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BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

(S)-(+)-3-Hydroxy-2-methylpropionic Acid Methyl Ester

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Methyl (S)-(+)-3-hydroxy-2-methylpropionate

Cas:80657-57-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Methyl (2s)-3-hydroxy-2-methylpropanoate CAS NO.80657-57-4

Cas:80657-57-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-(+)-3-Hydroxyisobutyric acid methyl ester

Cas:80657-57-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name (S)-(+)-methyl B-hydroxyisobutyrate CAS No. 80657-57-4

(S)-(+)-methyl B-hydroxyisobutyrate

Cas:80657-57-4

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE

Cas:80657-57-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 80657-57-4 with competitive price

Cas:80657-57-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE CAS:80657-57-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hi

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE CAS:80657-57-4

Cas:80657-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2S)-

Cas:80657-57-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2S)-

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(S)-(+)-METHYL B-HYDROXYISOBUTYRATE

Cas:80657-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Methyl (S)-3-hydroxyisobutanoate

Cas:80657-57-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (S)-(+)-methyl B-hydroxyisobutyrate

Cas:80657-57-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Methyl (2s)-3-hydroxy-2-methylpropanoate

Cas:80657-57-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Clear colorless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used in o

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2S)-

Cas:80657-57-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(S)-(+)-methylB-hydroxyisobutyrate

Cas:80657-57-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE Synonyms: (S)-(+)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER;(S)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER;(S)-(+)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER;methyl (S)-(+)-3-hydroxy-2

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE

Cas:80657-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

(S)-Methyl 3-hydroxy-2-methylpropanoate

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Methyl (S)-3-hydroxyisobutanoate

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Methyl (S)-(+)-3-Hydroxy-2-Methylpropionate cas no. 80657-57-4 98%

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(S)-(+)-methyl B-hydroxyisobutyrate

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

(S)-(+)-methyl B-hydroxyisobutyrate

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec (S)-()-methyl B-hydroxyisobutyrate 25g

Cas:80657-57-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

(S)-(+)-methyl B-hydroxyisobutyrate

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Good quantity Storage:R.T. Package:as per buyers Application:intermediate Transportation:by air/sea

(S)-(+)-3-Hydroxyisobutyric Acid Methyl Ester

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2S)-

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

(S)-Methyl 3-hydroxy-2-methylpropanoate

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

(S)-(+)-methyl B-hydroxyisobutyrate CAS No.80657-57-4

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

(S)-()-3-Hydroxy-2-methylpropionicAcidMethylEster

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2S)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

Propanoic acid,3-hydroxy-2-methyl-, methyl ester, (2S)-

Cas:80657-57-4

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

Conditions
ConditionsYield
With diisopropyl{1-[(S)-3,5-dioxa-4-phospha-cyclohepta(2,1-a;3,4-a')dinaphthalen-4-yl]-3-methyl-2-indolyl}phosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen In dichloromethane at -40℃; under 15001.5 Torr; for 15h; Reactivity; Pressure; Temperature; Concentration; Inert atmosphere; optical yield given as %ee; enantioselective reaction;87%
With N-methyl-N-{(S)-1-[2-(diphenylphosphino)phenyl]ethyl}-(S)-1,10-bi-2-naphthylphosphoramidite; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen In dichloromethane at 20℃; under 7500.75 Torr; for 24h; optical yield given as %ee;
With BF4(1-)*C8H10Rh(1+)*C17H27NO2P2; hydrogen In dichloromethane at 25℃; under 750.075 Torr; for 1.5h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
(S)-3-acetoxy-2-methyl-propionic acid methyl ester
73295-10-0

(S)-3-acetoxy-2-methyl-propionic acid methyl ester

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

Conditions
ConditionsYield
With potassium carbonate In methanol at 5 - 10℃; for 1h;75%
With potassium carbonate In methanol at 0 - 5℃;75%

A

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

B

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
In diethyl ether Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(S)-(+)-3-hydroxy-2-methyl-propanoic acid
26543-05-5

(S)-(+)-3-hydroxy-2-methyl-propanoic acid

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

Conditions
ConditionsYield
In diethyl ether
In diethyl ether 1.)0 deg C, 2 h, 2.)r.t., overnight; Yield given;
methyl 3-hydroxy-2-methylpropanoate
64809-29-6

methyl 3-hydroxy-2-methylpropanoate

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

arctiopicrin

arctiopicrin

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

Conditions
ConditionsYield
With sodium hydroxide und Behandeln der nach dem Ansaeuern erhaltenen Saeure mit Diazomethan in Aether;
methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

A

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

B

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With hydrogen; {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate In methanol at 30℃; under 3000.3 Torr; Product distribution; Further Variations:; Catalysts;
With hydrogen; Ru(cod)(η3-methylallyl)2/(R)-SYNPHOS/HBF4 In methanol at 50℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.;
With hydrogen; p-benzoquinone; [RuH(η6-cycloocta-1,3,5-triene)(S)-SYNPHOS]BF4 In methanol at 15℃; under 15001.5 Torr; for 23h; Title compound not separated from byproducts.;
C12H16O4

C12H16O4

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 0 - 20℃; for 2h;35 mg
methyl 3-hydroxy-2-methylpropanoate
64809-29-6

methyl 3-hydroxy-2-methylpropanoate

A

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

B

methyl (R)-3-hydroxy-2-methylpropionate
72657-23-9

methyl (R)-3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With [Rh(dppb)(COD)]BF4; hydrogen In methanol at 20℃; under 45004.5 Torr; for 20h;
With capillary column subsequently coated with 1) Co(d-Cam)1/2(bdc)1/2(tmdpy) (d-Cam=d-camphoric acid,bdc=1,4-benzenedicarboxylic acid, tmdpy=4,4’-trimethylenedipyridine), 2) peramylated β-cyclodextrin at 93℃; Reagent/catalyst; Resolution of racemate;
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

methyl 2(S)-methyl-3-tetrahydropyranyloxypropanoate
88557-53-3, 135910-72-4, 135910-76-8, 96895-76-0

methyl 2(S)-methyl-3-tetrahydropyranyloxypropanoate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 25℃; for 3h;100%
With toluene-4-sulfonic acid In diethyl ether100%
With toluene-4-sulfonic acid In diethyl ether100%
Benzyloxymethyl chloride
3587-60-8

Benzyloxymethyl chloride

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

(S)-(+)-(benzyloxy)methyl 3-<(benzyloxy)methoxy>-2-methylpropionate
116021-11-5

(S)-(+)-(benzyloxy)methyl 3-<(benzyloxy)methoxy>-2-methylpropionate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine for 12h; 0 deg C --> room temperature;100%
With N-ethyl-N,N-diisopropylamine at 0℃; for 2h;80%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 8.5h;70%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

(S)-methyl 2-methyl-3-(triisopropylsilyloxy)propanoate
158783-84-7

(S)-methyl 2-methyl-3-(triisopropylsilyloxy)propanoate

Conditions
ConditionsYield
With 1H-imidazole; dmap In dichloromethane at 20℃; for 2h;100%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃;99%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;98%
With 1H-imidazole; dmap In dichloromethane at 20℃; for 1.5h;
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(S)-3-(tert-butyldimethylsilyloxy)-2-methylpropionic acid methyl ester
93454-85-4

(S)-3-(tert-butyldimethylsilyloxy)-2-methylpropionic acid methyl ester

Conditions
ConditionsYield
With 1H-imidazole100%
With 1H-imidazole In N,N-dimethyl-formamide Substitution;100%
With 1H-imidazole In N,N-dimethyl-formamide100%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester
95514-03-7

(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

Conditions
ConditionsYield
With Imd100%
With N-ethyl-N,N-diisopropylamine In dichloromethane100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;100%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

methyl (2S)-3-hydroxy-2-methyl-3-(methylsulfonyloxy)propanoate
142402-78-6

methyl (2S)-3-hydroxy-2-methyl-3-(methylsulfonyloxy)propanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
With triethylamine In dichloromethane at 0℃; for 1h;100%
With triethylamine91%
With triethylamine In dichloromethane at 0 - 20℃; for 1h;
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

diphenyldisulfane
882-33-7

diphenyldisulfane

(R)-2-methyl-3-(phenylsulfanyl)propanoic acid methyl ester
165457-66-9

(R)-2-methyl-3-(phenylsulfanyl)propanoic acid methyl ester

Conditions
ConditionsYield
With tributylphosphine In tetrahydrofuran at 20℃; for 24h;100%
With tributylphosphine In tetrahydrofuran for 24h; Ambient temperature;99%
With tributylphosphine In N,N-dimethyl-formamide at 0 - 20℃; for 4h;85%
With tributylphosphine In N,N-dimethyl-formamide at 0 - 25℃; for 5h; Yield given;
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

methyl (S)-2-methyl-3-(((trifluoromethyl)sulfonyl)oxy)propanoate

methyl (S)-2-methyl-3-(((trifluoromethyl)sulfonyl)oxy)propanoate

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 0.25h;100%
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 0.25h;
With 2,6-dimethylpyridine In dichloromethane at 5℃; for 1h;
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

O-(4-methoxybenzyl)-trichloroacetimidate
89238-99-3

O-(4-methoxybenzyl)-trichloroacetimidate

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate
132969-71-2

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane for 16h; Inert atmosphere;99%
With camphor-10-sulfonic acid In dichloromethane for 16h; Inert atmosphere; Schlenk technique;99%
With (1S)-10-camphorsulfonic acid In dichloromethane for 16h; Inert atmosphere;99%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

benzyl trityl ether
5333-62-0

benzyl trityl ether

(2S)-2-methyl-3-(trityloxy)propionic acid methyl ester
116021-13-7

(2S)-2-methyl-3-(trityloxy)propionic acid methyl ester

Conditions
ConditionsYield
With 4 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 30℃; for 36h;99%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

acetic anhydride
108-24-7

acetic anhydride

(S)-3-acetoxy-2-methyl-propionic acid methyl ester
73295-10-0

(S)-3-acetoxy-2-methyl-propionic acid methyl ester

Conditions
ConditionsYield
zinc(II) perchlorate at 20℃; for 4.5h;99%
With magnesium(II) perchlorate at 20℃; for 3h;95%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

(S)-4-methyl-benzoic acid 2-methoxycarbonyl-propyl ester

(S)-4-methyl-benzoic acid 2-methoxycarbonyl-propyl ester

Conditions
ConditionsYield
With 4-vinylpyridine In dichloromethane at 20℃; for 6h;99%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester
95514-03-7

(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

Conditions
ConditionsYield
With 1H-imidazole; tert-butylchlorodiphenylsilane In dichloromethane99%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

triethylsilyl chloride
994-30-9

triethylsilyl chloride

methyl (S)-2-methyl-3-<(triethylsilyl)oxy>propanoate
178113-84-3

methyl (S)-2-methyl-3-<(triethylsilyl)oxy>propanoate

Conditions
ConditionsYield
With 1H-imidazole; dmap In dichloromethane for 2h; Ambient temperature;98%
With 1H-imidazole; dmap In N,N-dimethyl-formamide90%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; for 4h;90%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

methyl (S)-3-benzyloxy-2-methylpropanoate
74924-27-9

methyl (S)-3-benzyloxy-2-methylpropanoate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane for 38h; Inert atmosphere;98%
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane for 18h; Ambient temperature;97%
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane for 18h; Ambient temperature;97%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(S)-(+)-Methyl-3-<(tert-butyldimethylsilyl)oxy>-2-methylpropionate

(S)-(+)-Methyl-3-<(tert-butyldimethylsilyl)oxy>-2-methylpropionate

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 25℃; for 24h;98%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

ethyl vinyl ether
109-92-2

ethyl vinyl ether

Methyl (S)-(+)-3-(1-ethoxyethoxy)-2-methylpropanoate
104199-85-1, 115166-84-2, 115166-87-5, 142459-19-6, 142459-20-9

Methyl (S)-(+)-3-(1-ethoxyethoxy)-2-methylpropanoate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 25℃; for 0.5h;98%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(2S)-(+)-2-methyl-3-(toluene-4-sulfonyloxy)propionic acid methyl ester
84341-89-9

(2S)-(+)-2-methyl-3-(toluene-4-sulfonyloxy)propionic acid methyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 12h;98%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 20h;96%
With dmap; triethylamine In dichloromethane at 20℃; for 20h;96%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate
132969-71-2

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

Conditions
ConditionsYield
Stage #1: 4-Methoxybenzyl alcohol With sodium hydride In diethyl ether; mineral oil for 0.75h; Inert atmosphere;
Stage #2: With trichloroacetonitrile In diethyl ether; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #3: 3-hydroxy-(2S)-methylpropionate With camphor-10-sulfonic acid In dichloromethane for 2h;
98%
Stage #1: 4-Methoxybenzyl alcohol With sodium hydride; trichloroacetonitrile In diethyl ether; hexane at -5 - 20℃; for 4h;
Stage #2: 3-hydroxy-(2S)-methylpropionate; trifluorormethanesulfonic acid In dichloromethane Further stages.;
94%
With (1S)-(+)-10-camphorsulfonic acid; sodium hydride; trichloroacetonitrile In dichloromethane; cyclohexane
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

4-methoxybenzyl-2,2,2-trichloroacetimidate

4-methoxybenzyl-2,2,2-trichloroacetimidate

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate
132969-71-2

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane at 25℃; Inert atmosphere;98%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

trityl chloride
76-83-5

trityl chloride

(2S)-2-methyl-3-(trityloxy)propionic acid methyl ester
116021-13-7

(2S)-2-methyl-3-(trityloxy)propionic acid methyl ester

Conditions
ConditionsYield
97%
With dmap; triethylamine In dichloromethane at 20℃; for 12h;96%
95%
isobutyl vinyl ether
109-53-5

isobutyl vinyl ether

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

methyl (S)-2-methyl-3-(1-isobutoxyethoxy)propionate

methyl (S)-2-methyl-3-(1-isobutoxyethoxy)propionate

Conditions
ConditionsYield
With sodium hydroxide; pyridinium p-toluenesulfonate In water97%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal
104701-87-3

(2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal

Conditions
ConditionsYield
Stage #1: 3-hydroxy-(2S)-methylpropionate; tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 0 - 23℃;
Stage #2: With diisobutylaluminium hydride In dichloromethane at -78℃;
97%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

N-(4-methoxybenzyl)-2,2,2-trichloroacetamide
123558-64-5

N-(4-methoxybenzyl)-2,2,2-trichloroacetamide

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate
132969-71-2

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

Conditions
ConditionsYield
95%
With trifluorormethanesulfonic acid In diethyl ether at -78 - 20℃; for 2.5h; Inert atmosphere;83%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

2-Methoxypropene
116-11-0

2-Methoxypropene

Methyl 3-(1-Methoxy-1-methyl)ethoxy-2-(S)-methylpropionate
189217-49-0

Methyl 3-(1-Methoxy-1-methyl)ethoxy-2-(S)-methylpropionate

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 0℃; for 0.25h; Etherification;95%
With pyridinium p-toluenesulfonate In dichloromethane
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

benzyl-2,2,2-trichloroacetimidate

benzyl-2,2,2-trichloroacetimidate

methyl (S)-3-benzyloxy-2-methylpropanoate
74924-27-9

methyl (S)-3-benzyloxy-2-methylpropanoate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 0 - 20℃;95%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(S)-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal
183293-41-6

(S)-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal

Conditions
ConditionsYield
Stage #1: 3-hydroxy-(2S)-methylpropionate; p-toluenesulfonyl chloride With dmap; triethylamine In dichloromethane at 20℃; for 12h;
Stage #2: With diisobutylaluminium hydride In toluene at -90℃; for 1h;
95%
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

MOM ether of (S)-(+)-methyl 3-hydroxy-2-methylpropionate
105164-20-3

MOM ether of (S)-(+)-methyl 3-hydroxy-2-methylpropionate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane94%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide
With diisopropylamine In dichloromethane at 20℃;
3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide
18303-04-3

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

methyl (2S)-3-[N-(tert-butoxycarbonyl)-N-(4-methylphenylsulfonyl)]amino-2-methylpropanoate
1192544-73-2

methyl (2S)-3-[N-(tert-butoxycarbonyl)-N-(4-methylphenylsulfonyl)]amino-2-methylpropanoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction; Inert atmosphere;94%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

3-hydroxy-(2S)-methylpropionate
80657-57-4

3-hydroxy-(2S)-methylpropionate

methyl (S)-(+)-3-(tetrahydro-2-pyranyloxy)-2-methylpropionate

methyl (S)-(+)-3-(tetrahydro-2-pyranyloxy)-2-methylpropionate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In diethyl ether at 20℃; for 12h;93%
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