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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-(4-methoxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol

Cas:68592-15-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

shanghai Tauto Biotech Co., Ltd

18-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2008 quality management system Leader Supplier of Botanical Reference Materials in China

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-(4-methoxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol 68592-15-4

Cas:68592-15-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol CAS:68592-15-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates,

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol CAS:68592-15-4

Cas:68592-15-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-(4-methoxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol

Cas:68592-15-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-(4-methoxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol

Cas:68592-15-4

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol

Cas:68592-15-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:Herbal extr

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-(4-methoxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

4-O-Methylhonokiol Application:4-O-Methylhonokiol

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Other

inquiry

DB BIOTECH CO., LTD

best seller Application:API

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

2-(4-methoxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol cas 68592-15-4Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell. https://www.bocsci.com/product/4-o-m

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

68592-15-4

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

4-O-MethylhonokiolAppearance:Oil Storage:4℃ Package:Brown reagent bottle with plastic screw cap Application:analysis,activity test,Botanical Reference Materials,Standard materials Transportation:By express (Door to door) such as FEDEX, DHL, EMS for s

4-O-Methylhonokiol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

4-O-Methyl honokiol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization. Company has strong ability of research and development

4-O-Methyl honokiolwith factory price

Cas:68592-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

potassium 3-allyl-4-methoxyphenyltrifluoroborate

potassium 3-allyl-4-methoxyphenyltrifluoroborate

4-allyl-2-bromo-phenol
17269-79-3

4-allyl-2-bromo-phenol

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; ruphos In 1,2-dimethoxyethane; water at 130℃; for 0.166667h; Suzuki-Miyaura coupling; Microwave irradiation;72%
With palladium diacetate; potassium carbonate; ruphos In 1,2-dimethoxyethane; water at 130℃; Reagent/catalyst; Solvent; Temperature; Suzuki-Miyaura Coupling; Sealed tube; Microwave irradiation;72%
4-allyl-2-bromo-phenol
17269-79-3

4-allyl-2-bromo-phenol

4-methoxy-3-allyl-1-phenylboronic acid
1378871-34-1

4-methoxy-3-allyl-1-phenylboronic acid

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water Suzuki coupling; Reflux; Inert atmosphere;52%
2-allyl-4-bromo-1-methoxybenzene
114303-65-0

2-allyl-4-bromo-1-methoxybenzene

1-allyl-4-oxocyclohexa-2,5-dienylethanoate
108886-90-4

1-allyl-4-oxocyclohexa-2,5-dienylethanoate

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Stage #1: 2-allyl-4-bromo-1-methoxybenzene With magnesium; ethylene dibromide In diethyl ether for 1h; Reflux;
Stage #2: 1-allyl-4-oxocyclohexa-2,5-dienylethanoate In diethyl ether at 0℃; for 0.5h;
50%
Honokiol
35354-74-6

Honokiol

methyl iodide
74-88-4

methyl iodide

A

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol
68592-19-8

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol

B

methylhonokiol
68592-15-4

methylhonokiol

C

Dimethylhonokiol
68592-18-7

Dimethylhonokiol

Conditions
ConditionsYield
With potassium carbonate In water; dimethyl sulfoxide at 60℃;A 50%
B 20%
C 15%
With sodium hydroxide In water; dimethyl sulfoxide at 60℃;A 46%
B 20%
C 30%
With caesium carbonate In water; dimethyl sulfoxide at 60℃; Reagent/catalyst;A 21%
B 35%
C 15%
Honokiol
35354-74-6

Honokiol

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

A

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol
68592-19-8

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol

B

methylhonokiol
68592-15-4

methylhonokiol

C

Dimethylhonokiol
68592-18-7

Dimethylhonokiol

Conditions
ConditionsYield
In methanolA 13%
B 13%
C 47%
Honokiol
35354-74-6

Honokiol

methyl iodide
74-88-4

methyl iodide

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;41%
2-[(2R,4aR,8R,8aR)-8-(5,3'-Diallyl-4'-methoxy-biphenyl-2-yloxy)-4a,8-dimethyl-decahydro-naphthalen-2-yl]-propan-2-ol
143051-79-0

2-[(2R,4aR,8R,8aR)-8-(5,3'-Diallyl-4'-methoxy-biphenyl-2-yloxy)-4a,8-dimethyl-decahydro-naphthalen-2-yl]-propan-2-ol

A

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
With trifluoroacetic acid In benzene for 10h; Ambient temperature;A 6 mg
B 2 mg
eudeshonokiol B
133056-10-7

eudeshonokiol B

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether / 36 h / Ambient temperature
2: 6 mg / CF3COOH / benzene / 10 h / Ambient temperature
View Scheme
Estragole
140-67-0

Estragole

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: boron trichloride-dimethyl sulfide / trans-1,2-dichloroethylene; dichloromethane / 18 h / Reflux
2.1: acetic acid / 8 h
3.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
3.2: 0.5 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: methyl magnesium iodide / 180 °C
2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; isopropylmagnesium chloride / diethyl ether / 24 h / -78 - 20 °C
3: palladium diacetate; potassium carbonate; ruphos / 1,2-dimethoxyethane; water / 0.17 h / 130 °C / Microwave irradiation
View Scheme
Multi-step reaction with 3 steps
1.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / diethyl ether / 1.05 h / -78 °C / Inert atmosphere
2.2: 21 h / -78 - 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere
View Scheme
4-(prop-2-enyl)phenol
501-92-8

4-(prop-2-enyl)phenol

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid / 8 h
2.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
2.2: 0.5 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; isopropylmagnesium chloride / diethyl ether / 24 h / -78 - 20 °C
2: palladium diacetate; potassium carbonate; ruphos / 1,2-dimethoxyethane; water / 0.17 h / 130 °C / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / diethyl ether / 1.05 h / -78 °C / Inert atmosphere
1.2: 21 h / -78 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / diethyl ether / 0.67 h / -78 °C / Inert atmosphere
1.2: 2.5 h / 20 °C / Inert atmosphere
2.1: potassium carbonate; palladium diacetate; ruphos / 1,2-dimethoxyethane; water / 130 °C / Sealed tube; Microwave irradiation
View Scheme
5-bromo-2-methoxy-benzyl alcohol
80866-82-6

5-bromo-2-methoxy-benzyl alcohol

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Oxalyl bromide; Triphenylphosphine oxide / chloroform / 7 h
2.1: [2,2]bipyridinyl; copper(l) iodide / benzene / 5 - 20 °C
3.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
3.2: 0.5 h / 0 °C
View Scheme
4-bromo-2-(bromomethyl)-1-methoxybenzene
184970-28-3

4-bromo-2-(bromomethyl)-1-methoxybenzene

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: [2,2]bipyridinyl; copper(l) iodide / benzene / 5 - 20 °C
2.1: magnesium; ethylene dibromide / diethyl ether / 1 h / Reflux
2.2: 0.5 h / 0 °C
View Scheme
2-allyl-4-bromophenol
13997-74-5

2-allyl-4-bromophenol

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 0.5 h
1.2: 4 h / 20 °C
2.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
2.2: 0.5 h / 20 °C
3.1: palladium diacetate; potassium carbonate; ruphos / 1,2-dimethoxyethane; water / 0.17 h / 130 °C / Microwave irradiation
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 0.25 h / Inert atmosphere
1.2: 1.5 h / Reflux
2.1: n-butyllithium / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran
4.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 0.5 h
1.2: 4 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 20 °C / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
3.1: potassium carbonate; palladium diacetate; ruphos / 1,2-dimethoxyethane; water / 130 °C / Sealed tube; Microwave irradiation
View Scheme
2-allyl-4-bromo-1-methoxybenzene
114303-65-0

2-allyl-4-bromo-1-methoxybenzene

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
1.2: 0.5 h / 20 °C
2.1: palladium diacetate; potassium carbonate; ruphos / 1,2-dimethoxyethane; water / 0.17 h / 130 °C / Microwave irradiation
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C
2.1: hydrogenchloride; water / tetrahydrofuran
3.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere
View Scheme
C16H25BO3

C16H25BO3

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride; water / tetrahydrofuran
2: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere
View Scheme
4-(allyloxy)bromobenzene
25244-30-8

4-(allyloxy)bromobenzene

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Reflux
2.1: potassium carbonate / acetone / 0.25 h / Inert atmosphere
2.2: 1.5 h / Reflux
3.1: n-butyllithium / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C
4.1: hydrogenchloride; water / tetrahydrofuran
5.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere
View Scheme
Honokiol
35354-74-6

Honokiol

dimethyl sulfate
77-78-1

dimethyl sulfate

A

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol
68592-19-8

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol

B

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
With potassium hydroxide Microwave irradiation;
4-bromo-phenol
106-41-2

4-bromo-phenol

methylhonokiol
68592-15-4

methylhonokiol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 5 h / Reflux
2.1: potassium carbonate / acetone / 0.5 h
2.2: 4 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 20 °C / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
4.1: potassium carbonate; palladium diacetate; ruphos / 1,2-dimethoxyethane; water / 130 °C / Sealed tube; Microwave irradiation
View Scheme
methylhonokiol
68592-15-4

methylhonokiol

4'-methoxy-3',5-di-n-propyl-[1,1'-biphenyl]-2-ol
82793-36-0

4'-methoxy-3',5-di-n-propyl-[1,1'-biphenyl]-2-ol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃;99%
With palladium 10% on activated carbon; hydrogen In methanol for 1h;98%
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 21h;97%
With palladium on activated charcoal; hydrogen97%
methylhonokiol
68592-15-4

methylhonokiol

4'-O-methyl-3-nitro-honokiol
1315334-03-2

4'-O-methyl-3-nitro-honokiol

Conditions
ConditionsYield
With nitric acid In hexane; water at 20℃;99%
With nitric acid In ethyl acetate
methylhonokiol
68592-15-4

methylhonokiol

methyl iodide
74-88-4

methyl iodide

Dimethylhonokiol
68592-18-7

Dimethylhonokiol

Conditions
ConditionsYield
Stage #1: methylhonokiol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 3h;
98%
2-methyl-but-2-ene
513-35-9

2-methyl-but-2-ene

methylhonokiol
68592-15-4

methylhonokiol

4'-methoxy-3',5-bis(3-methylbut-2-en-1-yl)-[1,1'-biphenyl]-2-ol
1375102-90-1

4'-methoxy-3',5-bis(3-methylbut-2-en-1-yl)-[1,1'-biphenyl]-2-ol

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 24h; Inert atmosphere;95%
acetic anhydride
108-24-7

acetic anhydride

methylhonokiol
68592-15-4

methylhonokiol

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl acetate
68592-20-1

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl acetate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 0.333333h; Inert atmosphere;93%
With pyridine87%
methylhonokiol
68592-15-4

methylhonokiol

methyl chloroacetate
96-34-4

methyl chloroacetate

C22H24O4

C22H24O4

Conditions
ConditionsYield
With caesium carbonate; triethylamine; potassium iodide In acetone at 20℃; for 24h;89%
methylhonokiol
68592-15-4

methylhonokiol

4'-methoxy-3',5-bis(oxiran-2-ylmethyl)-[1,1'-biphenyl]-2-ol
1375102-87-6

4'-methoxy-3',5-bis(oxiran-2-ylmethyl)-[1,1'-biphenyl]-2-ol

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In benzene87%
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at -78 - 20℃; for 24h; Inert atmosphere;53%
methylhonokiol
68592-15-4

methylhonokiol

prenyl bromide
870-63-3

prenyl bromide

3',5-diallyl-4'-methoxy-2-((3-methylbut-2-en-1-yl)oxy)-1,1'-biphenyl
1375102-74-1

3',5-diallyl-4'-methoxy-2-((3-methylbut-2-en-1-yl)oxy)-1,1'-biphenyl

Conditions
ConditionsYield
Stage #1: methylhonokiol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: prenyl bromide In N,N-dimethyl-formamide at 20℃; for 5h;
86%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

methylhonokiol
68592-15-4

methylhonokiol

benzylamine
100-46-9

benzylamine

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl benzylcarbamate
1375102-79-6

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl benzylcarbamate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; methylhonokiol With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;
Stage #2: benzylamine In dichloromethane at 20℃; for 12h; Inert atmosphere;
81%
morpholine
110-91-8

morpholine

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

methylhonokiol
68592-15-4

methylhonokiol

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl morpholine-4-carboxylate
1389251-25-5

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl morpholine-4-carboxylate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; methylhonokiol With pyridine In dichloromethane at 0 - 20℃; for 2h;
Stage #2: morpholine In dichloromethane at 20℃; for 12h;
68%
methylhonokiol
68592-15-4

methylhonokiol

3'-bromo-3,5'-diallyl-2'-hydroxy-4-methoxy-1,1'-biphenyl
1375102-84-3

3'-bromo-3,5'-diallyl-2'-hydroxy-4-methoxy-1,1'-biphenyl

Conditions
ConditionsYield
Stage #1: methylhonokiol With isopropylmagnesium chloride In tetrahydrofuran; diethyl ether at -78℃; for 0.666667h; Inert atmosphere;
Stage #2: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In tetrahydrofuran; diethyl ether at 20℃; for 2h; Inert atmosphere;
66%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

methylhonokiol
68592-15-4

methylhonokiol

1-amino-2-propene
107-11-9

1-amino-2-propene

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl allylcarbamate
1375102-77-4

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl allylcarbamate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; methylhonokiol With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;
Stage #2: 1-amino-2-propene In dichloromethane at 20℃; for 12h; Inert atmosphere;
65%
methylhonokiol
68592-15-4

methylhonokiol

isopropyl bromide
75-26-3

isopropyl bromide

3',5-diallyl-2-isopropoxy-4'-methoxy-1,1'-biphenyl
1375102-72-9

3',5-diallyl-2-isopropoxy-4'-methoxy-1,1'-biphenyl

Conditions
ConditionsYield
Stage #1: methylhonokiol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: isopropyl bromide In N,N-dimethyl-formamide at 20℃; for 4h;
60%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

methylhonokiol
68592-15-4

methylhonokiol

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl benzyl(methyl)carbamate
1375102-80-9

3',5-diallyl-4'-methoxy-[1,1'-biphenyl]-2-yl benzyl(methyl)carbamate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; methylhonokiol With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;
Stage #2: benzyl-methyl-amine In dichloromethane at 20℃; for 12h; Inert atmosphere;
59%
13-(5-iodopentyl)-9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium iodide

13-(5-iodopentyl)-9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium iodide

methylhonokiol
68592-15-4

methylhonokiol

13-(5-((3′,5-diallyl-4′-methoxy-[1,1′-biphenyl]-2-yl)oxy)pentyl)-9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]-isoquinolin-7-ium iodide

13-(5-((3′,5-diallyl-4′-methoxy-[1,1′-biphenyl]-2-yl)oxy)pentyl)-9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]-isoquinolin-7-ium iodide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;48%
With potassium carbonate In acetone at 50℃;
methylhonokiol
68592-15-4

methylhonokiol

3',5-di-(2,3-dihydroxypropyl)-4'-methoxy-biphenyl-2-ol
1315333-89-1

3',5-di-(2,3-dihydroxypropyl)-4'-methoxy-biphenyl-2-ol

Conditions
ConditionsYield
With pyridine; osmium(VIII) oxide; trimethylamine-N-oxide In water; tert-butyl alcohol for 2h; Inert atmosphere; Reflux;40%
methylhonokiol
68592-15-4

methylhonokiol

5-allyl-3'-(3-hydroxypropyl)-4'-methoxy-[1,1'-biphenyl]-2-ol
1375102-89-8

5-allyl-3'-(3-hydroxypropyl)-4'-methoxy-[1,1'-biphenyl]-2-ol

Conditions
ConditionsYield
Stage #1: methylhonokiol With borane-THF In tetrahydrofuran at 0 - 20℃; for 2.08333h; Inert atmosphere;
Stage #2: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at -10 - 70℃; for 2h; Inert atmosphere;
36%
methylhonokiol
68592-15-4

methylhonokiol

3',5-diallyl-3-chloro-4'-methoxy-[1,1'-biphenyl]-2-ol
1375102-82-1

3',5-diallyl-3-chloro-4'-methoxy-[1,1'-biphenyl]-2-ol

Conditions
ConditionsYield
Stage #1: methylhonokiol With isopropylmagnesium chloride In tetrahydrofuran; diethyl ether at -78 - 20℃; for 0.666667h; Inert atmosphere;
Stage #2: With 1,3-dichloro-5,5-dimethylhydantoin In tetrahydrofuran; diethyl ether at 20℃; for 2h; Inert atmosphere;
32%
methylhonokiol
68592-15-4

methylhonokiol

A

4'-methoxy-3'-((Z)-1-propenyl)-5-(2-propenyl)biphenyl-2-ol
1178919-03-3

4'-methoxy-3'-((Z)-1-propenyl)-5-(2-propenyl)biphenyl-2-ol

B

4'-methoxy-3'-((E)-1-propenyl)-5-(2-propenyl)biphenyl-2-ol
1178919-00-0

4'-methoxy-3'-((E)-1-propenyl)-5-(2-propenyl)biphenyl-2-ol

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 21h; Inert atmosphere; Reflux;
With potassium tert-butylate In tetrahydrofuran

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