Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma
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inquiryMullein Extract Product Name: Verbascum Thapsus Extract Latin Name: Verbascum thapsus L. Plant source: The Dry Fleshy stem of Verbascum thapsus L. Ratio Extract: 10:1 20:1 CAS NO . : 61276-17-3 Mullein or Ver
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryHigh Quality 66575-29-9 98% Forskolin 66575-29-9 Top quality Forskolin Forskolin acts as an adenylyl cyclase activator. It is used in the treatment of hypertension, asthma, eczema, psoriasis, congestive heart failure, angina, stomachache, gastric an
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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inquiryForskolin CAS:66575-29-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1.Free sample(10-20g or enough to detection) and Unconditional assume respons 2.100% Natural porduct, without any synthetize ingredient 3.Manufacturer direct supply, provide OEM, R&D service 4.ISO/HACCP/KOSHER/GMP/FDA 5.Leading plant ex
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inquiryShanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye
Cas:66575-29-9
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inquiryProduct Detail Minimum Order Qty. 10 Gram
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryChengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
We are leading fine chemicals supplier in China and Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Flu
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle
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inquiryConditions | Yield |
---|---|
In pyridine at 0℃; for 18h; | 100% |
With pyridine at 0 - 20℃; for 18h; | 100% |
With pyridine at 0℃; for 20h; | 83% |
(13R)-Spiroforskolin
forskolin
Conditions | Yield |
---|---|
In methanol for 96h; |
7-deacetyl forskolin
acetyl chloride
A
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(acetyloxy)-3-ethenyldodecahydro-5,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
B
forskolin
Conditions | Yield |
---|---|
With diisopropylamine In toluene for 3h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 3h; Ambient temperature; Yield given. Yields of byproduct given; |
(1S,6S,12S,16S,2R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.0.2,607,12]heptadecan-11-one
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 2: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 3: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 4: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 5: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 6: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(2S,7S,13S,14S,6R,9R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,607,12]heptadec-11-one
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 2: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 3: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 4: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(1S,6S,12S,16S,2R,11R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11-ol
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 2: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 3: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 4: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 5: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 6: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 7: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(1S,6S,11S,12S,2R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11-ol
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 2: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 3: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 4: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 5: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(1S,6S,11S,12S,2R,16R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.02,607,12]heptadec-13-en-11-ol
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 2: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 3: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(6S,11S,16S,1R,2R,12R,13R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11,13-diol
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 2: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(1S,7S,9S,3R,5R,8R,14R)-14-acetyloxy-8,9-dihydroxy-1,5,7,11,11-pentamethyl-6-oxa-5-vinyltricyclo[8.4.0.02,7]tetradec-3-yl acetate
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C 2: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C 3: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C 4: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C 5: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 6: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 7: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 8: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 9: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 10: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 11: 100 percent / pyridine / 18 h / 0 °C View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 100 percent / potassium hydroxide / methanol / 13.5 h / 20 °C 2: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C 3: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C 4: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C 5: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C 6: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 7: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 8: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 9: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 10: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 11: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 12: 100 percent / pyridine / 18 h / 0 °C View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 89 percent / potassium hydroxide / methanol / 13.5 h / 20 °C 2: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C 3: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C 4: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C 5: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C 6: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 7: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 8: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 9: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 10: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 11: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 12: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(2S,7S,13S,6R,9R,14R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,6.07,12]heptadecan-11-one
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C 2: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 3: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 4: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 5: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 6: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 7: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 8: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(1S,6S,12S,2R,11R,14R,16R)-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.02,6.07,12]heptadecane-11,14-diol
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C 2: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C 3: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 4: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 5: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 6: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 7: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 8: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 9: 100 percent / pyridine / 18 h / 0 °C View Scheme |
(2S,7S,13S,6R,9R,11R,14R)-14-acetyloxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,6.07,12]heptadec-11-yl acetate
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C 2: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C 3: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C 4: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C 5: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C 6: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C 7: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C 8: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C 9: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C 10: 100 percent / pyridine / 18 h / 0 °C View Scheme |
rac-5α<<(tert-Butyl)dimethylsilyl>oxy>-4β-ethinyl-1,4,4a,5,6,7,8,8aα-octahydro-4-hydroxy-3,4aα,8,8-tetramethylnaphthalin-1(4H)-on
B
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C 2.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C 3.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve 4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 5.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 6.1: triethylamine / chloroform / 1 h / 23 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 8.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 9.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 10.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 11.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 12.1: n-butyllithium / hexane / 0.5 h / 23 °C 12.2: 1.17 h / -78 - -30 °C 13.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 14.1: pyridine / 20 h / 0 °C 15.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
rac-5α<<(tert-Butyl)dimethylsilyl>oxy>-4β-ethinyl-1,4,4a,5,6,7,8,8aα-octahydro-4-hydroxy-3,4aα,8,8-tetramethylnaphthalin-1(4H)-on
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 17 steps 1.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C 2.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C 3.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve 4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 5.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 6.1: triethylamine / chloroform / 1 h / 23 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 8.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 9.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 10.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 11.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 12.1: n-butyllithium / hexane / 0.5 h / 23 °C 12.2: 1.17 h / -78 - -30 °C 13.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 14.1: pyridine / 20 h / 0 °C 15.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 16.1: potassium carbonate / methanol; water / 6 h / 23 °C 17.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C 2.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve 3.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 4.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 5.1: triethylamine / chloroform / 1 h / 23 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 7.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 8.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 9.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 10.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 11.1: n-butyllithium / hexane / 0.5 h / 23 °C 11.2: 1.17 h / -78 - -30 °C 12.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 13.1: pyridine / 20 h / 0 °C 14.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 16 steps 1.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C 2.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve 3.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 4.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 5.1: triethylamine / chloroform / 1 h / 23 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 7.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 8.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 9.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 10.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 11.1: n-butyllithium / hexane / 0.5 h / 23 °C 11.2: 1.17 h / -78 - -30 °C 12.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 13.1: pyridine / 20 h / 0 °C 14.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 15.1: potassium carbonate / methanol; water / 6 h / 23 °C 16.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve 2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 3.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 4.1: triethylamine / chloroform / 1 h / 23 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 6.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 7.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 8.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 9.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 10.1: n-butyllithium / hexane / 0.5 h / 23 °C 10.2: 1.17 h / -78 - -30 °C 11.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 12.1: pyridine / 20 h / 0 °C 13.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve 2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 3.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 4.1: triethylamine / chloroform / 1 h / 23 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 6.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 7.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 8.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 9.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 10.1: n-butyllithium / hexane / 0.5 h / 23 °C 10.2: 1.17 h / -78 - -30 °C 11.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 12.1: pyridine / 20 h / 0 °C 13.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 14.1: potassium carbonate / methanol; water / 6 h / 23 °C 15.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 2.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 3.1: triethylamine / chloroform / 1 h / 23 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 5.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 6.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 7.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 8.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 9.1: n-butyllithium / hexane / 0.5 h / 23 °C 9.2: 1.17 h / -78 - -30 °C 10.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 11.1: pyridine / 20 h / 0 °C 12.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C 2.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 3.1: triethylamine / chloroform / 1 h / 23 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 5.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 6.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 7.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 8.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 9.1: n-butyllithium / hexane / 0.5 h / 23 °C 9.2: 1.17 h / -78 - -30 °C 10.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 11.1: pyridine / 20 h / 0 °C 12.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 13.1: potassium carbonate / methanol; water / 6 h / 23 °C 14.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 2.1: triethylamine / chloroform / 1 h / 23 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 4.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 5.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 6.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 7.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 8.1: n-butyllithium / hexane / 0.5 h / 23 °C 8.2: 1.17 h / -78 - -30 °C 9.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 10.1: pyridine / 20 h / 0 °C 11.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C 2.1: triethylamine / chloroform / 1 h / 23 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 4.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 5.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 6.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 7.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 8.1: n-butyllithium / hexane / 0.5 h / 23 °C 8.2: 1.17 h / -78 - -30 °C 9.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 10.1: pyridine / 20 h / 0 °C 11.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 12.1: potassium carbonate / methanol; water / 6 h / 23 °C 13.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: triethylamine / chloroform / 1 h / 23 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 3.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 4.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 5.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 6.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 7.1: n-butyllithium / hexane / 0.5 h / 23 °C 7.2: 1.17 h / -78 - -30 °C 8.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 9.1: pyridine / 20 h / 0 °C 10.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: triethylamine / chloroform / 1 h / 23 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 3.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 4.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 5.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 6.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 7.1: n-butyllithium / hexane / 0.5 h / 23 °C 7.2: 1.17 h / -78 - -30 °C 8.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 9.1: pyridine / 20 h / 0 °C 10.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 11.1: potassium carbonate / methanol; water / 6 h / 23 °C 12.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 2.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 3.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 4.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 5.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 6.1: n-butyllithium / hexane / 0.5 h / 23 °C 6.2: 1.17 h / -78 - -30 °C 7.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 8.1: pyridine / 20 h / 0 °C 9.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate View Scheme |
forskolin
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve 2.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C 3.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C 4.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique 5.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C 6.1: n-butyllithium / hexane / 0.5 h / 23 °C 6.2: 1.17 h / -78 - -30 °C 7.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C 8.1: pyridine / 20 h / 0 °C 9.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C 10.1: potassium carbonate / methanol; water / 6 h / 23 °C 11.1: pyridine / 20 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; for 4h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 22℃; for 2h; Inert atmosphere; | 92% |
With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane at 80 - 85℃; for 2h; | 77% |
p-methoxybenzyloxy acetic acid
forskolin
7β-acetoxy-6β,9α-dihydroxy-8,13-epoxy-1α-<(4-methoxybenzyloxy)acetoxy>labd-14-en-11-one
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In ethyl acetate for 3h; Ambient temperature; | 92% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In acetone at 0 - 20℃; for 6h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With 4-tert-Butylcatechol; sodium hydrogencarbonate In dichloromethane; benzene at 20℃; for 3h; Darkness; | 91% |
forskolin
14,15-dihydroforskolin
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; | 90% |
palladium-carbon In methanol |
forskolin
1-deoxy-1-oxoforskolin
Conditions | Yield |
---|---|
With 4-methyl-morpholine; 6C13H13P*4CF3O3S(1-)*2Ru(2+); acetone at 65℃; for 3h; Inert atmosphere; Sealed tube; | 88% |
With Collins oxidation agent In dichloromethane for 2.5h; | 1.2 g |
Conditions | Yield |
---|---|
With ammonium cerium (IV) nitrate In acetonitrile at 20℃; for 24h; Inert atmosphere; regioselective reaction; | 87% |
Conditions | Yield |
---|---|
With pyridine In toluene at 0 - 20℃; for 4.5h; | 86% |
With pyridine In toluene at 0℃; for 1h; | 1.22 g |
forskolin
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 16h; | 82.3% |
forskolin
7-deacetyl forskolin
Conditions | Yield |
---|---|
With ethylenediamine In methanol for 0.0833333h; Microwave irradiation; | 80% |
With sodium hydroxide In methanol; water | |
With potassium carbonate In methanol at 25℃; for 0.75h; | |
With water first-order plots of degradation in water and phosphate buffer (pH 6.0-8.0); | |
In methanol; potassium carbonate |
forskolin
tert-butyldimethylsilyl chloride
7β-acetoxy-1α-<(tert-butyldimethylsilyl)oxy>-6β,9α-dihydroxy-8,13-epoxylabd-14-en-11-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 70℃; for 22h; | 80% |
forskolin
Conditions | Yield |
---|---|
With Amberlist-15 wet In 1,2-dichloro-ethane at 20℃; for 24h; | 75% |
Conditions | Yield |
---|---|
With aluminium trichloride In diethyl ether for 0.3h; Ambient temperature; | 74% |
Conditions | Yield |
---|---|
With pyridine Ambient temperature; | 72% |
forskolin
acetyl chloride
Acetic acid (3S,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-3-ethyl-6,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-benzo[f]chromen-10-yl ester
Conditions | Yield |
---|---|
With pyridine Ambient temperature; | 72% |
Conditions | Yield |
---|---|
With 4-tert-Butylcatechol; sodium hydrogencarbonate In dichloromethane; benzene at 20℃; for 3h; Darkness; | 63% |
Conditions | Yield |
---|---|
With pyridine Ambient temperature; | 55% |
Conditions | Yield |
---|---|
With pyridine Ambient temperature; | 55% |
forskolin
forskolin-14,15-dibromide
Conditions | Yield |
---|---|
With bromine In carbon disulfide at 0 - 20℃; for 2.75h; | 50% |
Conditions | Yield |
---|---|
In toluene for 20h; Heating; | 48% |
forskolin
Conditions | Yield |
---|---|
47% |
forskolin
(13R)-Spiroforskolin
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In benzene at 0 - 5℃; | 45% |
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 36h; Ambient temperature; | 45% |
forskolin
A
7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclo-α-phosphite
B
7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclo-β-phosphite
Conditions | Yield |
---|---|
With pyridine; bis(trifluoroethyl)hydrogen phosphite for 16h; Ambient temperature; | A 39% B 13% |
forskolin
propargyl bromide
A
1-O-propargyl-forskolin
B
1-O-propargyl-6-O-acetyl-7-deacetyl-forskolin
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetone at 20℃; Reflux; | A 36% B 35% |
With potassium carbonate; potassium iodide In acetone for 24h; Reflux; | A 1.8 g B 1.7 g |
forskolin
A
7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclophospho-α-chloridate
B
7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclophospho-β-chloridate
Conditions | Yield |
---|---|
With pyridine; triethylamine; trichlorophosphate In diethyl ether 1) -10 deg C, 1 h, 2) RT, 60 h; other substrate, various phosphorylating agents; | A 33% B 12% |
With pyridine; triethylamine; trichlorophosphate In diethyl ether 1) -10 deg C, 1 h, 2) RT, 60 h; | A 33% B 12% |
forskolin
3,5-dinitrobenoyl chloride
Conditions | Yield |
---|---|
With pyridine at 20℃; for 1.5h; | 31% |
forskolin
7β-acetoxy-8,13-epoxy-6β,9α-dihydroxy-11-oxolabd-14-en-1α-yl dihydrogen phosphate
Conditions | Yield |
---|---|
With dihydro-(1,2-dibromo-2-phenyl-1-ethyl)phosphonic acid; N-ethyl-N,N-diisopropylamine In dichloromethane for 48h; Ambient temperature; | 30% |
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