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DB BIOTECH CO., LTD

Idebenone Quick Details CAS No.: 58186-27-9 Other Names: Idebenone MF: C19H30O5 EINECS No.: / Place of Origin: Shaanxi, China (Mainland) Type: Central Nervous System Agents Grade Standard: Medicine Grade Usage: Animal Pharmaceuticals

Pharma grade pure Idebenone CAS 58186-27-9

Cas:58186-27-9

Min.Order:1 Kilogram

FOB Price: $900.0 / 950.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Orange yellow crystalline powder Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Any port of china

China supplier Idebenone

Cas:58186-27-9

Min.Order:1 Kilogram

FOB Price: $1000.0 / 1750.0

Type:Lab/Research institutions

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ShangHai Soyoung Biotechnology Inc

Trade Assurance Get full protection for your orders 100% Product quality protection 100% On-time shipment protection 100% Payment protection Appearance:An orange yellow or orange, crystalline powder Storage:Store in tight containers, in a cool dry

Idebenone powder 58186-27-9 Idevenone

Cas:58186-27-9

Min.Order:1 Kilogram

FOB Price: $1480.0

Type:Lab/Research institutions

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Xi'an Yinherb Bio-Tech Co., Ltd.

Xi'an Yinherb Bio-Tech Co., Ltd was founded in 2009, We have more than 10 experienced doctors and scientists and professional managers, specializing in Nootropics, Sarms and Peptides researching and developing, and become the lead

Idebenone

Cas:58186-27-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Kono chem is located in Xi'an, Shaanxi Province, equipped with a number of engineers in Pharmaceutical, Nutrition, Bioengineering, committed themselves to create products that meet customer requirements. At present, Kono's main products cov

Idebenone CAS58186-27-9

Cas:58186-27-9

Min.Order:1 Kilogram

FOB Price: $1100.0 / 1360.0

Type:Other

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Idebenone supplier in China

Cas:58186-27-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Idebenone CAS 58186-27-9

Cas:58186-27-9

Min.Order:10 Gram

FOB Price: $3.5 / 10.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Idebenone Cas 58186-27-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Orange yellow or yellow crystalline powder Storage:cool dry place Package:1g/

Manufacturer high quality Idebenone Cas 58186-27-9 with good price

Cas:58186-27-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Natural Idebenone, 58186-27-9

Cas:58186-27-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Quanao Biotech Co., Ltd.

Buy cosmetic raw material API intermediate Idebenone powder/Idebenone Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed addi

Buy cosmetic raw material API intermediate Idebenone powder/Idebenone

Cas:58186-27-9

Min.Order:2 Kilogram

FOB Price: $82.0 / 899.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial since 1987 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We can do dif

99% up by HPLC Idebenone 58186-27-9

Cas:58186-27-9

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Idebenone CAS:58186-27-9 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, think

Good quality Idebenone USP/EP/CP with GMP

Cas:58186-27-9

Min.Order:100 Gram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Idebenone

Cas:58186-27-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Idebenone

Cas:58186-27-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Idebenone 58186-27-9 ISO Producer

Cas:58186-27-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

Idebenone CAS: 58186-27-9 Molecular Formula: C19H30O5 Home Product Category Drug substance Nervous system medication 58186-27-9 58186-27-9 - Names and Identifiers Name Idebenone Synonyms cv 2619 Idebenon Ideb

Factory high quality Idebenone

Cas:58186-27-9

Min.Order:1 Gram

FOB Price: $159.0 / 170.0

Type:Trading Company

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Idebenone

Cas:58186-27-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

Idebenone

Cas:58186-27-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Idebenone

Cas:58186-27-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Idebenone The alias:2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione; cv 2619 CAS NO:58186-27-9 Molecular formula:C19H30O5 Molecular weight:338.4385 Product Quality 12 years of chemical raw materials Mature ope

Idebenone/CAS:58186-27-9/with best price

Cas:58186-27-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: Idebenone Synonyms: 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone;Avan;Daruma;Mnesis;IDEBENONE(PATENTED-NOSUPPLY);5,6-Dimethoxy-2-(10-hydroxydecyl)-3-methyl-1,4-benzoquinone;5,6-dimethoxy-2-(10-hydroxydecyl)

58186-27-9 Idebenone

Cas:58186-27-9

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Idebenone / LIDE PHARMA- Factory supply / Best price

Cas:58186-27-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Idebenone

Cas:58186-27-9

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best CAS 58186-27-9 with competitive price

Cas:58186-27-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Idebenone Powder Synonyms: Idebenona, Idebenonum Specification: HPLC 99% CAS NO.: 58186-27-9 Molecular formula: C19H30O5 Characteristic: Yellow to orange crystalline powder Molecular weight: 338.44 Boiling point: 497.3±

Idebenone

Cas:58186-27-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Orange yellow or yellow crystalline powder Storage:Store in

99% Pure Nootropics Powder Idebenone CAS 58186-27-9 Brain Improvement

Cas:58186-27-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Idebenone 58186-27-9

Cas:58186-27-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

α-Lipoic Acid fatty acid

Cas:58186-27-9

Min.Order:1 Kilogram

FOB Price: $55.0 / 65.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Idebenone CAS:58186-27-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Idebenone CAS:58186-27-9

Cas:58186-27-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol
1286209-74-2

10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With ammonium peroxydisulfate; nitric acid In water; acetone at 50℃; for 2.16h;98%
Multi-step reaction with 3 steps
1: iodine / 1 h / 25 °C
2: dihydrogen peroxide; toluene-4-sulfonic acid / acetic acid / 0.42 h / 75 °C
3: sodium carbonate / methanol; water / 20 h / 25 °C
View Scheme
disodium nitrosodisulfonate

disodium nitrosodisulfonate

6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol
77712-29-9

6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
In methanol; water96.9%
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol
77712-29-9

6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With oxygen; salcomine In N,N-dimethyl-formamide for 72h; Ambient temperature;87%
With potassium nitrososulfonate In sodium hydroxide for 1h; Ambient temperature;67%
With oxygen; salcomine In N,N-dimethyl-formamide Quantum yield; Ambient temperature; reaction time, additive;
2,3-dimethoxy-6-methyl-5-benzyloxydecyl-p-benzoquinone
1251831-79-4

2,3-dimethoxy-6-methyl-5-benzyloxydecyl-p-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Stage #1: 2,3-dimethoxy-6-methyl-5-benzyloxydecyl-p-benzoquinone With palladium 10% on activated carbon; hydrogen In methanol at 23℃; for 24h;
Stage #2: With palladium 10% on activated carbon; oxygen In methanol at 23℃; for 24h;
82%
2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone
58186-28-0

2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With sodium carbonate In methanol; water at 25℃; for 20h;80%
With water; sodium carbonate In methanol at 0℃; for 36h;61%
With hydrogenchloride; sodium chloride In methanol
11-hydroxyundecanoic acid
3669-80-5

11-hydroxyundecanoic acid

2,3-Dimethoxy-5-methyl-1,4-benzoquinone
605-94-7

2,3-Dimethoxy-5-methyl-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With dihydrogen peroxide; oxygen In water; acetone at 75℃; Catalytic behavior; Reagent/catalyst; Temperature;80%
With dipotassium peroxodisulfate; oxygen; silver nitrate In water; acetonitrile at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent;80%
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 80℃; for 4h;75%
Stage #1: 11-hydroxyundecanoic acid; 2,3-Dimethoxy-5-methyl-1,4-benzoquinone With silver nitrate In water; acetonitrile
Stage #2: With dipotassium peroxodisulfate In water; acetonitrile at 75℃; for 3h; Solvent; Reagent/catalyst;
65%
C19H30O5

C19H30O5

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Stage #1: C19H30O5 With dipotassium hydrogenphosphate; potassium hydroxylamine-N,N-disulphonate In N,N-dimethyl-formamide at 50℃; for 8h;
Stage #2: With hydrogenchloride In ethanol; N,N-dimethyl-formamide at 50℃; for 8h;
Stage #3: With lithium aluminium tetrahydride In N,N-dimethyl-formamide at 80℃; for 3h;
63%
2,3-dimethoxy-5-methyl-6-(9'-methoxycarbonylnonyl)-1,4-benzoquinone
58186-02-0

2,3-dimethoxy-5-methyl-6-(9'-methoxycarbonylnonyl)-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
(i) LiAlH4, (ii) aq. FeCl3; Multistep reaction;
ester of 6-(9-carboxynonyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

ester of 6-(9-carboxynonyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With lithium aluminium tetrahydride; iron(III) chloride 1.) diethyl ether, RT, 1 h, 2.) diethyl ether; Yield given. Multistep reaction;
methyl 10-chloro-10-oxodecanoate
14065-32-8

methyl 10-chloro-10-oxodecanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 71 percent / AlCl3 / CH2Cl2 / 24 h / Heating
2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
3: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
4: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
5: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
6: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
7: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
sebacic acid mono methyl ester
818-88-2

sebacic acid mono methyl ester

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: thionyl chloride
2: 71 percent / AlCl3 / CH2Cl2 / 24 h / Heating
3: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
4: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
5: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
6: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
7: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
8: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
1-(2,3,4,5-tetramethoxy-6-methylphenyl)-1,10-decenediol
374622-25-0

1-(2,3,4,5-tetramethoxy-6-methylphenyl)-1,10-decenediol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
2: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
3: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
4: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
5: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
methyl 10-(2,3,4,5-tetramethoxy-6-methylphenyl)-10-undecenoate
374622-17-0

methyl 10-(2,3,4,5-tetramethoxy-6-methylphenyl)-10-undecenoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
2: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
3: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
4: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
5: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
6: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
10-(2,3,4,5-tetramethoxy-6-methylphenyl)-9-decenylacetate

10-(2,3,4,5-tetramethoxy-6-methylphenyl)-9-decenylacetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
2: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
3: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
10-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate
374622-20-5

10-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
2: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
10-methylcarbonyloxy-1-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate
374622-18-1

10-methylcarbonyloxy-1-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
2: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
3: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
4: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
methyl 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoate
58185-89-0

methyl 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
2: 67 percent / ON(SO3K)2 / aq. NaOH / 1 h / Ambient temperature
View Scheme
methyl 9-(2'-hydroxy-3',4'-dimethoxy-6'-methylbenzoyl)nonanoate
58185-88-9

methyl 9-(2'-hydroxy-3',4'-dimethoxy-6'-methylbenzoyl)nonanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaBH4, 2.) H2 / 2.) Pd/C
2: LiAlH4 / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
3: 67 percent / ON(SO3K)2 / aq. NaOH / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: potassium dihydrogenphosphate; potassium nitrososulfonate
2: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
9-bromononan-1-ol
55362-80-6

9-bromononan-1-ol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
9-bromononyl acetate
53596-82-0

9-bromononyl acetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
methyl 10-hydroxydecanoate
2640-94-0

methyl 10-hydroxydecanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
10-acetoxydecanoic acid
92038-37-4

10-acetoxydecanoic acid

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
10-acetoxydecanoyl chloride
104967-12-6

10-acetoxydecanoyl chloride

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 5 steps
1: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 5 steps
1: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 5 steps
1: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 72 h / 4 °C
1.2: 8 h / 25 °C
2.1: dipotassium hydrogenphosphate; potassium hydroxylamine-N,N-disulphonate / N,N-dimethyl-formamide / 8 h / 50 °C
2.2: 8 h / 50 °C
2.3: 3 h / 80 °C
View Scheme
9-acetoxydecanenitrile
104967-00-2

9-acetoxydecanenitrile

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
6-(10-hydroxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol
104966-97-4

6-(10-hydroxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
2: NaOH / methanol / 24 h / 5 °C
3: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol
77712-30-2

6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / methanol / 24 h / 5 °C
2: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Acetic acid 10-(2-hydroxy-3,4-dimethoxy-6-methyl-phenyl)-10-oxo-decyl ester
104966-92-9

Acetic acid 10-(2-hydroxy-3,4-dimethoxy-6-methyl-phenyl)-10-oxo-decyl ester

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 79 percent / NaOH / methanol / 2 h / Ambient temperature
2: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
3: NaOH / methanol / 24 h / 5 °C
4: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
9-ethoxycarbonylnonanoic acid chloride
6946-46-9

9-ethoxycarbonylnonanoic acid chloride

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: (i) AlCl3, (ii) (hydrolysis)
2: hydrogenchloride
3: potassium dihydrogenphosphate; potassium nitrososulfonate
4: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
3,4,5-trimethoxytoluene
6443-69-2

3,4,5-trimethoxytoluene

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid; potassium bromide / acetic anhydride / 1.25 h / 20 °C
2.1: palladium diacetate; triethylamine; triphenylphosphine / 72 h / 120 °C / Inert atmosphere
2.2: 3 h / 25 °C
3.1: iodine / 1 h / 25 °C
4.1: dihydrogen peroxide; toluene-4-sulfonic acid / acetic acid / 0.42 h / 75 °C
5.1: sodium carbonate / methanol; water / 20 h / 25 °C
View Scheme
Multi-step reaction with 4 steps
1: (i) AlCl3, (ii) (hydrolysis)
2: hydrogenchloride
3: potassium dihydrogenphosphate; potassium nitrososulfonate
4: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
9-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)nonanoic acid
58185-79-8

9-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)nonanoic acid

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride
2: potassium dihydrogenphosphate; potassium nitrososulfonate
3: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
nonanoic acid
112-05-0

nonanoic acid

Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl nonanoate

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl nonanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;100%
Idebenone
58186-27-9

Idebenone

[bromo(difluoro)methyl](trimethyl)silane
115262-01-6

[bromo(difluoro)methyl](trimethyl)silane

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With potassium hydrogen difluoride In dichloromethane; water at 20℃; for 10h; Reagent/catalyst;98%
Idebenone
58186-27-9

Idebenone

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

C35H60O6

C35H60O6

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;97.4%
Idebenone
58186-27-9

Idebenone

2-(10-iododecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-iododecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;96%
Octanoic acid
124-07-2

Octanoic acid

Idebenone
58186-27-9

Idebenone

Idebenone octanoate
1177393-72-4

Idebenone octanoate

Conditions
ConditionsYield
With novozym 435 In toluene at 20℃; for 48h; 4A molecular sieves;92%
In ethyl acetate; toluene630 mg (92%)
silica gel In ethyl acetate; toluene630 mg (92%)
Idebenone
58186-27-9

Idebenone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl methanesulfonate
845959-53-7

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl methanesulfonate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;91%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;91%
With triethylamine In dichloromethane at 10 - 15℃; for 1.5 - 1.75h;
Idebenone
58186-27-9

Idebenone

acetic anhydride
108-24-7

acetic anhydride

2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone
58186-28-0

2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone

Conditions
ConditionsYield
With pyridine In dichloromethane for 15h; Ambient temperature;90.7%
In pyridine
With pyridine
1-decanoic acid
334-48-5

1-decanoic acid

Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl decanoate

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl decanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;90.2%
valproic acid
99-66-1

valproic acid

Idebenone
58186-27-9

Idebenone

C27H44O6

C27H44O6

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;90.2%
linoleic acid
60-33-3

linoleic acid

Idebenone
58186-27-9

Idebenone

Idebenone Linoleate
1177393-70-2

Idebenone Linoleate

Conditions
ConditionsYield
With novozym 435 In toluene at 20℃; for 48h; 4A molecular sieves;87%
Idebenone
58186-27-9

Idebenone

Ag(1+)*CF3S(1-)*(x)C2H3N

Ag(1+)*CF3S(1-)*(x)C2H3N

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)thio)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)thio)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With 1,2-Diiodoethane; tetra-(n-butyl)ammonium iodide; Diphenylvinylphosphine In N,N-dimethyl-formamide; acetonitrile at 80℃; for 0.25h; Inert atmosphere; Sealed tube;86%
Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decanal
89048-27-1

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decanal

Conditions
ConditionsYield
Stage #1: Idebenone With oxalyl dichloride; dimethyl sulfoxide In dichloromethane for 0.166667h;
Stage #2: With triethylamine In dichloromethane for 1h;
84%
With oxalyl dichloride; triethylamine In dichloromethane; dimethyl sulfoxide at -78℃; for 1.5h;84%
With sodium acetate; pyridinium chlorochromate In dichloromethane for 2.5h; Ambient temperature;38.7%
With Dess-Martin periodane In dichloromethane at 0℃; for 4h; Inert atmosphere;
Idebenone
58186-27-9

Idebenone

10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid
58185-99-2

10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid

Conditions
ConditionsYield
With Jones reagent In acetone83%
With phosphate buffer; D-glucose; rat liver slices at 37℃; for 1h; incubation, pH=7.4;
With Jones reagent In acetone at 0℃; for 0.333333h;
oxalyl dichloride
79-37-8

oxalyl dichloride

Idebenone
58186-27-9

Idebenone

C40H58O12

C40H58O12

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 3h; Inert atmosphere; Cooling with ice;83%
Idebenone
58186-27-9

Idebenone

3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid 10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl ester

3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid 10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In acetonitrile at 0 - 20℃; for 1.5h; Inert atmosphere;82%
Idebenone
58186-27-9

Idebenone

2-(10-fluorodecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-fluorodecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; N-tosyl-4-chlorobenzenesulfonimidoyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; for 0.5h; Sealed tube;82%
lauric acid
143-07-7

lauric acid

Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl dodecanoate

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl dodecanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;81.1%
Idebenone
58186-27-9

Idebenone

trimethyl(pentafluoroethyl)silane
124898-13-1

trimethyl(pentafluoroethyl)silane

2,3-dimethoxy-5-methyl-6-(10-(perfluoroethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-(perfluoroethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With potassium fluoride; 2-fluoropyridine; silver trifluoromethanesulfonate; lithium trifluoromethanesulfonate; Selectfluor In ethyl acetate at 20℃; for 12h; Inert atmosphere;80%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Idebenone
58186-27-9

Idebenone

di-tert-butyl 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-phenylene dicarbonate
1431987-50-6

di-tert-butyl 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-phenylene dicarbonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃;79%
Idebenone
58186-27-9

Idebenone

C19H16ClNO4

C19H16ClNO4

C38H44ClNO8

C38H44ClNO8

Conditions
ConditionsYield
With sulfuric acid In cyclohexane at 25 - 65℃; Reflux;78%
Idebenone
58186-27-9

Idebenone

difluoromethyl-(4-nitrophenyl) bis(carbomethoxy) methylide sulfonium ylide

difluoromethyl-(4-nitrophenyl) bis(carbomethoxy) methylide sulfonium ylide

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With lithium tetrafluoroborate In dichloromethane at 30℃; for 1h;77%
Idebenone
58186-27-9

Idebenone

tetramethylammonium trifluoromethylselenate(0)
75264-92-5

tetramethylammonium trifluoromethylselenate(0)

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)selanyl)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)selanyl)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With calcium chloride In acetonitrile at 60℃; Temperature; Inert atmosphere; Sealed tube; Glovebox;77%
Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl nitrate
1431986-91-2

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl nitrate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; tetrabutylammonium nitrate In dichloromethane at -70℃; for 2h;75%
With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; tetrabutylammonium nitrate In dichloromethane at -70℃; for 2h;75%
Multi-step reaction with 2 steps
1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C
2: tetrabutylammonium nitrate; sodium nitrate / acetic acid butyl ester; acetonitrile / 18 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C
2: sodium nitrate; tetrabutylammonium nitrate / acetic acid butyl ester; acetonitrile / 18 h / 80 °C
View Scheme
Idebenone
58186-27-9

Idebenone

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2,3-dimethoxy-5-methyl-6-(10-(trifluoromethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-(trifluoromethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With potassium fluoride; 2-fluoropyridine; silver trifluoromethanesulfonate; Selectfluor In ethyl acetate at 20℃; for 12h; Glovebox; Inert atmosphere;64%
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