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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

cis-4-Hydroxy-L-proline Manufacturer/High quality/Best price/In stock

Cas:618-27-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cis-4-Hydroxy-L-Proline

Cas:618-27-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 618-27-9 H-CIS-HYP-OH Manufacturer

Cas:618-27-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

cis-4-Hydroxy-L-proline CAS No.:618-27-9/pharmaceutical intermediate

Cas:618-27-9

Min.Order:1 Gram

FOB Price: $5.0 / 6.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of

cis-4-Hydroxy-L-proline Manufacturer

Cas:618-27-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 618-27-9--High purity cis-4-Hydroxy-L-proline in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable bus

TIANFUCHEM-- 618-27-9--High purity cis-4-Hydroxy-L-proline in stock

Cas:618-27-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

618-27-9 cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 618-27-9 with best quality

Cas:618-27-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: cis-4-hydroxy-L-proline Synonyms: (2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid CAS: 618-27-9 MF: C5H9NO3 Appearance: White powder Storage:Store in cool and dry place, away from sun light. Package:25KG/Drum Application:Organic Chemicals

cis-4-hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

L-Proline,4-hydroxy-, (4S)- 618-27-9

Cas:618-27-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

cis-4-Hydroxy-L-proline CAS:618-27-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

cis-4-Hydroxy-L-proline CAS:618-27-9

Cas:618-27-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

L-Proline,4-hydroxy-, (4S)-

Cas:618-27-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:618-27-9

Cas:618-27-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales L-Hydroxyproline CAS 618-27-9

Cas:618-27-9

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid

Cas:618-27-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:white to beige powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Hydroxy

L-Proline,4-hydroxy-, (4S)-

Cas:618-27-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting Cis-4-hydroxy-L-proline, CAS NO: 618-27-9 Please contact us by email freely. We are leading exporter in China. If you really need this cargo, ple

Cis-4-hydroxy-L-proline, CAS NO:618-27-9

Cas:618-27-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid

Cas:618-27-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

cis-4-Hydroxy-L-proline USP/EP/BP

Cas:618-27-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

cis-4-Hydroxy-L-proline Chemical Properties Melting point 257 °C (dec.) (lit.) alpha -59 º (c=2, H2O) Boiling point 242.42°C (rough estimate) density 1.3121 (rough estimate) refractive index -59 ° (C=2, H2O) stora

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

cis-4-Hydroxy-L-proline

Cas:618-27-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(2S,4S)-4-Benzoyloxy-pyrrolidine-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
157401-62-2

(2S,4S)-4-Benzoyloxy-pyrrolidine-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With hydrogenchloride at 140℃; for 3h;100%
L-proline
147-85-3

L-proline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With ferrous(II) sulfate heptahydrate; cis-4-proline hydroxylase; sodium L-ascorbate at 25℃; for 16h; stereospecific reaction;100%
With iron(II) sulfate; α-ketoglutaric acid disodium salt In culture medium at 28℃; for 72h; Enzymatic reaction; regioselective reaction;35%
With Mesorhizobium loti L-proline cis-4-hydroxylase; iron(II) sulfate at 25℃; for 20h; Reagent/catalyst; Enzymatic reaction; stereoselective reaction;
With hydrogenchloride; α-ketoglutaric acid; ammonium iron (II) sulfate; l-proline cis-4-hydroxylase; sodium L-ascorbate In aq. buffer at 21℃; for 14h; pH=6.5; Enzymatic reaction;> 95 %Chromat.
With ferrous(II) sulfate heptahydrate; α-ketoglutaric acid disodium salt; ascorbic acid In aq. phosphate buffer at 37℃; for 16h; pH=8; Enzymatic reaction;201 mg
(2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline
13504-86-4

(2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With hydrogenchloride In water at 80℃; for 1h;87%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 4h;64%
With hydrogen bromide; acetic acid
With hydrogen; palladium on activated charcoal In water at 25℃; under 2660 Torr; for 3h;496 mg
(2S,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)
132592-07-5

(2S,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl ester)

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 760 Torr; for 2h; Ambient temperature;68%
(6S,7aS)-6-hydroxy-3,3-bis(trifluoromethyl)tetrahydro-pyrrolo[1,2-c]oxazol-1-one
148429-59-8

(6S,7aS)-6-hydroxy-3,3-bis(trifluoromethyl)tetrahydro-pyrrolo[1,2-c]oxazol-1-one

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With water In isopropyl alcohol Ambient temperature;41%
N-acetyl-cis-4-hydroxy-L-proline
66267-44-5

N-acetyl-cis-4-hydroxy-L-proline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With hydrogenchloride
cis-1-ethoxycarbonyl-4-hydroxy-L-proline
19887-35-5, 118712-71-3

cis-1-ethoxycarbonyl-4-hydroxy-L-proline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With hydrogenchloride
cis-4-hydroxy-N-triphenylmethyl-L-proline
129431-03-4

cis-4-hydroxy-N-triphenylmethyl-L-proline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With acetic acid for 0.25h; Ambient temperature;1.2 g
cis-L-hydroxyproline methyl ester
81102-38-7

cis-L-hydroxyproline methyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With sodium hydroxide for 2h; Yield given;
(2S,4S)-4-(2-Methoxy-propionyloxy)-pyrrolidine-2-carboxylic acid methyl ester

(2S,4S)-4-(2-Methoxy-propionyloxy)-pyrrolidine-2-carboxylic acid methyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With sodium hydroxide In methanol for 2h; Ambient temperature; Yield given;
1-anilinoformyl-l-b-<4-oxy-proline >

1-anilinoformyl-l-b-<4-oxy-proline >

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
With ammonia at 90 - 100℃; im Rohr;
N-tert-butoxycarbonyl-L-cis-4-hydroxyproline
87691-27-8

N-tert-butoxycarbonyl-L-cis-4-hydroxyproline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-cis-4-hydroxyproline With hydrogenchloride In 1,4-dioxane at 20℃; for 19h;
Stage #2: With TEA In ethanol
(2S,4R)-1-tert-butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate
440678-63-7

(2S,4R)-1-tert-butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C
2.1: 2M HCl / dioxane / 19 h / 20 °C
2.2: TEA / ethanol
View Scheme
ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-4,5-dihydroxy-2-pentenoate
502442-53-7

ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-4,5-dihydroxy-2-pentenoate

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 84 percent / DMAP; TEA / CH2Cl2 / 20 °C
2.1: 100 percent / imidazole / dimethylformamide / 20 °C
3.1: 98 percent / 1.5M HCl / ethanol / 2 h / 20 °C
4.1: 61 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C
5.1: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C
6.1: 91 percent / TBAF / tetrahydrofuran / 20 °C
7.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C
8.1: 2M HCl / dioxane / 19 h / 20 °C
8.2: TEA / ethanol
View Scheme
ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-4,5-isopropylidenedioxy-2-pentenoate

ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-4,5-isopropylidenedioxy-2-pentenoate

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 85 percent / 0.5M HCl / ethanol / 20 °C
2.1: 84 percent / DMAP; TEA / CH2Cl2 / 20 °C
3.1: 100 percent / imidazole / dimethylformamide / 20 °C
4.1: 98 percent / 1.5M HCl / ethanol / 2 h / 20 °C
5.1: 61 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C
6.1: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C
7.1: 91 percent / TBAF / tetrahydrofuran / 20 °C
8.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C
9.1: 2M HCl / dioxane / 19 h / 20 °C
9.2: TEA / ethanol
View Scheme
ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-2-pentenoate
502442-56-0

ethyl (4S)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-2-pentenoate

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 100 percent / imidazole / dimethylformamide / 20 °C
2.1: 98 percent / 1.5M HCl / ethanol / 2 h / 20 °C
3.1: 61 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C
5.1: 91 percent / TBAF / tetrahydrofuran / 20 °C
6.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C
7.1: 2M HCl / dioxane / 19 h / 20 °C
7.2: TEA / ethanol
View Scheme
(R)-3-Allyl-6-methyl-4-((S)-1-phenyl-ethyl)-morpholine-2,5-dione

(R)-3-Allyl-6-methyl-4-((S)-1-phenyl-ethyl)-morpholine-2,5-dione

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) 1M aq. NaOH, 2.) NaH
2: 80 percent / I2 / tetrahydrofuran; H2O / 2 h / Ambient temperature
3: H2 / Pd(OH)2 / methanol / 5 h / Ambient temperature
4: 1M aq. NaOH / methanol / 2 h / Ambient temperature
View Scheme
2-[((R)-2-Methoxy-propionyl)-((S)-1-phenyl-ethyl)-amino]-pent-4-enoic acid methyl ester

2-[((R)-2-Methoxy-propionyl)-((S)-1-phenyl-ethyl)-amino]-pent-4-enoic acid methyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / I2 / tetrahydrofuran; H2O / 2 h / Ambient temperature
2: H2 / Pd(OH)2 / methanol / 5 h / Ambient temperature
3: 1M aq. NaOH / methanol / 2 h / Ambient temperature
View Scheme
(S)-4-(2-Methoxy-propionyloxy)-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid methyl ester

(S)-4-(2-Methoxy-propionyloxy)-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid methyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / Pd(OH)2 / methanol / 5 h / Ambient temperature
2: 1M aq. NaOH / methanol / 2 h / Ambient temperature
View Scheme
(S)-2-((S)-1-Phenyl-ethylamino)-pent-4-enoic acid amide
177186-30-0

(S)-2-((S)-1-Phenyl-ethylamino)-pent-4-enoic acid amide

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iodine / tetrahydrofuran; H2O / 0.5 h / Ambient temperature
2: H2 / Pd(OH)2 / ethanol / 5 h / 1861.7 Torr / Ambient temperature
3: 1M NaOH / 2 h
View Scheme
(3S,5S)-5-Iodomethyl-3-((S)-1-phenyl-ethylamino)-dihydro-furan-2-one
176966-58-8

(3S,5S)-5-Iodomethyl-3-((S)-1-phenyl-ethylamino)-dihydro-furan-2-one

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / Pd(OH)2 / ethanol / 5 h / 1861.7 Torr / Ambient temperature
2: 1M NaOH / 2 h
View Scheme
(3S,6R,1'S)-4-(1'-phenylethyl)-3-(2-propen-1-yl)-6-methyl-1,4-morpholin-2,5-dione
177186-28-6

(3S,6R,1'S)-4-(1'-phenylethyl)-3-(2-propen-1-yl)-6-methyl-1,4-morpholin-2,5-dione

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NH3 / ethanol / 0.5 h / 0 °C
2: iodine / tetrahydrofuran; H2O / 0.5 h / Ambient temperature
3: H2 / Pd(OH)2 / ethanol / 5 h / 1861.7 Torr / Ambient temperature
4: 1M NaOH / 2 h
View Scheme
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate
64187-48-0

methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h
2: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C
3: 496 mg / H2 / Pd-C / H2O / 3 h / 25 °C / 2660 Torr
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / toluene / 4 h / 5 - 20 °C
2: sodium hydroxide; water / 3 h / 80 °C
3: hydrogenchloride / water / 1 h / 80 °C
View Scheme
(2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester
170159-62-3

(2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C
2: 496 mg / H2 / Pd-C / H2O / 3 h / 25 °C / 2660 Torr
View Scheme
4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 635 g / aq. NaHCO3 / tetrahydrofuran / 17 h / 25 °C
2: 90 percent / SOCl2 / 17 h / 25 °C
3: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h
4: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C
5: 496 mg / H2 / Pd-C / H2O / 3 h / 25 °C / 2660 Torr
View Scheme
Multi-step reaction with 4 steps
1: 86 percent / aqueous NaHCO3 / 3 h / from 0 deg C to r.t.
2: 84 percent / K2CO3 / dimethylformamide / 2 h / 0 °C
3: 1.) EtO2CN=NCOOEt, Ph3P, 2.) aq. NaOH / 1.) HCO2H, THF, from 0 deg C to r.t., 18 h; 2.) 1,4-dioxane, 0 deg C, 0.25 h
4: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
2: CrO3
3: NaBH4
4: HBr, AcOH
View Scheme
Multi-step reaction with 5 steps
1: thionyl chloride / 6 h / 15 - 60 °C
2: sodium carbonate / water / 5 h / 10 - 20 °C
3: triethylamine / toluene / 4 h / 5 - 20 °C
4: sodium hydroxide; water / 3 h / 80 °C
5: hydrogenchloride / water / 1 h / 80 °C
View Scheme
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
13504-85-3

(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / SOCl2 / 17 h / 25 °C
2: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h
3: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C
4: 496 mg / H2 / Pd-C / H2O / 3 h / 25 °C / 2660 Torr
View Scheme
Multi-step reaction with 3 steps
1: 84 percent / K2CO3 / dimethylformamide / 2 h / 0 °C
2: 1.) EtO2CN=NCOOEt, Ph3P, 2.) aq. NaOH / 1.) HCO2H, THF, from 0 deg C to r.t., 18 h; 2.) 1,4-dioxane, 0 deg C, 0.25 h
3: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: CrO3
2: NaBH4
3: HBr, AcOH
View Scheme
N-Benzoyl-2(S)-(2-propenyl)glycin-(1R,2S,5R)-menthylester
157401-61-1

N-Benzoyl-2(S)-(2-propenyl)glycin-(1R,2S,5R)-menthylester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / I2, H2O / tetrahydrofuran / 3 h / 20 °C
2: 100 percent / 2 M aq. HCl / 3 h / 140 °C
View Scheme
N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester
13500-53-3

N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) EtO2CN=NCOOEt, Ph3P, 2.) aq. NaOH / 1.) HCO2H, THF, from 0 deg C to r.t., 18 h; 2.) 1,4-dioxane, 0 deg C, 0.25 h
2: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature
View Scheme
(S)-2,2-Bis(trifluormethyl)-4-(3-diazo-2-oxopropyl)-1,3-oxazolidin-5-on
146197-81-1

(S)-2,2-Bis(trifluormethyl)-4-(3-diazo-2-oxopropyl)-1,3-oxazolidin-5-on

hydroxy L-proline
618-27-9

hydroxy L-proline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 73 percent / 2 / CH2Cl2 / 24 h / Ambient temperature
2: 68 percent / Na(BH3CN), glacial HOAc / propan-2-ol / 1 h / 0 °C
3: 41 percent / H2O / propan-2-ol / Ambient temperature
View Scheme
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

hydroxy L-proline
618-27-9

hydroxy L-proline

(2S,4S)-1-(9H-fluorene-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
189249-10-3

(2S,4S)-1-(9H-fluorene-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃; Inert atmosphere;100%
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃;92%
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃; for 9h;
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

hydroxy L-proline
618-27-9

hydroxy L-proline

1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid
16257-78-6

1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water for 4h;99.99%
4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

hydroxy L-proline
618-27-9

hydroxy L-proline

4-hydroxy-1-(4-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid

4-hydroxy-1-(4-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water for 4h;99.97%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

hydroxy L-proline
618-27-9

hydroxy L-proline

4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid
16257-64-0

4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water for 4h;99.86%
N-methylmaleimide
930-88-1

N-methylmaleimide

hydroxy L-proline
618-27-9

hydroxy L-proline

acenaphthene quinone
82-86-0

acenaphthene quinone

7′-hydroxy-2′-methyl-3a′,6′,7′,8′,8a′,8b′-hexahydro-1′H,2Hspiro[acenaphthylene-1,4′-pyrrolo[3,4-a]pyrrolizine]-1′,2,3′(2′H)-trione

7′-hydroxy-2′-methyl-3a′,6′,7′,8′,8a′,8b′-hexahydro-1′H,2Hspiro[acenaphthylene-1,4′-pyrrolo[3,4-a]pyrrolizine]-1′,2,3′(2′H)-trione

Conditions
ConditionsYield
In methanol at 60℃; for 3h;90%
benzyl chloroformate
501-53-1

benzyl chloroformate

hydroxy L-proline
618-27-9

hydroxy L-proline

(2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline
13504-86-4

(2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at 20℃;84%
With sodium hydrogencarbonate for 3h; from 0 deg C to r.t.;81%
With sodium hydroxide
ethanol
64-17-5

ethanol

hydroxy L-proline
618-27-9

hydroxy L-proline

cis-4-hydroxy-L-prolin-ethyl ester
440678-43-3

cis-4-hydroxy-L-prolin-ethyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 16h; Reflux;83%
With hydrogenchloride
indan-1,2,3-trione hydrate
485-47-2

indan-1,2,3-trione hydrate

4,5-dimethyl-1,2-phenylenediamine
3171-45-7

4,5-dimethyl-1,2-phenylenediamine

hydroxy L-proline
618-27-9

hydroxy L-proline

1,8-dimethyl-11-(1H-pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline

1,8-dimethyl-11-(1H-pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline

Conditions
ConditionsYield
Montmorillonite K10 In dimethyl sulfoxide microwave irradiation;80%
Hexanoyl chloride
142-61-0

Hexanoyl chloride

hydroxy L-proline
618-27-9

hydroxy L-proline

C17H29NO5

C17H29NO5

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water for 4h; Reflux;79%
indan-1,2,3-trione hydrate
485-47-2

indan-1,2,3-trione hydrate

4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

hydroxy L-proline
618-27-9

hydroxy L-proline

8-methyl-11-(1H-pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline

8-methyl-11-(1H-pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline

Conditions
ConditionsYield
Montmorillonite K10 In dimethyl sulfoxide microwave irradiation;78%
7-chloro-2-(2-methyl-[1,1'-biphenyl]-3-yl)-2H-indazole-5-carbaldehyde

7-chloro-2-(2-methyl-[1,1'-biphenyl]-3-yl)-2H-indazole-5-carbaldehyde

hydroxy L-proline
618-27-9

hydroxy L-proline

(2S,4S)-1-((7-chloro-2-(2-methyl-[1,1’-biphenyl]-3-yl)-2H-indazol-5-yl)methyl)-4-hydroxypyrrolidine-2-carboxylic acid

(2S,4S)-1-((7-chloro-2-(2-methyl-[1,1’-biphenyl]-3-yl)-2H-indazol-5-yl)methyl)-4-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 7-chloro-2-(2-methyl-[1,1'-biphenyl]-3-yl)-2H-indazole-5-carbaldehyde; hydroxy L-proline With acetic acid In methanol at 20℃; for 1h;
Stage #2: With sodium cyanoborohydride In methanol at 20℃;
46%
C24H18N4O7
855781-84-9

C24H18N4O7

hydroxy L-proline
618-27-9

hydroxy L-proline

C25H22N4O7

C25H22N4O7

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; for 24h;39%
4-([1,1′:2′,1″-terphenyl]-3′-ylmethoxy)-3-bromobenzaldehyde

4-([1,1′:2′,1″-terphenyl]-3′-ylmethoxy)-3-bromobenzaldehyde

hydroxy L-proline
618-27-9

hydroxy L-proline

(2S,4S)-1-(4-([1,1′:2′,1″-terphenyl]-3′-ylmethoxy)-3-bromobenzyl)-4-hydroxypyrrolidine-2-carboxylic acid

(2S,4S)-1-(4-([1,1′:2′,1″-terphenyl]-3′-ylmethoxy)-3-bromobenzyl)-4-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 4-([1,1′:2′,1″-terphenyl]-3′-ylmethoxy)-3-bromobenzaldehyde; hydroxy L-proline With acetic acid In N,N-dimethyl-formamide at 25℃; for 2h;
Stage #2: With sodium cyanoborohydride In N,N-dimethyl-formamide for 20h;
37%
6-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-naphthaldehyde

6-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-naphthaldehyde

hydroxy L-proline
618-27-9

hydroxy L-proline

(2S,4S)-1-((6-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)naphthalen-2-yl)methyl)-4-hydroxypyrrolidine-2-carboxylic acid

(2S,4S)-1-((6-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)naphthalen-2-yl)methyl)-4-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol at 60℃; for 12h;20%
1-benzyl-1H-pyrrole-2,5-dione
1631-26-1

1-benzyl-1H-pyrrole-2,5-dione

β-naphthaldehyde
66-99-9

β-naphthaldehyde

hydroxy L-proline
618-27-9

hydroxy L-proline

(-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione
935468-53-4

(-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 85℃; for 20h;17%
6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-2-naphthaldehyde

6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-2-naphthaldehyde

hydroxy L-proline
618-27-9

hydroxy L-proline

(2S,4S)-4-hydroxy-1-((6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)naphthalen-2-yl)methyl)pyrrolidine-2-carboxylic acid

(2S,4S)-4-hydroxy-1-((6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)naphthalen-2-yl)methyl)pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol at 60℃; for 12h;15%

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