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Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Quality Manufacturer Supply High Purity Forskolin 66575-29-9 with Reasonable Price

Cas:66575-29-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

Mullein Extract Product Name: Verbascum Thapsus Extract Latin Name: Verbascum thapsus L. Plant source: The Dry Fleshy stem of Verbascum thapsus L. Ratio Extract: 10:1 20:1 CAS NO . : 61276-17-3 Mullein or Ver

Verbascum Thapsus Extract/Mullein Extract

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $20.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality forskolin supplier in China

Cas:66575-29-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Xi'an Quanao Biotech Co., Ltd.

High Quality 66575-29-9 98% Forskolin 66575-29-9 Top quality Forskolin Forskolin acts as an adenylyl cyclase activator. It is used in the treatment of hypertension, asthma, eczema, psoriasis, congestive heart failure, angina, stomachache, gastric an

High Quality 66575-29-9 98% Forskolin 66575-29-9 Top quality Forskolin

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 161.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply forskolin

Cas:66575-29-9

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Forskolin 66575-29-9 GMP Manufacturer

Cas:66575-29-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Forskolin

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Forskolin

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 66575-29-9 with best quality

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

FORSKOLIN CAS66575-29-9

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

Forskolin CAS:66575-29-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Forskolin CAS:66575-29-9

Cas:66575-29-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Guangdong Juda Chemical Industrial Co.,Limited

1.Free sample(10-20g or enough to detection) and Unconditional assume respons 2.100% Natural porduct, without any synthetize ingredient 3.Manufacturer direct supply, provide OEM, R&D service 4.ISO/HACCP/KOSHER/GMP/FDA 5.Leading plant ex

CAS No.66575-29-9 FORSKOLIN

Cas:66575-29-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Coleus Forskohlii Extract 10%-20% Forskohlin

Cas:66575-29-9

Min.Order:25 Kilogram

FOB Price: $130.0 / 235.0

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Coleus Forskohlii Extract Forskolin 10%-98%

Cas:66575-29-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

FORSKOLIN

Cas:66575-29-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Forskolin

Cas:66575-29-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Forskolin

Cas:66575-29-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Natural Forskolin from Verbascum Thapsus Extract

Cas:66575-29-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality forskolin

Cas:66575-29-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Forskolin

Cas:66575-29-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Flu

FORSKOLINCAS NO.: 66575-29-9

Cas:66575-29-9

Min.Order:1 Gram

FOB Price: $9.0 / 10.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Forskolin

Cas:66575-29-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Forskolin.99%

Cas:66575-29-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

7-deacetyl forskolin
64657-20-1

7-deacetyl forskolin

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
In pyridine at 0℃; for 18h;100%
With pyridine at 0 - 20℃; for 18h;100%
With pyridine at 0℃; for 20h;83%
(13R)-Spiroforskolin
220423-84-7

(13R)-Spiroforskolin

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
In methanol for 96h;
7-deacetyl forskolin
64657-20-1

7-deacetyl forskolin

acetyl chloride
75-36-5

acetyl chloride

A

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(acetyloxy)-3-ethenyldodecahydro-5,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
64657-21-2

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(acetyloxy)-3-ethenyldodecahydro-5,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

B

forskolin
66575-29-9

forskolin

C

1-acetyl-7-deacetylforskolin

1-acetyl-7-deacetylforskolin

Conditions
ConditionsYield
With diisopropylamine In toluene for 3h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 3h; Ambient temperature; Yield given. Yields of byproduct given;
(1S,6S,12S,16S,2R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.0.2,607,12]heptadecan-11-one
898546-13-9

(1S,6S,12S,16S,2R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.0.2,607,12]heptadecan-11-one

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
2: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
3: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
4: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
5: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
6: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(2S,7S,13S,14S,6R,9R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,607,12]heptadec-11-one
93108-68-0

(2S,7S,13S,14S,6R,9R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,607,12]heptadec-11-one

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
2: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
3: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
4: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(1S,6S,12S,16S,2R,11R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11-ol
898546-12-8

(1S,6S,12S,16S,2R,11R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11-ol

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
2: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
3: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
4: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
5: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
6: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
7: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(1S,6S,11S,12S,2R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11-ol
115155-11-8

(1S,6S,11S,12S,2R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11-ol

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
2: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
3: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
4: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
5: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(1S,6S,11S,12S,2R,16R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.02,607,12]heptadec-13-en-11-ol
115155-09-4

(1S,6S,11S,12S,2R,16R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.02,607,12]heptadec-13-en-11-ol

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
2: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
3: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(6S,11S,16S,1R,2R,12R,13R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11,13-diol
898546-14-0

(6S,11S,16S,1R,2R,12R,13R)-14-methoxy-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.0.2,607,12]heptadec-14-en-11,13-diol

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
2: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(1S,7S,9S,3R,5R,8R,14R)-14-acetyloxy-8,9-dihydroxy-1,5,7,11,11-pentamethyl-6-oxa-5-vinyltricyclo[8.4.0.02,7]tetradec-3-yl acetate
157201-96-2

(1S,7S,9S,3R,5R,8R,14R)-14-acetyloxy-8,9-dihydroxy-1,5,7,11,11-pentamethyl-6-oxa-5-vinyltricyclo[8.4.0.02,7]tetradec-3-yl acetate

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C
2: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C
3: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C
4: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C
5: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
6: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
7: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
8: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
9: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
10: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
11: 100 percent / pyridine / 18 h / 0 °C
View Scheme
ptychantin A

ptychantin A

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 100 percent / potassium hydroxide / methanol / 13.5 h / 20 °C
2: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C
3: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C
4: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C
5: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C
6: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
7: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
8: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
9: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
10: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
11: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
12: 100 percent / pyridine / 18 h / 0 °C
View Scheme
ptychantin B

ptychantin B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 89 percent / potassium hydroxide / methanol / 13.5 h / 20 °C
2: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C
3: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C
4: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C
5: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C
6: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
7: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
8: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
9: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
10: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
11: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
12: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(2S,7S,13S,6R,9R,14R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,6.07,12]heptadecan-11-one
537038-62-3

(2S,7S,13S,6R,9R,14R)-14-hydroxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,6.07,12]heptadecan-11-one

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C
2: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
3: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
4: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
5: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
6: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
7: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
8: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(1S,6S,12S,2R,11R,14R,16R)-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.02,6.07,12]heptadecane-11,14-diol
536742-35-5

(1S,6S,12S,2R,11R,14R,16R)-1,4,4,8,8,12,16-heptamethyl-3,5,17-trioxa-16-vinyltetracyclo[11.4.0.02,6.07,12]heptadecane-11,14-diol

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C
2: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C
3: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
4: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
5: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
6: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
7: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
8: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
9: 100 percent / pyridine / 18 h / 0 °C
View Scheme
(2S,7S,13S,6R,9R,11R,14R)-14-acetyloxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,6.07,12]heptadec-11-yl acetate
536742-34-4

(2S,7S,13S,6R,9R,11R,14R)-14-acetyloxy-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,6.07,12]heptadec-11-yl acetate

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C
2: 89 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C
3: 54 percent / potassium hydride / tetrahydrofuran / 0.5 h / 0 °C
4: 80 percent / pyridine; chromium oxide / CH2Cl2 / 24 h / 20 °C
5: 100 percent / sodium / 2-methyl-propan-2-ol / 29 h / 30 °C
6: 100 percent / aqueous hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
7: 96 percent / potassium hydride / tetrahydrofuran / 0.13 h / 20 °C
8: 61 percent / potassium carbonate; m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / 0 °C
9: 59 percent / perchloric acid / tetrahydrofuran / 264 h / 20 °C
10: 100 percent / pyridine / 18 h / 0 °C
View Scheme
rac-5α<<(tert-Butyl)dimethylsilyl>oxy>-4β-ethinyl-1,4,4a,5,6,7,8,8aα-octahydro-4-hydroxy-3,4aα,8,8-tetramethylnaphthalin-1(4H)-on
123218-03-1, 123218-04-2

rac-5α<<(tert-Butyl)dimethylsilyl>oxy>-4β-ethinyl-1,4,4a,5,6,7,8,8aα-octahydro-4-hydroxy-3,4aα,8,8-tetramethylnaphthalin-1(4H)-on

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C
2.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C
3.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve
4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
5.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
6.1: triethylamine / chloroform / 1 h / 23 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
8.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
9.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
10.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
11.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
12.1: n-butyllithium / hexane / 0.5 h / 23 °C
12.2: 1.17 h / -78 - -30 °C
13.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
14.1: pyridine / 20 h / 0 °C
15.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
rac-5α<<(tert-Butyl)dimethylsilyl>oxy>-4β-ethinyl-1,4,4a,5,6,7,8,8aα-octahydro-4-hydroxy-3,4aα,8,8-tetramethylnaphthalin-1(4H)-on
123218-03-1, 123218-04-2

rac-5α<<(tert-Butyl)dimethylsilyl>oxy>-4β-ethinyl-1,4,4a,5,6,7,8,8aα-octahydro-4-hydroxy-3,4aα,8,8-tetramethylnaphthalin-1(4H)-on

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 17 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C
2.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C
3.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve
4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
5.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
6.1: triethylamine / chloroform / 1 h / 23 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
8.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
9.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
10.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
11.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
12.1: n-butyllithium / hexane / 0.5 h / 23 °C
12.2: 1.17 h / -78 - -30 °C
13.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
14.1: pyridine / 20 h / 0 °C
15.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
16.1: potassium carbonate / methanol; water / 6 h / 23 °C
17.1: pyridine / 20 h / 0 °C
View Scheme
C22H38O3Si

C22H38O3Si

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C
2.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve
3.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
4.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
5.1: triethylamine / chloroform / 1 h / 23 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
7.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
8.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
9.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
10.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
11.1: n-butyllithium / hexane / 0.5 h / 23 °C
11.2: 1.17 h / -78 - -30 °C
12.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
13.1: pyridine / 20 h / 0 °C
14.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
C22H38O3Si

C22H38O3Si

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 16 steps
1.1: dmap / N,N-dimethyl-formamide / 13 h / 65 °C
2.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve
3.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
4.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
5.1: triethylamine / chloroform / 1 h / 23 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
7.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
8.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
9.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
10.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
11.1: n-butyllithium / hexane / 0.5 h / 23 °C
11.2: 1.17 h / -78 - -30 °C
12.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
13.1: pyridine / 20 h / 0 °C
14.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
15.1: potassium carbonate / methanol; water / 6 h / 23 °C
16.1: pyridine / 20 h / 0 °C
View Scheme
C29H42O4Si

C29H42O4Si

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve
2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
3.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
4.1: triethylamine / chloroform / 1 h / 23 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
6.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
7.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
8.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
9.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
10.1: n-butyllithium / hexane / 0.5 h / 23 °C
10.2: 1.17 h / -78 - -30 °C
11.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
12.1: pyridine / 20 h / 0 °C
13.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
C29H42O4Si

C29H42O4Si

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 72 h / 30 °C / Molecular sieve
2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
3.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
4.1: triethylamine / chloroform / 1 h / 23 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
6.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
7.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
8.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
9.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
10.1: n-butyllithium / hexane / 0.5 h / 23 °C
10.2: 1.17 h / -78 - -30 °C
11.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
12.1: pyridine / 20 h / 0 °C
13.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
14.1: potassium carbonate / methanol; water / 6 h / 23 °C
15.1: pyridine / 20 h / 0 °C
View Scheme
C29H40O4Si

C29H40O4Si

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
2.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
3.1: triethylamine / chloroform / 1 h / 23 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
5.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
6.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
7.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
8.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
9.1: n-butyllithium / hexane / 0.5 h / 23 °C
9.2: 1.17 h / -78 - -30 °C
10.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
11.1: pyridine / 20 h / 0 °C
12.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
C29H40O4Si

C29H40O4Si

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
2.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
3.1: triethylamine / chloroform / 1 h / 23 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
5.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
6.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
7.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
8.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
9.1: n-butyllithium / hexane / 0.5 h / 23 °C
9.2: 1.17 h / -78 - -30 °C
10.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
11.1: pyridine / 20 h / 0 °C
12.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
13.1: potassium carbonate / methanol; water / 6 h / 23 °C
14.1: pyridine / 20 h / 0 °C
View Scheme
C22H38O3Si

C22H38O3Si

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
2.1: triethylamine / chloroform / 1 h / 23 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
4.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
5.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
6.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
7.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
8.1: n-butyllithium / hexane / 0.5 h / 23 °C
8.2: 1.17 h / -78 - -30 °C
9.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
10.1: pyridine / 20 h / 0 °C
11.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
C22H38O3Si

C22H38O3Si

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: pyridinium p-toluenesulfonate / dichloromethane / 0.25 h / 23 °C
2.1: triethylamine / chloroform / 1 h / 23 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
4.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
5.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
6.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
7.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
8.1: n-butyllithium / hexane / 0.5 h / 23 °C
8.2: 1.17 h / -78 - -30 °C
9.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
10.1: pyridine / 20 h / 0 °C
11.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
12.1: potassium carbonate / methanol; water / 6 h / 23 °C
13.1: pyridine / 20 h / 0 °C
View Scheme
C25H42O3Si

C25H42O3Si

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: triethylamine / chloroform / 1 h / 23 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
3.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
4.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
5.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
6.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
7.1: n-butyllithium / hexane / 0.5 h / 23 °C
7.2: 1.17 h / -78 - -30 °C
8.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
9.1: pyridine / 20 h / 0 °C
10.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
C25H42O3Si

C25H42O3Si

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: triethylamine / chloroform / 1 h / 23 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
3.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
4.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
5.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
6.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
7.1: n-butyllithium / hexane / 0.5 h / 23 °C
7.2: 1.17 h / -78 - -30 °C
8.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
9.1: pyridine / 20 h / 0 °C
10.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
11.1: potassium carbonate / methanol; water / 6 h / 23 °C
12.1: pyridine / 20 h / 0 °C
View Scheme
C27H45NO4Si

C27H45NO4Si

A

C22H34O7

C22H34O7

B

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
2.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
3.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
4.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
5.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
6.1: n-butyllithium / hexane / 0.5 h / 23 °C
6.2: 1.17 h / -78 - -30 °C
7.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
8.1: pyridine / 20 h / 0 °C
9.1: Chiralpak® AD-H / hexane; ethanol / Resolution of racemate
View Scheme
C27H45NO4Si

C27H45NO4Si

forskolin
66575-29-9

forskolin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 23 °C / Molecular sieve
2.1: citric acid; potassium osmate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 120 h / 23 °C
3.1: toluene-4-sulfonic acid / acetone / 48 h / 23 °C
4.1: hydrogen / ethanol / 6 h / 23 °C / Schlenk technique
5.1: hydrogenchloride / toluene; 1,4-dioxane / 3 h / 23 °C
6.1: n-butyllithium / hexane / 0.5 h / 23 °C
6.2: 1.17 h / -78 - -30 °C
7.1: toluene-4-sulfonic acid / water; tetrahydrofuran / 288 h / 23 °C
8.1: pyridine / 20 h / 0 °C
9.1: dmap; triethylamine / dichloromethane / 1 h / 23 °C
10.1: potassium carbonate / methanol; water / 6 h / 23 °C
11.1: pyridine / 20 h / 0 °C
View Scheme
forskolin
66575-29-9

forskolin

1,1'-Thiocarbonyldiimidazole
6160-65-2

1,1'-Thiocarbonyldiimidazole

C23H32O7S

C23H32O7S

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 4h; Inert atmosphere;97%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

forskolin
66575-29-9

forskolin

1-(trimethylsilyl)forskolin
84010-19-5

1-(trimethylsilyl)forskolin

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 22℃; for 2h; Inert atmosphere;92%
With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane at 80 - 85℃; for 2h;77%
p-methoxybenzyloxy acetic acid
88920-24-5

p-methoxybenzyloxy acetic acid

forskolin
66575-29-9

forskolin

7β-acetoxy-6β,9α-dihydroxy-8,13-epoxy-1α-<(4-methoxybenzyloxy)acetoxy>labd-14-en-11-one
120370-89-0

7β-acetoxy-6β,9α-dihydroxy-8,13-epoxy-1α-<(4-methoxybenzyloxy)acetoxy>labd-14-en-11-one

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In ethyl acetate for 3h; Ambient temperature;92%
forskolin
66575-29-9

forskolin

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

C25H38O7
119603-26-8

C25H38O7

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetone at 0 - 20℃; for 6h; Inert atmosphere;92%
triethyl borane
97-94-9

triethyl borane

forskolin
66575-29-9

forskolin

ethyl iodoacetae
623-48-3

ethyl iodoacetae

C28H45BO9

C28H45BO9

Conditions
ConditionsYield
With 4-tert-Butylcatechol; sodium hydrogencarbonate In dichloromethane; benzene at 20℃; for 3h; Darkness;91%
forskolin
66575-29-9

forskolin

14,15-dihydroforskolin
64657-24-5

14,15-dihydroforskolin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃;90%
palladium-carbon In methanol
forskolin
66575-29-9

forskolin

1-deoxy-1-oxoforskolin
81873-10-1

1-deoxy-1-oxoforskolin

Conditions
ConditionsYield
With 4-methyl-morpholine; 6C13H13P*4CF3O3S(1-)*2Ru(2+); acetone at 65℃; for 3h; Inert atmosphere; Sealed tube;88%
With Collins oxidation agent In dichloromethane for 2.5h;1.2 g
forskolin
66575-29-9

forskolin

allyl alcohol
107-18-6

allyl alcohol

1,9-O-[(3-allyloxy)propylidene]forskolin

1,9-O-[(3-allyloxy)propylidene]forskolin

Conditions
ConditionsYield
With ammonium cerium (IV) nitrate In acetonitrile at 20℃; for 24h; Inert atmosphere; regioselective reaction;87%
phosgene
75-44-5

phosgene

forskolin
66575-29-9

forskolin

forskolin 1,9-carbonate
81826-81-5

forskolin 1,9-carbonate

Conditions
ConditionsYield
With pyridine In toluene at 0 - 20℃; for 4.5h;86%
With pyridine In toluene at 0℃; for 1h;1.22 g
4-[(dimethylamino)methyl]benzoic acid hydrochloride

4-[(dimethylamino)methyl]benzoic acid hydrochloride

forskolin
66575-29-9

forskolin

7β-acetoxy-6β,9α-dihydroxy-1α-(4-dimethylaminomethylbenzoyloxy)-8,13-epoxy-labd-14-en-11-one hydrochloride

7β-acetoxy-6β,9α-dihydroxy-1α-(4-dimethylaminomethylbenzoyloxy)-8,13-epoxy-labd-14-en-11-one hydrochloride

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 16h;82.3%
forskolin
66575-29-9

forskolin

7-deacetyl forskolin
64657-20-1

7-deacetyl forskolin

Conditions
ConditionsYield
With ethylenediamine In methanol for 0.0833333h; Microwave irradiation;80%
With sodium hydroxide In methanol; water
With potassium carbonate In methanol at 25℃; for 0.75h;
With water first-order plots of degradation in water and phosphate buffer (pH 6.0-8.0);
In methanol; potassium carbonate
forskolin
66575-29-9

forskolin

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

7β-acetoxy-1α-<(tert-butyldimethylsilyl)oxy>-6β,9α-dihydroxy-8,13-epoxylabd-14-en-11-one
105559-76-0

7β-acetoxy-1α-<(tert-butyldimethylsilyl)oxy>-6β,9α-dihydroxy-8,13-epoxylabd-14-en-11-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 70℃; for 22h;80%
forskolin
66575-29-9

forskolin

1-(prop-2-yn-1-yl)-1H-indole-3-carbaldehyde

1-(prop-2-yn-1-yl)-1H-indole-3-carbaldehyde

1,9-O-(N-propargyl-3-indolylidene)forskolin

1,9-O-(N-propargyl-3-indolylidene)forskolin

Conditions
ConditionsYield
With Amberlist-15 wet In 1,2-dichloro-ethane at 20℃; for 24h;75%
forskolin
66575-29-9

forskolin

acetone
67-64-1

acetone

C25H38O7
119603-26-8

C25H38O7

Conditions
ConditionsYield
With aluminium trichloride In diethyl ether for 0.3h; Ambient temperature;74%
forskolin
66575-29-9

forskolin

benzoyl chloride
98-88-4

benzoyl chloride

1-benzoylforskolin
84048-17-9

1-benzoylforskolin

Conditions
ConditionsYield
With pyridine Ambient temperature;72%
forskolin
66575-29-9

forskolin

acetyl chloride
75-36-5

acetyl chloride

Acetic acid (3S,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-3-ethyl-6,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-benzo[f]chromen-10-yl ester
84010-29-7

Acetic acid (3S,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetoxy-3-ethyl-6,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-benzo[f]chromen-10-yl ester

Conditions
ConditionsYield
With pyridine Ambient temperature;72%
triethyl borane
97-94-9

triethyl borane

((Iodomethyl)sulfonyl)benzene
65492-21-9

((Iodomethyl)sulfonyl)benzene

forskolin
66575-29-9

forskolin

C31H45BO9S

C31H45BO9S

Conditions
ConditionsYield
With 4-tert-Butylcatechol; sodium hydrogencarbonate In dichloromethane; benzene at 20℃; for 3h; Darkness;63%
pivaloyl chloride
3282-30-2

pivaloyl chloride

forskolin
66575-29-9

forskolin

7-deacetyl-1,7-dipivaloylforskolin
84010-28-6

7-deacetyl-1,7-dipivaloylforskolin

Conditions
ConditionsYield
With pyridine Ambient temperature;55%
forskolin
66575-29-9

forskolin

benzoyl chloride
98-88-4

benzoyl chloride

C34H40O8
84048-21-5

C34H40O8

Conditions
ConditionsYield
With pyridine Ambient temperature;55%
forskolin
66575-29-9

forskolin

forskolin-14,15-dibromide
84010-25-3

forskolin-14,15-dibromide

Conditions
ConditionsYield
With bromine In carbon disulfide at 0 - 20℃; for 2.75h;50%
forskolin
66575-29-9

forskolin

phenyl isocyanate
103-71-9

phenyl isocyanate

1-(anilinocarbonyl)forskolin
84048-18-0

1-(anilinocarbonyl)forskolin

Conditions
ConditionsYield
In toluene for 20h; Heating;48%
forskolin
66575-29-9

forskolin

(13R)-Spiroforskolin
220423-84-7

(13R)-Spiroforskolin

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In benzene at 0 - 5℃;45%
forskolin
66575-29-9

forskolin

benzoic acid
65-85-0

benzoic acid

1β-Benzoyloxy-1-deoxycoleonol
132620-05-4

1β-Benzoyloxy-1-deoxycoleonol

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 36h; Ambient temperature;45%
forskolin
66575-29-9

forskolin

A

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclo-α-phosphite
144426-70-0, 144539-48-0

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclo-α-phosphite

B

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclo-β-phosphite
144426-70-0, 144539-48-0

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclo-β-phosphite

Conditions
ConditionsYield
With pyridine; bis(trifluoroethyl)hydrogen phosphite for 16h; Ambient temperature;A 39%
B 13%
forskolin
66575-29-9

forskolin

propargyl bromide
106-96-7

propargyl bromide

A

1-O-propargyl-forskolin
1350721-63-9

1-O-propargyl-forskolin

B

1-O-propargyl-6-O-acetyl-7-deacetyl-forskolin
1350721-66-2

1-O-propargyl-6-O-acetyl-7-deacetyl-forskolin

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone at 20℃; Reflux;A 36%
B 35%
With potassium carbonate; potassium iodide In acetone for 24h; Reflux;A 1.8 g
B 1.7 g
forskolin
66575-29-9

forskolin

A

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclophospho-α-chloridate
144426-66-4, 144491-36-1

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclophospho-α-chloridate

B

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclophospho-β-chloridate
144426-66-4, 144491-36-1

7β-acetoxy-8,13-epoxy-6β-hydroxy-11-oxolabd-14-ene-1α,9α-diyl cyclophospho-β-chloridate

Conditions
ConditionsYield
With pyridine; triethylamine; trichlorophosphate In diethyl ether 1) -10 deg C, 1 h, 2) RT, 60 h; other substrate, various phosphorylating agents;A 33%
B 12%
With pyridine; triethylamine; trichlorophosphate In diethyl ether 1) -10 deg C, 1 h, 2) RT, 60 h;A 33%
B 12%
forskolin
66575-29-9

forskolin

3,5-dinitrobenoyl chloride
99-33-2

3,5-dinitrobenoyl chloride

6β-acetoxy-7β-(3,5-dinitro)benzoyloxy-8,13-epoxy-1α,9-dihydroxy-labd-14-en-11-one

6β-acetoxy-7β-(3,5-dinitro)benzoyloxy-8,13-epoxy-1α,9-dihydroxy-labd-14-en-11-one

Conditions
ConditionsYield
With pyridine at 20℃; for 1.5h;31%
forskolin
66575-29-9

forskolin

7β-acetoxy-8,13-epoxy-6β,9α-dihydroxy-11-oxolabd-14-en-1α-yl dihydrogen phosphate
144426-76-6

7β-acetoxy-8,13-epoxy-6β,9α-dihydroxy-11-oxolabd-14-en-1α-yl dihydrogen phosphate

Conditions
ConditionsYield
With dihydro-(1,2-dibromo-2-phenyl-1-ethyl)phosphonic acid; N-ethyl-N,N-diisopropylamine In dichloromethane for 48h; Ambient temperature;30%

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