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Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers

Formestane 566-48-3

Cas:566-48-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Formestane CAS No.:566-48-3 Name: Formestane Synonyms: 4-Hydroxyandrost-4-ene-3,17-dione Molecular Structure Mol

High purity Formestane CAS No.:566-48-3

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 4-androsten-4-ol-3,17-dione 566-48-3 Producer

Cas:566-48-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Formestane

Cas:566-48-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

566-48-3 Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name: Formestane CAS No.: 566-48-3 Molecular Fomula: C20H28O2 Molecular weight: 300.4351 Appearance:colorless liquid Assay:99%min Appearance: Colorless Liquid Storage:Preserve in well-closed, light-resistant and airtight containers. P

Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Formestane Anabolic Steroid Hormones 4-Hydroxyandrost-4-ene-3 17-dione

Cas:566-48-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Androst-4-ene-3,17-dione,4-hydroxy- 566-48-3

Cas:566-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical i

FormestaneCAS:566-48-3

Cas:566-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

Formestan Powder Chemical Intermediates CAS 566-48-3 with Best Price Safe Transportation

Cas:566-48-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Androst-4-ene-3,17-dione,4-hydroxy-

Cas:566-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

Formestane

Cas:566-48-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Androst-4-ene-3,17-dione,4-hydroxy-

Cas:566-48-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Main Service 1.Own made fine chemical products 2.Out sourcing and quality controlling service in China 3. COM for Chemical synthesis 4.Lab custom synthesis of API and intermadiates Quality Assurance 1. NMR,HPLC and COA can be supplied 2. Fr

Formestane

Cas:566-48-3

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Formestane

Cas:566-48-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Formestane

Cas:566-48-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Formestane

Cas:566-48-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-androsten-4-ol-3,17-dione

Cas:566-48-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Formestane

Cas:566-48-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Needles Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:An antitumor drug. An aromatase inhibi

Androst-4-ene-3,17-dione,4-hydroxy-

Cas:566-48-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Formestane

Cas:566-48-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder ha

Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: Fomestane CAS No.:566-48-3 Molecule Formula:C20H28O2 Molecule Weight:300.44 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Fomestane on stock

Cas:566-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Formestane CAS:566-48-3 Safe delivery Free of customs clearance

Cas:566-48-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity Formestane

Cas:566-48-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Formestane

Cas:566-48-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Synthetic route

4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid; silica gel; acetic acid at 70℃; for 0.05h;86%
With boron trifluoride diethyl etherate In benzene for 19h; Ambient temperature;47%
With formic acid for 0.75h; Heating;45%
Multi-step reaction with 2 steps
1: 62 percent / aq. sodium hydroxide / 3 h / Heating
2: 53 percent / hydrochloric acid / dioxane / 24 h / Heating
View Scheme
3-hydroxy-5α-androst-2-ene-4,17-dione
180303-17-7

3-hydroxy-5α-androst-2-ene-4,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium In methanol for 1h; Ambient temperature;80%
With sodium In methanol at 20℃; for 1h;80%
With sodium methylate In methanol
3-hydroxy-5α-androst-2-ene-4,17-dione

3-hydroxy-5α-androst-2-ene-4,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium In methanol for 1h; Ambient temperature;80%
3β,4α-dihydroxy-5β-androstan-17-one
434939-05-6

3β,4α-dihydroxy-5β-androstan-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Stage #1: 3β,4α-dihydroxy-5β-androstan-17-one With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride In dichloromethane at -60℃; for 3h;
Stage #2: With sodium In methanol at 20℃; for 3h;
80%
Stage #1: 3β,4α-dihydroxy-5β-androstan-17-one With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride at -60℃; for 3.25h; Swern oxidation;
Stage #2: With sodium methylate In methanol
Multi-step reaction with 2 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
3-hydroxy-5β-androst-2-ene-4,17-dione
434939-09-0

3-hydroxy-5β-androst-2-ene-4,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium In methanol at 20℃; for 1h;80%
5α/β-androst-3-en-17-one
501433-34-7

5α/β-androst-3-en-17-one

A

Androstenedione
63-05-8

Androstenedione

B

androstane-3,17-dione
1229-12-5

androstane-3,17-dione

C

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multistep reaction;A n/a
B n/a
C 54%
4-methoxy-4-androstene-3,17-dione
20986-46-3

4-methoxy-4-androstene-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 24h; Heating;53%
acetic acid
64-19-7

acetic acid

4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

2α-acetoxyandrost-4-ene-3,17-dione
2241-85-2

2α-acetoxyandrost-4-ene-3,17-dione

B

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

D

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid a) RT, 4 h, b) 4 deg C, 12 h; Further byproducts given;A 23%
B 52%
C 0.58 g
D 0.7 g
acetic acid
64-19-7

acetic acid

4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

4α-acetoxy-5α-hydroxyandrostane-3,17-dione
140223-19-4

4α-acetoxy-5α-hydroxyandrostane-3,17-dione

Conditions
ConditionsYield
With sulfuric acid a) RT, 4h,b) 4 deg C, 12 h; Further byproducts given;A 52%
B 0.58 g
C 0.7 g
D 3%
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

2α-acetoxyandrost-4-ene-3,17-dione
2241-85-2

2α-acetoxyandrost-4-ene-3,17-dione

B

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

D

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a) RT, 4 h, b) 4 deg C, 12 h; Further byproducts given;A 23%
B 52%
C 0.58 g
D 0.7 g
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

2α-acetoxyandrost-4-ene-3,17-dione
2241-85-2

2α-acetoxyandrost-4-ene-3,17-dione

B

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

4α-acetoxy-5α-hydroxyandrostane-3,17-dione
140223-19-4

4α-acetoxy-5α-hydroxyandrostane-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a) RT, 4h , b) 4 deg C, 12 h; Further byproducts given;A 23%
B 52%
C 0.7 g
D 3%
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

4α-acetoxy-5α-hydroxyandrostane-3,17-dione
140223-19-4

4α-acetoxy-5α-hydroxyandrostane-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a> RT, 4 h, b) 4 deg C, 12 h; Further byproducts given;A 52%
B 0.58 g
C 0.7 g
D 3%
(4β,5)-epoxy-5β-androstan-3,17-dione
7430-11-7

(4β,5)-epoxy-5β-androstan-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid for 18h; Ambient temperature;50%
With pyridine; hydrogen fluoride at 55℃;
acetic acid
64-19-7

acetic acid

4,5-epoxyandrost-9(11)-ene-3,17-dione
88509-24-4

4,5-epoxyandrost-9(11)-ene-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2α-hydroxyandrost-4,9(11)-diene-3,17-dione
140111-67-7

2α-hydroxyandrost-4,9(11)-diene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

2α-acetoxyandrost-4,9(11)-diene-3,17-dione
140111-66-6

2α-acetoxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid a) RT, 4h, b) 4 deg C, 12 h;A 13.6%
B n/a
C 390 mg
D 9%
4,5-epoxyandrost-9(11)-ene-3,17-dione
88509-24-4

4,5-epoxyandrost-9(11)-ene-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2α-hydroxyandrost-4,9(11)-diene-3,17-dione
140111-67-7

2α-hydroxyandrost-4,9(11)-diene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

2α-acetoxyandrost-4,9(11)-diene-3,17-dione
140111-66-6

2α-acetoxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a) RT, 4 h, b) 4 deg C, 12h;A 13.6%
B n/a
C 390 mg
D 9%
With sulfuric acid In acetic acid a) RT, 4 h, b) 4 deg C, 12 h;A 13.6%
B n/a
C 390 mg
D 9%
With sulfuric acid In acetic acid a) RT, 4h, b) 4 deg C, 12 h;A 13.6%
B n/a
C 390 mg
D 9%
Androstenedione
63-05-8

Androstenedione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium hydroxide; sulfuric acid; dihydrogen peroxide 1a) 0 to 4 deg C, 30 min, MeOH, 1b) 5 to 7 deg C, 22 h, MeOH, 2) HOAc, RT, 45 min; Yield given. Multistep reaction;
Multi-step reaction with 4 steps
1: 60 percent / Zn; AcOH / 0.25 h / 118 °C
2: 96 percent / aq. H2O2; HCO2H / 1 h / 20 °C
3: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
4: NaOMe / methanol
View Scheme
Multi-step reaction with 2 steps
1: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
Multi-step reaction with 2 steps
1: osmium tetroxide, 35percent H2O2 / 2-methyl-propan-2-ol / 72 h / Ambient temperature
2: potassium hydroxide / methanol / 0.17 h / 55 °C
View Scheme
Multi-step reaction with 2 steps
1: osmium(VIII) oxide; dihydrogen peroxide / tert-butyl alcohol / 72 h / 20 °C
2: potassium hydroxide / methanol / 0.17 h / 55 °C
View Scheme
4ξ,5-dihydroxy-5ξ-androstane-3,17-dione
110267-65-7

4ξ,5-dihydroxy-5ξ-androstane-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With potassium hydroxide In methanol at 55℃; for 0.166667h; Yield given;
With potassium hydroxide In methanol at 55℃; for 0.166667h;0.452 g
5α-androst-3-en-17β-ol
14935-81-0

5α-androst-3-en-17β-ol

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 96 percent / aq. H2O2; HCO2H / 1 h / 20 °C
2: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
3: NaOMe / methanol
View Scheme
Multi-step reaction with 3 steps
1: 96 percent / H2O2; formic acid / CH2Cl2; H2O / 1 h / 20 °C
2: 98 percent / TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
3: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 1.) 30percent H2O2, 90percent aq. HCOOH 2.) aq. NaOH / 1.) r.t., 1 h, 2.) MeOH,
2: 1.) DMSO, TFAA 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) -60 deg C, 15 min; -60 deg C to 5 deg C
3: 80 percent / Na / methanol / 1 h / Ambient temperature
View Scheme
5α/β-androst-3-en-17-one
501433-34-7

5α/β-androst-3-en-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. H2O2; HCO2H / CH2Cl2 / 6 h / 20 °C
2.1: 48 percent / HCO2H / 0.5 h / 20 °C
3.1: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
3.2: NaOMe / methanol
View Scheme
CGP 79318
37716-99-7

CGP 79318

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
2: NaOMe / methanol
View Scheme
Multi-step reaction with 2 steps
1: 98 percent / TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 1.) DMSO, TFAA 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) -60 deg C, 15 min; -60 deg C to 5 deg C
2: 80 percent / Na / methanol / 1 h / Ambient temperature
View Scheme
3β,4β-epoxy-5β-androstan-17-one
192192-77-1

3β,4β-epoxy-5β-androstan-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 48 percent / HCO2H / 0.5 h / 20 °C
2.1: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
2.2: NaOMe / methanol
View Scheme
androstane-3,17-dione
1229-12-5

androstane-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Na / methanol / 1 h / 20 °C
2: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
3β,5β-dihydroxyandrostan-17-one
33386-50-4

3β,5β-dihydroxyandrostan-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
Multi-step reaction with 4 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: Na / methanol / 1 h / 20 °C
3: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
3α,4β-dihydroxy-5β-androstane-17-one
434939-07-8

3α,4β-dihydroxy-5β-androstane-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
testosterone
58-22-0

testosterone

androstene-(5)-diol-(3.17)

androstene-(5)-diol-(3.17)

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 1) DMSO, trifluoroacetic anhydride, 2) Et3N / 1) CH2Cl2, -60 deg C, 3 h, 2) CH3Cl2, -60 deg C, 15 min, -60 deg C to 5 deg C
3: 80 percent / Na / methanol / 1 h / Ambient temperature
View Scheme
5α-androstane-3β,4α,17β-triol
1038-63-7

5α-androstane-3β,4α,17β-triol

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) DMSO, trifluoroacetic anhydride, 2) Et3N / 1) CH2Cl2, -60 deg C, 3 h, 2) CH3Cl2, -60 deg C, 15 min, -60 deg C to 5 deg C
2: 80 percent / Na / methanol / 1 h / Ambient temperature
View Scheme
testosterone
58-22-0

testosterone

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Jones reagent / acetone / -20 °C
2: osmium(VIII) oxide; dihydrogen peroxide / tert-butyl alcohol / 72 h / 20 °C
3: potassium hydroxide / methanol / 0.17 h / 55 °C
View Scheme
4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

acetyl chloride
75-36-5

acetyl chloride

3,17-dioxoandrost-4-en-4-yl acetate
61630-32-8

3,17-dioxoandrost-4-en-4-yl acetate

Conditions
ConditionsYield
In pyridine for 3h; cooling;98%
With pyridine at 0 - 20℃; for 21.5h;72%
4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

4-(1H-Imidazol-1-yl)androst-4-ene-3,17-dione

4-(1H-Imidazol-1-yl)androst-4-ene-3,17-dione

Conditions
ConditionsYield
In acetonitrile for 2h; Substitution; Heating;85%
perfluorotoluene
434-64-0

perfluorotoluene

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>androst-4-en-3,17-dione

4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>androst-4-en-3,17-dione

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water for 1h; Ambient temperature;79%
acetic anhydride
108-24-7

acetic anhydride

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

3,17-dioxoandrost-4-en-4-yl acetate
61630-32-8

3,17-dioxoandrost-4-en-4-yl acetate

Conditions
ConditionsYield
With pyridine Ambient temperature;67%
Pentafluoropyridine
700-16-3

Pentafluoropyridine

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

4-(2,3,5,6-tetrafluoropyridyloxy)androst-4-en-3,17-dione

4-(2,3,5,6-tetrafluoropyridyloxy)androst-4-en-3,17-dione

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water for 0.166667h; Ambient temperature;66%
4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

4-hydroxy-16-oximino-4-androsten-3,17-dione
134797-42-5

4-hydroxy-16-oximino-4-androsten-3,17-dione

Conditions
ConditionsYield
With n-Amyl nitrite; potassium tert-butylate In tert-butyl alcohol for 2h;55%
carbon monoxide
201230-82-2

carbon monoxide

1-cyclopropyl-1,3,3-trimethylurea

1-cyclopropyl-1,3,3-trimethylurea

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C27H40N2O5

C27H40N2O5

Conditions
ConditionsYield
With di(rhodium)tetracarbonyl dichloride In 1,2-dichloro-benzene at 130℃; under 760.051 Torr; for 96h; Glovebox;55%
With di(rhodium)tetracarbonyl dichloride; tris(pentafluorophenyl)phosphine In 1,2-dichloro-benzene at 130℃; for 96h;55%
4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

benzoyl chloride
98-88-4

benzoyl chloride

Benzoic acid (8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-4-yl ester
76942-05-7

Benzoic acid (8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-4-yl ester

Conditions
ConditionsYield
With pyridine Ambient temperature;48%
4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

ethylene glycol
107-21-1

ethylene glycol

3,4;17,17-bis(ethylenedioxy)androsta-3,5-diene

3,4;17,17-bis(ethylenedioxy)androsta-3,5-diene

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 48h; Reflux; Dean-Stark;47%
d-ribonic acid hydrazide
862191-36-4

d-ribonic acid hydrazide

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C24H36N2O7

C24H36N2O7

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 1h; Inert atmosphere;40%
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid; silica gel; acetic acid at 70℃; for 0.05h;86%
With boron trifluoride diethyl etherate In benzene for 19h; Ambient temperature;47%
With formic acid for 0.75h; Heating;45%
Multi-step reaction with 2 steps
1: 62 percent / aq. sodium hydroxide / 3 h / Heating
2: 53 percent / hydrochloric acid / dioxane / 24 h / Heating
View Scheme
3-hydroxy-5α-androst-2-ene-4,17-dione
180303-17-7

3-hydroxy-5α-androst-2-ene-4,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium In methanol for 1h; Ambient temperature;80%
With sodium In methanol at 20℃; for 1h;80%
With sodium methylate In methanol
3-hydroxy-5α-androst-2-ene-4,17-dione

3-hydroxy-5α-androst-2-ene-4,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium In methanol for 1h; Ambient temperature;80%
3β,4α-dihydroxy-5β-androstan-17-one
434939-05-6

3β,4α-dihydroxy-5β-androstan-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Stage #1: 3β,4α-dihydroxy-5β-androstan-17-one With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride In dichloromethane at -60℃; for 3h;
Stage #2: With sodium In methanol at 20℃; for 3h;
80%
Stage #1: 3β,4α-dihydroxy-5β-androstan-17-one With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride at -60℃; for 3.25h; Swern oxidation;
Stage #2: With sodium methylate In methanol
Multi-step reaction with 2 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
3-hydroxy-5β-androst-2-ene-4,17-dione
434939-09-0

3-hydroxy-5β-androst-2-ene-4,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium In methanol at 20℃; for 1h;80%
5α/β-androst-3-en-17-one
501433-34-7

5α/β-androst-3-en-17-one

A

Androstenedione
63-05-8

Androstenedione

B

androstane-3,17-dione
1229-12-5

androstane-3,17-dione

C

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multistep reaction;A n/a
B n/a
C 54%
4-methoxy-4-androstene-3,17-dione
20986-46-3

4-methoxy-4-androstene-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 24h; Heating;53%
acetic acid
64-19-7

acetic acid

4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

2α-acetoxyandrost-4-ene-3,17-dione
2241-85-2

2α-acetoxyandrost-4-ene-3,17-dione

B

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

D

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid a) RT, 4 h, b) 4 deg C, 12 h; Further byproducts given;A 23%
B 52%
C 0.58 g
D 0.7 g
acetic acid
64-19-7

acetic acid

4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

4α-acetoxy-5α-hydroxyandrostane-3,17-dione
140223-19-4

4α-acetoxy-5α-hydroxyandrostane-3,17-dione

Conditions
ConditionsYield
With sulfuric acid a) RT, 4h,b) 4 deg C, 12 h; Further byproducts given;A 52%
B 0.58 g
C 0.7 g
D 3%
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

2α-acetoxyandrost-4-ene-3,17-dione
2241-85-2

2α-acetoxyandrost-4-ene-3,17-dione

B

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

D

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a) RT, 4 h, b) 4 deg C, 12 h; Further byproducts given;A 23%
B 52%
C 0.58 g
D 0.7 g
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

2α-acetoxyandrost-4-ene-3,17-dione
2241-85-2

2α-acetoxyandrost-4-ene-3,17-dione

B

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

4α-acetoxy-5α-hydroxyandrostane-3,17-dione
140223-19-4

4α-acetoxy-5α-hydroxyandrostane-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a) RT, 4h , b) 4 deg C, 12 h; Further byproducts given;A 23%
B 52%
C 0.7 g
D 3%
4,5-epoxyandrostane-3,17-dione
77057-73-9

4,5-epoxyandrostane-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2alpha-Hydroxyandrost-4-ene-3,17-dione
571-17-5

2alpha-Hydroxyandrost-4-ene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

4α-acetoxy-5α-hydroxyandrostane-3,17-dione
140223-19-4

4α-acetoxy-5α-hydroxyandrostane-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a> RT, 4 h, b) 4 deg C, 12 h; Further byproducts given;A 52%
B 0.58 g
C 0.7 g
D 3%
(4β,5)-epoxy-5β-androstan-3,17-dione
7430-11-7

(4β,5)-epoxy-5β-androstan-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid for 18h; Ambient temperature;50%
With pyridine; hydrogen fluoride at 55℃;
acetic acid
64-19-7

acetic acid

4,5-epoxyandrost-9(11)-ene-3,17-dione
88509-24-4

4,5-epoxyandrost-9(11)-ene-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2α-hydroxyandrost-4,9(11)-diene-3,17-dione
140111-67-7

2α-hydroxyandrost-4,9(11)-diene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

2α-acetoxyandrost-4,9(11)-diene-3,17-dione
140111-66-6

2α-acetoxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid a) RT, 4h, b) 4 deg C, 12 h;A 13.6%
B n/a
C 390 mg
D 9%
4,5-epoxyandrost-9(11)-ene-3,17-dione
88509-24-4

4,5-epoxyandrost-9(11)-ene-3,17-dione

A

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

B

2α-hydroxyandrost-4,9(11)-diene-3,17-dione
140111-67-7

2α-hydroxyandrost-4,9(11)-diene-3,17-dione

C

4-hydroxyandrost-4,9(11)-diene-3,17-dione
88509-26-6

4-hydroxyandrost-4,9(11)-diene-3,17-dione

D

2α-acetoxyandrost-4,9(11)-diene-3,17-dione
140111-66-6

2α-acetoxyandrost-4,9(11)-diene-3,17-dione

Conditions
ConditionsYield
With sulfuric acid In acetic acid a) RT, 4 h, b) 4 deg C, 12h;A 13.6%
B n/a
C 390 mg
D 9%
With sulfuric acid In acetic acid a) RT, 4 h, b) 4 deg C, 12 h;A 13.6%
B n/a
C 390 mg
D 9%
With sulfuric acid In acetic acid a) RT, 4h, b) 4 deg C, 12 h;A 13.6%
B n/a
C 390 mg
D 9%
Androstenedione
63-05-8

Androstenedione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With sodium hydroxide; sulfuric acid; dihydrogen peroxide 1a) 0 to 4 deg C, 30 min, MeOH, 1b) 5 to 7 deg C, 22 h, MeOH, 2) HOAc, RT, 45 min; Yield given. Multistep reaction;
Multi-step reaction with 4 steps
1: 60 percent / Zn; AcOH / 0.25 h / 118 °C
2: 96 percent / aq. H2O2; HCO2H / 1 h / 20 °C
3: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
4: NaOMe / methanol
View Scheme
Multi-step reaction with 2 steps
1: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
Multi-step reaction with 2 steps
1: osmium tetroxide, 35percent H2O2 / 2-methyl-propan-2-ol / 72 h / Ambient temperature
2: potassium hydroxide / methanol / 0.17 h / 55 °C
View Scheme
Multi-step reaction with 2 steps
1: osmium(VIII) oxide; dihydrogen peroxide / tert-butyl alcohol / 72 h / 20 °C
2: potassium hydroxide / methanol / 0.17 h / 55 °C
View Scheme
4ξ,5-dihydroxy-5ξ-androstane-3,17-dione
110267-65-7

4ξ,5-dihydroxy-5ξ-androstane-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With potassium hydroxide In methanol at 55℃; for 0.166667h; Yield given;
With potassium hydroxide In methanol at 55℃; for 0.166667h;0.452 g
5α-androst-3-en-17β-ol
14935-81-0

5α-androst-3-en-17β-ol

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 96 percent / aq. H2O2; HCO2H / 1 h / 20 °C
2: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
3: NaOMe / methanol
View Scheme
Multi-step reaction with 3 steps
1: 96 percent / H2O2; formic acid / CH2Cl2; H2O / 1 h / 20 °C
2: 98 percent / TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
3: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 1.) 30percent H2O2, 90percent aq. HCOOH 2.) aq. NaOH / 1.) r.t., 1 h, 2.) MeOH,
2: 1.) DMSO, TFAA 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) -60 deg C, 15 min; -60 deg C to 5 deg C
3: 80 percent / Na / methanol / 1 h / Ambient temperature
View Scheme
5α/β-androst-3-en-17-one
501433-34-7

5α/β-androst-3-en-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. H2O2; HCO2H / CH2Cl2 / 6 h / 20 °C
2.1: 48 percent / HCO2H / 0.5 h / 20 °C
3.1: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
3.2: NaOMe / methanol
View Scheme
CGP 79318
37716-99-7

CGP 79318

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
2: NaOMe / methanol
View Scheme
Multi-step reaction with 2 steps
1: 98 percent / TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 80 percent / Na / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 1.) DMSO, TFAA 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) -60 deg C, 15 min; -60 deg C to 5 deg C
2: 80 percent / Na / methanol / 1 h / Ambient temperature
View Scheme
3β,4β-epoxy-5β-androstan-17-one
192192-77-1

3β,4β-epoxy-5β-androstan-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 48 percent / HCO2H / 0.5 h / 20 °C
2.1: dimethyl sulfoxide; (CF3CO)2O; Et3N / 3.25 h / -60 °C
2.2: NaOMe / methanol
View Scheme
androstane-3,17-dione
1229-12-5

androstane-3,17-dione

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Na / methanol / 1 h / 20 °C
2: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
3β,5β-dihydroxyandrostan-17-one
33386-50-4

3β,5β-dihydroxyandrostan-17-one

4-hydroxyandrost-4-ene-3,17-dione
566-48-3

4-hydroxyandrost-4-ene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
Multi-step reaction with 4 steps
1: TFAA; Et3N; DMSO / CH2Cl2 / 3 h / -60 °C
2: Na / methanol / 1 h / 20 °C
3: 467 mg / Zn; glacial acetic acid / 0.17 h
View Scheme
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