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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Fmoc-L-Valine

Cas:68858-20-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

GL Biochem (Shanghai) Ltd.

GL Biochem (Shanghai) Ltd. founded in 1998, has become an internationally recognized biochemical manufacturing company that specializes in producing/synthesizing and providing peptide reagents, custom peptides and antibodies. GL Biochem is

Fmoc-Val-OH, MFCD00037124, High Purity & High Chirality SPPS Building Blocks

Cas:68858-20-8

Min.Order:5 Gram

FOB Price: $1.0 / 1.5

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Fmoc-L-Valine supplier in China

Cas:68858-20-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:biochemical Transportation:by cour

Manufacturer high quality FMOC-L-Valine Cas 68858-20-8 with good price

Cas:68858-20-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

FMOC--L-Val-OH

Cas:68858-20-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fmoc-L-Valine

Cas:68858-20-8

Min.Order:1

Negotiable

Type:Other

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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality manage

Fmoc-L-Valine

Cas:68858-20-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nα-9-Fluorenylmethoxycarbonyl-L-valine

Cas:68858-20-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:FMOC-L-Valine CAS NO:68858-20-8 Grade:Medical scientific research and export Molecular formula:C20H21NO4 Molecular weight:339.39 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Dat

FMOC-L-Valine/ CAS:68858-20-8/FMOC-L-Valine raw material/ high-quality

Cas:68858-20-8

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Leader Biochemical Group

Product Name: FMOC-L-Valine Synonyms: N-FMOC-VAL-OH;N-FMOC-L-VAL;N-FMOC-L-VALINE;N-(9-FLUORENYLMETHOXYCARBONYL)-L-VALINE;N-9-FLUORENYLMETHYLOXYCARBONYL-L-VALINE;N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-VALINE;N-ALPHA-(9-FLUORENY

China Biggest Factory & Manufacturer supply FMOC-L-Valine CAS: 68858-20-8

Cas:68858-20-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.2270 (rough estimate) Melting point: 143-145 ° C (lit.) Boiling point: 475.36 ° C (rough estimate) Specific rotation: -16 º (c=1, DMF) Flash point: 287.5 ° C Steam pressure: 5.19E-13mmHg at 25 ° C Solubility in methano

FMOC-L-Valine 68858-20-8

Cas:68858-20-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Fmoc-L-Valine

Cas:68858-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Competitve Price in stockCAS 68858-20-8 with high-quality service

Cas:68858-20-8

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-CAS68858-20-8

Cas:68858-20-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 30.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material FMOC-L-Valine CAS 68858-20-8

Cas:68858-20-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name N-alpha-FMOC-L-valine Alias FMOC-Val-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]valine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valine; (2S)-2

N-alpha-FMOC-L-valine

Cas:68858-20-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

68858-20-8 FMOC-L-Valine

Cas:68858-20-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Fmoc-L-Valine 68858-20-8

Cas:68858-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Fmoc-Val-OH, MFCD00037124, High Purity & High Chirality SPPS Building Blocks

Cas:68858-20-8

Min.Order:5 Gram

FOB Price: $1.5

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

FMOC-L-Valine CAS:68858-20-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

FMOC-L-Valine CAS:68858-20-8

Cas:68858-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Fmoc-L-Valine

Cas:68858-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:68858-20-8

Cas:68858-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Fmoc-L-Valine

Cas:68858-20-8

Min.Order:1 Kilogram

FOB Price: $180.0 / 220.0

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Product Name Fmoc-L-Val-OH Molecular Formula C20H21NO4 CAS Number 68858-20-8 Molecular Weight 339.40 Appearance White to off-white microcrystalline powd

FMOC-L-Valine manufacture

Cas:68858-20-8

Min.Order:1 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Fmoc-L-Val

Cas:68858-20-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

N-(9H-FLUOREN-9-YLMETHOXYCARBONYL)-L-VALINE

Cas:68858-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Fmoc-L-Val

Cas:68858-20-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

Fmoc-Val-OH

Cas:68858-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Fmoc-L-Valine

Cas:68858-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Methyl-5-nitropyridine

Cas:68858-20-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

L-valine
72-18-4

L-valine

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane at 0 - 20℃;96%
Stage #1: L-valine With sodium hydrogencarbonate In 1,4-dioxane; water
Stage #2: (fluorenylmethoxy)carbonyl chloride In 1,4-dioxane; water at 0 - 20℃;
70%
With pyridine; HOBT bound to the polystyrene-divinylbenzene copolymer resin 1.) DMF, H2O, 25 deg C, 2.) DMF, H2O, 25 deg C; Yield given. Multistep reaction;
L-valine
72-18-4

L-valine

3-(9-Fluorenylmethoxycarbonyl)-benzothiazoline-2-thione
100803-86-9

3-(9-Fluorenylmethoxycarbonyl)-benzothiazoline-2-thione

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 12h; Ambient temperature;91%
L-valine
72-18-4

L-valine

(9-fluorenyl)methyl pentafluorophenyl carbonate
88744-04-1

(9-fluorenyl)methyl pentafluorophenyl carbonate

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone Ambient temperature;90%
L-valine
72-18-4

L-valine

9-fluorenylmethyl N-succinimidyl carbonate
102774-86-7

9-fluorenylmethyl N-succinimidyl carbonate

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With triethylamine In water; acetonitrile for 1h;89%
L-valine
72-18-4

L-valine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide for 0.166667h; Ambient temperature;87%
With sodium hydrogencarbonate In water; acetone86%
Stage #1: L-valine With N-cyclohexyl-cyclohexanamine In acetone at 20℃;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium carbonate In water; acetonitrile at 0 - 20℃; pH=8;
Stage #3: With potassium hydrogensulfate In water; acetonitrile pH=2 - 3;
82%
With sodium hydrogencarbonate In water; N,N-dimethyl-formamide at 0 - 20℃; for 2h;
With sodium carbonate In 1,4-dioxane; water at 20℃; for 18h;
L-valine
72-18-4

L-valine

Carbonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester 9H-fluoren-9-ylmethyl ester

Carbonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester 9H-fluoren-9-ylmethyl ester

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 2h;86%
L-valine
72-18-4

L-valine

Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester 9H-fluoren-9-ylmethyl ester
99503-04-5

Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester 9H-fluoren-9-ylmethyl ester

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With tertiary amine In 1,4-dioxane; water for 3h;85%
N-(9-fluorenylmethoxycarbonyl)valine 1,1-dimethylallyl ester
851713-90-1

N-(9-fluorenylmethoxycarbonyl)valine 1,1-dimethylallyl ester

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 25℃;82%
L-valine
72-18-4

L-valine

4-(9-fluorenylmethoxycarbonyloxy) phenyl dimethylsulfonium methylsulfate

4-(9-fluorenylmethoxycarbonyloxy) phenyl dimethylsulfonium methylsulfate

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With triethylamine In water Ambient temperature;75%
L-valine
72-18-4

L-valine

polymer-bound Fmoc-O-succinimide

polymer-bound Fmoc-O-succinimide

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;75%
N-Fmoc-L-valine phenacyl ester

N-Fmoc-L-valine phenacyl ester

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With magnesium; acetic acid In methanol; N,N-dimethyl-formamide at 20℃; for 75h;
9-Fluorenylmethanol
24324-17-2

9-Fluorenylmethanol

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / pyridine / CH2Cl2 / 5 h / Ambient temperature
2: 86 percent / NaHCO3 / H2O; acetone
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: sodium carbonate / water; 1,4-dioxane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: sodium carbonate / water; 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere
View Scheme
dicyclohexylamine salt of N-hydroxysuccinimide
82911-72-6

dicyclohexylamine salt of N-hydroxysuccinimide

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / CHCl3
2: 86 percent / NaHCO3 / H2O; acetone
View Scheme
N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

chromium oxide activated nickel catalyst

chromium oxide activated nickel catalyst

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / acetone
2: 90 percent / CHCl3
3: 86 percent / NaHCO3 / H2O; acetone
View Scheme
N-hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2

N-hydroxy-5-norbornene-2,3-dicarboximide

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaOH / 1.) MeOH; 2.) benzene, 10-15 deg C, 2 h
2: pyridine / 1.) room temp., 1 h; 2.) 35 deg C, 3 h
3: 85 percent / tertiary amine / H2O; dioxane / 3 h
View Scheme
Chlorameisensaeure-N-hydroxy-norborn-5-en-2,3-dicarboximidester
99502-89-3

Chlorameisensaeure-N-hydroxy-norborn-5-en-2,3-dicarboximidester

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 1.) room temp., 1 h; 2.) 35 deg C, 3 h
2: 85 percent / tertiary amine / H2O; dioxane / 3 h
View Scheme
Fmoc-Val-OPfp
86060-87-9

Fmoc-Val-OPfp

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With benzotriazol-1-ol; 17O-water In tetrahydrofuran; water at 20℃; for 240h;
C38H50NO6PolSi

C38H50NO6PolSi

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With pyridine; pyridine hydrogenfluoride In tetrahydrofuran at 20℃; for 3h;
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

L-valine hydrochloride
17498-50-9, 25616-14-2, 31320-20-4

L-valine hydrochloride

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / dichloromethane; water / 20.5 h / 0 - 20 °C
2: sodium carbonate / water; acetone / 4 h / 20 °C / pH 9 - 10
View Scheme
L-valine
72-18-4

L-valine

N-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-2-amino-2-oxoacetimidoyl cyanide
1370440-28-0

N-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-2-amino-2-oxoacetimidoyl cyanide

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Conditions
ConditionsYield
With sodium carbonate In water; acetone at 20℃; for 4h; pH=9 - 10;
D,L-valine
516-06-3

D,L-valine

A

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

B

N-(9-fluorenylmethoxycarbonyl)-D-valine
84624-17-9

N-(9-fluorenylmethoxycarbonyl)-D-valine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate / water; 1,4-dioxane / Cooling with ice
1.2: 5 h / 20 °C
2.1: trifluoroacetic acid / isopropyl alcohol; hexane / 25 °C / Resolution of racemate
View Scheme
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

A

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

B

N-(9-fluorenylmethoxycarbonyl)-D-valine
84624-17-9

N-(9-fluorenylmethoxycarbonyl)-D-valine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate / water; 1,4-dioxane / Cooling with ice
1.2: 5 h / 20 °C
2.1: trifluoroacetic acid / isopropyl alcohol; hexane / 25 °C / Resolution of racemate
View Scheme
Fmoc-valine
126727-02-4

Fmoc-valine

A

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

B

N-(9-fluorenylmethoxycarbonyl)-D-valine
84624-17-9

N-(9-fluorenylmethoxycarbonyl)-D-valine

Conditions
ConditionsYield
With trifluoroacetic acid In hexane; isopropyl alcohol at 25℃; Reagent/catalyst; Resolution of racemate;
With chiral column based on 3,5-dimethylphenylcarbamoylated β-cyclodextrin combining cinchona alkaloid immobilized on silica gel In methanol; formic acid; triethylamine; acetonitrile at 25℃; Resolution of racemate; enantioselective reaction;
Fmoc-Val-OBt
124007-51-8

Fmoc-Val-OBt

A

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

B

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

Conditions
ConditionsYield
With water for 24h; Kinetics;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

2,5-dioxopyrrolidin-1-yl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valinate
130878-68-1

2,5-dioxopyrrolidin-1-yl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valinate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 9h;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; dichloromethane at 0 - 25℃;96%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃;96%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

(S)-(9H-fluoren-9-yl)methyl 1-chloro-3-methyl-1-oxobutan-2-ylcarbamate
103321-53-5

(S)-(9H-fluoren-9-yl)methyl 1-chloro-3-methyl-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 55 - 60℃; for 1h; Inert atmosphere;100%
With thionyl chloride In dichloromethane at 50 - 55℃; for 1h; Inert atmosphere;100%
With thionyl chloride In dichloromethane for 24h; Ambient temperature;90%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

(9H-fluoren-9-yl)methyl (S)-(1-fluoro-3-methyl-1-oxobutan-2-yl)carbamate
130858-93-4

(9H-fluoren-9-yl)methyl (S)-(1-fluoro-3-methyl-1-oxobutan-2-yl)carbamate

Conditions
ConditionsYield
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane at 20℃; for 15h;100%
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane for 4h; Ambient temperature;85%
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane for 2h;70.2%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine
75755-40-7

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

(9H-fluoren-9-yl)methyl 1-{(2S)-2-methyl-1-[({1,1-dimethyl-2-[methyl(phenyl)amino]-2-oxoethyl}amino)carbonyl]propyl}carbamate
259217-20-4

(9H-fluoren-9-yl)methyl 1-{(2S)-2-methyl-1-[({1,1-dimethyl-2-[methyl(phenyl)amino]-2-oxoethyl}amino)carbonyl]propyl}carbamate

Conditions
ConditionsYield
In dichloromethane at 20℃; for 72h; Condensation;100%
Leu-Cys(Trt)-Ala-Wang resin

Leu-Cys(Trt)-Ala-Wang resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Val-Leu-Cys(Trt)-Ala-Wang resin

Val-Leu-Cys(Trt)-Ala-Wang resin

Conditions
ConditionsYield
Stage #1: Leu-Cys(Trt)-Ala-Wang resin; Fmoc-Val-OH With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.25h;
100%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

monomethoxy-polyethylene glycol

monomethoxy-polyethylene glycol

N-(9-fluorenylmethoxycarbonyl)-L-valine terminated monomethoxy-polyethylene glycol

N-(9-fluorenylmethoxycarbonyl)-L-valine terminated monomethoxy-polyethylene glycol

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;100%
L-valinamide
4540-60-7

L-valinamide

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Fmoc-Val-Val-NH2

Fmoc-Val-Val-NH2

Conditions
ConditionsYield
With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 2h;100%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Product distribution; Further Variations:; Reagents;
6-(tert-butoxycarbonylamino)hexanoic acid
6404-29-1

6-(tert-butoxycarbonylamino)hexanoic acid

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Boc-Ahx-Val-Ala-OH
1000018-75-6

Boc-Ahx-Val-Ala-OH

Conditions
ConditionsYield
Multistep reaction.;100%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester
1089192-59-5

(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane Cooling with ice;100%
C36H37N3O4S3

C36H37N3O4S3

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

C56H56N4O7S3

C56H56N4O7S3

Conditions
ConditionsYield
With dmap; 2,4,6-trichlorobenzoyl chloride In toluene100%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

C6H12NO2Pol

C6H12NO2Pol

Conditions
ConditionsYield
Stage #1: Fmoc-Val-OH With pyridine; 2,6-Dichlorobenzoyl chloride In 1-methyl-pyrrolidin-2-one hydroxymethyl Merrifield resin;
Stage #2: With piperidine In 1-methyl-pyrrolidin-2-one for 0.5h; hydroxymethyl Merrifield resin;
100%
Stage #1: Fmoc-Val-OH With pyridine; acetic anhydride; 2,6-Dichlorobenzoyl chloride In 1-methyl-pyrrolidin-2-one for 18h; Sasrin resin;
Stage #2: With acetic anhydride In 1-methyl-pyrrolidin-2-one at 45℃; for 3h; Sasrin resin;
Stage #3: With piperidine In 1-methyl-pyrrolidin-2-one for 1h; Sasrin resin;
100%
fmoc-Leu-Alko Resin

fmoc-Leu-Alko Resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

C32H53N5O6

C32H53N5O6

Conditions
ConditionsYield
Stage #1: fmoc-Leu-Alko Resin With piperidine In N,N-dimethyl-formamide Wang resin;
Stage #2: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1.5h; Wang resin; Heating;
Stage #3: Fmoc-Val-OH; N-Fmoc L-Phe Further stages;
100%
fmoc-Leu-Alko Resin

fmoc-Leu-Alko Resin

N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

C28H45N5O6
1613374-23-4

C28H45N5O6

Conditions
ConditionsYield
Stage #1: fmoc-Leu-Alko Resin With piperidine In N,N-dimethyl-formamide Wang resin;
Stage #2: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1.5h; Wang resin; Heating;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; N-Fmoc L-Phe Further stages;
100%
fmoc-Leu-Alko Resin

fmoc-Leu-Alko Resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

N-(9-fluorenylmethyloxycarbonyl)-4-aminobutyric acid
116821-47-7

N-(9-fluorenylmethyloxycarbonyl)-4-aminobutyric acid

C30H49N5O6
1613374-25-6

C30H49N5O6

Conditions
ConditionsYield
Stage #1: fmoc-Leu-Alko Resin With piperidine In N,N-dimethyl-formamide Wang resin;
Stage #2: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1.5h; Wang resin; Heating;
Stage #3: Fmoc-Val-OH; N-Fmoc L-Phe; N-(9-fluorenylmethyloxycarbonyl)-4-aminobutyric acid Further stages;
100%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Fmoc-Leu-OH
35661-60-0

Fmoc-Leu-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

Fmoc-Tyr(tBu)-OH
71989-38-3

Fmoc-Tyr(tBu)-OH

Fmoc-Thr(tBu)-OH
71989-35-0

Fmoc-Thr(tBu)-OH

H2N-Thr(tBu)-Phe-Leu-Tyr(tBu)-Val-Gly-OH

H2N-Thr(tBu)-Phe-Leu-Tyr(tBu)-Val-Gly-OH

Conditions
ConditionsYield
Stage #1: Fmoc-Thr(tBu)-OH With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.1h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; Fmoc-Leu-OH; N-Fmoc L-Phe; Fmoc-Tyr(tBu)-OH Further stages;
100%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

C65H124N2O5

C65H124N2O5

C85H143N3O8

C85H143N3O8

Conditions
ConditionsYield
With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 20 - 40℃;100%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

C69H130N4O7

C69H130N4O7

C89H149N5O10

C89H149N5O10

Conditions
ConditionsYield
With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 20 - 40℃; for 2h;100%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)aniline
1421051-27-5

2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)aniline

(9H-fluoren-9-yl)methyl (S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-3-methyl-1-oxobutan-2-ylcarbamate
1421051-33-3

(9H-fluoren-9-yl)methyl (S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-3-methyl-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 3h;99.5%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

Phorbol 13,20-diacetate
41621-85-6

Phorbol 13,20-diacetate

C44H51NO11

C44H51NO11

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane99%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

3-(Dimethylamino)-2,2-dimethyl-2H-azirine

3-(Dimethylamino)-2,2-dimethyl-2H-azirine

Fmoc-Val-Aib-NMe2
128422-14-0

Fmoc-Val-Aib-NMe2

Conditions
ConditionsYield
In diethyl ether Ambient temperature;99%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

cyanomethylene triphenylphosphorane
16640-68-9

cyanomethylene triphenylphosphorane

C40H35N2O3P
1124196-12-8

C40H35N2O3P

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h; Inert atmosphere;99%
pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-oxime

pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-oxime

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-O-(N-Fmoc-L-valine)-E-oxime
1185296-45-0

pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-O-(N-Fmoc-L-valine)-E-oxime

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane Inert atmosphere;99%
pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-oxime
1185296-44-9

pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-oxime

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-O-(N-Fmoc-L-valine)-Z-oxime
1185296-48-3

pregn-4-ene-3,20-dione cyclic 20-(ethylene acetal) 3-O-(N-Fmoc-L-valine)-Z-oxime

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane Inert atmosphere;99%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

tert-butyl hexa-4,5-dienoate
1598407-82-9

tert-butyl hexa-4,5-dienoate

(R)-tert-butyl 4-(((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoyl)oxy)hex-5-enoate
1598407-88-5

(R)-tert-butyl 4-(((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoyl)oxy)hex-5-enoate

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; (S,S)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane In 1,2-dichloro-ethane at 10℃; for 48h; Schlenk technique; Inert atmosphere; diastereoselective reaction;99%
Fmoc-alanine-Wang-resin

Fmoc-alanine-Wang-resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

acetic anhydride
108-24-7

acetic anhydride

(2S,3R)-Fmoc-O-benzyl-threonine
117872-75-0

(2S,3R)-Fmoc-O-benzyl-threonine

N-acetyl-L-valyl-L-(OBn)threonyl-L-alanine

N-acetyl-L-valyl-L-(OBn)threonyl-L-alanine

Conditions
ConditionsYield
Stage #1: Fmoc-alanine-Wang-resin With piperidine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #2: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #3: Fmoc-Val-OH; acetic anhydride; (2S,3R)-Fmoc-O-benzyl-threonine Further stages;
99%
Fmoc-Gly-Wang resin

Fmoc-Gly-Wang resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

acetic anhydride
108-24-7

acetic anhydride

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucine
71989-23-6

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucine

N-acetyl-L-isoleucyl-L-valylglycine

N-acetyl-L-isoleucyl-L-valylglycine

Conditions
ConditionsYield
Stage #1: Fmoc-Gly-Wang resin With piperidine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #2: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #3: Fmoc-Val-OH; acetic anhydride; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucine Further stages;
99%
Fmoc-Gly-Wang resin

Fmoc-Gly-Wang resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

acetic anhydride
108-24-7

acetic anhydride

N-acetyl-L-phenylalanyl-L-valylglycine

N-acetyl-L-phenylalanyl-L-valylglycine

Conditions
ConditionsYield
Stage #1: Fmoc-Gly-Wang resin With piperidine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #2: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #3: Fmoc-Val-OH; N-Fmoc L-Phe; acetic anhydride Further stages;
99%
Fmoc-Gly-Wang resin

Fmoc-Gly-Wang resin

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

acetic anhydride
108-24-7

acetic anhydride

Fmoc-Phg-OH
102410-65-1

Fmoc-Phg-OH

N-acetyl-L-phenylglycyl-L-valylglycine

N-acetyl-L-phenylglycyl-L-valylglycine

Conditions
ConditionsYield
Stage #1: Fmoc-Gly-Wang resin With piperidine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #2: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 75℃; for 0.05h; Fmoc-Ala-Wang-resin; Inert atmosphere; Microwave irradiation;
Stage #3: Fmoc-Val-OH; acetic anhydride; Fmoc-Phg-OH Further stages;
99%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

(4-(hydroxymethyl)phenyl)diphenylphosphine oxide
5068-20-2

(4-(hydroxymethyl)phenyl)diphenylphosphine oxide

C39H36NO5P

C39H36NO5P

Conditions
ConditionsYield
Stage #1: Fmoc-Val-OH; (4-(hydroxymethyl)phenyl)diphenylphosphine oxide With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h;
Stage #2: With dmap In dichloromethane at 20℃; for 2h;
99%
Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

(((R)-2'-(((S,E)-6-((tert-butoxycarbonyl)amino)-3-hydroxyhex-4-enamido)methyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carbonyl)oxy)fermium

(((R)-2'-(((S,E)-6-((tert-butoxycarbonyl)amino)-3-hydroxyhex-4-enamido)methyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carbonyl)oxy)fermium

(((R)-2'-((5S,8S)-8-((1E,3E)-3-((tert-butoxycarbonyl)iminio)prop-1-en-1-yl)-1-(9H-fluoren-9-yl)-5-isopropyl-3,6,10-trioxo-2,7-dioxa-4,11-diazadodecan-12-yl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carbonyl)oxy)fermium

(((R)-2'-((5S,8S)-8-((1E,3E)-3-((tert-butoxycarbonyl)iminio)prop-1-en-1-yl)-1-(9H-fluoren-9-yl)-5-isopropyl-3,6,10-trioxo-2,7-dioxa-4,11-diazadodecan-12-yl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carbonyl)oxy)fermium

Conditions
ConditionsYield
Stage #1: Fmoc-Val-OH With 2,4,6-trichlorobenzoyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h; Yamaguchi Lactonization; Inert atmosphere;
Stage #2: (((R)-2'-(((S,E)-6-((tert-butoxycarbonyl)amino)-3-hydroxyhex-4-enamido)methyl)-4-methyl-4,5-dihydro-[2,4'-bithiazole]-4-carbonyl)oxy)fermium With dmap In tetrahydrofuran at 0 - 25℃; for 0.5h; Yamaguchi Lactonization; Inert atmosphere;
99%

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