O10

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
propan-1-ol
71-23-8

propan-1-ol

hesperidin
520-26-3

hesperidin

A

C15H28O10
168172-05-2

C15H28O10

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
ethanol
64-17-5

ethanol

hesperidin
520-26-3

hesperidin

A

ethyl α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside
187539-57-7

ethyl α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

hesperidin
520-26-3

hesperidin

A

C16H30O10

C16H30O10

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
pentan-1-ol
71-41-0

pentan-1-ol

hesperidin
520-26-3

hesperidin

A

C17H32O10
189187-99-3

C17H32O10

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
isopropyl alcohol
67-63-0

isopropyl alcohol

hesperidin
520-26-3

hesperidin

A

C15H28O10
1174639-57-6

C15H28O10

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
Conditions
ConditionsYield
With water at 60℃; for 0.5h; pH=5; aq. buffer; Enzymatic reaction;
With ethanol; α-rhamnosyl-β-glucosidase at 30℃; for 2h; Enzymatic reaction;
With α-rhamnosyl-β-glucosidase; water Enzymatic reaction;
With sulfuric acid In methanol; water for 6h; Reflux;
With 6-O-α-rhamnosyl-β-glucosidase from Acremonium sp. DSM24697; choline chloride; urea In aq. phosphate buffer at 60℃; for 1h; pH=6; Reagent/catalyst; Enzymatic reaction;
hesperidin
520-26-3

hesperidin

benzyl alcohol
100-51-6

benzyl alcohol

A

1′-O-benzyl-α-L-rhamnopyranosyl-(1″→6′)-β-D-glucopyranoside
88510-10-5

1′-O-benzyl-α-L-rhamnopyranosyl-(1″→6′)-β-D-glucopyranoside

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
hesperidin
520-26-3

hesperidin

butan-1-ol
71-36-3

butan-1-ol

A

n-butyl α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside

n-butyl α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water at 30℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;
hesperetin 7‐O‐β‐D‐glucopyranoside

hesperetin 7‐O‐β‐D‐glucopyranoside

A

β-D-glucose
492-61-5

β-D-glucose

B

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With water Enzymatic reaction;
Conditions
ConditionsYield
With solid phase supported Acremonium sp. DSM24697 α-rhamnosyl-β-glucosidase at 60℃; for 1h; pH=5; Kinetics; aq. buffer; Enzymatic reaction;
Conditions
ConditionsYield
With sulfuric acid In methanol; water for 6h; Reflux;
hesperetin 7‐O‐β‐D‐glucopyranoside

hesperetin 7‐O‐β‐D‐glucopyranoside

hesperetin
520-33-2

hesperetin

Conditions
ConditionsYield
With β-D-glucosidase In aq. buffer at 50 - 100℃; for 0.583333h; pH=4; Kinetics; Enzymatic reaction;
Conditions
ConditionsYield
With DL-dithiothreitol; recombinant Plagiochasma appendiculatum flavone 6-O-methyltransferase; magnesium chloride In aq. buffer at 37℃; for 0.5h; pH=7.5; Enzymatic reaction;
hesperetin
520-33-2

hesperetin

diosmetin
520-34-3

diosmetin

Conditions
ConditionsYield
With pyridine; iodine at 90℃; for 22h;100%
With iodine In pyridine at 90℃; for 8h;85%
With pyridine; iodine at 90 - 95℃;
With trifluoroacetic anhydride; potassium iodide In dimethyl sulfoxide; N,N-dimethyl-formamide at 100 - 120℃; for 4h; Temperature; Reagent/catalyst;37.6 g
1-deoxy-1-fluoro-α-D-glucose
2106-10-7

1-deoxy-1-fluoro-α-D-glucose

hesperetin
520-33-2

hesperetin

hesperetin 7-α-O-glucoside

hesperetin 7-α-O-glucoside

Conditions
ConditionsYield
With α-glucosidase from sulfolobus solfataricus In dimethyl sulfoxide at 45℃; for 2h; pH=9; Enzymatic reaction;99%
temozolomide
85622-93-1

temozolomide

hesperetin
520-33-2

hesperetin

C6H6N6O2*C16H14O6

C6H6N6O2*C16H14O6

Conditions
ConditionsYield
In ethanol for 1h;94%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

hesperetin
520-33-2

hesperetin

3',5,7-tri-O-tert-butyldimethylsilylhesperetin

3',5,7-tri-O-tert-butyldimethylsilylhesperetin

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; silylation;89%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

hesperetin
520-33-2

hesperetin

hesperetin (2-hydroxybenzoyl)hydrazone
1261060-91-6

hesperetin (2-hydroxybenzoyl)hydrazone

Conditions
ConditionsYield
With acetic acid In ethanol for 24h; Reflux;83.6%
benzenesulfonic acid
98-11-3

benzenesulfonic acid

hesperetin
520-33-2

hesperetin

(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxochroman-7-yl benzenesulfonate

(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxochroman-7-yl benzenesulfonate

Conditions
ConditionsYield
With sodium carbonate; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃; for 6h;80.9%
hesperetin
520-33-2

hesperetin

3-(3-hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxyphenyl)propan-1 -one
35400-60-3

3-(3-hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxyphenyl)propan-1 -one

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; palladium on activated charcoal at 30℃; under 2280 Torr; for 0.5h;80%
formaldehyd
50-00-0

formaldehyd

4-(2-(piperazin-1-yl)ethyl)morpholine
4892-89-1

4-(2-(piperazin-1-yl)ethyl)morpholine

hesperetin
520-33-2

hesperetin

6-[4-(2-morpholin-4-ylethyl)piperazine-1-yl]methyl-3',5,7-trihydroxyflavanone

6-[4-(2-morpholin-4-ylethyl)piperazine-1-yl]methyl-3',5,7-trihydroxyflavanone

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;80%
o-trifluoromethylbenzyl bromide
395-44-8

o-trifluoromethylbenzyl bromide

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[2-(trifluoromethyl)benzyl]oxy}chroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[2-(trifluoromethyl)benzyl]oxy}chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;80%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

formaldehyd
50-00-0

formaldehyd

hesperetin
520-33-2

hesperetin

C23H28N2O6

C23H28N2O6

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;79%
formaldehyd
50-00-0

formaldehyd

tert-butylamine
75-64-9

tert-butylamine

hesperetin
520-33-2

hesperetin

C21H25NO6

C21H25NO6

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;78%
formaldehyd
50-00-0

formaldehyd

phenethylamine
64-04-0

phenethylamine

hesperetin
520-33-2

hesperetin

C25H25NO6

C25H25NO6

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;78%
4-Fluorobenzyl bromide
459-46-1

4-Fluorobenzyl bromide

hesperetin
520-33-2

hesperetin

(S)-7-[(4-fluorobenzyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

(S)-7-[(4-fluorobenzyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;78%
1-bromomethyl-3-trifluoromethylbenzene
402-23-3

1-bromomethyl-3-trifluoromethylbenzene

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[3-(trifluoromethyl)benzyl]oxy}chroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[3-(trifluoromethyl)benzyl]oxy}chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;78%
4-bromomethyltrifluoromethylbenzene
402-49-3

4-bromomethyltrifluoromethylbenzene

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[4-(trifluoromethyl)benzyl]oxy}chroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[4-(trifluoromethyl)benzyl]oxy}chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;77%
propyl bromide
106-94-5

propyl bromide

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-propoxychroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-propoxychroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;75%
1-(Bromomethyl)-3-fluorobenzene
456-41-7

1-(Bromomethyl)-3-fluorobenzene

hesperetin
520-33-2

hesperetin

(S)-7-[(3-fluorobenzyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

(S)-7-[(3-fluorobenzyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;75%
2-methylbenzyl bromide
89-92-9

2-methylbenzyl bromide

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2-methylbenzyl)oxy]chroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2-methylbenzyl)oxy]chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;74%
formaldehyd
50-00-0

formaldehyd

isopropylamine
75-31-0

isopropylamine

hesperetin
520-33-2

hesperetin

C20H23NO6

C20H23NO6

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;73%
4-Methylbenzyl bromide
104-81-4

4-Methylbenzyl bromide

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(4-methylbenzyl)oxy]chroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(4-methylbenzyl)oxy]chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;73%
o-fluorobenzyl bromide
446-48-0

o-fluorobenzyl bromide

hesperetin
520-33-2

hesperetin

(S)-7-[(2-fluorobenzyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

(S)-7-[(2-fluorobenzyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;72%
benzyl bromide
100-39-0

benzyl bromide

hesperetin
520-33-2

hesperetin

(S)-7-(benzyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
1403990-90-8

(S)-7-(benzyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;71%
With potassium carbonate In acetone at 56℃; for 10.5h;70.1%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

formaldehyd
50-00-0

formaldehyd

hesperetin
520-33-2

hesperetin

C22H26N2O6

C22H26N2O6

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;70%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

hesperetin
520-33-2

hesperetin

7-O-(2-ethoxy-2-oxoethyl)hesperetin

7-O-(2-ethoxy-2-oxoethyl)hesperetin

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethanol for 1h; Reflux;70%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h;68%
With potassium carbonate; potassium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;50%
Stage #1: hesperetin With potassium carbonate; potassium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 0.5h;
Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide for 1h;
50%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h;
4-cyanobenzyl bromide
17201-43-3

4-cyanobenzyl bromide

hesperetin
520-33-2

hesperetin

(S)-4-{[(5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxochroman-7-yl)oxy]methyl}benzonitrile

(S)-4-{[(5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxochroman-7-yl)oxy]methyl}benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;70%
C35H56O5
1186389-76-3

C35H56O5

hesperetin
520-33-2

hesperetin

C51H68O10
1314678-14-2

C51H68O10

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 60℃; for 2.5h; Inert atmosphere;68%
ethyl crotonate
10544-63-5

ethyl crotonate

hesperetin
520-33-2

hesperetin

C22H22O8

C22H22O8

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;68%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

formaldehyd
50-00-0

formaldehyd

hesperetin
520-33-2

hesperetin

C23H28N2O7

C23H28N2O7

Conditions
ConditionsYield
In methanol; water for 0.5h; Mannich Aminomethylation;67%
1-bromomethyl-3-methyl-benzene
620-13-3

1-bromomethyl-3-methyl-benzene

hesperetin
520-33-2

hesperetin

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(3-methylbenzyl)oxy]chroman-4-one

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(3-methylbenzyl)oxy]chroman-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Alkaline conditions;67%

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