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Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Alpha-Mangostin 6147-11-1

Cas:6147-11-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

Grosvenor Momordica Extract Latin name: Momordica grosvenori Main Contents: Mogroside & Mogroside V Plant Resource: Siraitia grosvenorii Main Specification: 80-98% Mogroside, 25-45% Mogroside V Plant Part Used: Fruit Melting Poi

Grosvenor Momordica Extract powder

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $30.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Mangostin Manufacturer/High quality/Best price/In stock

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Mangostin Α, Β, Γ supplier in China

Cas:6147-11-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Specifications Type: Mangosteen Powder, Mangosteen Powder Form: Powder Part: Fruit Extraction Type: Solvent Extraction Packaging: Dr

CAS NO.: 6147-11-1 Mangosteen Fruit Extract 90% mangostin

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $600.0 / 700.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Mangostin Α, Β, Γ

Cas:6147-11-1

Min.Order:1

Negotiable

Type:Other

inquiry

Baoding Faithful Industry Co., Ltd.

China mangosteen extract spirulina exporter α-reverse zirone is an oxygen-hybrid ketone compound extracted from plant mountain bamboo. In addition, α-reverse zirconium comes from the active ingredients of natural mountain bamboo, has t

China mangosteen extract? spirulina exporter

Cas:6147-11-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Mangosteen Extract powder from GMP manufacture with reasonable price

Cas:6147-11-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Mangostin

Cas:6147-11-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM Mangostin

Cas:6147-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

10%~40% Mangostin Mangosteen Extract CAS 6147-11-1

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 6147-11-1 with competitive price

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

9H-Xanthen-9-one,1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)- 6147-11-1

Cas:6147-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Natural Mangosteen Extract Alpha Mangostin powder 10% 6147-11-1

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $26.0 / 30.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Mangostin CAS: 6147-11-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Mangostin CAS: 6147-11-1

Cas:6147-11-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

9H-Xanthen-9-one,1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-

Cas:6147-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

1.Free sample(10-20g or enough to detection) and Unconditional assume respons 2.100% Natural porduct, without any synthetize ingredient 3.Manufacturer direct supply, provide OEM, R&D service 4.ISO/HACCP/KOSHER/GMP/FDA 5.Leading plant ex

CAS No.6147-11-1 Mangostin

Cas:6147-11-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Mangostin

Cas:6147-11-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

GARCININA MANGOSTEEN POWDER

Cas:6147-11-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

9H-Xanthen-9-one,1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-

Cas:6147-11-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Mangostin

Cas:6147-11-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Natural Organic Mangostin Powder

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Mangosteen Extract

Cas:6147-11-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Mangostin

Cas:6147-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

MangostinCAS NO.: 6147-11-1

Cas:6147-11-1

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

α-mangostin

Cas:6147-11-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Alpha-Mangostin 6147-11-1 CAS NO.6147-11-1 CAS NO.6147-11-1

Cas:6147-11-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Mangostin

Cas:6147-11-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Alpha-Mangostin 6147-11-1 CAS NO.6147-11-1 CAS NO.6147-11-1

Cas:6147-11-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Alpha-Mangostin 6147-11-1 CAS NO.6147-11-1 CAS NO.6147-11-1

Cas:6147-11-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 1h; Concentration; Reagent/catalyst; Solvent; Reflux;57.1%
With potassium hydroxide
dimethylmangostin
15404-76-9

dimethylmangostin

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
With 1-thiopropane; sodium hydride In N,N-dimethyl-formamide for 6h; Inert atmosphere; Reflux;60%
With sodium methylate In dimethyl sulfoxide for 6h; Reflux; Inert atmosphere;59.8%
1,3,6-tri-O-acetyl-α-mangostin
107389-90-2

1,3,6-tri-O-acetyl-α-mangostin

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 1h; Concentration; Reagent/catalyst; Solvent; Reflux;57.1%
With potassium hydroxide
6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate
31271-10-0

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 1h; Reflux;50.4%
1,3-dihydroxy-6-O-benzoyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone
1140525-42-3

1,3-dihydroxy-6-O-benzoyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
With sodium hydroxide In water for 1h; Reflux;44%
[4,6-dihydroxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-dihydroxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanone
426820-49-7

[4,6-dihydroxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-dihydroxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanone

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Stage #1: [4,6-dihydroxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-dihydroxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanone With tetrachloromethane; triphenylphosphine In tetrahydrofuran at 20℃;
Stage #2: With silica gel
43%
3,6-di-O-benzoyl-α-mangostin
1449384-89-7

3,6-di-O-benzoyl-α-mangostin

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 1h; Reflux;40%
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1.1: 96 percent / NaH / dimethylformamide / 20 °C
2.1: nBuLi
2.2: 89 percent / tetrahydrofuran / 0 °C
3.1: nBuLi
3.2: 95 percent / tetrahydrofuran / 0 °C
4.1: 100 percent / CSA; MeOH / 60 °C
5.1: 100 percent / DMAP; Et3N / dimethylformamide / 20 °C
6.1: 78 percent / DIBAL-H / toluene / -78 °C
7.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
8.1: 65 percent / NaH / CH2Cl2 / 20 °C
9.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
10.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
11.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
12.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
13.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
14.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
14.2: 43 percent / silica gel
View Scheme
2,4-bis(benzyloxy)phenol
6195-80-8

2,4-bis(benzyloxy)phenol

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 84 percent / Br2 / CHCl3 / 20 °C
2.1: 80 percent / K2CO3 / dimethylformamide / 20 °C
3.1: 73 percent / 160 °C
4.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
5.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
6.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
7.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
8.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
9.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
10.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
10.2: 43 percent / silica gel
View Scheme
2,4-dibenzyloxybenzaldehyde
13246-46-3

2,4-dibenzyloxybenzaldehyde

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: mCPBA / CH2Cl2 / 20 °C
2.1: HCl / methanol / 20 °C
3.1: 84 percent / Br2 / CHCl3 / 20 °C
4.1: 80 percent / K2CO3 / dimethylformamide / 20 °C
5.1: 73 percent / 160 °C
6.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
7.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
8.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
9.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
10.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
11.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
12.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
12.2: 43 percent / silica gel
View Scheme
1,3,5-tris(methoxymethoxy)benzene
120677-47-6

1,3,5-tris(methoxymethoxy)benzene

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: nBuLi
1.2: 89 percent / tetrahydrofuran / 0 °C
2.1: nBuLi
2.2: 95 percent / tetrahydrofuran / 0 °C
3.1: 100 percent / CSA; MeOH / 60 °C
4.1: 100 percent / DMAP; Et3N / dimethylformamide / 20 °C
5.1: 78 percent / DIBAL-H / toluene / -78 °C
6.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
7.1: 65 percent / NaH / CH2Cl2 / 20 °C
8.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
9.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
10.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
11.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
12.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
13.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
13.2: 43 percent / silica gel
View Scheme
2,4-Dihydroxybenzaldehyde
95-01-2

2,4-Dihydroxybenzaldehyde

Me-X (X=Br or Cl)

Me-X (X=Br or Cl)

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 96 percent / K2CO3 / dimethylformamide / 20 °C
2.1: mCPBA / CH2Cl2 / 20 °C
3.1: HCl / methanol / 20 °C
4.1: 84 percent / Br2 / CHCl3 / 20 °C
5.1: 80 percent / K2CO3 / dimethylformamide / 20 °C
6.1: 73 percent / 160 °C
7.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
8.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
9.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
10.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
11.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
12.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
13.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
13.2: 43 percent / silica gel
View Scheme
4,6-dihydroxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde
426820-54-4

4,6-dihydroxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
2.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
3.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
4.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
5.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
5.2: 43 percent / silica gel
View Scheme
formic acid 2,4-bis-benzyloxy-phenyl ester

formic acid 2,4-bis-benzyloxy-phenyl ester

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: HCl / methanol / 20 °C
2.1: 84 percent / Br2 / CHCl3 / 20 °C
3.1: 80 percent / K2CO3 / dimethylformamide / 20 °C
4.1: 73 percent / 160 °C
5.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
6.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
7.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
8.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
9.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
10.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
11.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
11.2: 43 percent / silica gel
View Scheme
1,3,5-tris-methoxymethoxy-2-(3-methyl-but-2-enyl)-benzene
426820-42-0

1,3,5-tris-methoxymethoxy-2-(3-methyl-but-2-enyl)-benzene

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: nBuLi
1.2: 95 percent / tetrahydrofuran / 0 °C
2.1: 100 percent / CSA; MeOH / 60 °C
3.1: 100 percent / DMAP; Et3N / dimethylformamide / 20 °C
4.1: 78 percent / DIBAL-H / toluene / -78 °C
5.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
6.1: 65 percent / NaH / CH2Cl2 / 20 °C
7.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
8.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
9.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
10.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
11.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
12.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
12.2: 43 percent / silica gel
View Scheme
2,4,6-trihydroxy-3-(3-methyl-but-2-enyl)-benzoic acid ethyl ester

2,4,6-trihydroxy-3-(3-methyl-but-2-enyl)-benzoic acid ethyl ester

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 100 percent / DMAP; Et3N / dimethylformamide / 20 °C
2.1: 78 percent / DIBAL-H / toluene / -78 °C
3.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
4.1: 65 percent / NaH / CH2Cl2 / 20 °C
5.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
6.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
7.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
8.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
9.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
10.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
10.2: 43 percent / silica gel
View Scheme
2,4-bis-benzyloxy-5-bromo-phenol
426820-51-1

2,4-bis-benzyloxy-5-bromo-phenol

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 80 percent / K2CO3 / dimethylformamide / 20 °C
2.1: 73 percent / 160 °C
3.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
4.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
5.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
6.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
7.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
8.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
9.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
9.2: 43 percent / silica gel
View Scheme
1-Allyloxy-2,4-bis-benzyloxy-5-bromo-benzene
426820-39-5

1-Allyloxy-2,4-bis-benzyloxy-5-bromo-benzene

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 73 percent / 160 °C
2.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
3.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
4.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
5.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
6.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
7.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
8.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
8.2: 43 percent / silica gel
View Scheme
(3,5-bis-benzyloxy-2-bromo-6-methoxy-phenyl)-acetaldehyde
426820-52-2

(3,5-bis-benzyloxy-2-bromo-6-methoxy-phenyl)-acetaldehyde

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
2.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
3.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
4.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
5.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
5.2: 43 percent / silica gel
View Scheme
2-allyl-4,6-bis-benzyloxy-3-bromo-phenol
426820-56-6

2-allyl-4,6-bis-benzyloxy-3-bromo-phenol

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 87 percent / K2CO3 / dimethylformamide / 20 °C
2.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
3.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
4.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
5.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
6.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
7.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
7.2: 43 percent / silica gel
View Scheme
3-Allyl-1,5-bis-benzyloxy-2-bromo-4-methoxy-benzene
426820-40-8

3-Allyl-1,5-bis-benzyloxy-2-bromo-4-methoxy-benzene

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 95 percent / OsO4; NaIO4 / H2O; diethyl ether / 20 °C
2.1: 72 percent / nBuLi / tetrahydrofuran / 0 °C
3.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
4.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
5.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
6.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
6.2: 43 percent / silica gel
View Scheme
2,4,6-tris-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzoic acid ethyl ester
426820-43-1

2,4,6-tris-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzoic acid ethyl ester

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 100 percent / CSA; MeOH / 60 °C
2.1: 100 percent / DMAP; Et3N / dimethylformamide / 20 °C
3.1: 78 percent / DIBAL-H / toluene / -78 °C
4.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
5.1: 65 percent / NaH / CH2Cl2 / 20 °C
6.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
7.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
8.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
9.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
10.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
11.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
11.2: 43 percent / silica gel
View Scheme
1,5-Bis-benzyloxy-2-bromo-4-methoxy-3-(3-methyl-but-2-enyl)-benzene
426820-41-9

1,5-Bis-benzyloxy-2-bromo-4-methoxy-3-(3-methyl-but-2-enyl)-benzene

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
2.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
3.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
4.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
4.2: 43 percent / silica gel
View Scheme
4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde
426820-47-5

4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
2.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
3.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
4.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
4.2: 43 percent / silica gel
View Scheme
4,6-bis-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-3-(3-methyl-but-2-enyl)-benzaldehyde
426820-45-3

4,6-bis-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-3-(3-methyl-but-2-enyl)-benzaldehyde

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 65 percent / NaH / CH2Cl2 / 20 °C
2.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
3.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
4.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
5.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
6.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
7.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
7.2: 43 percent / silica gel
View Scheme
4,6-bis-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde
426820-46-4

4,6-bis-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
2.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
3.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
4.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
5.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
6.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
6.2: 43 percent / silica gel
View Scheme
[2,4,6-tris-(tert-butyl-dimethyl-silanyloxy)-3-(3-methyl-but-2-enyl)-phenyl]-methanol
426820-44-2

[2,4,6-tris-(tert-butyl-dimethyl-silanyloxy)-3-(3-methyl-but-2-enyl)-phenyl]-methanol

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
2.1: 65 percent / NaH / CH2Cl2 / 20 °C
3.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
4.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
5.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
6.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
7.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
8.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
8.2: 43 percent / silica gel
View Scheme
2,4,6-tris-(tert-butyl-dimethyl-silanyloxy)-3-(3-methyl-but-2-enyl)-benzoic acid ethyl ester

2,4,6-tris-(tert-butyl-dimethyl-silanyloxy)-3-(3-methyl-but-2-enyl)-benzoic acid ethyl ester

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 78 percent / DIBAL-H / toluene / -78 °C
2.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
3.1: 65 percent / NaH / CH2Cl2 / 20 °C
4.1: 100 percent / TBAF / tetrahydrofuran / 0 °C
5.1: 98 percent / K2CO3 / dimethylformamide / 20 °C
6.1: 49 percent / sBuLi / tetrahydrofuran / -78 °C
7.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
8.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
9.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
9.2: 43 percent / silica gel
View Scheme
[4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-bis-benzyloxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanone
426820-55-5

[4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-bis-benzyloxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanone

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
2.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
2.2: 43 percent / silica gel
View Scheme
[4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-bis-benzyloxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanol
426820-48-6

[4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-[4,6-bis-benzyloxy-3-methoxy-2-(3-methyl-but-2-enyl)-phenyl]-methanol

α-mangostin
6147-11-1

α-mangostin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 76 percent / IBX / toluene; dimethylsulfoxide / 20 °C
2.1: 63 percent / HCO2NH4 / Pd/C / acetone / 20 °C
3.1: PPh3; CCl4 / tetrahydrofuran / 20 °C
3.2: 43 percent / silica gel
View Scheme
garcinone D
107390-08-9

garcinone D

A

α-mangostin
6147-11-1

α-mangostin

B

ethanolic KOH-solution

ethanolic KOH-solution

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / 2 h / 100 °C
2: POCl3/Py / Ambient temperature
3: 5percent methanolic KOH
View Scheme
α-mangostin
6147-11-1

α-mangostin

1,3,6-trihydroxy-2,8-diisopentyl-7-methoxy-9H-xanthene-9-one
182317-42-6

1,3,6-trihydroxy-2,8-diisopentyl-7-methoxy-9H-xanthene-9-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol for 12h;99%
With palladium 10% on activated carbon; hydrogen In methanol for 12h;99%
With palladium on activated charcoal; hydrogen In methanol for 6h;98%
α-mangostin
6147-11-1

α-mangostin

acetic anhydride
108-24-7

acetic anhydride

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate
31271-10-0

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate

Conditions
ConditionsYield
With triethylamine In toluene at 20℃; for 2h;99%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 3.5h;47.3%
morpholine
110-91-8

morpholine

formaldehyd
50-00-0

formaldehyd

α-mangostin
6147-11-1

α-mangostin

1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-4-(morpholinomethyl)-9H-xanthen-9-one

1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-4-(morpholinomethyl)-9H-xanthen-9-one

Conditions
ConditionsYield
In benzene Mannich Aminomethylation; Reflux;94%
α-mangostin
6147-11-1

α-mangostin

3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one
19275-46-8

3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one

Conditions
ConditionsYield
With polyphosphoric acid; air In N,N-dimethyl-formamide at 130℃; for 2h;91%
With toluene-4-sulfonic acid In benzene Reflux;70%
With toluene-4-sulfonic acid In benzene Reflux;70%
α-mangostin
6147-11-1

α-mangostin

ethylene dibromide
106-93-4

ethylene dibromide

3,6-bis(2-bromoethoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

3,6-bis(2-bromoethoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;89%
With potassium carbonate In acetone for 20h; Reflux;75%
α-mangostin
6147-11-1

α-mangostin

ethyl isocyanate
109-90-0

ethyl isocyanate

1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3,6-diyl bis(ethylcarbamate)

1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3,6-diyl bis(ethylcarbamate)

Conditions
ConditionsYield
With triethylamine In acetonitrile at 85℃; for 5h;87%
(Z)-2-methyl-2-butenoic anhydride
94487-74-8

(Z)-2-methyl-2-butenoic anhydride

α-mangostin
6147-11-1

α-mangostin

C34H38O8

C34H38O8

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;85.3%
α-mangostin
6147-11-1

α-mangostin

9-hydroxycalabaxanthone
35349-68-9

9-hydroxycalabaxanthone

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 40℃; for 5h;85%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 40℃; for 5h;85%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene at 80℃; for 3h;82%
α-mangostin
6147-11-1

α-mangostin

acetic anhydride
108-24-7

acetic anhydride

A

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate
31271-10-0

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate

B

1,3,6-tri-O-acetyl-α-mangostin
107389-90-2

1,3,6-tri-O-acetyl-α-mangostin

Conditions
ConditionsYield
With pyridine at 70℃; for 2h;A 84.3%
B 12.4%
With dmap In dichloromethane at 20℃; for 24h; Cooling;
α-mangostin
6147-11-1

α-mangostin

Isopropyl isocyanate
1795-48-8

Isopropyl isocyanate

1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3,6-diyl bis(isopropylcarbamate)

1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3,6-diyl bis(isopropylcarbamate)

Conditions
ConditionsYield
With triethylamine In acetonitrile at 85℃; for 5h;83%
α-mangostin
6147-11-1

α-mangostin

acetic anhydride
108-24-7

acetic anhydride

A

3-O-acetyl-α-mangostin

3-O-acetyl-α-mangostin

B

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate
31271-10-0

6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate

Conditions
ConditionsYield
With pyridine at 60℃; for 1h;A 11%
B 81%
α-mangostin
6147-11-1

α-mangostin

1,10-dibromodecane

1,10-dibromodecane

3,6-bis((10-bromodecyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

3,6-bis((10-bromodecyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;81%
α-mangostin
6147-11-1

α-mangostin

benzyl bromide
100-39-0

benzyl bromide

3,6-di-O-benzyl α-mangostin
1193121-18-4

3,6-di-O-benzyl α-mangostin

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;80%
With potassium carbonate In acetone at 40℃; for 4h;
α-mangostin
6147-11-1

α-mangostin

methyl iodide
74-88-4

methyl iodide

dimethylmangostin
15404-76-9

dimethylmangostin

Conditions
ConditionsYield
With potassium carbonate In acetone at 60 - 65℃; for 24h;80%
With potassium carbonate In acetone at 40℃; for 4h;
1,8-dibromooctane

1,8-dibromooctane

α-mangostin
6147-11-1

α-mangostin

3,6-bis((8-bromooctyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

3,6-bis((8-bromooctyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;78%
α-mangostin
6147-11-1

α-mangostin

A

1,3,6-trihydroxy-2-(3-methyl-2-butenyl)-7-methoxy-8-(2,3-dihydroxy-3-methylbutyl)xanthone

1,3,6-trihydroxy-2-(3-methyl-2-butenyl)-7-methoxy-8-(2,3-dihydroxy-3-methylbutyl)xanthone

B

1,3,6-trihydroxy-2-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-8-(3-methyl-2-butenyl)xanthone

1,3,6-trihydroxy-2-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-8-(3-methyl-2-butenyl)xanthone

C

1,3,6-trihydroxy-7-methoxy-2,8-bis(2,3-dihydroxy-3-methylbutyl)-9H-xanthen-9-one

1,3,6-trihydroxy-7-methoxy-2,8-bis(2,3-dihydroxy-3-methylbutyl)-9H-xanthen-9-one

Conditions
ConditionsYield
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In water; acetone; tert-butyl alcohol at 20℃; for 24h;A 12%
B 10%
C 78%
With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide In acetone; tert-butyl alcohol at 20℃; for 24h;A 12%
B 10%
C 78%
α-mangostin
6147-11-1

α-mangostin

allyl bromide
106-95-6

allyl bromide

3,6-bis(allyloxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthene-9-one

3,6-bis(allyloxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthene-9-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 65℃; for 24h;78%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

α-mangostin
6147-11-1

α-mangostin

C32H40Br2O6
1427187-01-6

C32H40Br2O6

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;76.5%
With potassium carbonate In acetone for 24h; Reflux;
With potassium carbonate In acetone for 24h; Reflux;
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

4-hydroxybenzenesulphonamide
1576-43-8

4-hydroxybenzenesulphonamide

α-mangostin
6147-11-1

α-mangostin

C44H52N2O14S2

C44H52N2O14S2

Conditions
ConditionsYield
Stage #1: 1,4-dibromo-butane; α-mangostin With potassium carbonate In acetone for 24h; Reflux;
Stage #2: 4-hydroxybenzenesulphonamide
76.5%
α-mangostin
6147-11-1

α-mangostin

prenyl bromide
870-63-3

prenyl bromide

3,6-di-O-3,3-dimethylallyl α-mangostin
1193121-15-1

3,6-di-O-3,3-dimethylallyl α-mangostin

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;76%
With potassium carbonate In acetone at 65℃; for 12h;15%
With potassium carbonate In acetone at 40℃; for 4h;
α-mangostin
6147-11-1

α-mangostin

4-bromobenzenesulfonyl chloride
98-58-8

4-bromobenzenesulfonyl chloride

C36H32Br2O10S2

C36H32Br2O10S2

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃; for 24h;76%
piperidine
110-89-4

piperidine

formaldehyd
50-00-0

formaldehyd

α-mangostin
6147-11-1

α-mangostin

1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-4-(piperidin-1-ylmethyl)-9H-xanthen-9-one

1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-4-(piperidin-1-ylmethyl)-9H-xanthen-9-one

Conditions
ConditionsYield
In benzene Mannich Aminomethylation; Reflux;75%
α-mangostin
6147-11-1

α-mangostin

allyl bromide
106-95-6

allyl bromide

1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-3,6-dipropoxy-9H-xanthen-9-one

1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-3,6-dipropoxy-9H-xanthen-9-one

Conditions
ConditionsYield
Stage #1: α-mangostin; allyl bromide With potassium carbonate In acetone at 65℃; for 24h;
Stage #2: With palladium on activated charcoal; hydrogen In methanol at 20℃;
75%
α-mangostin
6147-11-1

α-mangostin

ethyl iodide
75-03-6

ethyl iodide

C28H34O6
189945-36-6

C28H34O6

Conditions
ConditionsYield
With potassium carbonate In acetone at 60 - 65℃; for 24h;75%
1,12-dibromododecane
3344-70-5

1,12-dibromododecane

α-mangostin
6147-11-1

α-mangostin

3,6-bis((12-bromododecyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

3,6-bis((12-bromododecyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;73%
bis-(dimethylamino)methane
51-80-9

bis-(dimethylamino)methane

α-mangostin
6147-11-1

α-mangostin

4-dimethylaminomethyl-1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

4-dimethylaminomethyl-1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Conditions
ConditionsYield
In benzene at 20℃; for 0.75h; Mannich Aminomethylation;73%
α-mangostin
6147-11-1

α-mangostin

A

3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one
19275-46-8

3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one

B

1-isomangostin
19275-44-6

1-isomangostin

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 0.5h; Reflux; Dean-Stark;A 65%
B 15%
α-mangostin
6147-11-1

α-mangostin

A

1-isomangostin hydrate
26063-95-6

1-isomangostin hydrate

B

3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one
19275-46-8

3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one

Conditions
ConditionsYield
With sulfuric acid In toluene at 40℃; for 4h; Inert atmosphere; Molecular sieve;A 63%
B 29%
1,4-Diiodobutane
628-21-7

1,4-Diiodobutane

α-mangostin
6147-11-1

α-mangostin

1,3,6-tris(4-iodobutoxy)-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

1,3,6-tris(4-iodobutoxy)-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;62%
With potassium carbonate In acetone for 24h; Reflux;62%

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