Chemwill Asia Co., Ltd.
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:571188-81-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryHenan Tianfu Chemical Co., Ltd.
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:571188-81-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryShandong Hanjiang Chemical Co., Ltd.
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:571188-81-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co., Ltd.
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:571188-81-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryKAISA GROUP INC
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:571188-81-3
Min.Order:1 Metric Ton
FOB Price: $7.0 / 8.0
Type:Trading Company
inquiryHangzhou J&H Chemical Co., Ltd.
J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryXian Changyue Biological Technology Co., Ltd.
best seller Application:API
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAntimex Chemical Limied
Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryDB BIOTECH CO., LTD
best seller Application:API
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryChangchun Artel lmport and Export trade company
Supply top quality products with a reasonable price Application:api
Henan Kanbei Chemical Co.,LTD
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Other
inquiryShanghai Chinqesen Biotechnology Co., Ltd.
Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Hebei Muhuang Technology Co., Ltd
best seller Application:API
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryChemsigma International Co.,Ltd.
bulk?production Application:Pharmaceutical intermediates
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZHEJIANG JIUZHOU CHEM CO.,LTD
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryHWRK Chem
in store Package:100g Application:Organic Chemicals
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryChemtn Biological Technology Limited
6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one Basic information Product Name: 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-on
Cas:571188-81-3
Min.Order:1 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryJilin haofei import and export trade Co.,Ltd
Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
hdzhl co., ltd
Product Details Keywords 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one,C14H16BrN3O2S 571188-
Cas:571188-81-3
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquirycoolpharm Ltd
Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. The reason that you should buy our products： 1.We not only can provide large quantity but also can provide small quantity product
Cas:571188-81-3
Min.Order:1 Gram
FOB Price: $100.0
Type:Other
inquiryShanghai Caerulum Pharma Discovery Co.,Ltd
Shanghai Caerulum Pharma Discovery was established in 2012 as an integrated CRO (Contract Research Organization), providing professional chemical services. As a customer-oriented company, Caerulum Pharma Discovery has distinguished itself from others
Cas:571188-81-3
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryAlchemist-pharm chemical Technology Co. Ltd.
R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
NovaChemistry
high purity Application:Drug intermediates Materials intermediates and active molecules
Cas:571188-81-3
Min.Order:0
Negotiable
Type:Trading Company
inquirySynthetic route
-
-
362656-25-5
6-bromo-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| With 2-benzylsulfonyl-3-phenyloxaziridine In dichloromethane | 94% |
| With N-(benzenesulfonyl)-3-phenyloxaziridine In dichloromethane at 20℃; for 18h; | 40.9% |
| With N-(benzenesulfonyl)-3-phenyloxaziridine In dichloromethane at 20℃; for 18h; |
-
-
362656-23-3
8‑cyclopentyl‑5‑methyl‑2‑(methylthio)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide; acetic acid In water; acetonitrile for 2h; | 87% |
| With N-Bromosuccinimide; acetic acid In water; acetonitrile at 20℃; for 8h; | 85.6% |
| With N-Bromosuccinimide; water; acetic acid In acetonitrile at 20℃; for 8h; | 85.6% |
-
-
5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: manganese(IV) oxide / chloroform 4.1: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere; Cooling with ice 4.2: 22 h / Reflux 5.1: sodium hydride / tetrahydrofuran 6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme | |
| Multi-step reaction with 7 steps 1.1: triethylamine / tetrahydrofuran / 14 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 12 - 20 °C 3.1: manganese(IV) oxide / chloroform / 16 h / 20 °C 4.1: tetrahydrofuran / 1.5 h / Inert atmosphere; Cooling with ice 4.2: 16 h / 20 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 36 h / Inert atmosphere; Cooling; Reflux 6.1: bromine / dichloromethane / 16 h / 20 °C 7.1: N-(benzenesulfonyl)-3-phenyloxaziridine / dichloromethane / 18 h / 20 °C View Scheme | |
| Multi-step reaction with 7 steps 1: triethylamine / dichloromethane 2: lithium aluminium tetrahydride / tetrahydrofuran 3: manganese(IV) oxide / chloroform 4: tetrahydrofuran; diethyl ether / Inert atmosphere; Cooling with ice 5: manganese(IV) oxide / chloroform / 22 h / Reflux 6: sodium hydride / tetrahydrofuran 7: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
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1003-03-8
Cyclopentamine
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-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: manganese(IV) oxide / chloroform 4.1: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere; Cooling with ice 4.2: 22 h / Reflux 5.1: sodium hydride / tetrahydrofuran 6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme | |
| Multi-step reaction with 7 steps 1.1: triethylamine / tetrahydrofuran / 14 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 12 - 20 °C 3.1: manganese(IV) oxide / chloroform / 16 h / 20 °C 4.1: tetrahydrofuran / 1.5 h / Inert atmosphere; Cooling with ice 4.2: 16 h / 20 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 36 h / Inert atmosphere; Cooling; Reflux 6.1: bromine / dichloromethane / 16 h / 20 °C 7.1: N-(benzenesulfonyl)-3-phenyloxaziridine / dichloromethane / 18 h / 20 °C View Scheme | |
| Multi-step reaction with 7 steps 1: triethylamine / dichloromethane 2: lithium aluminium tetrahydride / tetrahydrofuran 3: manganese(IV) oxide / chloroform 4: tetrahydrofuran; diethyl ether / Inert atmosphere; Cooling with ice 5: manganese(IV) oxide / chloroform / 22 h / Reflux 6: sodium hydride / tetrahydrofuran 7: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
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-
211245-64-6
4-cyclopentylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere; Cooling with ice 1.2: 22 h / Reflux 2.1: sodium hydride / tetrahydrofuran 3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: tetrahydrofuran / 1.5 h / Inert atmosphere; Cooling with ice 1.2: 16 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 36 h / Inert atmosphere; Cooling; Reflux 3.1: bromine / dichloromethane / 16 h / 20 °C 4.1: N-(benzenesulfonyl)-3-phenyloxaziridine / dichloromethane / 18 h / 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1: tetrahydrofuran; diethyl ether / Inert atmosphere; Cooling with ice 2: manganese(IV) oxide / chloroform / 22 h / Reflux 3: sodium hydride / tetrahydrofuran 4: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
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-
211245-62-4
4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran 2.1: manganese(IV) oxide / chloroform 3.1: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere; Cooling with ice 3.2: 22 h / Reflux 4.1: sodium hydride / tetrahydrofuran 5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme | |
| Multi-step reaction with 6 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 12 - 20 °C 2.1: manganese(IV) oxide / chloroform / 16 h / 20 °C 3.1: tetrahydrofuran / 1.5 h / Inert atmosphere; Cooling with ice 3.2: 16 h / 20 °C 4.1: sodium hydride / tetrahydrofuran; mineral oil / 36 h / Inert atmosphere; Cooling; Reflux 5.1: bromine / dichloromethane / 16 h / 20 °C 6.1: N-(benzenesulfonyl)-3-phenyloxaziridine / dichloromethane / 18 h / 20 °C View Scheme | |
| Multi-step reaction with 6 steps 1: lithium aluminium tetrahydride / tetrahydrofuran 2: manganese(IV) oxide / chloroform 3: tetrahydrofuran; diethyl ether / Inert atmosphere; Cooling with ice 4: manganese(IV) oxide / chloroform / 22 h / Reflux 5: sodium hydride / tetrahydrofuran 6: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
-
-
211245-63-5
[4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-yl]methanol
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: manganese(IV) oxide / chloroform 2.1: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere; Cooling with ice 2.2: 22 h / Reflux 3.1: sodium hydride / tetrahydrofuran 4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme | |
| Multi-step reaction with 5 steps 1.1: manganese(IV) oxide / chloroform / 16 h / 20 °C 2.1: tetrahydrofuran / 1.5 h / Inert atmosphere; Cooling with ice 2.2: 16 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 36 h / Inert atmosphere; Cooling; Reflux 4.1: bromine / dichloromethane / 16 h / 20 °C 5.1: N-(benzenesulfonyl)-3-phenyloxaziridine / dichloromethane / 18 h / 20 °C View Scheme |
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362656-11-9
1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethanone
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 36 h / Inert atmosphere; Cooling; Reflux 2: bromine / dichloromethane / 16 h / 20 °C 3: N-(benzenesulfonyl)-3-phenyloxaziridine / dichloromethane / 18 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran 2: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
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362656-31-3
1-(4-cyclopentylamino-2-methylsulfanylpyrimidin-5-yl)ethanol
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: manganese(IV) oxide / chloroform / 22 h / Reflux 2: sodium hydride / tetrahydrofuran 3: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
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1065075-68-4
4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carboxylic acid
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: manganese(IV) oxide / chloroform 2: tetrahydrofuran; diethyl ether / Inert atmosphere; Cooling with ice 3: manganese(IV) oxide / chloroform / 22 h / Reflux 4: sodium hydride / tetrahydrofuran 5: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C View Scheme |
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5751-20-2
2-Methylthiouracil
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-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / dichloromethane / 6 h / Reflux 2.1: pyridine; trichlorophosphate / 5 h / 80 °C 3.1: triethylamine / tetrahydrofuran / 2.5 h / Cooling with ice 4.1: triethylamine; lead acetate / 1-methyl-pyrrolidin-2-one / 3.5 h / 65 °C / Inert atmosphere 4.2: 8 h / 65 °C / Inert atmosphere 5.1: N-Bromosuccinimide; acetic acid / acetonitrile; water / 2 h View Scheme | |
| Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 40 °C 2.1: N-Bromosuccinimide / methanol; acetonitrile / 20 °C 3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 100 °C 4.1: N-ethyl-N,N-diisopropylamine; bis(benzonitrile)palladium(II) dichloride; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 4.2: 4 h / 70 °C 5.1: N-Bromosuccinimide; acetic acid / acetonitrile; water / 8 h / 20 °C View Scheme | |
| Multi-step reaction with 5 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 40 °C 2.1: N-Bromosuccinimide / methanol; acetonitrile 3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 100 °C 4.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 4.2: 4 h / 70 °C 5.1: N-Bromosuccinimide; acetic acid; water / acetonitrile / 8 h / 20 °C View Scheme |
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81560-03-4
2-methylsulfanyl-5-bromopyrimidin-4-one
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-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: pyridine; trichlorophosphate / 5 h / 80 °C 2.1: triethylamine / tetrahydrofuran / 2.5 h / Cooling with ice 3.1: triethylamine; lead acetate / 1-methyl-pyrrolidin-2-one / 3.5 h / 65 °C / Inert atmosphere 3.2: 8 h / 65 °C / Inert atmosphere 4.1: N-Bromosuccinimide; acetic acid / acetonitrile; water / 2 h View Scheme |
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63810-78-6
4‑chloro‑5‑bromo‑2‑(methylthio)pyrimidine
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-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 2.5 h / Cooling with ice 2.1: triethylamine; lead acetate / 1-methyl-pyrrolidin-2-one / 3.5 h / 65 °C / Inert atmosphere 2.2: 8 h / 65 °C / Inert atmosphere 3.1: N-Bromosuccinimide; acetic acid / acetonitrile; water / 2 h View Scheme | |
| Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 100 °C 2.1: N-ethyl-N,N-diisopropylamine; bis(benzonitrile)palladium(II) dichloride; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 2.2: 4 h / 70 °C 3.1: N-Bromosuccinimide; acetic acid / acetonitrile; water / 8 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 100 °C 2.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 2.2: 4 h / 70 °C 3.1: N-Bromosuccinimide; acetic acid; water / acetonitrile / 8 h / 20 °C View Scheme |
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49844-90-8
4-Chloro-2-methylthiopyrimidine
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-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / methanol; acetonitrile / 20 °C 2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 100 °C 3.1: N-ethyl-N,N-diisopropylamine; bis(benzonitrile)palladium(II) dichloride; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 3.2: 4 h / 70 °C 4.1: N-Bromosuccinimide; acetic acid / acetonitrile; water / 8 h / 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / methanol; acetonitrile 2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 100 °C 3.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 3.2: 4 h / 70 °C 4.1: N-Bromosuccinimide; acetic acid; water / acetonitrile / 8 h / 20 °C View Scheme |
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-
733039-23-1
5‑bromo‑N‑cyclopentyl‑2‑(methylthio)pyrimidin‑4‑amine
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere 1.2: 4 h / 70 °C 2.1: N-Bromosuccinimide; acetic acid; water / acetonitrile / 8 h / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
2393-23-9
4-methoxy-benzylamine
-
-
571190-14-2
6-bromo-8-cyclopentyl-2-(4-methoxybenzylamino)-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| In toluene | 86.4% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-32-7
2-{5-[bis-(2-methoxy-ethyl)amino]pyridin-2-ylamino}-6-bromo-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| In toluene at 110℃; for 5h; | 85% |
| In ethyl acetate; toluene | 85% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine
-
-
362656-71-1
4-[4-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| In dimethyl sulfoxide at 100℃; | 81% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
887906-41-4
4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]azepane-1-carboxylic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| In toluene for 12h; Heating; | 39% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-73-6
4-(6-amino-pyridin-3-yl)-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester
-
-
571189-74-7
4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,6-dimethylpiperazine-1-carboxylic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| In toluene for 16h; Heating; | 38% |
| In toluene | 37.6% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
-
-
571188-82-4
tert‑butyl 4‑(6‑((6‑bromo‑8‑cyclopentyl‑5‑methyl‑7‑oxo‑7,8‑dihydropyrido[2,3‑d]pyrimidin‑2‑yl)amino)pyridin‑3‑yl)piperazine‑1‑carboxylate
| Conditions | Yield |
|---|---|
| In toluene for 7h; Heating; | 38% |
| In toluene for 25h; Heating / reflux; | 38% |
| In toluene | 38% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-68-9
4-(6-amino-pyridin-3-yl)-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester
-
-
571189-69-0
4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| In toluene for 16h; Heating; | 32% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-68-9
4-(6-amino-pyridin-3-yl)-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester
-
A
-
571189-69-0
4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| In toluene | A n/a B 31.8% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
504-29-0
2-aminopyridine
| Conditions | Yield |
|---|---|
| In toluene | 30% |
| In toluene at 110℃; for 18h; | 22 mg |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-49-6
5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine
| Conditions | Yield |
|---|---|
| In toluene for 4h; Heating; | 29% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
94924-94-4
3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-6'-ylamine
-
-
571189-82-7
6-bromo-8-cyclopentyl-5-methyl-2-(3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-6'-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| In toluene for 16h; Heating; | 27% |
| In toluene | 27.3% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571190-02-8
5-(2,6-dimethylmorpholin-4-yl)pyridin-2-ylamine
-
-
571190-03-9
6-bromo-8-cyclopentyl-2-[5-(2,6-dimethylmorpholin-4-yl)pyridin-2-ylamino]-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| In toluene for 16h; Heating; | 27% |
| In toluene | 27.3% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-78-1
5-morpholinopyridin-2-amine
-
-
571189-79-2
6-bromo-8-cyclopentyl-5-methyl-2-(5-morpholin-4-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| In toluene for 16h; Heating; | 27% |
| In ethyl acetate; toluene | 26.7% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-27-0
6'-amino-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-4-ol
-
-
571189-55-4
6-bromo-8-cyclopentyl-2-(4-hydroxy-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-6'-ylamino)-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| In toluene for 4h; Heating; | 17% |
| In toluene |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| In toluene for 18h; Inert atmosphere; Reflux; | 7.4% |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-53-2
{1-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| In toluene for 16h; Heating; |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 38 percent / toluene / 16 h / Heating 2: aq. HCl / CH2Cl2 / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 27 percent / toluene / 16 h / Heating 2: 90 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 12 h / Heating 3: 38 percent / aq. HCl / ethyl acetate / 48 h / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 27 percent / toluene / 16 h / Heating 2: 59 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 2 h / Heating 3: 71 percent / aq. HCl / ethyl acetate / 2 h / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 27 percent / toluene / 16 h / Heating 2: 39 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 3 h / Heating 3: HCl / CH2Cl2; diethyl ether / 16 h / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 85 percent / toluene / 5 h / 110 °C 2: palladium tetrakistriphenylphosphine / toluene / 2 h / 110 °C 3: 120 mg / aq. HCl / ethyl acetate / 1 h / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 17 percent / toluene / 4 h / Heating 2: 83 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 12 h / 110 °C 3: 88 percent / HCl / CHCl3; diethyl ether / 12 h / 20 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571190-10-8
8-cyclopentyl-2-[5-(2,6-dimethylmorpholin-4-yl)pyridin-2-ylamino]-6-(1-ethoxyvinyl)-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 27 percent / toluene / 16 h / Heating 2: 90 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 12 h / Heating View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-80-5
8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-2-(5-morpholin-4-ylpyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 27 percent / toluene / 16 h / Heating 2: 39 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 3 h / Heating View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-83-8
8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-2-(3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-6'-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 27 percent / toluene / 16 h / Heating 2: 59 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 2 h / Heating View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-50-9
8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-2-[5-(4-methylpiperazin-1-yl)pyridin-2-ylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 29 percent / toluene / 4 h / Heating 2: 91 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 12 h / 110 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 85 percent / toluene / 5 h / 110 °C 2: palladium tetrakistriphenylphosphine / toluene / 2 h / 110 °C View Scheme |
-
-
571188-81-3
6‑bromo‑8‑cyclopentyl‑5‑methyl‑2‑(methylsulfinyl)pyrido[2,3‑d]pyrimidin‑7(8H)‑one
-
-
571189-56-5
8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-2-(4-hydroxy-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-6'-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 17 percent / toluene / 4 h / Heating 2: 83 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / 12 h / 110 °C View Scheme |
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