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Yangzhou Qinyuan Pharmatech Co.,Ltd

3-Methyl-6-nitro-1H-indazole Cas no. 6494-19-5 Pazopanib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Pr

3-Methyl-6-nitro-1H-indazole

Cas:6494-19-5

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Methyl-6-nitroindazole Manufacturer/High quality/Best price/In stock

Cas:6494-19-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Methyl-6-Nitroindazole supplier in China

Cas:6494-19-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3-Methyl-6-Nitroindazole

Cas:6494-19-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Methyl-6-nitro-1H-indazole

Cas:6494-19-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

3-Methyl-6-nitroindole

Cas:6494-19-5

Min.Order:1 Kilogram

FOB Price: $0.6 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Methyl-6-Nitro-1h-Indazole CAS 6494-19-5

Cas:6494-19-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 6494-19-5 with competitive price

Cas:6494-19-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Methyl-6-nitroindazole 6494-19-5

Cas:6494-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:off-white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai

Poroduce/Synthesis 3-Methyl-6-nitroindazole 6494-19-5 99%

Cas:6494-19-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

3-Methyl-6-nitroindazole 6494-19-5

Cas:6494-19-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-METHYL-6-NITROINDAZOLE

Cas:6494-19-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Methyl-6-nitro-1H-indazole

Cas:6494-19-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3-methyl-6-nitro-1H-indazole

Cas:6494-19-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Methyl-6-nitroindazole/High quality/Best price

Cas:6494-19-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

lower price 6494-19-5 3-Methyl-6-nitroindazole manufacturerAppearance:white to light-brown powder Storage:ventilated dry place Package:according to customers' requirements Application:pharma intermediate Transportation:By air(EMS or EUB or FedEx or T

lower price 6494-19-5 3-Methyl-6-nitroindazole manufacturer

Cas:6494-19-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

3-Methyl-6-nitroindazole Basic information Product Name: 3-Methyl-6-nitroindazole Synonyms: 3-Methyl-6-nitro-1h-indazole 99%;1H-Indazole, 3-Methyl-6-nitro-;3-Methyl-6-Nitro-1H-;6-Nitro-3-Methylindazole;3-Methyl-6-nitro-1H-indazole≥ 99% (HPLC);

6494-19-5 3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Metric Ton

FOB Price: $1000.0 / 1800.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 3-Methyl-6-Nitro-1H-Indazole CAS No.: 6494-19-5 Molecule Formula:C8H7N3O2 Molecule Weight:177.16 Purity: 99.0% Package: 25kg/drum Description:Brown solid Manufacture Standards:Enterprise Standard TEST

Lower Price 3-Methyl-6-Nitro-1H-Indazole

Cas:6494-19-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3-Methyl-6-nitroindazole

Cas:6494-19-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

2-ethyl-5-nitroaniline
20191-74-6

2-ethyl-5-nitroaniline

3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
With acetic acid; isopentyl nitrite at 20℃; for 0.75h;98%
With tert.-butylnitrite In acetic acid at 20℃; for 0.75h; Inert atmosphere;98%
With tert.-butylnitrite; acetic acid for 0.5h;98%
diazotized 2-ethyl-5-nitro-aniline

diazotized 2-ethyl-5-nitro-aniline

3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
With acetic acid
ortho-ethylaniline
578-54-1

ortho-ethylaniline

3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C
2: acetic acid; isopentyl nitrite / 1.5 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / 0.5 h / 0 - 5 °C
2: tert.-butylnitrite; acetic acid / 0.5 h
View Scheme
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3-methyl-6-nitro-1-(toluene-4-sulfonyl)-1H-indazole
62271-21-0

3-methyl-6-nitro-1-(toluene-4-sulfonyl)-1H-indazole

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane at 20℃;100%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-methyl-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

3-methyl-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 12h;98%
With methanesulfonic acid In tetrahydrofuran at 80℃; for 8h; Inert atmosphere;74%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

2,3-dimethyl-6-amino-2H-indazole
444731-72-0

2,3-dimethyl-6-amino-2H-indazole

Conditions
ConditionsYield
With ammonium formate; palladium 10% on activated carbon In methanol; water at 25 - 30℃; for 6h;96.7%
Multi-step reaction with 2 steps
1: sulfuric acid / N,N-dimethyl-formamide; toluene / 3 h / Reflux
2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol
View Scheme
Multi-step reaction with 2 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 6 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C
View Scheme
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 3-methyl-6-nitro-1H-indazole-1-carboxylate
219507-74-1

tert-butyl 3-methyl-6-nitro-1H-indazole-1-carboxylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 192h;95%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;70.28%
With triethylamine; dmap In dichloromethane at 20℃; for 3h;
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-methyl-1H-indazol-6-amine
79173-62-9

3-methyl-1H-indazol-6-amine

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride In diethylene glycol dimethyl ether; water at 0 - 100℃; for 0.583333h;92%
With nickel Hydrogenation;
With hydrogenchloride; water; iron Hydrogenation;
With ammonium formate; iron In ethanol; water at 90℃; for 2h;
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 10h;
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-methyl-1H-indazol-6-amine hydrochloride

3-methyl-1H-indazol-6-amine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride In diethylene glycol dimethyl ether; water at 0 - 100℃; for 0.583333h; Cooling with ice; Inert atmosphere;92%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

methyl iodide
74-88-4

methyl iodide

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

Conditions
ConditionsYield
Stage #1: 3-methyl-6-nitro-1H-indazole With sodium In isopropyl alcohol for 3h; Reflux;
Stage #2: methyl iodide In isopropyl alcohol for 5h; Reflux;
87.6%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

2-fluoro-6-methoxybenzonitrile
94088-46-7

2-fluoro-6-methoxybenzonitrile

1-(2-cyano-3-methoxyphenyl)-3-methyl-6-nitroindazole

1-(2-cyano-3-methoxyphenyl)-3-methyl-6-nitroindazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h; Product distribution / selectivity;86.7%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

dimethyl sulfate
77-78-1

dimethyl sulfate

1,2,3-trimethyl-6-nitro-1H-indazol-2-ium perchlorate

1,2,3-trimethyl-6-nitro-1H-indazol-2-ium perchlorate

Conditions
ConditionsYield
Stage #1: 3-methyl-6-nitro-1H-indazole; dimethyl sulfate In toluene for 48h; Reflux;
Stage #2: With sodium perchlorate In water
86%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

2-bromo-6-methoxybenzoic acid
31786-45-5

2-bromo-6-methoxybenzoic acid

1-(2-carboxy-3-methoxy)phenyl-3-methyl-6-nitro-1H-indazole
126955-75-7

1-(2-carboxy-3-methoxy)phenyl-3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;84%
With hydrogenchloride; potassium carbonate In water; nitrobenzene7.45 g (75.9%)
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

trimethoxonium tetrafluoroborate
420-37-1

trimethoxonium tetrafluoroborate

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

Conditions
ConditionsYield
In ethyl acetate at 25 - 30℃; for 20h;82.4%
In acetone at 20℃; for 3h; Product distribution / selectivity;73%
In acetone at 20℃; for 3h;73%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

Conditions
ConditionsYield
Stage #1: 3-methyl-6-nitro-1H-indazole With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: carbonic acid dimethyl ester In N,N-dimethyl-formamide for 6h; Reflux;
81.1%
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide; isopropyl alcohol at 70℃; for 20h; Concentration; Reagent/catalyst; Temperature; Solvent;70.6%
With sodium hydride for 5h; Reflux;
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

dimethyl sulfate
77-78-1

dimethyl sulfate

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

Conditions
ConditionsYield
With sulfuric acid In dimethyl sulfoxide at 50℃; for 72h; Product distribution / selectivity;70%
With sulfuric acid In dimethyl sulfoxide at 50℃; for 72h;70%
With sulfuric acid In dimethyl sulfoxide at 50℃; for 72h; Product distribution / selectivity;70%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

trimethyl orthoformate
149-73-5

trimethyl orthoformate

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

Conditions
ConditionsYield
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In dichloromethane at -30 - 0℃; for 0.25h;
Stage #2: 3-methyl-6-nitro-1H-indazole In dichloromethane at 20℃; for 17h;
65%
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In dichloromethane at -30 - 0℃; for 0.25h;
Stage #2: 3-methyl-6-nitro-1H-indazole In dichloromethane at -70 - 20℃; for 17.25h;
Stage #3: With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity;
65%
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In dichloromethane at -30 - 0℃; for 0.283333h;
Stage #2: 3-methyl-6-nitro-1H-indazole In dichloromethane at -70 - 20℃; for 17.25h; Product distribution / selectivity;
65%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

Conditions
ConditionsYield
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In dichloromethane at -70 - 0℃; for 0.25h;
Stage #2: 3-methyl-6-nitro-1H-indazole In dichloromethane at -70 - 20℃; for 17.25h; Product distribution / selectivity;
65%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

A

2,3‑dimethyl‑6‑nitro‑2H‑indazole
444731-73-1

2,3‑dimethyl‑6‑nitro‑2H‑indazole

B

1,3-dimethyl-6-nitro-1H-indazole

1,3-dimethyl-6-nitro-1H-indazole

Conditions
ConditionsYield
Stage #1: 3-methyl-6-nitro-1H-indazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.75h;
Stage #2: carbonic acid dimethyl ester In N,N-dimethyl-formamide at 120℃; for 5h;
A 61%
B 33%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

1-(2-cyano-3-fluorophenyl)-3-methyl-6-nitroindazole
786658-39-7

1-(2-cyano-3-fluorophenyl)-3-methyl-6-nitroindazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 5h;32.5%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

ethanol
64-17-5

ethanol

1-(1-ethoxyethyl)-3-methyl-6-nitro-1H-indazole

1-(1-ethoxyethyl)-3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
With tert.-butylhydroperoxide In decane at 120℃; for 12h; Schlenk technique; Sealed tube;20%
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-methyl-6-nitro-1(2)H-indazol-7-ylamine
99584-38-0

3-methyl-6-nitro-1(2)H-indazol-7-ylamine

Conditions
ConditionsYield
With hydrogenchloride; propan-1-ol; sodium hydroxide; hydroxylamine
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

5-methyl-3-phenylisoxazole-4-carbonyl chloride
16883-16-2

5-methyl-3-phenylisoxazole-4-carbonyl chloride

3-methyl-1-(5-methyl-3-phenyl-isoxazole-4-carbonyl)-6-nitro-1H-indazole
62235-34-1

3-methyl-1-(5-methyl-3-phenyl-isoxazole-4-carbonyl)-6-nitro-1H-indazole

Conditions
ConditionsYield
With triethylamine In benzene
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-methyl-5-phenylisoxazole-4-carbonyl chloride
91182-77-3

3-methyl-5-phenylisoxazole-4-carbonyl chloride

3-methyl-1-(3-methyl-5-phenyl-isoxazole-4-carbonyl)-6-nitro-1H-indazole
62235-33-0

3-methyl-1-(3-methyl-5-phenyl-isoxazole-4-carbonyl)-6-nitro-1H-indazole

Conditions
ConditionsYield
With triethylamine In benzene
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
25629-50-9

3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl chloride

1-[3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-3-methyl-6-nitro-1H-indazole
62235-35-2

1-[3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
With triethylamine In benzene
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride
4462-55-9

3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride

1-[3-(2,6-dichloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-3-methyl-6-nitro-1H-indazole
62235-36-3

1-[3-(2,6-dichloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-3-methyl-6-nitro-1H-indazole

Conditions
ConditionsYield
With triethylamine In benzene
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

5-bromo-7-hydroxy-2-methyl-6H-pyrazolo<4,5,1-de>acridin-6-one
142854-00-0

5-bromo-7-hydroxy-2-methyl-6H-pyrazolo<4,5,1-de>acridin-6-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 84 percent / K2CO3, CuI / dimethylformamide / 6 h / 100 °C
2: 88 percent / NH2NH2*H2O / 10percent Pd-C / H2O; ethanol / 2 h / Heating
3: 47percent aq. HBr, NaNO2 / methanol
4: 47percent HBr, CuBr / methanol
5: NaOMe / methanol; H2O
6: CF3SO3H / 4 h / 100 °C
View Scheme
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

5-bromo-7-methoxy-2-methyl-6H-pyrazolo<4,5,1-de>acridin-6-one
142853-99-4

5-bromo-7-methoxy-2-methyl-6H-pyrazolo<4,5,1-de>acridin-6-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 84 percent / K2CO3, CuI / dimethylformamide / 6 h / 100 °C
2: 88 percent / NH2NH2*H2O / 10percent Pd-C / H2O; ethanol / 2 h / Heating
3: 47percent aq. HBr, NaNO2 / methanol
4: 47percent HBr, CuBr / methanol
5: NaOMe / methanol; H2O
6: CF3SO3H / 4 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1: 84 percent / K2CO3, CuI / dimethylformamide / 6 h / 100 °C
2: 88 percent / NH2NH2*H2O / 10percent Pd-C / H2O; ethanol / 2 h / Heating
3: 47percent aq. HBr, NaNO2 / methanol
4: 47percent HBr, CuBr / methanol
5: NaOMe / methanol; H2O
6: 1.) CF3SO3H; 2.) K2CO3 / 1.) 100 deg C, 4 h; 2.) acetone, 10 h, reflux
View Scheme
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

2-(6-Bromo-3-methyl-indazol-1-yl)-6-methoxy-benzoic acid
791559-34-7

2-(6-Bromo-3-methyl-indazol-1-yl)-6-methoxy-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 84 percent / K2CO3, CuI / dimethylformamide / 6 h / 100 °C
2: 88 percent / NH2NH2*H2O / 10percent Pd-C / H2O; ethanol / 2 h / Heating
3: 47percent aq. HBr, NaNO2 / methanol
4: 47percent HBr, CuBr / methanol
View Scheme
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

6-amino-1-(2-carboxy-3-methoxyphenyl)-3-methylindazole
142854-09-9

6-amino-1-(2-carboxy-3-methoxyphenyl)-3-methylindazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / K2CO3, CuI / dimethylformamide / 6 h / 100 °C
2: 88 percent / NH2NH2*H2O / 10percent Pd-C / H2O; ethanol / 2 h / Heating
View Scheme
3-methyl-6-nitro-1H-indazole
6494-19-5

3-methyl-6-nitro-1H-indazole

6-bromo-1-(2-carboxy-3-methoxy)phenyl-3-methyl-1H-indazole sodium salt

6-bromo-1-(2-carboxy-3-methoxy)phenyl-3-methyl-1H-indazole sodium salt

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 84 percent / K2CO3, CuI / dimethylformamide / 6 h / 100 °C
2: 88 percent / NH2NH2*H2O / 10percent Pd-C / H2O; ethanol / 2 h / Heating
3: 47percent aq. HBr, NaNO2 / methanol
4: 47percent HBr, CuBr / methanol
5: NaOMe / methanol; H2O
View Scheme

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