Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:72657-23-9
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:72657-23-9
Min.Order:1 Kilogram
FOB Price: $5.0
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:72657-23-9
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:72657-23-9
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryTIANFUCHEM--72657-23-9--(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had es
Cas:72657-23-9
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:72657-23-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:72657-23-9
Min.Order:10 Kilogram
FOB Price: $100.0 / 120.0
Type:Trading Company
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:72657-23-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER CAS:72657-23-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali
Cas:72657-23-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:72657-23-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:72657-23-9
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAppearance/Colour:Clear Colorless Oil Vapor Pressure:0.361mmHg at 25°C Refractive Index:n20/D 1.425 Boiling Point:76-77 °C12 mm Hg(lit.) PKA:14.40±0.10(Predicted) Flash Point:80 ºC PSA:46.53000 Density:1.066 Log
Cas:72657-23-9
Min.Order:1 Gram
FOB Price: $8.0
Type:Trading Company
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:72657-23-9
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:72657-23-9
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:72657-23-9
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:72657-23-9
Min.Order:1 Kilogram
FOB Price: $50.0 / 100.0
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:72657-23-9
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryProduct Name: (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Synonyms: (R)-(-)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER;(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER;(R)-(-)-METHYL B-HYDROXYISOBUTYRATE;(R)-(-)-METHYL 3-HYDROXY-2-MET
Cas:72657-23-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Cas:72657-23-9
Min.Order:0
Negotiable
Type:Other
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:72657-23-9
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:72657-23-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:72657-23-9
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:72657-23-9
Min.Order:0
Negotiable
Type:Manufacturers
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:72657-23-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:72657-23-9
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:72657-23-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:72657-23-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
Cas:72657-23-9
Min.Order:0
Negotiable
Type:Manufacturers
inquirymethyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon | 88% |
diazomethane
(2R)-3-hydroxy-2-methylpropanoic acid
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
In diethyl ether | 86% |
methyl (2R)-3-(benzyloxy)-2-methylpropanoate
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 50℃; Industrial scale; | 84% |
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With t-butyl bromide In acetonitrile for 0.833333h; Reflux; chemoselective reaction; | 72% |
methyl 2-hydroxymethylacrylate
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With glucose dehydrogenase; potassium phosphate; D-glucose; ene reductase YqjM wild type enzyme; NADPH In 2-methyltetrahydrofuran; aq. phosphate buffer at 30℃; pH=7.5; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction; | 58% |
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (Rc,Ra)-THNAPhos; hydrogen In dichloromethane at 20℃; under 7500.75 Torr; for 24h; optical yield given as %ee; | |
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1-(3-(diphenylphosphanyl)phenyl)urea; (2S)-methyl (S)-2-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-ylamino)-2-isobutylethanoate; hydrogen In dichloromethane at 24.84℃; under 7500.75 Torr; for 16h; |
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
Stage #1: methyl (2R,5S,E)-5-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-3-enoate With ozone In methanol at -78℃; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; | 48% |
diazomethane
3-hydroxyisobutyric acid
A
3-hydroxy-(2S)-methylpropionate
B
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
In diethyl ether Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
methyl 2-hydroxymethylacrylate
A
3-hydroxy-(2S)-methylpropionate
B
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With hydrogen; {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate In methanol at 30℃; under 3000.3 Torr; Product distribution; Further Variations:; Catalysts; | |
With hydrogen; Ru(cod)(η3-methylallyl)2/(R)-SYNPHOS/HBF4 In methanol at 50℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.; | |
With hydrogen; p-benzoquinone; [RuH(η6-cycloocta-1,3,5-triene)(S)-SYNPHOS]BF4 In methanol at 15℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.; |
methyl 3-hydroxy-2-methylpropanoate
A
3-hydroxy-(2S)-methylpropionate
B
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With [Rh(dppb)(COD)]BF4; hydrogen In methanol at 20℃; under 45004.5 Torr; for 20h; | |
With capillary column subsequently coated with 1) Co(d-Cam)1/2(bdc)1/2(tmdpy) (d-Cam=d-camphoric acid,bdc=1,4-benzenedicarboxylic acid, tmdpy=4,4’-trimethylenedipyridine), 2) peramylated β-cyclodextrin at 93℃; Reagent/catalyst; Resolution of racemate; |
3,4-dihydro-2H-pyran
methyl (R)-3-hydroxy-2-methylpropionate
(R)-2-Methyl-3-(tetrahydro-pyran-2-yloxy)-propionic acid methyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran Ambient temperature; | 100% |
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; Inert atmosphere; | 100% |
With toluene-4-sulfonic acid In diethyl ether at 20℃; | 99% |
methyl (R)-3-hydroxy-2-methylpropionate
tert-butyldimethylsilyl chloride
methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 5℃; Etherification; silylation; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 3h; | 100% |
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
methyl (R)-3-hydroxy-2-methylpropionate
diphenyldisulfane
(S)-2-methyl-3-(phenylsulfanyl)propanoic acid methyl ester
Conditions | Yield |
---|---|
With tributylphosphine In acetonitrile for 4.5h; Ambient temperature; | 100% |
With tributylphosphine In N,N-dimethyl-formamide at 0 - 20℃; for 4h; | 95% |
methyl (R)-3-hydroxy-2-methylpropionate
tert-butylchlorodiphenylsilane
(R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane Ambient temperature; | 100% |
With 1H-imidazole In dichloromethane | 100% |
With 1H-imidazole In N,N-dimethyl-formamide Alkylation; | 100% |
methyl (R)-3-hydroxy-2-methylpropionate
O-(4-methoxybenzyl)-trichloroacetimidate
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; | 100% |
With camphor-10-sulfonic acid In dichloromethane for 16h; | 98% |
With camphor-10-sulfonic acid In hexane; dichloromethane at 20℃; for 12h; Inert atmosphere; | 96% |
triisopropylsilyl chloride
methyl (R)-3-hydroxy-2-methylpropionate
methyl (2R)-2-methyl-3-[(1,1,1-triisopropylsilyl)oxy]propanoate
Conditions | Yield |
---|---|
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 72h; silylation; | 100% |
With 1H-imidazole; dmap In dichloromethane at 20℃; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature; | 99% |
methyl (R)-3-hydroxy-2-methylpropionate
4,4'-dimethoxytrityl chloride
(R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-methyl-propionic acid methyl ester
Conditions | Yield |
---|---|
With 2,3,5-trimethyl-pyridine In dichloromethane at 25℃; Substitution; | 100% |
With pyridine at 20℃; for 4h; | |
With 2,4,6-trimethyl-pyridine In dichloromethane at 0℃; |
triethylsilyl chloride
methyl (R)-3-hydroxy-2-methylpropionate
methyl (R)-2-methyl-3-(triethylsilyl)oxypropanoate
Conditions | Yield |
---|---|
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
With 1H-imidazole; dmap | 99% |
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; for 4h; | |
With 1H-imidazole Inert atmosphere; |
methyl (R)-3-hydroxy-2-methylpropionate
trityl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
With dmap; triethylamine In dichloromethane at 20℃; for 18h; Inert atmosphere; Cooling with ice; | 90% |
With dmap; triethylamine In dichloromethane at 20℃; | 63% |
methyl (R)-3-hydroxy-2-methylpropionate
Trichloroacetyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1h; | 100% |
In dichloromethane at 20℃; for 1h; |
methyl (R)-3-hydroxy-2-methylpropionate
2-Mercaptobenzothiazole
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; | 100% |
methyl (R)-3-hydroxy-2-methylpropionate
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In diethyl ether at 20℃; for 18h; Inert atmosphere; | 100% |
3,4-dihydro-2H-pyran
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In diethyl ether Ambient temperature; | 99% |
methyl (R)-3-hydroxy-2-methylpropionate
methylmagnesium bromide
(R)-2,3-dimethyl-1,3-butanediol
Conditions | Yield |
---|---|
In diethyl ether at 0 - 25℃; for 1.5h; | 99% |
In tetrahydrofuran at -10℃; for 3h; Grignard Reaction; Inert atmosphere; | 77% |
In diethyl ether at 0 - 20℃; for 3h; | 72% |
In tetrahydrofuran; diethyl ether | 57% |
In tetrahydrofuran; diethyl ether at 0℃; for 2h; | 57% |
methyl (R)-3-hydroxy-2-methylpropionate
chloromethyl methyl ether
(R)-(-)-methyl 3-(methoxymethoxy)-2-methylpropionate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Ambient temperature; | 99% |
With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Ambient temperature; | 99% |
With diisopropylamine In dichloromethane for 16h; Ambient temperature; | 99% |
methyl (R)-3-hydroxy-2-methylpropionate
p-toluenesulfonyl chloride
methyl (R)-2-methyl-3-[(4'-toluenesulfonyl)oxy]propionate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 1h; | 99% |
With dmap; triethylamine In dichloromethane at 20℃; for 12h; Cooling with ice; | 98% |
With triethylamine In dichloromethane at 20℃; for 12h; | 98% |
methyl (R)-3-hydroxy-2-methylpropionate
acetic anhydride
Methyl (R)(-)-3-acetoxy-2-methylpropanoate
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-pyridine; sodium tetracarbonyl cobaltate In acetonitrile for 12h; | 99% |
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With 2,6-di-tert-butylpyridin-1-ium trifluoromethanesulfonate In 1,4-dioxane at 20℃; for 4h; Molecular sieve; | 99% |
methyl (R)-3-hydroxy-2-methylpropionate
ethyl vinyl ether
methyl (R)-3-(1'-ethoxyethoxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In dichloromethane for 4h; Ambient temperature; | 98.1% |
With toluene-4-sulfonic acid In diethyl ether at 20℃; for 2h; | 93% |
With pyridinium p-toluenesulfonate In dichloromethane for 0.25h; Ambient temperature; | |
With pyridinium p-toluenesulfonate | |
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; |
methyl (R)-3-hydroxy-2-methylpropionate
3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate
methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 1h; | 98% |
methyl (R)-3-hydroxy-2-methylpropionate
1-Phenyl-1H-tetrazole-5-thiol
(2S)-methyl-3-(1-phenyl-1H-tetrazol-5-ylsulfanyl)propionic acid methyl ester
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 5h; | 98% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; | 98% |
methyl (R)-3-hydroxy-2-methylpropionate
methyl (2R)-3-(benzyloxy)-2-methylpropanoate
Conditions | Yield |
---|---|
In α,α,α-trifluorotoluene at 120℃; for 0.333333h; Microwave irradiation; | 98% |
With magnesium oxide In α,α,α-trifluorotoluene at 80℃; for 24h; | 85% |
With magnesium oxide at 83℃; for 24h; Inert atmosphere; | 82% |
With magnesium oxide In 1,2-dichloro-ethane Heating; | 72% |
Benzyloxymethyl chloride
methyl (R)-3-hydroxy-2-methylpropionate
(2R)-3-benzyloxymethoxy-2-methylpropionic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: Benzyloxymethyl chloride; methyl (R)-3-hydroxy-2-methylpropionate With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃; for 16h; Stage #2: With tetra-(n-butyl)ammonium iodide In dichloromethane at 20℃; for 3h; | 97% |
Stage #1: Benzyloxymethyl chloride; methyl (R)-3-hydroxy-2-methylpropionate With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 20℃; Stage #2: With tetra-(n-butyl)ammonium iodide at 20℃; for 3h; | 97% |
With N-ethyl-N,N-diisopropylamine In dichloromethane for 44h; Ambient temperature; |
methyl (R)-3-hydroxy-2-methylpropionate
methyl (S)-3-iodo-2-methylpropanoate
Conditions | Yield |
---|---|
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether; acetonitrile at 0 - 20℃; for 2.5h; | 97% |
Stage #1: methyl (R)-3-hydroxy-2-methylpropionate With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 0 - 20℃; for 2.5h; Stage #2: With sodium iodide In acetonitrile at 70℃; for 16h; | 72% |
1.) tosylation; 2.) iodination; Multistep reaction; |
methyl (R)-3-hydroxy-2-methylpropionate
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With lanthanum(lll) triflate In toluene at 0 - 20℃; for 16h; Inert atmosphere; | 97% |
(R)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-amine
methyl (R)-3-hydroxy-2-methylpropionate
N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-(R)-(3-hydroxy-2-(R)-methyl)propionamide
Conditions | Yield |
---|---|
Stage #1: (R)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-amine With diisobutylaluminium hydride In tetrahydrofuran at 10 - 20℃; Inert atmosphere; Stage #2: methyl (R)-3-hydroxy-2-methylpropionate In tetrahydrofuran at -10 - 50℃; Stage #3: With water; Rochelle's salt In tetrahydrofuran for 2h; Inert atmosphere; | 96.8% |
methyl (R)-3-hydroxy-2-methylpropionate
methyl (2R)-3-(benzyloxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With magnesium oxide In 1,2-dimethoxyethane at 20℃; for 2h; Inert atmosphere; | 96% |
methyl (R)-3-hydroxy-2-methylpropionate
O-benzyl 2,2,2-trichloroacetimidate
methyl (2R)-3-(benzyloxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With trifluoroacetic acid In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; | 95% |
With trifluorormethanesulfonic acid In dichloromethane at 0℃; | 91% |
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 20℃; for 3h; | 88% |
methyl (R)-3-hydroxy-2-methylpropionate
3,4-dimethoxybenzyl 2,2,3,3,4,4,4-heptafluorobutyrimidate
methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 1h; | 95% |
methyl (R)-3-hydroxy-2-methylpropionate
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In 1,4-dioxane at 50℃; for 4h; Molecular sieve; | 95% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View