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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(R)-(-)-3-hydroxy-2-methylpropionic acid methyl ester

Cas:72657-23-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Methyl (R)-(-)-3-hydroxy-2-methylpropionate

Cas:72657-23-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(r)-(-)-3-hydroxy-2-methylpropionic Acid Methyl Ester CAS NO.72657-23-9

Cas:72657-23-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-(-)-3-Hydroxyisobutyric acid methyl ester

Cas:72657-23-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--72657-23-9--(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had es

TIANFUCHEM--72657-23-9--(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER in stock

Cas:72657-23-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 72657-23-9 with best quality

Cas:72657-23-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:10 Kilogram

FOB Price: $100.0 / 120.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2R)-

Cas:72657-23-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER CAS:72657-23-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER CAS:72657-23-9

Cas:72657-23-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2R)-

Cas:72657-23-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:72657-23-9

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Methyl (R)-(-)-3-hydroxy-2-methylpropionate

Cas:72657-23-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Appearance/Colour:Clear Colorless Oil Vapor Pressure:0.361mmHg at 25°C Refractive Index:n20/D 1.425 Boiling Point:76-77 °C12 mm Hg(lit.) PKA:14.40±0.10(Predicted) Flash Point:80 ºC PSA:46.53000 Density:1.066 Log

Fast Delivery 72657-23-9 (R)-Methyl 3-hydroxy-2-methylpropanoate

Cas:72657-23-9

Min.Order:1 Gram

FOB Price: $8.0

Type:Trading Company

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

Cas:72657-23-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(r)-(-)-3-hydroxy-2-methylpropionic Acid Methyl Ester

Cas:72657-23-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

Cas:72657-23-9

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(R)-(-)-3-Hydroxy-2-methylpropionicacidmethylester

Cas:72657-23-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Synonyms: (R)-(-)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER;(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER;(R)-(-)-METHYL B-HYDROXYISOBUTYRATE;(R)-(-)-METHYL 3-HYDROXY-2-MET

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

Cas:72657-23-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Methyl (R)-(-)-3-hydroxy-2-methylpropionate

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

(R)-Methyl 3-hydroxy-2-methylpropanoate

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Methyl (R)-(-)-3-hydroxy-2-methylpropionate

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester cas no. 72657-23-9 98%

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester/72657-23-9 high purity

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

(R)-(-)-methyl B-hydroxyisobutyrate

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(R)-Methyl 3-hydroxy-2-Methylpropanoate

Cas:72657-23-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

C16H24O3Si

C16H24O3Si

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon88%
(2R)-3-hydroxy-2-methylpropanoic acid
1910-47-0

(2R)-3-hydroxy-2-methylpropanoic acid

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
In diethyl ether86%
methyl (2R)-3-(benzyloxy)-2-methylpropanoate
56850-58-9, 59965-24-1, 74924-27-9, 112068-34-5

methyl (2R)-3-(benzyloxy)-2-methylpropanoate

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 50℃; Industrial scale;84%
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
212051-35-9

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With t-butyl bromide In acetonitrile for 0.833333h; Reflux; chemoselective reaction;72%
methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With glucose dehydrogenase; potassium phosphate; D-glucose; ene reductase YqjM wild type enzyme; NADPH In 2-methyltetrahydrofuran; aq. phosphate buffer at 30℃; pH=7.5; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction;58%
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (Rc,Ra)-THNAPhos; hydrogen In dichloromethane at 20℃; under 7500.75 Torr; for 24h; optical yield given as %ee;
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1-(3-(diphenylphosphanyl)phenyl)urea; (2S)-methyl (S)-2-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-ylamino)-2-isobutylethanoate; hydrogen In dichloromethane at 24.84℃; under 7500.75 Torr; for 16h;
methyl (2R,5S,E)-5-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-3-enoate

methyl (2R,5S,E)-5-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-3-enoate

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
Stage #1: methyl (2R,5S,E)-5-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-3-enoate With ozone In methanol at -78℃;
Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃;
48%

A

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

B

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
In diethyl ether Yield given. Yields of byproduct given. Title compound not separated from byproducts;
methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

A

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

B

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With hydrogen; {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate In methanol at 30℃; under 3000.3 Torr; Product distribution; Further Variations:; Catalysts;
With hydrogen; Ru(cod)(η3-methylallyl)2/(R)-SYNPHOS/HBF4 In methanol at 50℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.;
With hydrogen; p-benzoquinone; [RuH(η6-cycloocta-1,3,5-triene)(S)-SYNPHOS]BF4 In methanol at 15℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.;
methyl 3-hydroxy-2-methylpropanoate
64809-29-6

methyl 3-hydroxy-2-methylpropanoate

A

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

B

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With [Rh(dppb)(COD)]BF4; hydrogen In methanol at 20℃; under 45004.5 Torr; for 20h;
With capillary column subsequently coated with 1) Co(d-Cam)1/2(bdc)1/2(tmdpy) (d-Cam=d-camphoric acid,bdc=1,4-benzenedicarboxylic acid, tmdpy=4,4’-trimethylenedipyridine), 2) peramylated β-cyclodextrin at 93℃; Reagent/catalyst; Resolution of racemate;
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

(R)-2-Methyl-3-(tetrahydro-pyran-2-yloxy)-propionic acid methyl ester
88557-53-3

(R)-2-Methyl-3-(tetrahydro-pyran-2-yloxy)-propionic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran Ambient temperature;100%
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; Inert atmosphere;100%
With toluene-4-sulfonic acid In diethyl ether at 20℃;99%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate
105859-44-7

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 5℃; Etherification; silylation;100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 3h;100%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;100%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

diphenyldisulfane
882-33-7

diphenyldisulfane

(S)-2-methyl-3-(phenylsulfanyl)propanoic acid methyl ester
121783-48-0

(S)-2-methyl-3-(phenylsulfanyl)propanoic acid methyl ester

Conditions
ConditionsYield
With tributylphosphine In acetonitrile for 4.5h; Ambient temperature;100%
With tributylphosphine In N,N-dimethyl-formamide at 0 - 20℃; for 4h;95%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate
95514-03-7

(R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane Ambient temperature;100%
With 1H-imidazole In dichloromethane100%
With 1H-imidazole In N,N-dimethyl-formamide Alkylation;100%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

O-(4-methoxybenzyl)-trichloroacetimidate
89238-99-3

O-(4-methoxybenzyl)-trichloroacetimidate

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
212051-35-9

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 20℃;100%
With camphor-10-sulfonic acid In dichloromethane for 16h;98%
With camphor-10-sulfonic acid In hexane; dichloromethane at 20℃; for 12h; Inert atmosphere;96%
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

methyl (2R)-2-methyl-3-[(1,1,1-triisopropylsilyl)oxy]propanoate
232280-22-7

methyl (2R)-2-methyl-3-[(1,1,1-triisopropylsilyl)oxy]propanoate

Conditions
ConditionsYield
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 72h; silylation;100%
With 1H-imidazole; dmap In dichloromethane at 20℃;100%
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature;99%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

(R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-methyl-propionic acid methyl ester
286458-65-9

(R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-methyl-propionic acid methyl ester

Conditions
ConditionsYield
With 2,3,5-trimethyl-pyridine In dichloromethane at 25℃; Substitution;100%
With pyridine at 20℃; for 4h;
With 2,4,6-trimethyl-pyridine In dichloromethane at 0℃;
triethylsilyl chloride
994-30-9

triethylsilyl chloride

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

methyl (R)-2-methyl-3-(triethylsilyl)oxypropanoate
343764-58-9

methyl (R)-2-methyl-3-(triethylsilyl)oxypropanoate

Conditions
ConditionsYield
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;100%
With 1H-imidazole; dmap99%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; for 4h;
With 1H-imidazole Inert atmosphere;
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

trityl chloride
76-83-5

trityl chloride

methyl (R)-(-)-3-trityloxy-2-methylpropionate

methyl (R)-(-)-3-trityloxy-2-methylpropionate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
With dmap; triethylamine In dichloromethane at 20℃; for 18h; Inert atmosphere; Cooling with ice;90%
With dmap; triethylamine In dichloromethane at 20℃;63%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Trichloroacetyl isocyanate
3019-71-4

Trichloroacetyl isocyanate

(R)-2-Methyl-3-(2,2,2-trichloro-acetylcarbamoyloxy)-propionic acid methyl ester

(R)-2-Methyl-3-(2,2,2-trichloro-acetylcarbamoyloxy)-propionic acid methyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h;100%
In dichloromethane at 20℃; for 1h;
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

(S)-3-(Benzothiazol-2-ylsulfanyl)-2-methyl-propionic acid methyl ester

(S)-3-(Benzothiazol-2-ylsulfanyl)-2-methyl-propionic acid methyl ester

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;100%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
212051-35-9

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In diethyl ether at 20℃; for 18h; Inert atmosphere;100%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

methyl (R)-(-)-3-hydroxy-2-methylpropionate THP ether

methyl (R)-(-)-3-hydroxy-2-methylpropionate THP ether

Conditions
ConditionsYield
With toluene-4-sulfonic acid In diethyl ether Ambient temperature;99%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

methylmagnesium bromide
75-16-1

methylmagnesium bromide

(R)-2,3-dimethyl-1,3-butanediol
73295-16-6

(R)-2,3-dimethyl-1,3-butanediol

Conditions
ConditionsYield
In diethyl ether at 0 - 25℃; for 1.5h;99%
In tetrahydrofuran at -10℃; for 3h; Grignard Reaction; Inert atmosphere;77%
In diethyl ether at 0 - 20℃; for 3h;72%
In tetrahydrofuran; diethyl ether57%
In tetrahydrofuran; diethyl ether at 0℃; for 2h;57%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

(R)-(-)-methyl 3-(methoxymethoxy)-2-methylpropionate
112763-36-7

(R)-(-)-methyl 3-(methoxymethoxy)-2-methylpropionate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Ambient temperature;99%
With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Ambient temperature;99%
With diisopropylamine In dichloromethane for 16h; Ambient temperature;99%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

methyl (R)-2-methyl-3-[(4'-toluenesulfonyl)oxy]propionate
84341-94-6

methyl (R)-2-methyl-3-[(4'-toluenesulfonyl)oxy]propionate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 1h;99%
With dmap; triethylamine In dichloromethane at 20℃; for 12h; Cooling with ice;98%
With triethylamine In dichloromethane at 20℃; for 12h;98%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

acetic anhydride
108-24-7

acetic anhydride

Methyl (R)(-)-3-acetoxy-2-methylpropanoate
73295-10-0, 96641-50-8

Methyl (R)(-)-3-acetoxy-2-methylpropanoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-pyridine; sodium tetracarbonyl cobaltate In acetonitrile for 12h;99%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

1,3-diallyl-6-[4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-benzyloxy]-1,3,5-triazine-2,4(1H,3H)-dione

1,3-diallyl-6-[4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-benzyloxy]-1,3,5-triazine-2,4(1H,3H)-dione

methyl (2R)-3-[4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-benzyloxy]-2-methylpropionate

methyl (2R)-3-[4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-benzyloxy]-2-methylpropionate

Conditions
ConditionsYield
With 2,6-di-tert-butylpyridin-1-ium trifluoromethanesulfonate In 1,4-dioxane at 20℃; for 4h; Molecular sieve;99%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

ethyl vinyl ether
109-92-2

ethyl vinyl ether

methyl (R)-3-(1'-ethoxyethoxy)-2-methylpropanoate
910131-57-6

methyl (R)-3-(1'-ethoxyethoxy)-2-methylpropanoate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane for 4h; Ambient temperature;98.1%
With toluene-4-sulfonic acid In diethyl ether at 20℃; for 2h;93%
With pyridinium p-toluenesulfonate In dichloromethane for 0.25h; Ambient temperature;
With pyridinium p-toluenesulfonate
With pyridinium p-toluenesulfonate In dichloromethane at 20℃;
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate
212051-23-5

3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate

methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate
212051-39-3

methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 1h;98%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

1-Phenyl-1H-tetrazole-5-thiol
86-93-1

1-Phenyl-1H-tetrazole-5-thiol

(2S)-methyl-3-(1-phenyl-1H-tetrazol-5-ylsulfanyl)propionic acid methyl ester
845734-61-4

(2S)-methyl-3-(1-phenyl-1H-tetrazol-5-ylsulfanyl)propionic acid methyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 5h;98%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;98%
2-benzyloxy-1-methylpyridinium triflate

2-benzyloxy-1-methylpyridinium triflate

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

methyl (2R)-3-(benzyloxy)-2-methylpropanoate
56850-58-9, 59965-24-1, 74924-27-9, 112068-34-5

methyl (2R)-3-(benzyloxy)-2-methylpropanoate

Conditions
ConditionsYield
In α,α,α-trifluorotoluene at 120℃; for 0.333333h; Microwave irradiation;98%
With magnesium oxide In α,α,α-trifluorotoluene at 80℃; for 24h;85%
With magnesium oxide at 83℃; for 24h; Inert atmosphere;82%
With magnesium oxide In 1,2-dichloro-ethane Heating;72%
Benzyloxymethyl chloride
3587-60-8

Benzyloxymethyl chloride

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

(2R)-3-benzyloxymethoxy-2-methylpropionic acid methyl ester
116021-11-5

(2R)-3-benzyloxymethoxy-2-methylpropionic acid methyl ester

Conditions
ConditionsYield
Stage #1: Benzyloxymethyl chloride; methyl (R)-3-hydroxy-2-methylpropionate With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃; for 16h;
Stage #2: With tetra-(n-butyl)ammonium iodide In dichloromethane at 20℃; for 3h;
97%
Stage #1: Benzyloxymethyl chloride; methyl (R)-3-hydroxy-2-methylpropionate With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃;
Stage #2: With tetra-(n-butyl)ammonium iodide at 20℃; for 3h;
97%
With N-ethyl-N,N-diisopropylamine In dichloromethane for 44h; Ambient temperature;
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

methyl (S)-3-iodo-2-methylpropanoate
149093-02-7

methyl (S)-3-iodo-2-methylpropanoate

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether; acetonitrile at 0 - 20℃; for 2.5h;97%
Stage #1: methyl (R)-3-hydroxy-2-methylpropionate With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 0 - 20℃; for 2.5h;
Stage #2: With sodium iodide In acetonitrile at 70℃; for 16h;
72%
1.) tosylation; 2.) iodination; Multistep reaction;
4-methoxybenzyl trichloroacetimidate

4-methoxybenzyl trichloroacetimidate

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
212051-35-9

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

Conditions
ConditionsYield
With lanthanum(lll) triflate In toluene at 0 - 20℃; for 16h; Inert atmosphere;97%
(R)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-amine
470662-82-9

(R)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-amine

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-(R)-(3-hydroxy-2-(R)-methyl)propionamide
1169760-41-1

N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-(R)-(3-hydroxy-2-(R)-methyl)propionamide

Conditions
ConditionsYield
Stage #1: (R)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-amine With diisobutylaluminium hydride In tetrahydrofuran at 10 - 20℃; Inert atmosphere;
Stage #2: methyl (R)-3-hydroxy-2-methylpropionate In tetrahydrofuran at -10 - 50℃;
Stage #3: With water; Rochelle's salt In tetrahydrofuran for 2h; Inert atmosphere;
96.8%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

4-(4,6-diphenoxy-1,3,5-triazine-2-yl)-4-benzylmorpholinium trifluoromethanesulfonate

4-(4,6-diphenoxy-1,3,5-triazine-2-yl)-4-benzylmorpholinium trifluoromethanesulfonate

methyl (2R)-3-(benzyloxy)-2-methylpropanoate
56850-58-9, 59965-24-1, 74924-27-9, 112068-34-5

methyl (2R)-3-(benzyloxy)-2-methylpropanoate

Conditions
ConditionsYield
With magnesium oxide In 1,2-dimethoxyethane at 20℃; for 2h; Inert atmosphere;96%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

methyl (2R)-3-(benzyloxy)-2-methylpropanoate
56850-58-9, 59965-24-1, 74924-27-9, 112068-34-5

methyl (2R)-3-(benzyloxy)-2-methylpropanoate

Conditions
ConditionsYield
With trifluoroacetic acid In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;95%
With trifluorormethanesulfonic acid In dichloromethane at 0℃;91%
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 20℃; for 3h;88%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

3,4-dimethoxybenzyl 2,2,3,3,4,4,4-heptafluorobutyrimidate
212051-26-8

3,4-dimethoxybenzyl 2,2,3,3,4,4,4-heptafluorobutyrimidate

methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate
212051-39-3

methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 1h;95%
methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

1,3-diallyl-6-(4-nitrobenzyloxy)-1,3,5-triazine-2,4(1H,3H)-dione

1,3-diallyl-6-(4-nitrobenzyloxy)-1,3,5-triazine-2,4(1H,3H)-dione

methyl (2R)-3-[(4-nitrobenzyl)oxy]-2-methylpropionate

methyl (2R)-3-[(4-nitrobenzyl)oxy]-2-methylpropionate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In 1,4-dioxane at 50℃; for 4h; Molecular sieve;95%

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