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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

Antibacterial standardized herbal extract Honokiol CAS:35354-74-6

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $92.0 / 96.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Honokiol Manufacturer/High quality/Best price/In stock

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Honokiol supplier in China

Cas:35354-74-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

Honokiol Cistanche Extract with best price and top quality

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Honokiol

Cas:35354-74-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Honokiol HACCP manufacturer

Cas:35354-74-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Honokiol

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

Honokiol Mol Download Chemical properties CAS: 35354-74-6 MF: C18H18O2 MW: 266.33 EINECS: 609-119-8 MDL No.: MFCD00016674 Properties Melting point: 86℃ Boiling point: 400.1±40.0 °C(Predicted) Density 1.107±0.06

Top Quality Natural Honokiol

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $35.0 / 49.0

Type:Trading Company

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Magnolia Cortex Extract 2% Honokiol

Cas:35354-74-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,5'-Diallyl-4,2'-dihydroxybiphenyl

Cas:35354-74-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of

Honokiol Manufacturer

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Honokiol Basic information Product Name: Honokiol Synonyms: 5,3'-DIALLYL-2,4'-DIHYDROXYBIPHENYL;5,3'-DIALLYL-2,4'-DIHYDROXYDIPHENYL;5,3'-DIALLYL-BIPHENYL-2,4'-DIO

TIANFU-CHEM CAS:35354-74-6 Honokiol

Cas:35354-74-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 35354-74-6 98% Honokiol Plant Extract

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 35354-74-6 with best quality

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

Best price magnolia bark extract 98% honokiol powder CAS NO.35354-74-6

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $2.0 / 6.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:off-white powder Storage: Keep in a

Topsale 100% Natural Magnolia extract Honokiol

Cas:35354-74-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Honokiol CAS:35354-74-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Honokiol CAS:35354-74-6

Cas:35354-74-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Honokiol

Cas:35354-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:35354-74-6

Cas:35354-74-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales Honokiol CAS 35354-74-6

Cas:35354-74-6

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Honokiol

Cas:35354-74-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Honokiol

Cas:35354-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

honokiol

Cas:35354-74-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

HONOKIOL

Cas:35354-74-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Nano Liposomal Honokiol

Cas:35354-74-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Natural Honokiol from Magnolia Officinalis Bark extract

Cas:35354-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Honokiol

Cas:35354-74-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD

Natural product : 100% natural product, without any synthetic ingredients. Manufacturer : China's leading manufacturer of plant extracts. Quality : Our products have undergone comprehensive inspection and all have passed strict testing. In s

Honokiol supplier in China Antibacterial standardized herbal extract CAS NO.35354-74-6

Cas:35354-74-6

Min.Order:5 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Honokiol

Cas:35354-74-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-phenyl-6,6-bis(prop-2-enyl)cyclohexa-1,3-diene-1,3-diol CAS NO.35354-74-6

Cas:35354-74-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Dimethylhonokiol
68592-18-7

Dimethylhonokiol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
With aluminum (III) chloride at -5 - 0℃; for 0.333333h;97%
With boron tribromide-dimethyl sulfide complex In 1,2-dichloro-ethane at 65℃; for 15h; Reagent/catalyst; Temperature; Inert atmosphere;95%
Stage #1: Dimethylhonokiol With triethylsilane; tris(pentafluorophenyl)borate In dichloromethane at 20℃; for 0.333333h; Inert atmosphere; Schlenk technique;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #3: With water In tetrahydrofuran
57.8%
3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol
68592-19-8

3,5′-diallyl-2′-methoxy-[1,1′-biphenyl]-4-ol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
With boron trichloride - methyl sulfide complex In dichloromethane; 1,2-dichloro-ethane for 18h; Reflux;91%
With boron tribromide In dichloromethane at 20℃; for 0.416667h; Inert atmosphere;90%
With boron tribromide at -15 - 20℃;
With boron tribromide In dichloromethane at 20℃; for 0.416667h; Inert atmosphere;430 mg
5-allyl-4'-(allyloxy)-[1,1'-biphenyl]-2-ol
108886-93-7

5-allyl-4'-(allyloxy)-[1,1'-biphenyl]-2-ol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
With N,N-diethylaniline at 200℃; for 24h; Claisen Rearrangement; Sealed tube; Schlenk technique; Inert atmosphere;90%
With boron trichloride In chlorobenzene at -15℃; for 1h;80%
5,3'-diallyl-2,4'-bis-methoxymethoxy-biphenyl
711012-14-5

5,3'-diallyl-2,4'-bis-methoxymethoxy-biphenyl

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 44h;89%
3,5'-diallyl-2'-(methoxymethoxy)-[1,1'-biphenyl]-4-ol

3,5'-diallyl-2'-(methoxymethoxy)-[1,1'-biphenyl]-4-ol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
With methanol; chloro-trimethyl-silane at 0 - 20℃; for 6h;85%
2,4'-bis-O-allylbiphenyl
911812-86-7

2,4'-bis-O-allylbiphenyl

A

3,3'-diallyl biphenyl-2,4'-diol

3,3'-diallyl biphenyl-2,4'-diol

B

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
for 1.33333h; Claisen Rearrangement; Microwave irradiation; Heating; Sealed tube;A 40%
B 60%
at 180℃; for 1.33333h; Claisen Rearrangement; Microwave irradiation;A 40%
B 60%
at 190℃; for 12h; Claisen Rearrangement; Sealed tube;A 55%
B 40%
at 190℃; for 12h; Claisen Rearrangement; Sealed tube;A 55%
B 40%
5-allyl-4'-(allyloxy)-2-methoxybiphenyl
1133087-04-3

5-allyl-4'-(allyloxy)-2-methoxybiphenyl

A

Honokiol
35354-74-6

Honokiol

B

5-allyl-[1,1'-biphenyl]-2,4'-diol
1253950-18-3

5-allyl-[1,1'-biphenyl]-2,4'-diol

Conditions
ConditionsYield
With boron trichloride - methyl sulfide complex In dichloromethane; 1,2-dichloro-ethane for 18h; Claisen rearrangement; Reflux;A 47%
B 49%
Conditions
ConditionsYield
With trifluoroacetic acid In benzene
Conditions
ConditionsYield
With trifluoroacetic acid In benzene for 10h; Ambient temperature;A 7 mg
B 3 mg
5-bromosalicyclic acid
89-55-4

5-bromosalicyclic acid

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 100 percent / aq. H2SO4 / Heating
2: 100 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C
3: 86 percent / PdCl2(dppf); dppf; AcOK / dioxane / 80 °C
4: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
5: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
6: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
7: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
8: 52 percent / CuI / tetrahydrofuran / -26 °C
9: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
methyl 3-bromo-4-hydroxybenzoate
29415-97-2

methyl 3-bromo-4-hydroxybenzoate

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 98 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C
2: 100 percent / DIBAL-H / CH2Cl2 / 2 h / -78 °C
3: 100 percent / imidazole / dimethylformamide / 20 °C
4: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
5: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
6: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
7: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
8: 52 percent / CuI / tetrahydrofuran / -26 °C
9: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
5-bromo-2-hydroxy-benzoic acid methyl ester
4068-76-2

5-bromo-2-hydroxy-benzoic acid methyl ester

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 100 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C
2: 86 percent / PdCl2(dppf); dppf; AcOK / dioxane / 80 °C
3: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
4: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
5: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
6: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
7: 52 percent / CuI / tetrahydrofuran / -26 °C
8: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 80 percent / HBF4; N-bromosuccinimide / acetonitrile / -20 - 20 °C
2: 98 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C
3: 100 percent / DIBAL-H / CH2Cl2 / 2 h / -78 °C
4: 100 percent / imidazole / dimethylformamide / 20 °C
5: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
6: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
7: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
8: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
9: 52 percent / CuI / tetrahydrofuran / -26 °C
10: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
(3-bromo-4-methoxymethoxy-phenyl)-methanol
162269-91-2

(3-bromo-4-methoxymethoxy-phenyl)-methanol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 100 percent / imidazole / dimethylformamide / 20 °C
2: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
3: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
4: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
5: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
6: 52 percent / CuI / tetrahydrofuran / -26 °C
7: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
5-bromo-2-methoxymethoxy-benzoic acid methyl ester
711012-12-3

5-bromo-2-methoxymethoxy-benzoic acid methyl ester

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86 percent / PdCl2(dppf); dppf; AcOK / dioxane / 80 °C
2: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
3: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
4: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
5: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
6: 52 percent / CuI / tetrahydrofuran / -26 °C
7: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
3-bromo-4-methoxymethoxybenzoic acid methyl ester
672922-57-5

3-bromo-4-methoxymethoxybenzoic acid methyl ester

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 100 percent / DIBAL-H / CH2Cl2 / 2 h / -78 °C
2: 100 percent / imidazole / dimethylformamide / 20 °C
3: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
4: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
5: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
6: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
7: 52 percent / CuI / tetrahydrofuran / -26 °C
8: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
(3-bromo-4-methoxymethoxy-benzyloxy)-tert-butyl-dimethyl-silane
711012-11-2

(3-bromo-4-methoxymethoxy-benzyloxy)-tert-butyl-dimethyl-silane

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
2: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
3: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
4: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
5: 52 percent / CuI / tetrahydrofuran / -26 °C
6: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

acid

acid

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 99 percent / aq. H2SO4 / Heating
2: 80 percent / HBF4; N-bromosuccinimide / acetonitrile / -20 - 20 °C
3: 98 percent / i-Pr2NEt / dimethylformamide / 3 h / 20 °C
4: 100 percent / DIBAL-H / CH2Cl2 / 2 h / -78 °C
5: 100 percent / imidazole / dimethylformamide / 20 °C
6: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
7: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
8: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
9: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
10: 52 percent / CuI / tetrahydrofuran / -26 °C
11: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
2-methoxymethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester
711012-10-1

2-methoxymethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 87 percent / PdCl2(dppf); dppf; K3PO4 / dioxane / 108 °C
2: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
3: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
4: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
5: 52 percent / CuI / tetrahydrofuran / -26 °C
6: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
5,3'-bis-bromomethyl-2,4'-bis-methoxymethoxy-biphenyl
711012-16-7

5,3'-bis-bromomethyl-2,4'-bis-methoxymethoxy-biphenyl

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 52 percent / CuI / tetrahydrofuran / -26 °C
2: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
(3'-hydroxymethyl-6,4'-bis-methoxymethoxy-biphenyl-3-yl)-methanol
711012-13-4

(3'-hydroxymethyl-6,4'-bis-methoxymethoxy-biphenyl-3-yl)-methanol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
2: 52 percent / CuI / tetrahydrofuran / -26 °C
3: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-carboxylic acid methyl ester
711012-09-8

5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-carboxylic acid methyl ester

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 99 percent / LiAlH4 / tetrahydrofuran / 0 °C
2: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
3: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
4: 52 percent / CuI / tetrahydrofuran / -26 °C
5: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
[5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-yl]-methanol
711012-15-6

[5'-(tert-butyl-dimethyl-silanyloxymethyl)-4,2'-bis-methoxymethoxy-biphenyl-3-yl]-methanol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 98 percent / HF; pyridine / acetonitrile / 1 h / 20 °C
2: 80 percent / N-bromosuccinimide; triphenylphosphine / CH2Cl2
3: 52 percent / CuI / tetrahydrofuran / -26 °C
4: 89 percent / aq. HCl / methanol / 44 h / 20 °C
View Scheme
4-(prop-2-enyl)phenol
501-92-8

4-(prop-2-enyl)phenol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 29.2 percent / acetic acid / 0.25 h / Ambient temperature
2: 1.) methyl iodide, Mg / 1.) ether, reflux, 5 h; 2.) ether, -15 deg C, 30 min
3: 80 percent / BCl3 / chlorobenzene / 1 h / -15 °C
View Scheme
1-allyl-4-oxocyclohexa-2,5-dienylethanoate
108886-90-4

1-allyl-4-oxocyclohexa-2,5-dienylethanoate

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) methyl iodide, Mg / 1.) ether, reflux, 5 h; 2.) ether, -15 deg C, 30 min
2: 80 percent / BCl3 / chlorobenzene / 1 h / -15 °C
View Scheme
methylhonokiol
68592-15-4

methylhonokiol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Stage #1: methylhonokiol With boron tribromide In dichloromethane at -78℃;
Stage #2: With water
Grignard reaction;
5-allyl-4'-(allyloxy)-2-methoxybiphenyl
1133087-04-3

5-allyl-4'-(allyloxy)-2-methoxybiphenyl

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
4-allyl-2-bromo-1-methoxybenzene
87688-94-6

4-allyl-2-bromo-1-methoxybenzene

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 24 h / 20 °C / Inert atmosphere
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice
3.2: 2.08 h / 20 °C / Inert atmosphere
3.3: 18 h / 140 °C / Inert atmosphere
4.1: sodium iodide; zinc / N,N-dimethyl-formamide / 18 h / 140 °C / Inert atmosphere
5.1: potassium carbonate / acetone / 20 °C / Inert atmosphere
6.1: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
7.1: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 24 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere; Cooling
3.2: 2 h / 20 °C / Inert atmosphere; Cooling
3.3: 18 h / 140 °C / Inert atmosphere
4.1: potassium carbonate / acetone / 20 °C / Inert atmosphere
5.1: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
6.1: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
5'-allyl-2'-methoxy-biphenyl-4-ol
1133087-02-1

5'-allyl-2'-methoxy-biphenyl-4-ol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 20 °C / Inert atmosphere
2: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
3: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 20 °C / Inert atmosphere
2: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
3: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
3-(3-bromo-4-methoxy-phenyl)-propane-1,2-diol
1355483-89-4

3-(3-bromo-4-methoxy-phenyl)-propane-1,2-diol

Honokiol
35354-74-6

Honokiol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice
2.2: 2.08 h / 20 °C / Inert atmosphere
2.3: 18 h / 140 °C / Inert atmosphere
3.1: sodium iodide; zinc / N,N-dimethyl-formamide / 18 h / 140 °C / Inert atmosphere
4.1: potassium carbonate / acetone / 20 °C / Inert atmosphere
5.1: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
6.1: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere; Cooling
2.2: 2 h / 20 °C / Inert atmosphere; Cooling
2.3: 18 h / 140 °C / Inert atmosphere
3.1: potassium carbonate / acetone / 20 °C / Inert atmosphere
4.1: diethylaluminium chloride / hexane / 2 h / 20 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / 0.42 h / 20 °C / Inert atmosphere
View Scheme
Honokiol
35354-74-6

Honokiol

benzoyl chloride
98-88-4

benzoyl chloride

3',5-diallyl-2,4'-diphenylformyloxybiphenyl

3',5-diallyl-2,4'-diphenylformyloxybiphenyl

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice;98.4%
Honokiol
35354-74-6

Honokiol

allyl bromide
106-95-6

allyl bromide

3',5-diallyl-2,4'-bis(allyloxy)-1,1'-biphenyl

3',5-diallyl-2,4'-bis(allyloxy)-1,1'-biphenyl

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃; for 12h;97%
formaldehyd
50-00-0

formaldehyd

Honokiol
35354-74-6

Honokiol

ethylamine
75-04-7

ethylamine

C26H32N2O2

C26H32N2O2

Conditions
ConditionsYield
In 1,4-dioxane; toluene at 120℃; for 24h;95.5%
formaldehyd
50-00-0

formaldehyd

hexan-1-amine
111-26-2

hexan-1-amine

Honokiol
35354-74-6

Honokiol

C34H48N2O2

C34H48N2O2

Conditions
ConditionsYield
In 1,4-dioxane; toluene at 110℃; for 43h;95.5%
Honokiol
35354-74-6

Honokiol

acetic anhydride
108-24-7

acetic anhydride

2,4'-diacetoxy-5,3'-di(2-propenyl)biphenyl
35347-50-3

2,4'-diacetoxy-5,3'-di(2-propenyl)biphenyl

Conditions
ConditionsYield
With pyridine95%
With potassium carbonate at 20℃; for 0.5h;56%
With pyridine at 25℃; for 18h;
With sodium hydrogencarbonate In ethyl acetate for 48h;
Honokiol
35354-74-6

Honokiol

Tetrahydrohonokiol
35406-31-6

Tetrahydrohonokiol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol for 5h; Reflux;94%
With sodium tetrahydroborate; nickel dichloride70%
With hydrogen; palladium on activated charcoal
With palladium on activated charcoal; hydrogen
With Lindlar's catalyst; hydrogen In ethanol at 20℃; under 760.051 Torr; for 24h;
formaldehyd
50-00-0

formaldehyd

Honokiol
35354-74-6

Honokiol

aniline
62-53-3

aniline

C34H32N2O2

C34H32N2O2

Conditions
ConditionsYield
In 1,4-dioxane; toluene at 100℃; for 58h;93.6%
formaldehyd
50-00-0

formaldehyd

furan-2-ylmethanamine
617-89-0

furan-2-ylmethanamine

Honokiol
35354-74-6

Honokiol

C32H32N2O4

C32H32N2O4

Conditions
ConditionsYield
In 1,4-dioxane; toluene at 100℃; for 52h;90.8%
4-Nitrophthalonitrile
31643-49-9

4-Nitrophthalonitrile

Honokiol
35354-74-6

Honokiol

C34H22N4O2

C34H22N4O2

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 40℃; for 48h; Inert atmosphere;90%
Honokiol
35354-74-6

Honokiol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diethyl 2,2'-((3',5-diallyl-[1,1'-biphenyl]-2,4'-diyl)bis(oxy))diacetate
1333391-01-7

diethyl 2,2'-((3',5-diallyl-[1,1'-biphenyl]-2,4'-diyl)bis(oxy))diacetate

Conditions
ConditionsYield
Stage #1: Honokiol With potassium carbonate In N,N-dimethyl-formamide at 20 - 25℃; Williamson synthesis;
Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide at 30℃; for 6h; Williamson synthesis;
89.3%
Honokiol
35354-74-6

Honokiol

4-allyl-2-(2-methyl-benzofuran-5-yl)phenol
1416567-14-0

4-allyl-2-(2-methyl-benzofuran-5-yl)phenol

Conditions
ConditionsYield
With oxygen; sodium acetate; palladium dichloride In N,N-dimethyl acetamide; water at 60℃; under 6080.41 Torr; for 16h; Autoclave;86%
With oxygen; sodium acetate; palladium dichloride In N,N-dimethyl acetamide; water at 60℃; under 6080.41 Torr; for 16h; Autoclave;86%
With oxygen; sodium acetate; palladium dichloride In N,N-dimethyl acetamide; water at 60℃; under 6000.6 Torr; for 16h; Wacker Oxidation;86%
formaldehyd
50-00-0

formaldehyd

Honokiol
35354-74-6

Honokiol

dimethyl amine
124-40-3

dimethyl amine

3',5-diallyl-3,5'-bis((dimethylamino)methyl)-[1,1'-biphenyl]-2,4'-diol

3',5-diallyl-3,5'-bis((dimethylamino)methyl)-[1,1'-biphenyl]-2,4'-diol

Conditions
ConditionsYield
In methanol; water at 20℃; for 16h;86%
Stage #1: formaldehyd; dimethyl amine With hydrogenchloride In methanol; water at 2 - 35℃; for 1h;
Stage #2: Honokiol In methanol; water at 75℃; for 6h;
60%
Honokiol
35354-74-6

Honokiol

methyl iodide
74-88-4

methyl iodide

Dimethylhonokiol
68592-18-7

Dimethylhonokiol

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;84%
With sodium hydride In water; dimethyl sulfoxide at 0℃;38%
Honokiol
35354-74-6

Honokiol

3',5-diallyl-3,5'-dinitroso-1,1'-biphenyl-2,4'-diphenol

3',5-diallyl-3,5'-dinitroso-1,1'-biphenyl-2,4'-diphenol

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water; acetonitrile at 20℃; for 1.5h; Cooling with ice;79%
With hydrogenchloride; sodium nitrite In water; acetonitrile at 20℃; for 1.5h;79.3%
Honokiol
35354-74-6

Honokiol

3-bromo-1-phenyl-1-propenyl bromide
4392-24-9

3-bromo-1-phenyl-1-propenyl bromide

3',5-diallyl-2E,4'E-bis(cinnamyloxy)-1,1'-biphenyl

3',5-diallyl-2E,4'E-bis(cinnamyloxy)-1,1'-biphenyl

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃;78%
Honokiol
35354-74-6

Honokiol

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

4-allyl-2-(2-((methylthio)methyl)-2,3-dihydrobenzofuran-5-yl)phenol

4-allyl-2-(2-((methylthio)methyl)-2,3-dihydrobenzofuran-5-yl)phenol

Conditions
ConditionsYield
With ammonium iodide at 130℃; for 18h; Schlenk technique;76%
formaldehyd
50-00-0

formaldehyd

Honokiol
35354-74-6

Honokiol

dimethyl amine
124-40-3

dimethyl amine

C21H25NO2

C21H25NO2

Conditions
ConditionsYield
Stage #1: formaldehyd; dimethyl amine In water at 55℃; for 0.666667h; Mannich Aminomethylation;
Stage #2: Honokiol In water
76%
Honokiol
35354-74-6

Honokiol

methyl 2-(2-chlorophenyl)-2-diazoacetate
264882-00-0

methyl 2-(2-chlorophenyl)-2-diazoacetate

methyl 2-(2-chlorophenyl)-2-((5,5'-diallyl-2'-hydroxy-[1,1'-biphenyl]-2-yl)oxy)acetate

methyl 2-(2-chlorophenyl)-2-((5,5'-diallyl-2'-hydroxy-[1,1'-biphenyl]-2-yl)oxy)acetate

Conditions
ConditionsYield
With sewage sludge-derived carbon material treated with perchloric acid In 1,2-dichloro-ethane at 70℃; for 24h;72%
Honokiol
35354-74-6

Honokiol

dimethyl sulfate
77-78-1

dimethyl sulfate

Dimethylhonokiol
68592-18-7

Dimethylhonokiol

Conditions
ConditionsYield
With sodium In ethanol for 5h; Inert atmosphere; Reflux;70%
Honokiol
35354-74-6

Honokiol

3,3'-(4,6'-dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(propane-1,2-diol)

3,3'-(4,6'-dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(propane-1,2-diol)

Conditions
ConditionsYield
Stage #1: Honokiol With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 2h;
Stage #2: With sodium hydroxide In tetrahydrofuran for 1h; Reflux;
66%
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 1 h / Reflux
View Scheme
Honokiol
35354-74-6

Honokiol

C18H17IO2

C18H17IO2

Conditions
ConditionsYield
With iodine In ethanol; water at 50℃; for 12h;65.87%
formaldehyd
50-00-0

formaldehyd

Honokiol
35354-74-6

Honokiol

3',5-diallyl-3,5'-bis(hydroxymethyl)biphenyl-2,4'-diol
1333391-05-1

3',5-diallyl-3,5'-bis(hydroxymethyl)biphenyl-2,4'-diol

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 24h;63.15%
Honokiol
35354-74-6

Honokiol

3',5-aiallyl-3,5'-dinitro-[1,1'-biphenyl]-2,4'-diol

3',5-aiallyl-3,5'-dinitro-[1,1'-biphenyl]-2,4'-diol

Conditions
ConditionsYield
Stage #1: Honokiol With acetic acid In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With nitric acid In dichloromethane at 0℃; for 6h;
61.3%
With nitric acid; acetic acid In dichloromethane at 10 - 20℃; for 1h;52%
Honokiol
35354-74-6

Honokiol

cyanomethyl bromide
590-17-0

cyanomethyl bromide

C22H20N2O2

C22H20N2O2

Conditions
ConditionsYield
With caesium carbonate; potassium iodide In acetone at 20℃; for 24h;61%
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