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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Diethyl fluoromalonate Manufacturer/High quality/Best price/In stock

Cas:685-88-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl Fluoromalonate with high purity

Cas:685-88-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Diethyl fluoromalonate CAS number 685-88-1 Assay ≥98% Appearance Colorless liquid Capacity 200mt/year Application Organic intermediate

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply Diethyl fluoromalonate CAS 685-88-1 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed

Factory supply Diethyl fluoromalonate CAS 685-88-1 with fast delivery

Cas:685-88-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Fluoromalonic acid diethyl ester

Cas:685-88-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 685-88-1 with best quality

Cas:685-88-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Diethyl fluoromalonate 685-88-1

Cas:685-88-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Diethyl fluoromalonate 99%

Cas:685-88-1

Min.Order:1 Kilogram

FOB Price: $85.0 / 96.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Diethyl fluoromalonate CAS:685-88-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

Diethyl fluoromalonate CAS:685-88-1

Cas:685-88-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:685-88-1

Cas:685-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:0

Negotiable

Type:Manufacturers

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Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Diethyl fluoromalonat

Cas:685-88-1

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Diethyl fluoromalonate/High quality/Best price

Cas:685-88-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Diethyl Fluoromalonate

Cas:685-88-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Diethyl Fluoromalonate CAS No.:685-88-1 Molecule Formula:C7H11FO4 Molecule Weight:178.15 Purity: 98% Package: 200kg/drum Description:Colorless liquid Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Diethyl Fluoromalonate in stock

Cas:685-88-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Diethyl fluoromalonate Basic information Product Name: Diethyl fluoromalonate Synonyms: Diethyl 2-fluoropropane-1,3-dioate;1,2-Difluoromalonate;1,3-diethyl 2-fluoropropanedioate;diethyl 2-fluoropropanedioate;Propanedio;diethylfluoropropanedioa

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Gram

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Diethyl2-fluoromalonate

Cas:685-88-1

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:light yellow liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Inter

Diethyl fluoromalonate

Cas:685-88-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

1,3-diethyl 2-fluoropropanedioate

Cas:685-88-1

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

Diethyl fluoroxaloacetate
392-58-5

Diethyl fluoroxaloacetate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
at 500℃; under 18751.9 - 22502.3 Torr; Temperature; Pressure;95.2%
at 220℃;
at 230 - 235℃;
diethyl 2-chloromalonate
14064-10-9

diethyl 2-chloromalonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With triethylamine tris(hydrogen fluoride); trimethylamine at 80 - 110℃; for 17h;94%
With triethylamine tris(hydrogen fluoride); triethylamine at 80 - 110℃; for 17h; Heating / reflux;84%
With potassium fluoride
diethyl malonate
105-53-3

diethyl malonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With copper nitrate hemi(pentahydrate); fluorine In acetonitrile at 0 - 5℃; for 2h; Time; Temperature; Concentration; Green chemistry;94%
With triethylamine pentahydrogen fluoride salt; iodosylbenzene In 1,2-dichloro-ethane at 70℃; for 24h; Reagent/catalyst; Concentration;85%
With fluorine; copper(II) nitrate In acetonitrile at 5 - 8℃; for 4h;78%
2-(Diethoxy-phosphoryl)-2-fluoro-malonic acid diethyl ester
171916-50-0

2-(Diethoxy-phosphoryl)-2-fluoro-malonic acid diethyl ester

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With water; silica gel In ethyl acetate at 20℃; for 16h; dephosphonylation;89%
Stage #1: With magnesium chloride In toluene at 20℃; for 2h; Disproportionation;
Stage #2: 2-(Diethoxy-phosphoryl)-2-fluoro-malonic acid diethyl ester With ammonium chloride In toluene at 20℃; for 6h; Disproportionation;
86%
1,3-diethyl 2-diazopropanedioate
5256-74-6

1,3-diethyl 2-diazopropanedioate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With hydrogen fluoride In neat (no solvent) at 0℃; for 5h; Inert atmosphere;84%
cupric nitrate 3H2O

cupric nitrate 3H2O

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

diethyl malonate
105-53-3

diethyl malonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
In acetonitrile78%
sodium diethylmalonate
996-82-7

sodium diethylmalonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate In tetrahydrofuran at 0℃; for 0.1h;73%
With xenon difluoride; dimethylsulfide; boron trifluoride diethyl etherate In dichloromethane at -78℃;42%
sodium diethylmalonate
996-82-7

sodium diethylmalonate

A

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

B

diethyl 2,2-difluoromalonate
680-65-9

diethyl 2,2-difluoromalonate

Conditions
ConditionsYield
With 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate In tetrahydrofuran at 0℃; for 0.1h;A 73%
B n/a
With perchloryl fluoride In tetrahydrofuran at 0℃; for 0.583333h;A 84 % Spectr.
B 16 % Spectr.
ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

Diethyl carbonate
105-58-8

Diethyl carbonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With potassium ethoxide for 2h; Reflux;65.5%
ethanol
64-17-5

ethanol

perfluoroacrylic acid
433-68-1

perfluoroacrylic acid

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With triethylamine Heating; var. reag.: LiOH, NaOEt;65%
2,3,3,3-tetrafluoropropionic acid ethyl ester
399-92-8

2,3,3,3-tetrafluoropropionic acid ethyl ester

sodium ethanolate
141-52-6

sodium ethanolate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
In methanol 1.) 0 deg C, 2.) room temperature, 30 min;63%
3,3,3-Triethoxy-2-fluoro-propionic acid ethyl ester
77778-67-7

3,3,3-Triethoxy-2-fluoro-propionic acid ethyl ester

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 1h; Ambient temperature;63%
With ethanolate Yield given;
2,3,3,3-tetrafluoropropionic acid ethyl ester
399-92-8

2,3,3,3-tetrafluoropropionic acid ethyl ester

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: 2,3,3,3-tetrafluoropropionic acid ethyl ester With sodium ethanolate In ethanol at 20 - 30℃; for 0.5h;
Stage #2: With hydrogenchloride In methanol at 20℃;
63%
Multi-step reaction with 2 steps
1: ethanol / 0.5 h / Ambient temperature
2: 63 percent / conc. HCl / ethanol / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: EtO-
2: EtO-
View Scheme
With sulfuric acid; sodium ethanolate In ethanol
ethoxycarbonylketene ethyltrimethylsilyl acetal
17906-37-5

ethoxycarbonylketene ethyltrimethylsilyl acetal

A

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

B

diethyl 2,2-difluoromalonate
680-65-9

diethyl 2,2-difluoromalonate

Conditions
ConditionsYield
With fluorine In trichlorofluoromethane at -78℃;A 59%
B n/a
ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
In tetrahydrofuran22%
(i) NaH, Et2O, (ii) /BRN= 385653/; Multistep reaction;
With sodium methylate In Petroleum ether for 1h; Heating;
diethyl acetylmalonate
570-08-1

diethyl acetylmalonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With perchloryl fluoride; ethanol; sodium ethanolate
Butyrylmalonsaeure-diethylester
21633-79-4

Butyrylmalonsaeure-diethylester

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With perchloryl fluoride; ethanol; sodium ethanolate
Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With potassium fluoride at 190℃;
ethanol
64-17-5

ethanol

7-chloro-7-fluoro-2,5-dioxabicyclo<4.1.0>heptane
40623-35-6, 40623-36-7, 120201-74-3

7-chloro-7-fluoro-2,5-dioxabicyclo<4.1.0>heptane

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With Oxone; sulfuric acid 1.) reflux, 7 d, 2.) RT, 16 h; Yield given. Multistep reaction;
2,3,3,3-tetrafluoropropionitrile
431-32-3

2,3,3,3-tetrafluoropropionitrile

sodium ethanolate
141-52-6

sodium ethanolate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With hydrogenchloride 1.) EtOH, r.t., 30 min, 2.) EtOH, r.t., 30 min; Multistep reaction;
ethyl bromofluoroacetate
401-55-8

ethyl bromofluoroacetate

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
Yield given. Multistep reaction;
(Bis-ethoxycarbonyl-fluoro-methyl)-tributyl-phosphonium; chloride

(Bis-ethoxycarbonyl-fluoro-methyl)-tributyl-phosphonium; chloride

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water for 6h; Ambient temperature; Yield given;
diethyl malonate
105-53-3

diethyl malonate

A

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

B

diethyl 2,2-difluoromalonate
680-65-9

diethyl 2,2-difluoromalonate

Conditions
ConditionsYield
With sodium hydride; fluorine In acetonitrile 1.) r.t., 1 h, 2.) -15 deg C, 1 h; Title compound not separated from byproducts;A 37 % Spectr.
B 23 % Spectr.
With aluminium trichloride; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate In 1,2-dichloro-ethane at 80℃; for 24h;A 19 % Spectr.
B 76 % Spectr.
With sodium hydride; fluorine In acetonitrile 1.) r.t., 1 h, 2.) -15 deg C, 1 h; Title compound not separated from byproducts;A 14 % Spectr.
B 37 % Spectr.
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

fluoroacetic acid ethyl ester, sodium-compound

fluoroacetic acid ethyl ester, sodium-compound

A

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

B

fluoro-fluoroacetyl-malonic acid diethyl ester
664-38-0

fluoro-fluoroacetyl-malonic acid diethyl ester

Conditions
ConditionsYield
With Petroleum ether
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

sodium-compound of fluoroacetic acid ethyl ester

sodium-compound of fluoroacetic acid ethyl ester

A

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

B

2-fluoro-2-fluoroacetyl-malonic acid diethyl ester

2-fluoro-2-fluoroacetyl-malonic acid diethyl ester

Conditions
ConditionsYield
With Petroleum ether
With diethyl ether
1,1,2,3,3,3-hexafluoropropyl ethyl ether
380-34-7

1,1,2,3,3,3-hexafluoropropyl ethyl ether

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / conc. sulfuric acid / 1 h / Ambient temperature
2: ethanol / 0.5 h / Ambient temperature
3: 63 percent / conc. HCl / ethanol / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: H+
2: EtO-
3: EtO-
View Scheme
Multi-step reaction with 2 steps
1: conc. sulfuric acid / 1 h / Ambient temperature
2: 63 percent / methanol / 1.) 0 deg C, 2.) room temperature, 30 min
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid / 20 - 30 °C
2.1: sodium ethanolate / ethanol / 0.5 h / 20 - 30 °C
2.2: 20 °C
View Scheme
copper(II) nitrate

copper(II) nitrate

diethyl malonate
105-53-3

diethyl malonate

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With fluorine In acetonitrile
1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
In N-methyl-acetamide; dichloromethane
caro's acid
7722-86-3

caro's acid

fluoromalonaldehyde bis(diethyl acetal)
120131-05-7

fluoromalonaldehyde bis(diethyl acetal)

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Conditions
ConditionsYield
With ammonium persulfate; sulfuric acid In ethanol; water
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide
1354044-23-7

1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide

5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one
1446359-42-7

5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-6-hydroxypyrimidin-4(3H)-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol at 70℃; for 24h;100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol at 70℃; for 24h;100%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

sodium fluoromalonate

sodium fluoromalonate

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 60℃; for 0.75h;100%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

potassium 3-ethoxy-2-fluoro-3-oxopropanoate

potassium 3-ethoxy-2-fluoro-3-oxopropanoate

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃;100%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

2-fluoromalonic acid
473-87-0

2-fluoromalonic acid

Conditions
ConditionsYield
With water; lithium hydroxide In methanol at 20℃; for 16h; air;99%
With water; sodium hydroxide In ethanol at 60℃; for 2h;98%
Stage #1: fluoromalonic acid diethyl ester With water; lithium hydroxide In ethanol at 25 - 50℃; for 16h;
Stage #2: With hydrogenchloride In tert-butyl methyl ether; water pH=1;
88%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

(4R,4S)-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-ylamine hydrochloride

(4R,4S)-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-ylamine hydrochloride

(2R,2S)-7-fluoro-8-hydroxy-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one

(2R,2S)-7-fluoro-8-hydroxy-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one

Conditions
ConditionsYield
With sodium methylate In methanol for 3h;99%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

4,4,4-trifluoro-1-(4‘-nitrophenyl)but-2-en-1-one

4,4,4-trifluoro-1-(4‘-nitrophenyl)but-2-en-1-one

(S)-diethyl 2-fluoro-2-(1,1,1-trifluoro-4-(4-nitrophenyl)-4-oxobutan-2-yl)malonate

(S)-diethyl 2-fluoro-2-(1,1,1-trifluoro-4-(4-nitrophenyl)-4-oxobutan-2-yl)malonate

Conditions
ConditionsYield
With potassium phosphate; N-((S)-1-(((S)-1-(diphenylphosphanyl)-3-ethylpentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,5-bis(trifluoromethyl)benzamide; acrylic acid methyl ester In toluene at -20℃; for 24h; Michael Addition; enantioselective reaction;99%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

N-butylammonium bromide
15567-09-6

N-butylammonium bromide

ethyl α-(N-butyl)carbamoylfluoroacetate

ethyl α-(N-butyl)carbamoylfluoroacetate

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 20℃; for 12h;99%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

(SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

(SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

(S)-diethyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]-2-fluoromalonate
1372420-76-2

(S)-diethyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]-2-fluoromalonate

Conditions
ConditionsYield
Stage #1: fluoromalonic acid diethyl ester With 1-ethyl-2,2,4,4,4-pentakis(dimethylamino)-2λ5,4λ5-catenadi(phosphazene) In toluene at -78℃; for 0.166667h; Mannich reaction; Inert atmosphere;
Stage #2: (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide In toluene at -78℃; for 24h; Mannich reaction; Inert atmosphere; optical yield given as %de; diastereoselective reaction;
98%
Stage #1: fluoromalonic acid diethyl ester With C13H36N6P2 In toluene at -78℃; for 0.166667h; Mannich Aminomethylation; Inert atmosphere;
Stage #2: (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide In toluene at -78℃; for 24h; Mannich Aminomethylation; Inert atmosphere; stereoselective reaction;
98%
N-isopropylurea
691-60-1

N-isopropylurea

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

5-fluoro-1-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione

5-fluoro-1-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione

Conditions
ConditionsYield
With sodium methylate In methanol at 85℃; for 4h;98%
With sodium methylate In methanol at 85℃; for 4h;98%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

urea
57-13-6

urea

5-fluorobarbituric acid
767-80-6

5-fluorobarbituric acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol97%
Stage #1: urea With sodium In ethanol Reflux;
Stage #2: fluoromalonic acid diethyl ester In ethanol for 1.16667h; Reflux;
51%
With sodium methylate
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

2-fluoropropanediamide
815-59-8

2-fluoropropanediamide

Conditions
ConditionsYield
With ammonia In methanol at 20℃; Inert atmosphere;97%
With ammonia In methanol Ambient temperature;94%
With ammonium hydroxide
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

3-(4-methoxyphenyl)-5-(bromomethyl)isoxazole
196877-76-6

3-(4-methoxyphenyl)-5-(bromomethyl)isoxazole

C18H20FNO6
1204423-81-3

C18H20FNO6

Conditions
ConditionsYield
Stage #1: fluoromalonic acid diethyl ester With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 5-(bromomethyl)-3-(4-methoxyphenyl)isoxazole In N,N-dimethyl-formamide at 20℃; for 1h;
97%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride

1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride

5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,6-diol

5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,6-diol

Conditions
ConditionsYield
With sodium methylate In methanol at 20 - 35℃; for 0.5h;97%
2-chloro-N-(quinolin-8-yl)acetamide
32889-11-5

2-chloro-N-(quinolin-8-yl)acetamide

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

phenylacetylene
536-74-3

phenylacetylene

C26H25FN2O5

C26H25FN2O5

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In tetrahydrofuran at 80℃; for 1.5h; Sonogashira Cross-Coupling; Inert atmosphere; Sealed tube;96%
2-chloro-N-(quinolin-8-yl)acetamide
32889-11-5

2-chloro-N-(quinolin-8-yl)acetamide

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

phenylacetylene
536-74-3

phenylacetylene

(E)-diethyl 2-fluoro-2-(4-oxo-1-phenyl-4-(quinolin-8-ylamino)but-1-en-2-yl)malonate

(E)-diethyl 2-fluoro-2-(4-oxo-1-phenyl-4-(quinolin-8-ylamino)but-1-en-2-yl)malonate

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In tetrahydrofuran at 80℃; for 1.5h; Inert atmosphere; stereoselective reaction;96%
Benzyloxymethyl chloride
3587-60-8

Benzyloxymethyl chloride

fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

2-fluoro-2-benzyloxymethylmalonic acid diethyl ester
133384-77-7

2-fluoro-2-benzyloxymethylmalonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: fluoromalonic acid diethyl ester With sodium hydride In tetrahydrofuran at -10 - -5℃;
Stage #2: Benzyloxymethyl chloride In tetrahydrofuran at -10 - -5℃;
95%
With sodium hydride In N,N-dimethyl-formamide for 1.5h; Ambient temperature;75%
In tetrahydrofuran; mineral oil
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

Cyclopropylamine
765-30-0

Cyclopropylamine

ethyl α-(N-cyclopropyl)carbamoylfluoroacetate

ethyl α-(N-cyclopropyl)carbamoylfluoroacetate

Conditions
ConditionsYield
at 20℃; for 16h;95%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

(1-furan-2-ylmethylidene)carbamic acid tert-butyl ester
479423-46-6

(1-furan-2-ylmethylidene)carbamic acid tert-butyl ester

diethyl 2-[(tert-butoxycarbonylamino)(furan-2-yl)methyl]-2-fluoromalonate
1236293-01-8

diethyl 2-[(tert-butoxycarbonylamino)(furan-2-yl)methyl]-2-fluoromalonate

Conditions
ConditionsYield
Stage #1: fluoromalonic acid diethyl ester With 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea In toluene at 20℃; for 0.0833333h; Mannich reaction;
Stage #2: (1-furan-2-ylmethylidene)carbamic acid tert-butyl ester In toluene at -78℃; for 96h; Mannich reaction; optical yield given as %ee; enantioselective reaction;
94%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

morpholinylguanidine hydrogen sulphate
88497-68-1

morpholinylguanidine hydrogen sulphate

5-fluoro-2-(morpholin-4-yl)pyrimidine-4,6-diol
944401-89-2

5-fluoro-2-(morpholin-4-yl)pyrimidine-4,6-diol

Conditions
ConditionsYield
With sodium In ethanol for 12h; Reflux;94%
Stage #1: fluoromalonic acid diethyl ester; morpholinylguanidine hydrogen sulphate With ethanol; sodium for 12.1667h; Reflux;
Stage #2: With hydrogenchloride In water at 10℃; pH=4;
94%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

(S)-diethyl 2-fluoro-2-(2-nitro-1-phenylethyl)malonate

(S)-diethyl 2-fluoro-2-(2-nitro-1-phenylethyl)malonate

Conditions
ConditionsYield
With C37H31F6N3O In dichloromethane at 20℃; for 48h; Michael reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;93%
With C35H31F17N4OS In toluene at 25℃; for 24h; Michael Addition;
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

urea
57-13-6

urea

5-fluoropyrimidine-2,4,6-triol
767-80-6

5-fluoropyrimidine-2,4,6-triol

Conditions
ConditionsYield
Stage #1: fluoromalonic acid diethyl ester; urea With sodium ethanolate In ethanol for 60h; Reflux;
Stage #2: With hydrogenchloride In water pH=2; Heating;
93%
Stage #1: fluoromalonic acid diethyl ester; urea With sodium acetate In ethanol for 60h; Reflux;
Stage #2: With hydrogenchloride In water pH=2;
93%
With sodium ethanolate In ethanol at 90℃;1.24 g
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

benzhydrilium tetrafluoroborate

benzhydrilium tetrafluoroborate

diethyl 2-(bis(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)methyl)-2-fluoromalonate

diethyl 2-(bis(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)methyl)-2-fluoromalonate

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 20℃; Inert atmosphere;92%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

C10H15N3O2

C10H15N3O2

C13H14FN3O4

C13H14FN3O4

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 70℃; for 7h; Temperature; Sealed tube; Inert atmosphere;90.5%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

benzyl alcohol
100-51-6

benzyl alcohol

dibenzyl 2-fluoromalonate
133384-81-3

dibenzyl 2-fluoromalonate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene Heating;90%
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

benzaldehyde N-boc imine
150884-50-7

benzaldehyde N-boc imine

A

(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate
1236292-94-6

(R)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

B

(S)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate
1236293-03-0

(S)-diethyl 2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)-2-fluoromalonate

Conditions
ConditionsYield
Stage #1: fluoromalonic acid diethyl ester With (S)-1-(1-(diphenylphosphino)-3-phenylpropan-2-yl)-3-(4-nitrophenyl)thiourea; acrylic acid methyl ester In dichloromethane at 20℃; for 0.166667h;
Stage #2: benzaldehyde N-boc imine In diethyl ether at 20℃; for 3h; Mannich Aminomethylation;
A n/a
B 90%
Stage #1: fluoromalonic acid diethyl ester With 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea In toluene at 20℃; for 0.0833333h; Mannich reaction;
Stage #2: benzaldehyde N-boc imine In toluene at -78℃; for 24h; Mannich reaction; optical yield given as %ee; enantioselective reaction;
fluoromalonic acid diethyl ester
685-88-1

fluoromalonic acid diethyl ester

1-(4-chlorophenyl)-4,4,4-trifluorobut-2-en-1-one
1092546-75-2

1-(4-chlorophenyl)-4,4,4-trifluorobut-2-en-1-one

(S)-diethyl 2-(4-(4-chlorophenyl)-1,1,1-trifluoro-4-oxobutan-2-yl)-2-fluoromalonate

(S)-diethyl 2-(4-(4-chlorophenyl)-1,1,1-trifluoro-4-oxobutan-2-yl)-2-fluoromalonate

Conditions
ConditionsYield
With potassium phosphate; N-((S)-1-(((S)-1-(diphenylphosphanyl)-3-ethylpentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,5-bis(trifluoromethyl)benzamide; acrylic acid methyl ester In toluene at -20℃; for 60h; Michael Addition; enantioselective reaction;90%

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