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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloro-6-Fluoronitrobenzene supplier in China

Cas:64182-61-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:Shanghai, Qingdao

2-Chloro-6-fluoronitrobenzene 64182-61-2

Cas:64182-61-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzene,1-chloro-3-fluoro-2-nitro- 64182-61-2

Cas:64182-61-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:64182-61-2

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-6-Fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzene,1-chloro-3-fluoro-2-nitro-

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

64182-61-2,2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Chloro-6-Fluoronitrobenzene CAS No.:64182-61-2 Molecule Formula:C6H3ClFNO2 Molecule Weight:175.54 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

High Quality 2-Chloro-6-Fluoronitrobenzene on stock

Cas:64182-61-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

2-Chloro-6-fluoronitrobenzene Manufacturer/High quality/Best price/In stock CAS NO.64182-61-2

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Chloro-6-Fluoronitrobenzene cas no. 64182-61-2 98%

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Chloro-6-Fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Grams, Kilograms Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2-Chloro-6-fluoronitrobenzene cas 64182-61-2Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-Chloro-6-fluoronitrobenzene cas 64182-61-2

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Ansciep Chemical Co.,Ltd.

2-Chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-chloro-6-fluoronitrobenzene

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-Chloro-6-fluoronitrobenzene 64182-61-2

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Application:Medical or chemical

64182-61-2

Cas:64182-61-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-chloro-4-fluoro-3-nitrobenzoic acid

2-chloro-4-fluoro-3-nitrobenzoic acid

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

Conditions
ConditionsYield
With sulfolane; sodium hydrogencarbonate at 195℃; for 2h; Temperature; Reagent/catalyst;92%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline With tetrafluoroboric acid; sodium nitrite at 0℃; for 0.5h;
Stage #2: With copper; sodium nitrite at 20℃; for 1h; Further stages.;
44%
2-chloro-6-fluoroaniline hydrochloride
59772-34-8

2-chloro-6-fluoroaniline hydrochloride

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

aniline
62-53-3

aniline

(3-chloro-2-nitro-phenyl)-phenyl-amine

(3-chloro-2-nitro-phenyl)-phenyl-amine

Conditions
ConditionsYield
Stage #1: aniline With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 1-chloro-3-fluoro-2-nitrobenzene In tetrahydrofuran at -78 - 20℃;
Stage #3: With ammonium chloride In tetrahydrofuran; water
100%
With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 3h;
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

ethylamine
75-04-7

ethylamine

3-chloro-N-ethyl-2-nitroaniline

3-chloro-N-ethyl-2-nitroaniline

Conditions
ConditionsYield
at 40℃; for 16h;98%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

phenol
108-95-2

phenol

1-chloro-2-nitro-3-phenoxybenzene
104272-69-7

1-chloro-2-nitro-3-phenoxybenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃;98%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

2-nitro-3-chlorophenol
17802-02-7

2-nitro-3-chlorophenol

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 60℃; for 72h;97%
Stage #1: 1-chloro-3-fluoro-2-nitrobenzene With lithium hydroxide; water; dihydrogen peroxide In tetrahydrofuran at 60℃; for 72h; Sealed vessel;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=< 3;
97%
Stage #1: 1-chloro-3-fluoro-2-nitrobenzene With lithium hydroxide; water; dihydrogen peroxide In tetrahydrofuran at 60℃; for 72h; Sealed;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=< 3;
97%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

1-(tert-butoxycarbonyl)-4-aminopiperidine
87120-72-7

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-((3-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate

tert-butyl 4-((3-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;93%
With potassium carbonate In dimethyl sulfoxide at 20℃; Inert atmosphere;
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

1-(3-chloro-2-nitrophenyl)-2-methyl-1H-indole

1-(3-chloro-2-nitrophenyl)-2-methyl-1H-indole

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 20℃; for 4h;90%
1-[trans-4-(methyloxy)-1-methylcyclohexyl]-4-piperidinamine dihydrochloride

1-[trans-4-(methyloxy)-1-methylcyclohexyl]-4-piperidinamine dihydrochloride

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

N-(5-chloro-2-nitrophenyl)-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine
950773-08-7

N-(5-chloro-2-nitrophenyl)-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 110℃; for 1h; Microwave reactor;85%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

1-pentanamine
110-58-7

1-pentanamine

3-chloro-2-nitro-N-pentylaniline

3-chloro-2-nitro-N-pentylaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 60℃; for 12h;83%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

(2-chloro-6-fluoro-phenyl)-carbamic acid tert-butyl ester

(2-chloro-6-fluoro-phenyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With tin; ammonium chloride In methanol at 25℃; for 5h; Sonication;82%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(2-chloro-6-fluoro-phenyl)-carbamic acid ethyl ester

(2-chloro-6-fluoro-phenyl)-carbamic acid ethyl ester

Conditions
ConditionsYield
With tin; ammonium chloride In methanol at 25℃; for 3.5h; Sonication;80%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

4-methoxyphenylacetylen
768-60-5

4-methoxyphenylacetylen

1-chloro-3-[(4-methoxyphenyl)ethynyl]-2-nitrobenzene

1-chloro-3-[(4-methoxyphenyl)ethynyl]-2-nitrobenzene

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at 60℃;71%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

tri-n-butyl(vinyl)tin
7486-35-3

tri-n-butyl(vinyl)tin

1-fluoro-2-nitro-3-vinylbenzene
1112241-39-0

1-fluoro-2-nitro-3-vinylbenzene

Conditions
ConditionsYield
With bis(tri-t-butylphosphine)palladium(0); cesium fluoride In 1,4-dioxane at 100℃; for 26h;70.6%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid
76387-70-7

(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid

(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid
1584150-11-7

(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

Conditions
ConditionsYield
With potassium carbonate In ethanol at 80℃; for 9h; Inert atmosphere;62%
aminomethylphosphonic acid diethyl ester
50917-72-1

aminomethylphosphonic acid diethyl ester

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[(3-chloro-2-nitro-phenylamino)-methyl]-phosphonic acid diethyl ester
345203-15-8

[(3-chloro-2-nitro-phenylamino)-methyl]-phosphonic acid diethyl ester

Conditions
ConditionsYield
In toluene for 8h; Heating;45%
4-(1,3,4-oxadiazol-2-yl)-phenol
5378-27-8

4-(1,3,4-oxadiazol-2-yl)-phenol

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

2-(4-(3-chloro-2-nitrophenoxy)phenyl)-1,3,4-oxadiazole

2-(4-(3-chloro-2-nitrophenoxy)phenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
Stage #1: 4-(1,3,4-oxadiazol-2-yl)-phenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: 1-chloro-3-fluoro-2-nitrobenzene In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;
28%
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[(3-chloro-2-amino-phenylamino)-methyl]-phosphonic acid diethyl ester
345203-17-0

[(3-chloro-2-amino-phenylamino)-methyl]-phosphonic acid diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 45 percent / toluene / 8 h / Heating
2: 89 percent / H2 / Rh/C / ethanol / 24 h / 760.05 Torr
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[R(-)]-2-amino-3-[4-chloro-1-(diethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid
345203-21-6

[R(-)]-2-amino-3-[4-chloro-1-(diethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 45 percent / toluene / 8 h / Heating
2: 89 percent / H2 / Rh/C / ethanol / 24 h / 760.05 Torr
3: 61 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 0 °C
4: 51 percent / p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating
5: 94 percent / acetic acid; H2 / Pd/C / 4 h
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[R(-)]-2-amino-3-(4-chloro-1-phosphonomethyl-1H-benzoimidazol-2-yl)-propionic acid hydrochloride

[R(-)]-2-amino-3-(4-chloro-1-phosphonomethyl-1H-benzoimidazol-2-yl)-propionic acid hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 45 percent / toluene / 8 h / Heating
2: 89 percent / H2 / Rh/C / ethanol / 24 h / 760.05 Torr
3: 61 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 0 °C
4: 51 percent / p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating
5: 94 percent / acetic acid; H2 / Pd/C / 4 h
6: 39 percent / aq. HCl / 0.75 h / Heating
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[R(-)]-2-(benzyloxycarbonylamino)-3-[1-(4-chloro-1-diethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester
345203-19-2

[R(-)]-2-(benzyloxycarbonylamino)-3-[1-(4-chloro-1-diethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 45 percent / toluene / 8 h / Heating
2: 89 percent / H2 / Rh/C / ethanol / 24 h / 760.05 Torr
3: 61 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 0 °C
4: 51 percent / p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[R(-)]-2-benzyloxycarbonylamino-N-{2-chloro-6-[(diethoxy-phosphorylmethyl)-amino]-phenyl}-succinamic acid benzyl ester
345203-18-1

[R(-)]-2-benzyloxycarbonylamino-N-{2-chloro-6-[(diethoxy-phosphorylmethyl)-amino]-phenyl}-succinamic acid benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 45 percent / toluene / 8 h / Heating
2: 89 percent / H2 / Rh/C / ethanol / 24 h / 760.05 Torr
3: 61 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 0 °C
View Scheme
4-carbobenzoxypiperazine-2-carboxylic acid hydrochloride

4-carbobenzoxypiperazine-2-carboxylic acid hydrochloride

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

4-Carbobenzoxy-1-(3-Chloro-2-Nitrophenyl)Piperazine-2-Carboxylic Acid
64182-62-3

4-Carbobenzoxy-1-(3-Chloro-2-Nitrophenyl)Piperazine-2-Carboxylic Acid

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

C12H9ClN2O4S
1314092-10-8

C12H9ClN2O4S

Conditions
ConditionsYield
With triethylbutylammonium chloride; potassium hydroxide In N,N-dimethyl-formamide at 0 - 20℃;
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

(S)-1-(4-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethylamine
1393176-11-8

(S)-1-(4-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: ammonium chloride; iron / water; methanol / 3 h / Reflux
3.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: acetic acid / 18 h / 65 °C
5.1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

3-chloro-N1-phenyl-o-phenylenediamine
109174-62-1

3-chloro-N1-phenyl-o-phenylenediamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: ammonium chloride; iron / water; methanol / 3 h / Reflux
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[(S)-1-(2-chloro-6-phenylaminophenylcarbamoyl)ethyl]carbamic acid tert-butyl ester
1393176-12-9

[(S)-1-(2-chloro-6-phenylaminophenylcarbamoyl)ethyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: ammonium chloride; iron / water; methanol / 3 h / Reflux
3.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
1-chloro-3-fluoro-2-nitrobenzene
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

[(S)-1-(4-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester
1393176-13-0

[(S)-1-(4-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: ammonium chloride; iron / water; methanol / 3 h / Reflux
3.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: acetic acid / 18 h / 65 °C
View Scheme

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