We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : 5-Hydroxymethylpyrrolidin-2-one
Cas:66673-40-3
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:66673-40-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:66673-40-3
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:66673-40-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:66673-40-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry5-Hydroxymethylpyrrolidin-2-one CAS:66673-40-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o
Cas:66673-40-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:66673-40-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
PRODUCT DETAILS
Cas:66673-40-3
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:66673-40-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:66673-40-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:66673-40-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:66673-40-3
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:66673-40-3
Min.Order:0 Metric Ton
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:66673-40-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:66673-40-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 5-Hydroxymethylpyrrolidin-2-one Synonyms: D-PYROGLUTAMINOL;(-)-D-PYROGLUTAMOL;(R)-5-HYDROXYMETHYL-PYRROLIDIN-2-ONE;(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;(R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROL
Cas:66673-40-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:66673-40-3
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
Cas:66673-40-3
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:66673-40-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:66673-40-3
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
Cas:66673-40-3
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:
Cas:66673-40-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:66673-40-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:66673-40-3
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiry1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
Cas:66673-40-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryOur advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientif
Cas:66673-40-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:66673-40-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With water; trifluoroacetic acid In dichloromethane at 50℃; for 5h; | 99% |
methyl (2R)-pyroglutamate
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate at 0℃; | 97% |
With methanol; sodium tetrahydroborate at 0℃; | 97% |
With methanol; sodium tetrahydroborate at 0℃; | 97% |
ethyl (R)-2-pyrrolidone-5-carboxylate
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With lithium borohydride In tetrahydrofuran for 16h; Ambient temperature; | 85% |
With sodium tetrahydroborate In tetrahydrofuran; methanol at 5℃; for 1h; | 80% |
With sodium tetrahydroborate In ethanol for 2h; Ambient temperature; | 79% |
D-pyrrolidone-5-carboxylic acid
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / SOCl2 / 1.5 h / 80 °C 2: 85 percent / LiBH4 / tetrahydrofuran / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 95 percent / thionyl chloride / 1.) 0 deg C, 30 min, 2.) room temp., 3 h 2: 78 percent / NaBH4 / ethanol / 2 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: SOCl2 / 48 h / Ambient temperature; pH=0 2: 58 percent / NaBH4 / propan-2-ol / 20 h / Ambient temperature View Scheme |
D-Glutamic acid
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1) thionyl chloride / 1a) room temp., 1 h, 1b) reflux, 30 min. 2: 32.5 g / 1.5 h / 150 °C / 15 Torr 3: 79 percent / sodium borohydride / ethanol / 2 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 88 percent / SOCl2, KOH / 150 °C 2: LiBH4 View Scheme | |
Multi-step reaction with 3 steps 1: H2O / 63 h / Heating 2: SOCl2 / 48 h / Ambient temperature; pH=0 3: 58 percent / NaBH4 / propan-2-ol / 20 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride 1.2: Amberlyst A-21 1.3: Reflux 2.1: sodium tetrahydroborate / isopropyl alcohol View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / 20 h / 20 °C 1.2: 2 h / Reflux 2.1: sodium tetrahydroborate / isopropyl alcohol / 20 h / 20 °C View Scheme |
D-glutamic acid diethyl ester
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 32.5 g / 1.5 h / 150 °C / 15 Torr 2: 79 percent / sodium borohydride / ethanol / 2 h / Ambient temperature View Scheme |
D-glutamic acid dimethyl ester hydrochloride
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 4 h / Reflux 2: isopropyl alcohol; sodium tetrahydroborate / 20 h / 20 °C View Scheme |
(R)-5-hydroxymethylpyrrolidin-2-one
tert-butyldimethylsilyl chloride
(R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane at 20℃; for 4h; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide for 24h; Ambient temperature; | 99% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; | 99% |
(R)-5-hydroxymethylpyrrolidin-2-one
methyl 3'-(cyanocarbonyl)-2,2'-binaphthalene-3-carboxylate
Conditions | Yield |
---|---|
With dmap In acetonitrile at 14℃; for 1.5h; | 100% |
(R)-5-hydroxymethylpyrrolidin-2-one
2,2-dimethoxy-propane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 1.5h; Dean-Stark; Reflux; | 100% |
With camphor-10-sulfonic acid at 75℃; for 20h; Reagent/catalyst; Temperature; Time; Concentration; | 78% |
With camphor-10-sulfonic acid at 75℃; for 20h; Time; Temperature; Reflux; | 78% |
(R)-5-hydroxymethylpyrrolidin-2-one
ethyl vinyl ether
(5R)-5-((tert-ethoxyethoxy)methyl)pyrrolidin-2-one
Conditions | Yield |
---|---|
With trichloroacetic acid In chloroform for 4h; Ambient temperature; | 97% |
With trichloroacetic acid In dichloromethane at 20℃; for 16h; | 37% |
With trichloroacetic acid In dichloromethane at 20℃; for 16h; | 37% |
With trichloroacetic acid In dichloromethane at 20℃; for 16h; | 37% |
With trichlorosilane; acetic acid In dichloromethane at 20℃; for 16h; | 37% |
(R)-5-hydroxymethylpyrrolidin-2-one
D-pyrrolidone-5-carboxylic acid
Conditions | Yield |
---|---|
With oxygen; sodium hydrogencarbonate; platinum In water for 4h; Ambient temperature; | 95% |
(R)-5-hydroxymethylpyrrolidin-2-one
p-toluenesulfonyl chloride
<(2R)-5-oxopyrrolidin-2-yl>methyl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; | 95% |
With dmap; triethylamine In dichloromethane at 0 - 23℃; for 12h; Inert atmosphere; | 93% |
With dmap; triethylamine In dichloromethane at 20℃; for 18h; Cooling with ice; | 81% |
(R)-5-hydroxymethylpyrrolidin-2-one
tert-butylchlorodiphenylsilane
(R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide for 12h; Ambient temperature; | 95% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 5h; | 95% |
With dmap; triethylamine In dichloromethane | 88% |
(R)-5-hydroxymethylpyrrolidin-2-one
methanesulfonyl chloride
<(2R)-5-oxopyrrolidin-2-yl>methyl methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 1.5h; | 93% |
With triethylamine In dichloromethane | 85% |
With triethylamine In chloroform at 0 - 20℃; | 70% |
With pyridine at 25℃; for 1.5h; | 60% |
Conditions | Yield |
---|---|
With potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine In acetonitrile for 18h; Heating / reflux; | 93% |
triisopropylsilyl chloride
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 88% |
With 1H-imidazole In dichloromethane at 0 - 20℃; for 16h; | 37% |
(R)-5-hydroxymethylpyrrolidin-2-one
Bromodiphenylmethane
Conditions | Yield |
---|---|
Stage #1: (R)-5-hydroxymethylpyrrolidin-2-one With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: Bromodiphenylmethane In tetrahydrofuran; mineral oil at 50℃; for 12h; | 88% |
(R)-5-hydroxymethylpyrrolidin-2-one
(R)-5-(azidomethyl)-2-pyrrolidone
Conditions | Yield |
---|---|
With hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 1h; | 87% |
With tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate |
(R)-5-hydroxymethylpyrrolidin-2-one
benzaldehyde
(2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Reflux; Dean-Stark; | 85% |
With 4 A molecular sieve; toluene-4-sulfonic acid In toluene Heating; | 72% |
With toluene-4-sulfonic acid Inert atmosphere; | 67% |
With water; toluene-4-sulfonic acid In toluene at 20℃; Reflux; | 62% |
With toluene-4-sulfonic acid In toluene for 16h; Reflux; | 52% |
4-Bromo-2-methylphenol
(R)-5-hydroxymethylpyrrolidin-2-one
(R)-5-(4-Bromo-2-methylphenoxymethyl)-2-pyrrolidinone
Conditions | Yield |
---|---|
In ethyl acetate; SiO2 | 83% |
(R)-5-hydroxymethylpyrrolidin-2-one
[1-(4-bromo-phenyl)-hexyloxy]-tert-butyl-dimethyl-silane
C23H39NO3Si
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In acetonitrile Heating / reflux; | 82% |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 6h; Inert atmosphere; | 80% |
3-bromo-2-chloro-5-nitropyridine
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 100℃; for 16h; Inert atmosphere; | 79% |
(R)-5-hydroxymethylpyrrolidin-2-one
(5R)-5-(bromomethyl)pyrrolidin-2-one
Conditions | Yield |
---|---|
With carbon tetrabromide; triphenylphosphine In dichloromethane for 1.5h; Ambient temperature; | 77% |
With carbon tetrabromide; triphenylphosphine In acetonitrile | 73% |
With carbon tetrabromide; triphenylphosphine In acetonitrile at 0 - 20℃; for 24h; |
1-iodo-4-(methoxymethoxy)benzene
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In N,N-dimethyl-formamide Heating; | 71% |
3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl ketone
(R)-5-hydroxymethylpyrrolidin-2-one
3-Methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl (R)-2-[4-(5-Oxopyrrolidin-2-ylmethoxy)phenyl]benzo[b]thiophen-3-yl Ketone
Conditions | Yield |
---|---|
With triethanolamine In tetrahydrofuran; SiO2 | 70% |
2-(4-bromophenyl)-1,3-thiazole
(R)-5-hydroxymethylpyrrolidin-2-one
C14H14N2O2S
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In acetonitrile for 18h; Heating / reflux; | 67% |
Conditions | Yield |
---|---|
With potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine In acetonitrile for 18h; Heating / reflux; | 67% |
(R)-5-hydroxymethylpyrrolidin-2-one
(R)-(+)-5-(chloromethyl)-2-pyrrolidone
Conditions | Yield |
---|---|
With methanesulfonyl chloride In N,N-dimethyl-formamide at 65℃; for 16h; | 65% |
1-bromo-4-n-hexylbenzene
(R)-5-hydroxymethylpyrrolidin-2-one
C17H25NO2
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In acetonitrile for 72h; Heating/reflux; | 63% |
With potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine In acetonitrile for 72h; Reflux; | 63% |
para-chlorotoluene
(R)-5-hydroxymethylpyrrolidin-2-one
Conditions | Yield |
---|---|
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In tert-butyl alcohol at 130℃; for 24h; Schlenk technique; | 58% |
di-tert-butyl dicarbonate
(R)-5-hydroxymethylpyrrolidin-2-one
tert-butylchlorodiphenylsilane
trimethyl orthoformate
(5R)-1-(tert-butoxycarbonyl)-2-methoxy-5-(tert-butyldiphenylsilanyloxymethyl)pyrrolidine
Conditions | Yield |
---|---|
Multistep reaction.; | 52% |
6-benzyloxy-2-(4-hydroxyphenyl)-3-[3-methoxy-4-[(1-pyrrolidinyl)methyl]benzyl]benzo[b]thiophene
(R)-5-hydroxymethylpyrrolidin-2-one
(R)-6-Benzyloxy-3-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-(5-oxopyrrolidin-2-ylmethoxy)phenyl]benzo[b]thiophene
Conditions | Yield |
---|---|
50% |
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