Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiry20-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2015 quality management system Leader Supplier of Botanical Reference Materials in China 3000 kinds of
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:54-28-4
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inquiryD-gamma-Tocopherol CAS:54-28-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirysuperior quality Appearance:clear light brown viscous liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:One of the naturally occurring forms
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea
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inquiryProduct Name: D-gamma-Tocopherol CAS: 54-28-4 MF: C28H48O2 MW: 416.68 EINECS: 200-201-5 Mol File: 54-28-4.mol D-gamma-Tocopherol Structure D-gamma-Tocopherol Chemical Properties alpha 30 º (C=2.0 IN ISOOCTANE 25 ºC)
Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
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inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
ADVANTAGE:1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day2. The products are provided with COA, HPLC, NMR, quality assurance, pac
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
(2R,4'R,8'R)-γ-tocopherol-5-carboxylic acid
gamma-tocopherol
Conditions | Yield |
---|---|
at 170℃; for 3h; | 91% |
phytylplastoquinol
gamma-tocopherol
Conditions | Yield |
---|---|
With 2,6-di-O-methyl-β-cyclodextrin; ascorbic acid In water at 35℃; for 15h; tocopherol-cyclase enzyme; | 90% |
With tocopherol cyclase from spheroplasts of Anabaena variabilis In acetone |
gamma-tocopherol
Conditions | Yield |
---|---|
Stage #1: (3R,7R,11R)-(E)-3,7,11,15-tetramethyl-1-(2,5-dimethoxy-3,4-dimethylphenyl)hexadecan-3-ol With ammonium cerium (IV) nitrate In water; acetonitrile at 0℃; for 2h; Stage #2: With sodium dithionite In water; acetone at 20℃; for 0.5h; Stage #3: With toluene-4-sulfonic acid In toluene at 65℃; for 0.5h; | 72% |
B
gamma-tocopherol
Conditions | Yield |
---|---|
With ethanol; ascorbic acid at 37℃; Product distribution; |
2-methyl-6-phythyl-1,4-benzoquinone
A
phytylplastoquinol
B
gamma-tocopherol
C
Tocopherol
Conditions | Yield |
---|---|
With SAM; chloroplast suspension In ethanol; sulfuric acid at 20℃; for 0.5h; Mechanism; Irradiation; |
6-phytyltoluquinol
A
phytylplastoquinol
B
gamma-tocopherol
C
Tocopherol
Conditions | Yield |
---|---|
With SAM; chloroplast suspension In ethanol; sulfuric acid at 20℃; for 0.5h; Mechanism; Irradiation; |
Conditions | Yield |
---|---|
With SAM; chloroplast suspension In ethanol; sulfuric acid at 20℃; for 0.5h; Mechanism; Irradiation; |
D
gamma-tocopherol
Conditions | Yield |
---|---|
With tocopherol cyclase from spheroplasts of Anabaena variabilis In acetone Title compound not separated from byproducts; | A 16 % Chromat. B 13 % Chromat. C 23 % Chromat. D 48 % Chromat. |
gamma-tocopherol
Conditions | Yield |
---|---|
With sodium L-ascorbate In ethanol; water at 25℃; Kinetics; |
5-bromomethyl-3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-chromen-6-ol
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: AcOH; H2SO4 / CH2Cl2 / 20 °C 2: N-methylmorpholine N-oxide / acetonitrile / 5 h / 20 °C 3: NH2SO3H; NaClO2 / dioxane; H2O / 0.83 h / 20 °C 4: KOH / methanol / 2 h / 50 °C 5: 91 percent / 3 h / 170 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: Br2 / hexane / 3 h / 20 °C 2: AcOH; H2SO4 / CH2Cl2 / 20 °C 3: N-methylmorpholine N-oxide / acetonitrile / 5 h / 20 °C 4: NH2SO3H; NaClO2 / dioxane; H2O / 0.83 h / 20 °C 5: KOH / methanol / 2 h / 50 °C 6: 91 percent / 3 h / 170 °C View Scheme |
5-(bromomethyl)-2,7,8-trimethyl-2-((4R, 8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N-methylmorpholine N-oxide / acetonitrile / 5 h / 20 °C 2: NH2SO3H; NaClO2 / dioxane; H2O / 0.83 h / 20 °C 3: KOH / methanol / 2 h / 50 °C 4: 91 percent / 3 h / 170 °C View Scheme |
5-formyl-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetate
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NH2SO3H; NaClO2 / dioxane; H2O / 0.83 h / 20 °C 2: KOH / methanol / 2 h / 50 °C 3: 91 percent / 3 h / 170 °C View Scheme |
6-O-acetyl-(2R,4'R,8'R)-γ-tocopherol-5-carboxylic acid
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOH / methanol / 2 h / 50 °C 2: 91 percent / 3 h / 170 °C View Scheme |
3,6-dimethoxy-o-xylene
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: N-Bromosuccinimide / dichloromethane / 6 h / Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -60 °C 3.1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C 4.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 5.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 6.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 7.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 8.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 9.1: hydrazine hydrate; oxygen / ethanol 10.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 10.2: 0.5 h / 20 °C 10.3: 0.5 h / 65 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: N-Bromosuccinimide / dichloromethane / 6 h / Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -60 °C 3.1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C 4.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 5.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 6.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 7.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 8.1: hydrazine hydrate; oxygen / ethanol 9.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 9.2: 0.5 h / 20 °C 9.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 2.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 3.1: hydrazine hydrate; oxygen / ethanol 4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 4.2: 0.5 h / 20 °C 4.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 2.1: hydrazine hydrate; oxygen / ethanol 3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 3.2: 0.5 h / 20 °C 3.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrazine hydrate; oxygen / ethanol 2.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 2.2: 0.5 h / 20 °C 2.3: 0.5 h / 65 °C View Scheme |
1-bromo-2,5-dimethoxy-3,4-dimethylbenzene
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -60 °C 2.1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C 3.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 4.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 5.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 6.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 7.1: hydrazine hydrate; oxygen / ethanol 8.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 8.2: 0.5 h / 20 °C 8.3: 0.5 h / 65 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -60 °C 2.1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C 3.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 4.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 5.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 6.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 7.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 8.1: hydrazine hydrate; oxygen / ethanol 9.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 9.2: 0.5 h / 20 °C 9.3: 0.5 h / 65 °C View Scheme |
2,5-dimethoxy-3,4-dimethylbenzaldehyde
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C 2.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 3.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 4.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 5.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 6.1: hydrazine hydrate; oxygen / ethanol 7.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 7.2: 0.5 h / 20 °C 7.3: 0.5 h / 65 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C 2.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 3.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 4.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 5.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 6.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 7.1: hydrazine hydrate; oxygen / ethanol 8.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 8.2: 0.5 h / 20 °C 8.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 2.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 3.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 4.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 5.1: hydrazine hydrate; oxygen / ethanol 6.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 6.2: 0.5 h / 20 °C 6.3: 0.5 h / 65 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: Oxone; sodium bromide / dichloromethane; water / 0 - 20 °C 2.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 3.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 4.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 5.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 6.1: hydrazine hydrate; oxygen / ethanol 7.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 7.2: 0.5 h / 20 °C 7.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 2.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 3.1: hydrazine hydrate; oxygen / ethanol 4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 4.2: 0.5 h / 20 °C 4.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 2.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 3.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 4.1: hydrazine hydrate; oxygen / ethanol 5.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 5.2: 0.5 h / 20 °C 5.3: 0.5 h / 65 °C View Scheme |
gamma-tocopherol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 2.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 3.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 4.1: hydrazine hydrate; oxygen / ethanol 5.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 5.2: 0.5 h / 20 °C 5.3: 0.5 h / 65 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 2.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux 3.1: copper(I) bromide dimethylsulfide complex; 223121-01-5 / tert-butyl methyl ether; diethyl ether / -78 °C / Schlenk technique; Inert atmosphere 4.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere 5.1: hydrazine hydrate; oxygen / ethanol 6.1: ammonium cerium (IV) nitrate / water; acetonitrile / 2 h / 0 °C 6.2: 0.5 h / 20 °C 6.3: 0.5 h / 65 °C View Scheme |
Conditions | Yield |
---|---|
With carbon dioxide In methanol; n-heptane at 40℃; under 67506.8 Torr; Supercritical conditions; |
(2RS,4'R,8'R)-γ-tocopherol
A
(2S,4’R,8’R)-γ-tocopherol
B
gamma-tocopherol
Conditions | Yield |
---|---|
With carbon dioxide In methanol; n-heptane at 40℃; under 67506.8 Torr; Supercritical conditions; |
allyl bromide
gamma-tocopherol
(R,R,R)-6-allyloxy-2,7,8-trimethyl-2-(4,8,12-trimethyl-tridecyl)-chroman
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 20h; Heating / reflux; | 100% |
butyraldehyde
gamma-tocopherol
7,9,10-trimethyl-2,4-dipropyl-7-(4,8,12-trimethyl-tridecyl)-4,5,6,7-tetrahydro-1,3,8-trioxa-phenanthrene
Conditions | Yield |
---|---|
With sulfuric acid; acetic acid for 18h; | 100% |
gamma-tocopherol
Conditions | Yield |
---|---|
With sulfuric acid; bromine In hexane at 0 - 20℃; | 100% |
With bromine In hexane at 0 - 20℃; Inert atmosphere; | 72% |
morpholine
paraformaldehyde-d2
gamma-tocopherol
(2R,4'R,8'R)-5-(morpholino[(2)H2]methyl)-γ-tocopherol
Conditions | Yield |
---|---|
Stage #1: morpholine; paraformaldehyde-d2 at 70 - 80℃; for 2.33333h; Stage #2: gamma-tocopherol at 20 - 80℃; for 0.75h; Mannich reaction; Further stages.; | 98.3% |
bromoacetic acid methyl ester
gamma-tocopherol
2,7,8-trimethyl-(2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxy) acetic acid
Conditions | Yield |
---|---|
Stage #1: bromoacetic acid methyl ester; gamma-tocopherol With sodium hydroxide In DMF (N,N-dimethyl-formamide) at 20℃; for 24h; Stage #2: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water | 97% |
With sodium hydroxide In DMF (N,N-dimethyl-formamide) at 20℃; for 24h; | 97% |
3-Chloro-2-methylpropene
gamma-tocopherol
(R,R,R)-2,7,8-trimethyl-6-(2-methyl-allyloxy)-2-(4,8,12-trimethyl-tridecyl)-chroman
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetone for 20h; Heating / reflux; | 95% |
5-bromomethyl-3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-chromen-6-ol
gamma-tocopherol
bis(5-γ-tocopheryl)methane
Conditions | Yield |
---|---|
Stage #1: 5-bromomethyl-3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-chromen-6-ol; gamma-tocopherol With boron trifluoride diacetate; acetic acid at 20℃; for 48h; Stage #2: With hydrogenchloride In methanol for 0.5h; | 94% |
Conditions | Yield |
---|---|
Stage #1: succinic acid anhydride; gamma-tocopherol With boron trifluoride diethyl etherate; chloroformic acid ethyl ester In 1,4-dioxane for 2h; Heating; Stage #2: With sodium tetrahydroborate; chloroformic acid ethyl ester In 1,4-dioxane at 0℃; for 0.5h; | 92% |
N,N-Dimethylthiocarbamoyl chloride
gamma-tocopherol
O-dimethylthiocarbamoyl-d-γ-tocopherol
Conditions | Yield |
---|---|
Stage #1: gamma-tocopherol With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.666667h; Inert atmosphere; Stage #2: N,N-Dimethylthiocarbamoyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; | 91% |
gamma-tocopherol
2-bromo-3-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-5,6-dimethyl-[1,4]benzoquinone
Conditions | Yield |
---|---|
With bromine In ethanol at 0 - 20℃; for 1.16667h; pH=6; aq. phosphate buffer; | 88% |
Conditions | Yield |
---|---|
Stage #1: cycl-isopropylidene malonate; gamma-tocopherol With boron trifluoride diethyl etherate; chloroformic acid ethyl ester In 1,4-dioxane for 2h; Heating; Stage #2: With sodium tetrahydroborate; chloroformic acid ethyl ester In 1,4-dioxane at 0℃; for 0.5h; | 84% |
trifluoromethylsulfonic anhydride
gamma-tocopherol
(2R,4'R,8'R)-γ-tocopheryl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine In dichloromethane at -20 - -10℃; for 3h; | 82% |
Conditions | Yield |
---|---|
Stage #1: glutaric anhydride,; gamma-tocopherol With boron trifluoride diethyl etherate; chloroformic acid ethyl ester In 1,4-dioxane for 2h; Heating; Stage #2: With sodium tetrahydroborate; chloroformic acid ethyl ester In 1,4-dioxane at 0℃; for 0.5h; | 81% |
Conditions | Yield |
---|---|
With silver(l) oxide | 78% |
paraformaldehyde-d2
gamma-tocopherol
(2R,4'R,8'R)-[C5-(2)H3]-α-tocopherol
Conditions | Yield |
---|---|
With hydrogen chloride; tin(ll) chloride In di-isopropyl ether at 88℃; for 2.5h; | 77% |
gamma-tocopherol
2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-5-nitro-6-chromanol
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In ethanol at 22℃; for 0.5h; | 72% |
With (2R,4'R,8'R)-α-tocopheramine; silver(l) oxide In hexane |
Conditions | Yield |
---|---|
With sulfuric acid In dichloromethane at 22℃; for 18h; Inert atmosphere; | 65% |
With pyridine |
Conditions | Yield |
---|---|
With triethylamine In chloroform at 60℃; | 65% |
Conditions | Yield |
---|---|
Stage #1: Adipic acid dichloride; gamma-tocopherol With boron trifluoride diethyl etherate In 1,4-dioxane for 2h; Heating; Stage #2: With sodium tetrahydroborate In 1,4-dioxane at 0℃; for 0.5h; | 64% |
gamma-tocopherol
Conditions | Yield |
---|---|
With borax; bromine; sodium hydroxide In tetrahydrofuran; hexane; water at 0℃; for 0.25h; pH=11; | 57% |
Conditions | Yield |
---|---|
With zinc(II) chloride In toluene Heating; | 51% |
With pyridine |
gamma-tocopherol
A
5-(γ-tocopheroxy)-γ-tocopherol
B
(R)-5,5'-bi-γ-tocopheryl
C
(S)-5,5'-bi-γ-tocopheryl
Conditions | Yield |
---|---|
With alkaline aq. ferricyanide In hexane Ambient temperature; | A 45% B 20% C 20% |
gamma-tocopherol
Conditions | Yield |
---|---|
With borax; bromine; sodium hydroxide In tetrahydrofuran; hexane; water pH=11; Mechanism; | A 13% B 36% C 39% |
formaldehyd
gamma-tocopherol
6-hydroxy-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-5-carbaldehyde
Conditions | Yield |
---|---|
With tributyl-amine; tin(IV) chloride In toluene at 90 - 95℃; for 2h; Vilsmeier-Haack formylation; | 19% |
Conditions | Yield |
---|---|
With toluene at -50℃; |
Conditions | Yield |
---|---|
With benzene |
gamma-tocopherol
(4R,8R,12R)-4-hydroxy-4,8,12,16-tetramethylheptadecanoic acid lactone
Conditions | Yield |
---|---|
With chromium(VI) oxide; acetic acid |
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